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All Journal Journal of Food and Pharmaceutical Science Indonesian Journal of Pharmaceutical Science and Technology Majalah Obat Tradisional The Indonesian Biomedical Journal Jurnal Biodjati JURNAL MANAJEMEN DAN PELAYANAN FARMASI (Journal of Management and Pharmacy Practice) Majalah Farmaseutik Indonesian Journal of Chemistry JFIOnline Pharmaceutical Sciences and Research (PSR) Journal of Food and Pharmaceutical Sciences
Marlyn Dian Laksitorini, Marlyn Dian
Faculty of Pharmacy Gadjah Mada University, Sekip Utara Yogyakarta
Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Computer Science & IT Earth & Planetary Sciences Health Professions Immunology & microbiology Materials Science & Nanotechnology Medicine & Pharmacology Neuroscience Public Health

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PROFIL TRANSPOR PERKUTAN PENTAGAMAVUNON MELEWATI KULIT MENCIT IN VITRO Nugroho, Akhmad Kharis; Respati, Anindita Kresna; Laksitorini, Marlyn Dian; Harsanti, Dian Dwi; Supraptiyah, Cicilia; Isdwiani, Renita; Suwarto, Tiekha Kencanasari
JFIOnline | Print ISSN 1412-1107 | e-ISSN 2355-696X Vol 3, No 4 (2007)
Publisher : Indonesian Research Gateway

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

Although pentagamavunon (PGV-0) is one potential curcumin derivative, its intensive first pass metabolism leads difficulties on the delivery via peroral route. Alternative route of delivery is therefore of crucial important, and one of great candidate is transdermal delivery. This research was aimed to examine the feasibility of transdermal delivery of PGV-0, based on in vitro diffusion study using a static-vertical-diffusion cell across the fresh mouse skin as the barrier membrane. Transport of two formulas of PGV-0  from the donor compartment, either as a suspension or as a solution in a solvent mixture was examined. Results indicated a time function reduction in the slope of the cumulative transport. As a consequence the lag time method cannot be used for the transport data analysis. Alternatively, compartmental-based transport model was applied. Curve fitting analysis indicated diffusion of PGV-0 can be adequately described by a model assuming a mass transport from the donor to the skin following a first order kinetic process. Based on this modeling consideration, in vivo flux and Cp profiles of PGV-0 could be simulated. Results indicated  the feasibility of transdermal delivery of PGV-0. ABSTRAK Sistem penghantaran peroral pentagamavunon (PGV-0), senyawa turunan kurkumin yang sangat potensial, dilaporkan tidak efektif karena tingkat metabolisme lintas pertama yang intensif. Sistem penghantaran alternatif oleh karenanya sangat diperlukan, dimana rute transdermal menjadi salah satu kandidat prospektif. Penelitian ini bertujuan menguji potensi tersebut secara in vitro melalui uji transpor pada sel difusi tipe statis-vertikal dengan kulit mencit segar sebagai model membran. Dua macam formula PGV-0 diujikan. dan ditempatkan pada fase donor. Larutan dapat fosfat pH 6,2 (mengandung 4% tween 80, volume: 16,5 ml) diisikan pada fase aseptor. Jumlah obat tertranspor ke aseptor pada interval waktu tertentu dianalisis secara spektrofotometri UV pada panjang gelombang 427nm. Hasil penelitian ini menunjukkkan slope data transpor kumulatif menurun dengan waktu sehingga metode lag time tidak dapat digunakan untuk menganalisis data difusi. Model transpor berbasis kompartemen diaplikasikan sebagai metode alternatif. Analisis curve fitting menunjukkan bahwa data difusi pada kedua formulasi bersesuaian dengan model transpor yang mengasumsikan perpindahan massa obat dari donor menuju kulit sebagai proses orde pertama. Berdasarkan pendekatan ini profil flux in vivo dan Cp dapat disimulasikan. Jika digunakan sebuah patch berukuran 20cm2 maka Cp pada kisaran 20 – 40 ng/ml diprediksikan akan dicapai yang dapat menjadi indikasi prospek baik sediaan transdermal PGV-0
PROFIL TRANSPOR PERKUTAN PENTAGAMAVUNON MELEWATI KULIT MENCIT IN VITRO Nugroho, Akhmad Kharis; Respati, Anindita Kresna; Laksitorini, Marlyn Dian; Harsanti, Dian Dwi; Supraptiyah, Cicilia; Isdwiani, Renita; Suwarto, Tiekha Kencanasari
Jurnal Farmasi Indonesia Vol 3, No 4 (2007)
Publisher : Jurnal Farmasi Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35617/jfi.v3i4.84

