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All Journal International Journal of Public Health Science (IJPHS) Indonesian Journal of Pharmaceutical Science and Technology Majalah Obat Tradisional Jurnal Kimia Riset Science and Technology Indonesia Majalah Farmaseutik
Sulaiman, Teuku Nanda Saifullah
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Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Computer Science & IT Environmental Science Health Professions Materials Science & Nanotechnology Medicine & Pharmacology Physics Public Health

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Journal : Indonesian Journal of Pharmaceutical Science and Technology

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Drug Solubility Enhancement Strategies Using Amorphous Solid Dispersion: Examination on Type and The Amount of the Polymer Seftian, Muhammad; Laksitorini, Marlyn Dian; Sulaiman, Teuku Nanda Saifullah
Indonesian Journal of Pharmaceutical Science and Technology Vol 11, No 2 (2024)
Publisher : Indonesian Journal of Pharmaceutical Science and Technology

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24198/ijpst.v11i2.46908

Abstract

Solubility is one of the critical factors affecting the biopharmaceutical process of drugs. Low solubility limits the dissolution rate and the oral bioavailability. As a result, a higher drug load is required to compensate for the low bioavailability. Amorphous solid dispersion (ASD) is a recent approach to increase drug solubility by dispersing the drug in a carrier-commonly a hydrophilic polymer. It improves the solubility and dissolution rate by affecting the thermodynamic equilibrium of the drug in solution. The amorphous system has a random molecular arrangement leading to higher thermodynamic activity. The amorphous system in ASD has a higher free energy which facilitates a higher solubility and dissolution rate. Polymer is the main component after the active substance in the ASD system. Therefore, the success of ASD formulation will be determined by the selection of polymers and additives as well as their proportions in the system. In addition to the polymer, surfactants are used as a ternary system to give a synergistic effect on the dissolution rate. The system maintains drug supersaturation in the solution state through two main mechanisms: reducing molecular mobility and plasticizing effect.
Co-Authors Azis Ikhsanudin BUDI SETIADI DARYONO Djoko Santosa Eka Noviana Jason Merari Peranginangin Marlyn Dian Laksitorini, Marlyn Dian Mochammad Imron Awalludin Pradana, Andi Rise Desnita, Rise Seftian, Muhammad Sudarmanto, B.S. Ari Wiratantri, Fitra Indah zai, Khadijah