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Rationality of Antibiotic Use on Pneumonia Patients at dr. Doris Sylvanus Hospital Palangkaraya in 2022 Nawan; Annisa, Farah; Handayani, Septi; Parhusip, Mual BE; Furtuna, Dewi; Trisia, Adelgrit; Toemon, Agnes I
Journal of Medicine and Health Vol 7 No 1 (2025)
Publisher : Universitas Kristen Maranatha

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.28932/jmh.v7i1.8586

Abstract

Pneumonia can be defined as a condition when a microorganism triggers inflammation of the lung parenchyma. The bronchioles and alveoli will be filled with inflammatory leukocyte exudate and fluid, causing respiratory difficulties and symptoms such as coughing, dyspnea, chest pain, and shock in severe cases. Pneumonia infections caused by bacteria can be treated with antibiotics. Bacterial patterns and sensitivity test results available at the hospital are used as a guide in selecting empiric therapy given to patients. Diagnostic limitations in differentiating viral and bacterial pathogens in pneumonia have led to increased use of antibiotics and contributed to the growth of antibiotic resistance. This research aims to determine the rationality of antibiotic use in pneumonia patients' resistance at RSUD dr.Doris Sylvanus Palangka Raya in 2022. A descriptive observational approach using a cross-sectional method was used to examine the medical records of pneumonia patients. Antibiotics commonly used by patients diagnosed with pneumonia at RSUD dr.Doris Sylvanus Palangka Raya in 2022 is Moxifloxacin with 153 patients (22.53%), then Levofloxacin with 143 patients (21.06%), and Ceftriaxone with 137 patients (20.18%). The total defined daily dose/100 days of antibiotics for pneumonia patients is 88.85 and according to the Gyssens criteria, the use of antibiotics is 82.62% rational.
Exploration Of Central Kalimantan Peatland Fungi As Antibacterial Agents Against Antibiotic-Resistant Staphylococcus Aureus and Salmonella Typhimurium Kusuma, Hari; Nawan; Alexandra, Francisca Dian
Barigas: Jurnal Riset Mahasiswa Vol. 3 No. 3 (2025): Barigas: Jurnal Riset Mahasiswa
Publisher : Fakultas Kedokteran Universitas Palangka Raya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37304/barigas.v3i3.21849

Abstract

Pathogens such as Staphylococcus aureus and Salmonella typhimurium show increasing level of resistance to various antibiotics, thus encouraging efforts to find new antibacterial agents from natural sources, including peat soil fungi. This study aims to examine the characteristics and potential antibacterial activity of fungal isolates from peat soil in three different locations in Palangka Raya City, namely Kereng Bengkirai, Yos Sudarso Street, and the and the environmental area of Palangka Raya, University, against Staphylococcus aureus and Salmonella typhimurium bacteria. The research design used was a true experimental with a post-test only control group design model. Fungal isolates were obtained through inoculation and isolation from peat soil samples, then cultivated, extracted, and tested for antibacterial activity using the disk diffusion method. against two test bacteria. The results showed that fungal isolates from the third locations did not show growth inhibitory activity against Staphylococcus aureus or Salmonella typhimurium at the concentrations and testing method used. Fungal isolates from peat soil in Kereng Bengkirai Yos Sudarso street, and the Palangka Raya University area do not have antibacterial activity against Staphylococcus aureus and Salmonella typhimurium under the conditions and test methods applied Keywords: peat soil fungi, antibacterial, Staphylococcus aureus, Salmonella typhimurium, antibiotic resistance.