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All Journal JURNAL FARMASIMED (JFM) Jurnal Pengabdian Pada Masyarakat METHABDI
Situmorang, Novrina
Unknown Affiliation
Religion Agriculture, Biological Sciences & Forestry Computer Science & IT Decision Sciences, Operations Research & Management Economics, Econometrics & Finance Education Immunology & microbiology Languange, Linguistic, Communication & Media Medicine & Pharmacology Physics Public Health

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EFEK KATEKIN DAUN GAMBIR (UNCARIA GAMBIR ROXB) TERHADAP KADAR MALONDIALDEHID SERUM DAN EKSPRESI GEN SIRTUIN 1 PADA HIPOKAMPUS MENCIT BETINA MODEL PENUAAN Situmorang, Novrina; ., Zulham; Feryawati, Lita
Jurnal FARMASIMED (JFM) Vol 3 No 2 (2021): Jurnal Farmasimed (JFM)
Publisher : Fakultas Farmasi Institut Kesehatan Medistra Lubuk Pakam

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35451/jfm.v3i2.597

Abstract

Aging is a physiological process characterized by progressive loss of physiological integrity that leads to impaired function and increased susceptibility to death. Oxidative stress is one of the factors that cause aging due to an imbalance between the amount of oxidants and antioxidants. In oxidative stress condition, malondialdehyde levels increase. D-galactose can induce aging in various organ systems. D-galactose induces oxidative stress in various organs through increased production of reactive oxygen species (ROS) and advanced glycation endproducts. In oxidative stress condition, sirtuin1 (Sirt1) produces ribose O-acetyl-ADP which, later, is reduced into ribose ADP. Both of them have a protective effect against oxidative stress. Consumption of antioxidants may prevent aging. Gambir contains health-promoting ingredients such as catechins. This study aims to determine the effect of gambier leaves catechin extract on serum malondialdehyde levels and the expression of sirtuin 1 gene in female mice aging model induced by d-galactose. This is an in vivo experiment with post test-only control group study. The samples were 28 female mice which were divided into 4 groups namely P0, P1, P2, and P3. Each group was injected 150 mg/kgBW d-galactose intraperitoneally. P1, P2, and P3 were treated orally with 100, 200, and 400 mg/kgBW gambir leaves catechin extract, respectively. Statistical test use descriftive analisys. There were significant differences in serum MDA levels in all groups (p=0.002) and there were significant differences between the P0 and P2 groups (p=0.010) and between the P0 and P3 groups (p=0.010). Sirtuin1 gene relative expressions decresead in P1 (0,49), P2 (0,74), and P3 (0,43) as compared to P0 (1.00). Conclusion. Gambir leaves catechin extract reduces serum malondialdehyde levels in aging mouse models induced by d-galactose with an optimal dose of 200mg/kgBW. and cannot reduce the relative expression of Sirt1
PENYULUHAN MANFAAT IMUNISASI DASAR KEPADA MASYARAKAT DESA AJIJULU, KABUPATEN KARO Anto, Endy Juli; Hutasoit, Eka Samuel P.; Rimbun, Surjadi; Sinaga, Inda M.; Manullang, Frengky S.; Situmorang, Novrina; Tiji, Widjaya Taufik; Situmeang, Ivonne Ruth Vitamaya Oishi; Tambunan, Ronald T. H.; Simanjuntak, Evirosa J.; Anjany, Larasaty; Kembaren, Alfri Yoganta S.
Jurnal Pengabdian Pada Masyarakat METHABDI Vol 3 No 1 (2023): Jurnal Pengabdian Pada Masyarakat METHABDI
Publisher : Universitas Methodist Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.46880/methabdi.Vol3No1.pp1-5

Abstract

Community Service carried out by the Faculty of Medicine at the Universitas Methodist Indonesia by providing counseling about the benefits of basic immunization. Community Service was held 14-16 April 2023 in Ajijulu Timur Village, Tigapanah District, Karo Regency, North Sumatra. The counseling method used is by giving lectures, discussions and providing motivation. Question and answer discussions were carried out with the aim of gaining understanding, understanding and solutions as a form of solving problems and constraints faced by the local community. The results of this community service counseling and outreach are very effective considering that there are still many people who do not receive information about the benefits of immunization. With this counseling, the community becomes more aware of the importance of basic immunization. It is hoped that the people of Ajijulu will become more responsive and know how important this basic immunization is for infants, children and adolescents.
PENYULUHAN PENCEGAHAN DIABETES MELITUS DI LEMBAGA PEMASYARAKATAN LABUHAN DELI Situmorang, Novrina; Hutasoit, Eka Samuel P.; Situmeang, Ivonne Ruth V. O.; Br. Sinaga, Inda M. H.; L. Tobing, Paul S. M.; Marpaung, Alexander P.; Simanjuntak, Maestro B. U.; Siregar, Romatiur Marantha B.
Jurnal Pengabdian Pada Masyarakat METHABDI Vol 3 No 2 (2023): Jurnal Pengabdian Pada Masyarakat METHABDI
Publisher : Universitas Methodist Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.46880/methabdi.Vol3No2.pp140-143

Abstract

Community Service (PKM) conducted by the Faculty of Medicine at the Indonesian Methodist University provides counseling on the benefits of basic immunization. Community Service was held on July 28 2023 at the Labuhan Deli Correctional Institution, Medan Labuhan District, Medan City, North Sumatra. Lectures, discussions and motivation are used as orientation methods. A question and answer discussion was held with the aim of gaining insight and understanding from the employees and residents of the Labuhan Deli correctional institution. The result of this outreach is that employees and residents of the Labuhan Deli Penitentiary have knowledge about Diabetes Mellitus, its symptoms, risk factors, and the complications it causes so that employees and the community can carry out prevention as early as possible.
Penyuluhan Pengaruh Gadget Terhadap Kualitas Tidur Remaja Dewasa di Gereja Pantekosta Tabernakel Sihombing, Rombadi Yuliana; Sitohang, Ricky Rich; Situmeang, Ivonne Ruth Vitamaya Oishi; Situmorang, Novrina; Sinaga, Inda M.
Jurnal Pengabdian Pada Masyarakat METHABDI Vol 4 No 1 (2024): Jurnal Pengabdian Pada Masyarakat METHABDI
Publisher : Universitas Methodist Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.46880/methabdi.Vol4No1.pp27-30

Abstract

Gadgets are modern technology developed with various applications and can provide various media news, social networks, and even entertainment. With the development of technology, gadgets have become commonplace among young people, so the younger generation needs to use gadgets every day. The time of gadget use, duration, and high levels of gadget use at night are one of the factors that influence sleep quality in teenagers. This counseling aims to provide information to help investigate the impact of gadget use on sleep quality among young adults at the Congregational Tabernacle Pentecostal Church Jl. Panci, Medan City.
Co-Authors ., Zulham Anjany, Larasaty Br. Sinaga, Inda M. H. Endy Juli Anto Feryawati, Lita Hutasoit, Eka Samuel P. Ivonne Ruth Vitamaya Oishi Situmeang Kembaren, Alfri Yoganta S. L. Tobing, Paul S. M. Manullang, Frengky S. Marpaung, Alexander P. Rimbun, Surjadi Sihombing, Rombadi Yuliana Simanjuntak, Evirosa J. Simanjuntak, Maestro B. U. Sinaga, Inda M. Siregar, Romatiur Marantha B. Sitohang, Ricky Rich Situmeang, Ivonne Ruth V. O. Situmeang, Ivonne Ruth Vitamaya Oishi Tambunan, Ronald T. H. Tiji, Widjaya Taufik