Abstract

Although pentagamavunon (PGV-0) is one potential curcumin derivative, its intensive first pass metabolism leads difficulties on the delivery via peroral route. Alternative route of delivery is therefore of crucial important, and one of great candidate is transdermal delivery. This research was aimed to examine the feasibility of transdermal delivery of PGV-0, based on in vitro diffusion study using a static-vertical-diffusion cell across the fresh mouse skin as the barrier membrane. Transport of two formulas of PGV-0  from the donor compartment, either as a suspension or as a solution in a solvent mixture was examined. Results indicated a time function reduction in the slope of the cumulative transport. As a consequence the lag time method cannot be used for the transport data analysis. Alternatively, compartmental-based transport model was applied. Curve fitting analysis indicated diffusion of PGV-0 can be adequately described by a model assuming a mass transport from the donor to the skin following a first order kinetic process. Based on this modeling consideration, in vivo flux and Cp profiles of PGV-0 could be simulated. Results indicated  the feasibility of transdermal delivery of PGV-0. ABSTRAK Sistem penghantaran peroral pentagamavunon (PGV-0), senyawa turunan kurkumin yang sangat potensial, dilaporkan tidak efektif karena tingkat metabolisme lintas pertama yang intensif. Sistem penghantaran alternatif oleh karenanya sangat diperlukan, dimana rute transdermal menjadi salah satu kandidat prospektif. Penelitian ini bertujuan menguji potensi tersebut secara in vitro melalui uji transpor pada sel difusi tipe statis-vertikal dengan kulit mencit segar sebagai model membran. Dua macam formula PGV-0 diujikan. dan ditempatkan pada fase donor. Larutan dapat fosfat pH 6,2 (mengandung 4% tween 80, volume: 16,5 ml) diisikan pada fase aseptor. Jumlah obat tertranspor ke aseptor pada interval waktu tertentu dianalisis secara spektrofotometri UV pada panjang gelombang 427nm. Hasil penelitian ini menunjukkkan slope data transpor kumulatif menurun dengan waktu sehingga metode lag time tidak dapat digunakan untuk menganalisis data difusi. Model transpor berbasis kompartemen diaplikasikan sebagai metode alternatif. Analisis curve fitting menunjukkan bahwa data difusi pada kedua formulasi bersesuaian dengan model transpor yang mengasumsikan perpindahan massa obat dari donor menuju kulit sebagai proses orde pertama. Berdasarkan pendekatan ini profil flux in vivo dan Cp dapat disimulasikan. Jika digunakan sebuah patch berukuran 20cm2 maka Cp pada kisaran 20 â?? 40 ng/ml diprediksikan akan dicapai yang dapat menjadi indikasi prospek baik sediaan transdermal PGV-0
The Development of Alternative Dosage Form for Creatine Monohydrate: A Floating Tablet Nur Hidayah, Arifatu; Ardiana Wati, Anas; Yuniarti, Nunung; Laksitorini, Marlyn Dian
Journal of Food and Pharmaceutical Sciences Vol 11, No 3 (2023): J.Food.Pharm.Sci
Publisher : Institute for Halal Industry and System (IHIS) Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/jfps.8284

