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Thyrotropin Receptor Antibody as a Risk Factor for the Occurrence and Severity of Graves' Ophthalmopathy Ikhsan, Mohammad Robikhul; Kertia, Nyoman; Supanji, Supanji; Rianto, Bambang Udji Djoko
Acta Interna The Journal of Internal Medicine Vol 12, No 1 (2023): Acta Interna The Journal of Internal Medicine
Publisher : Faculty of Medicine Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/actainterna.98158

Background. Graves' disease (GD) is an autoimmune disorder known to be the most common cause of hyperthyroidism. Thyrotropin receptor antibody (TRAb) might be involved in the occurrence and the disease process of Graves’ ophthalmopathy (GO).Objectives. This study aimed to evaluate whether TRAb levels are associated with the occurrence and severity of GO based on the clinical severity of The European Group on Graves' Orbitopathy (EUGOGO).Methods. A case-control study of 44 patients with newly diagnosed Graves’ disease (22 with GO compared to 22 without GO). Diagnosis of GO was made according to Bartley and Gorman’s criteria. Level of thyrotropin receptor antibody was tested with electrochemiluminescence immunoassay (ECLIA) method. Assessment of the clinical severity of GO was documented with EUGOGO scores.Results. Baseline characteristics were similar between 22 patients with GO compared to 22 patients non-GO group. Thyrotropin receptor antibody (TRAb) significantly increased in the GO group (11.223±7.116 IU/L) when compared to non-GO (6.720±3.442 IU/L; P=0.035). Multiple logistic regression analysis shows that 1 IU/L increase of TRAb has a 1.610-fold higher risk for developing GO. In the GO group, there is correlation between TRAb and the severity of GO-based on EUGOGO (r =0.794, P<0.001).Conclusion. Thyrotropin receptors antibody is a risk factor for the occurrence and severity of GO-based on EUGOGO.

The Position of Digital Signatures in Notarial Practice According to The Principle of Tabelionis Officium Fideliter Exercebo Supanji, Supanji; Adjie, Habib
UNES Law Review Vol. 6 No. 3 (2024): UNES LAW REVIEW (Maret 2024)
Publisher : LPPM Universitas Ekasakti Padang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31933/unesrev.v6i3.1769

This research aims to investigate the role of digital signatures in notarization, focusing on their implementation and impact. Against the backdrop of developments in information technology, the use of digital signatures by Notaries is becoming increasingly relevant but also poses challenges in the process of making notarial deeds. The implementation of digital signatures can increase efficiency and security in making notarial deeds, but there are still obstacles related to certainty of time, place of deed making, and the need for more specific regulations related to cyber notary in Indonesia. The results of this study provide an in-depth understanding of the role of digital signatures in notaries and provide a basis for further development in integrating information technology in notarial practice.

When do Ophthalmology Residents Study to Prepare for The National Exam? Widyandana, Doni; Widyaputri, Felicia; Sasongko, Muhammad Bayu; Supanji, Supanji; Alam, Irmastuti Lukitaning
Jurnal Pendidikan Kedokteran Indonesia: The Indonesian Journal of Medical Education Vol 13, No 3 (2024): September
Publisher : Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/jpki.89970

Background: Ophthalmology residents are occupied with clinical services in the hospital. They only have limited time to study. Since 2022, we established a progress test for a residents to facilitate their study especially during the national examination preparation that is obligated to be completed once per year.Aims: To report the allocated time for completing the progress test by ophthalmology residents to inform educational centres about the recommended study time for residents.Case Discussion: Data from the online progress test that was available from the Gadjah Mada e-Learning (GAMEL) platform was extracted ana analysed. The test was concisted of 60 multiple questions and opened for two weeks with a 24 hour access time. In this study, the scores, the time of the test, and time spent to complete the test were descriptively and quantitatively analysed.Results: Overall, 42 out of 55 (76.4%) and 42 out of 56 (75.0%) residents completed the progress test with a total test attempt of 60 and 51 times in 2022 and 2023, respectively. The mean score achieved was 43.3 (min-max 3.3-70.0). Majority of residents (65.8%) access the test at between 16.00 - 23.00 Western Indonesian Time (WIT), while 19.8% and 14.4% at between 09.00 - 16.00 and 03.00 - 09.00 WIT. The mean time spent to complete the test was 55.2 +- 20.9 minutes.Conclusion: Most ophthalmology residents spent their time for completing the progress test after working hours with an average duration of less than an hour. Any national exam preparation programs can be scheduled in this time for better resident’s engagements.