Abstract

Creatine monohydrate has been developed as a neuroprotective agent and can penetrate in vitro model of the blood-brain barrier. However, its delivery is hampered by its limited capacity of creatine transporter. The floating system is known to increase the residence time of drugs in the stomach; thus, the active substances can be absorbed more optimally. Therefore, this study is aimed to develop creatine monohydrate floating tablets by optimizing the proportion of HPMC K100M and NaHCO2 and evaluating the quality of floating tablets. The formula was designed Simplex Lattice Design method. Tablets were prepared by the wet granulation method and evaluated for granule and tablet parameters. The results showed that HPMC K100M significantly increased flow time, absorption rate, hardness, floating time, swelling index; decreased index tap, fragility, and floating lag time. Meanwhile, an increase in NaHCO2 significantly affects an increase in floating lag time. The optimum formula obtained was 18.87% HPMC K100M and 21.12% NaHCO2. Verification of the optimum formula showed that tablet parameters were not significantly different from the predicted formula. The studies suggest that this prototype can be developed to increase creatine residence time in the stomach.
The Development of Antioxidant Nutraceuticals containing Chrysanthemum indicum L. Gummy Candy Rahmasari, Firdaus Salvia; Sahid, Muhammad Novrizal Abdi; Siswanti, Dwi Umi; Darsih, Cici; Utami, Indrawati Dian; Alam, Lucky Prabowo Miftachul; Laksitorini, Marlyn Dian
Majalah Obat Tradisional Vol 29, No 1 (2024)
Publisher : Faculty of Pharmacy, Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/mot.87112

Abstract

Chrysanthemum flowers (Chrysanthemum indicum L.) have been shown to contain flavonoid compounds and exert antioxidant activity. This brings Chrysanthemum indicum potential to be developed as a nutraceutical product. This study aims to evaluate the antioxidant activity of Chrysanthemum flowers before and after the formulation of Chrysanthemum indicum flower extract as a gummy candy. Gummy candy formulas were developed using variations of gelatin and pectin as gelling agents. In this study, Chrysanthemum flower extract was formulated into gummy candy. The physical characteristics evaluated include organoleptic tests, weight uniformity, elasticity, and moisture content. Optimization was performed using the simplex lattice design (SLD) method with the aid of the Design Expert software Ver. 13. The antioxidant activity of the chrysanthemum flower extract and gummy candy extract was evaluated using the DPPH radical scavenging method. Ascorbic acid was used as a positive control. The optimum formula for preparing the gummy candy was 11.51% of gelatin and 1.24% of pectin. The evaluation of weight uniformity, elasticity, and moisture content suggested that there is no significant difference between the optimum formula and the predicted value. Both the chrysanthemum flower extract and chrysanthemum flower gummy candy had strong antioxidant activity. The IC50 value of the extract was 67.80 ± 2.37 mg/mL while the gummy candy IC50 value was 82.93 ± 2.55 mg/mL. The antioxidant activity of Chrysanthemum indicum was slightly decreased after being formulated into gummy candy. These studies suggested that scientists are expected to anticipate the decrease of Chrysanthemum antioxidant activity in the gummy manufacturing process.
Penggunaan Surfaktan pada Sistem Dispersi Padat Terner: Manfaat dan Risiko Seftian, Muhammad; Laksitorini, Marlyn Dian; Sulaiman, Teuku Nanda Saifullah
Majalah Farmaseutik Vol 19, No 4 (2023)
Publisher : Faculty of Pharmacy, Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/farmaseutik.v19i4.86720

Abstract

Beberapa decade terakhir, kelarutan menjadi tantangan besar dalam pengembangan obat. Diperkirakan lebih dari 90% kandidat obat baru memiliki kelarutan dalam air yang kurang baik. Berbagai inovasi teknologi telah diaplikasikan guna meningkatkan kelarutan obat dalam air, salah satunya dispersi padat. Seiring berkembangnya teknologi, dispersi padat generasi baru menambahkan surfaktan sebagai sistem terner. Penelitian sebelumnya mengungkapkan peningkatan kecepatan disolusi pada sistem terner obat-polimer-surfaktan terjadi lebih tinggi dibandingkan dengan dispersi padat tanpa surfaktan. Akan tetapi penelitian lain juga mengungkapan efek negatif dari surfaktan terhadap stabilitas sistem dispersi padat. Review ini mendiskusikan penggunaan surfaktan sebagai sistem terner dispersi padat. Salah satu tantangan pengembangan sistem dispersi padat adalah drug loading yang terbatas dan adanya rekristalisasi selama proses disolusi. Surfaktan mencegah kristalisasi obat selama proses disolusi melalui efek solubilisasi dengan cara mendispersikan molekul obat dalam bentuk nanodroplet. Di sisi lain, beberapa penelitian lain mengungkapkan hasil yang kontradiktif yang menyatakan surfaktan justru mempercepat nukleasi dan memberikan efek negatif terhadap stabilitas sistem dispersi padat. Efek surfaktan pada sistem dispersi padat akan tergantung pada struktur, afinitas interaksi, dan konsentrasi yang digunakan. Seleksi surfaktan yang kompatibel dengan sistem yang dikembangkan perlu dilakukan karena pada titik tertentu surfaktan dapat menjadi kompetitor yang menekan interaksi obat-polimer dan memicu kristalisasi
Perbandingan Disolusi Dispersi Padat Valsartan Dalam Bentuk Tablet dan Kapsul cahyani, sulastari; Laksitorini, Marlyn Dian; Sulaiman, Teuku Nanda
Majalah Farmaseutik Vol 20, No 2 (2024)
Publisher : Faculty of Pharmacy, Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/farmaseutik.v20i2.94205

Abstract

ABSTRAK Valsartan adalah zat aktif yang sukar larut air yang mana kelarutannya bergantung pada pH saluran cerna. Dispersi padat merupakan salah satu metode yang efektif untuk meningkatkan kelarutan dan disolusi zat aktif sukar larut. Penelitian sebelumnya telah didapatkan dispersi padat valsartan dengan pembawa PVP VA, poloxamer 188 dan poloxamer 407 yang memiliki kelarutan jenuh dan disolusi intrinsik yang baik. Kendati demikian pelepasan dispersi padat valsartan dalam bentuk sediaan khususnya tablet dan kapsul belum diketahui, sebagaimana diketahui bahwa pembawa yang digunakan dan bentuk sediaan obat mempengaruhi profil disolusi. Penelitian ini bertujuan untuk membandingkan disolusi dispersi padat valsartan dalam bentuk sediaan  tablet dan kapsul pada pH 1,2 dan 4,5. Karakteristik fisik tablet dispersi padat dispersi padat valsartan meliputi kekerasan, kerapuhan dan waktu hancur. Adanya PVP VA, poloxamer 188 dan poloxamer 407 pada sistem dispersi padat menghasilkan tablet yang memiliki pelepasan obat diperlama dan menghasilkan daya apung setelah diformulasi menjadi tablet. Kapsul dispersi padat valsartan memiliki profil disolusi yang lebih baik dibandingkan tablet dispersi padat valsartan pada pH 1,2 maupun pH 4,5.  Nilai Q60 kapsul dispersi padat valsartan pada pH 1,2 dan 4,5 berturut-turut 2,73% dan 103,28% sedangkan nilai Q60 tablet dispersi padat valsartan berturut-turut 2,89% dan 36,75%.Kata Kunci : dispersi padat, valsartan, tablet, kapsul
Drug Solubility Enhancement Strategies Using Amorphous Solid Dispersion: Examination on Type and The Amount of the Polymer Seftian, Muhammad; Laksitorini, Marlyn Dian; Sulaiman, Teuku Nanda Saifullah
Indonesian Journal of Pharmaceutical Science and Technology Vol 11, No 2 (2024)
Publisher : Indonesian Journal of Pharmaceutical Science and Technology