BROLUCIZUMAB FOR WET-AGED RELATED MACULAR DEGENERATION PATIENTS : TOO GOOD TO BE TRUE Purbonegoro, Tania; Prayogo, M. Eko; Agni, A. Nurini; W., Tri Wahyu; Supanji, Supanji; S.W., Firman; Sasongko, M. Bayu
Majalah Oftalmologi Indonesia Vol 49 No S1 (2023): Supplement Edition
Publisher : The Indonesian Ophthalmologists Association (IOA, Perhimpunan Dokter Spesialis Mata Indonesia (Perdami))

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35749/99z4g547

Introduction & Objective: Brolucizumab is the newest anti-vascular endothelial growth factor (anti-VEGF) drug. It showed superior anatomic outcomes compared to other anti-VEGF and noniferiority best corrected visual acuity (BCVA) results for Wet-Aged Related Macular Degeneration (Wet-AMD) patients. In Yogyakarta, its been only used in few patients and we want to report the Effectiveness and safety of brolucizumab in Wet-AMD patients in Yogyakarta. Method: In this retrospective study, all neovascular AMD (nAMD) Patients who underwent brolucizumab intravitreal injections between December 2021 and January 2023 at YAP Eye Hospital were studied. Patient’s demographic data, before and after intravitreal brolucizumab injections (central subfield thickness, intraocular pressure and BCVA) were assessed. Result :This study included 6 eyes of 6 patients ( 3 women) with a mean age of 69.5 years old. The mean follow- up period was 27 ± 10.1 weeks after the first injection of brolucizumab. Three patients were naïve nAMD patient, never got any intravitreal injections and three anti-VEGF experienced nAMD patients with ranibizumab or aflibercept injections prior to brolucizumab. Mean BCVA at baseline (before brolucizumab injection) was 0.12 decimal (6/48) and was 0.29 decimal (6/20) at the last follow-up. Five out of six patients visual acuity were improved,one patient had constant bcva. Four out of six patient central subfield thickness were reduced, none of the patient intraocular pressure increased over 21 mmhg. None of the patient reported any signs of inflammation, vasculitis, or any other ocular or systemic adverse effects. Conclusion :This limited data demonstrated that brolucizumab was safe and effective in stabilizing BCVA for both of nAMD patients who had undergone previous treatment with other anti-VEGFs agents and naive. Future larger multicenter collaborative studies are warranted.

SUTURELESS SCLERAL FIXATION OF INTRAOCULAR LENS IN APHAKIA: CHARACTERISTICS AND VISUAL OUTCOMES Rahma, Fatkhati Saida; S.W., Firman; W., Tri Wahyu; Supanji, Supanji; Sasongko, M. Bayu
Majalah Oftalmologi Indonesia Vol 49 No S1 (2023): Supplement Edition
Publisher : The Indonesian Ophthalmologists Association (IOA, Perhimpunan Dokter Spesialis Mata Indonesia (Perdami))

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35749/nvb60j82

Introduction & Objective: Sutureless Scleral fixation surgery is one of the secondary intraocular lens (IOL) implantation procedures for aphakic patients with absent or deficient capsular bag support that has gained more attention these days. This study aimed to describe the characteristics, indications for and visual outcomes of the patient who had undergone scleral fixation of intraocular lens at Sardjito Hospital. Methods: A retrospective cross-sectional study of 43 eyes that undergone sutureless scleral fixation intraocular lens at Sardjito Hospital, Yogyakarta. The data were collected from electronic medical records of the patient from October 2020 to December 2022. The data was analysed descriptively by presenting number and percentage for categorical variables and mean ± standard deviation (SD) for numerical variables. Outcome include pre- and postoperative uncorrected visual acuity (UCVA). Results: There were 43 eyes obtained from 40 patients who underwent scleral-fixation intraocular lens in this study, consisting of 35 males (79,55%) and 9 females (20,45%). The mean age of the subjects was 50.04 ± 19.2 years. Lens subluxation was the most of indication for surgery (32,56%), followed by intraocular lens luxation (20,93%), dropped nucleus (16,28%), lens luxation (16,28%), intraocular lens decentration (9,30%), and endophthalmitis (4,65%). Before surgery, most of the patients had visual acuity of less than 3/60 (81,4%) and after surgery, 32,56% had ?6/18, 34,88% had <6/18-6/60 and 18,60% had <6/60-3/60. Conclusion: The characteristics of patient who underwent scleral fixation intraocular lens in Sardjito Hospital was predominantly male and diagnosed with lens subluxation. There were enhancement in visual outcomes.

The Position of Digital Signatures in Notarial Practice According to The Principle of Tabelionis Officium Fideliter Exercebo Supanji, Supanji; Adjie, Habib
UNES Law Review Vol. 6 No. 3 (2024)
Publisher : Universitas Ekasakti

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31933/unesrev.v6i3.1769

This research aims to investigate the role of digital signatures in notarization, focusing on their implementation and impact. Against the backdrop of developments in information technology, the use of digital signatures by Notaries is becoming increasingly relevant but also poses challenges in the process of making notarial deeds. The implementation of digital signatures can increase efficiency and security in making notarial deeds, but there are still obstacles related to certainty of time, place of deed making, and the need for more specific regulations related to cyber notary in Indonesia. The results of this study provide an in-depth understanding of the role of digital signatures in notaries and provide a basis for further development in integrating information technology in notarial practice.

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