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24198/ijpst.v11i2.46908

Abstract

Solubility is one of the critical factors affecting the biopharmaceutical process of drugs. Low solubility limits the dissolution rate and the oral bioavailability. As a result, a higher drug load is required to compensate for the low bioavailability. Amorphous solid dispersion (ASD) is a recent approach to increase drug solubility by dispersing the drug in a carrier-commonly a hydrophilic polymer. It improves the solubility and dissolution rate by affecting the thermodynamic equilibrium of the drug in solution. The amorphous system has a random molecular arrangement leading to higher thermodynamic activity. The amorphous system in ASD has a higher free energy which facilitates a higher solubility and dissolution rate. Polymer is the main component after the active substance in the ASD system. Therefore, the success of ASD formulation will be determined by the selection of polymers and additives as well as their proportions in the system. In addition to the polymer, surfactants are used as a ternary system to give a synergistic effect on the dissolution rate. The system maintains drug supersaturation in the solution state through two main mechanisms: reducing molecular mobility and plasticizing effect.
Optimization of 3,4-Dimethoxychalcone and Rutin Containing Gel with Simplex Lattice Design and In Vitro-In Vivo Test as a Sunscreen Fatimi, Hana Anisa; Zulkarnain, Abdul Karim; Laksitorini, Marlyn Dian
Pharmaceutical Sciences and Research Vol. 10, No. 2
Publisher : UI Scholars Hub

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Abstract

3,4-Dimethoxychalcone and rutin, a flavonoid that contains chromophore groups, can absorb UV light and thus can be developed as a sunscreen. The objective of this study was to determine the optimum formula of 3,4-dimethoxychalcone and rutin containing gel, evaluate its physical stability, and activity of 3,4-dimethoxychalcone and rutin gel as a sunscreen through in vitro and in vivo tests. HPMC, CMC-Na, and methylcellulose were formulated into a gel base to obtain good adhesion and a clear appearance gel. Simplex Lattice Design (SLD) with Design Expert software version 10 was utilized to determine the optimum gel formulation. UVA-PF protection, photostability with transpore method, and acute dermal irritation test were performed to evaluate sunscreen activity of 3,4-dimethoxychalcone and rutin gel. The data were analyzed using SPSS version 25. The results showed that the optimum formula for 3,4-dimethoxychalcone-rutin gel consisted of 1.5% HPMC, 1.8% CMC-Na and 0.6% methylcellulose, which showed a pH of 6.96, viscosity of 89.10 dpa.s, and spreadability of 16.30 cm2. The pH, viscosity, and spreadability of base and 3,4-dimethoxychalcone- rutin gel was stable for 4 weeks of storage. The UVA-PF value is 6.48 which according to the FDA is included in the category of a two star (**) sunscreen label. The sunscreen did not exhibit a shift in wavelength after 6 hours of irradiation. Based on the primary irritation test, 3,4-dimethoxychalcone- rutin sunscreen produced zero (0) erythema and edema index. Thus, it did not cause irritation to the skin of experimental animals. Therefore, the gel containing 3,4-dimethoxychalcone and rutin had potential as a sunscreen product based on in vitro-in vivo tests and was safe on animal skin.
Porcine Derived Ingredients in Cosmetic Products and its Halal Authentication Method within Complex Matrices Nawwaruddin, Hazza' Hammam; Rohman, Abdul; Laksitorini, Marlyn Dian
Journal of Food and Pharmaceutical Sciences Vol 12, No 3 (2024): J.Food.Pharm.Sci
Publisher : Institute for Halal Industry and System (IHIS) Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/jfps.17717

Abstract

Nowadays cosmetics are an important commodity and the market for halal cosmetics is seeing growth. Cosmetics that contain porcine-derived ingredients are typically the source of halal problems. Gelatin and collagen are porcine derivatives that are extensively used in cosmetics. Hence, verifying the presence of porcine derivatives in cosmetics by developing analytical methods is critical. Despite this urgency, determining porcine-derived components in cosmetics is challenging, since cosmetics are quite complex with variable matrix forms. Moreover, to the best of our knowledge, there are only a few papers on developing porcine derivatives analysis in cosmetic items. This mini-review objective is to depict the current understanding of determining porcine collagen and gelatin in cosmetic matrixes. The findings revealed that the LC-MS/MS method is superior for determining gelatin and collagen sources in complex matrixes due to its sensitivity and accuracy. PCR and ELISA methods have challenges with the marker degradation problem since the derivatives undergo extensive processing conditions, thus lowering the methods’ specificity and sensitivity, especially in complex matrixes. The SDS-PAGE method applications are limited and the method is suitable for a relatively simple matrix. This review highlights findings that support future advancements in cosmetic analysis for halal authentication.
Formulation and Antioxidant Activity of Gotu Kola Jelly Candy with Plant-based Polymers as a Gelling Agent Devi, Dwitya Devi Nurlistyo; Darsih, Cici; Yuniarti, Nunung; Ardiningtyas, Bondan; Laksitorini, Marlyn Dian
Majalah Obat Tradisional Vol 29, No 3 (2024)
Publisher : Faculty of Pharmacy, Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/mot.89699

Abstract

Centella asiatica or gotu kola has a long history as a brain supplement. Gotu kola supplements are sold as liquid and dried extract which is less attractive for a younger generation. Jelly candy is an alternative dosage form with better acceptability across ages. However, the use of animal-derived polymers such as pork gelatine in the candy restricts those who practice vegetarian and halal lifestyles from consuming the products. This study aims to explore plant-based polymers glucomannan and kappa-carrageenan as gelling agents in the preparation of gotu kola jelly candy. Preparation of the jelly candy formula was designed based on Simplex Lattice Design. Evaluation of physical characteristics of jelly candy includes organoleptic, weight uniformity, moisture content, pH, and elasticity. The antioxidant activity of gotu kola before and after the manufacturing process was evaluated. The results showed that a combination of kappa-carrageenan 1.33% and glucomannan 0.67% is the optimum formula. Adding more proportion of kappa-carrageenan reduced jelly elasticity and moisture content. While adding glucomannan improved its elasticity responses but increased moisture content. Evaluation of the antioxidant activity of gotu kola in jelly candy suggested that gotu kola experienced a significant reduction in antioxidant activity following the production process. The IC50 of the crude extract initially was129.23 ppm while post jelly candy manufacturing, the IC50 increased to 197.49 ppm. This study suggested that improvement in extraction and production processes is necessary to maintain gotu kola antioxidant activity.
Co-Authors Abdul Karim Zulkarnain Abdul Rohman Afifah, Laelatul Akhmad Kharis Nugroho Alam, Lucky Prabowo Miftachul Almira, Deta Andyra, Vania Uly Ardiana Wati, Anas Ardiningtyas, Bondan cahyani, sulastari Cici Darsih Devi, Dwitya Devi Nurlistyo Dwi Umi Siswanti Endang Astuti Fatimi, Hana Anisa Fita Rahmawati Handayani, Sri Handoyo, Rumaisha Lale Hani Susanti, Hani Harsanti, Dian Dwi Harsanti, Dian Dwi Hidhayati, Noor Indrianingsih, Anastasia Wheni Isdwiani, Renita Isdwiani, Renita Larasati, Savira Wahyu Muhammad Thesa Ghozali Nawwaruddin, Hazza' Hammam Ni’maturrohmah, Dwi Nunung Yuniarti Nur Hidayah, Arifatu Nurcahya, Bekti Meilani Rahmasari, Firdaus Salvia Respati, Anindita Kresna Respati, Anindita Kresna Rizal Maulana Hasby, Rizal Maulana Sahid, Muhammad Novrizal Abdi Saifullah Sulaiman, Teuku Nanda Seftian, Muhammad Selalau, Waly Prakasa Sulaiman, Teuku Nanda Sulaiman, Teuku Nanda Saifullah Sumlang, Gavriel Hagai Paulus Supraptiyah, Cicilia Supraptiyah, Cicilia Suwarto, Tiekha Kencanasari Suwarto, Tiekha Kencanasari Tri Joko Raharjo Tri Rini Nuringtyas Utami, Indrawati Dian Utami, Nila Vidilia