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Inhibition Test of Ethanol from Extract Mangosteen Leaves (Garcinia mangostana L.) as an Acne Antibacterial Ginting, Junius Gian; Br. Singarimbun, Nurbaiti; Daeli, Mestika Clemesiya Yulianti; Simanjuntak, Helen Anjelina; Purba, Hermawan; Br. Barus, Lydia; Zega, Defcato Firmawati
JURNAL PEMBELAJARAN DAN BIOLOGI NUKLEUS Vol 9, No 3: Jurnal Pembelajaran Dan Biologi Nukleus November 2023
Publisher : Universitas Labuhanbatu

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36987/jpbn.v9i3.5066

Abstract

A prevalent global infection that manifests frequently in Indonesia. An example of an infectious disease that is commonly encountered during adolescence is acne (Acne vulgaris). Antibiotics can be used to treat acne; however, their misuse can lead to the development of resistance; therefore, we are searching for inexpensive, readily available alternatives that are also secure. Mangosteen leaves (Garcinia mangostana L.) are one alternative to synthetic ingredients when it comes to the treatment of acne. Mangosteen leaves comprise xanthone derivative compounds that exhibit significant biological activity, including antioxidant, antibacterial, and antimicrobial properties. Therefore, this this study aimed to ascertain the inhibitory power of an ethanol extract derived from mangosteen leaves in order to determine its antibacterial activity against Staphylococcus epidermidis bacteria. Additionally, the compound content of the ethanol extract of mangosteen leaves was determined. The inhibition test was conducted by utilizing the paper disc technique, while the extraction method employed the maceration method. As indicated by the phytochemical screening test results, simplicia and ethanol extract of mangosteen leaves were found to contain steroids/triterpenoids, alkaloids, flavonoids, saponins, and tannins. The inhibition test outcomes against Staphylococcus epidermidis bacteria revealed the following: a diameter of 3.3 mm for bacteria at a concentration of 20%, 9.4 mm for bacteria at 40%, 10.4 mm for bacteria at 60%, 12.9 mm for bacteria at 80%, and 13.2 mm for bacteria at 100%
The Utilisation of Coconut Water Waste into Nanocellulose and Potential Synergistic Effect of Asthma Plant (Euphorbia hirta L.) Extract as an Antibacterial Agent Barus, Lydia Br; Manihuruk, Fani Nuryana; Sari, Mesi Puspita; Simanjuntak, Helen Anjelina; Ginting, Junius Gian; Purba, Hermawan
JURNAL PEMBELAJARAN DAN BIOLOGI NUKLEUS Vol 9, No 3: Jurnal Pembelajaran Dan Biologi Nukleus November 2023
Publisher : Universitas Labuhanbatu

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36987/jpbn.v9i3.5060

Abstract

Skin infections contribute to one of the most significant global health issues. Acne, blisters, and abscesses are examples of skin infections that can be induced by Propionibacterium acnes, Staphylococcus aureus, and Staphylococcus epidermidis. Treatment can be attempted through the development of nanotechnology in the form of nanocellulose. Nanocellulose, an organic substance, can be produced through the conversion of coconut water waste and Acetobacter xylinum bacteria. Future applications of nanocellulose formulated with a blend of extracts derived from natural sources, including Patikan Kebo (Euphorbia hirta L.), are anticipated to include the treatment of wound dressings (patches). Determining the antibacterial potential of nanocellulose was the objective of this study. The experimental research technique is implemented in phases. The extraction process was conducted by means of maceration, while the parallel streak method was utilized for antibacterial testing. The findings of the study indicated that the mean zone of inhibition for each treatment variable was as follows: 0 mm, 15.1 mm, 23.53 mm, and 23.06 mm for nanocellulose (serving as the negative control), nanocellulose and 0.5% extract, 1% extract, 1.5% extract, and clindamycin, respectively. Conclusion: Antibacterial activity was observed in nanocellulose extracts containing 1% and 1.5%
Identifikasi Komponen Minyak Atsiri Daun Salam (Syzygium polyanthum (Wight Walp.) dengan GC-MS dan Potensinya Sebagai Antibakteri Sihotang, Santyria; Simanjuntak, Helen Anjelina; Purba, Hermawan; Iksen, Iksen; Sembiring, Mahral Effendi
Herbal Medicine Journal Vol 8 No 1 (2025): Herbal Medicine Journal
Publisher : Program Studi S1 Farmasi, STIKES Senior, Medan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.58996/hmj.v8i1.137

Abstract

Essential oils, known as volatile oils or essential oils, are oils produced from plants and have the property of easily evaporating at room temperature without undergoing decomposition. The bay leaf plant (Syzygium polyanthum (Wight.) Walp.) is one of the plants that is very often used as an alternative medicine. There is evidence that bay leaves, which contain compounds such as niacin, fiber, tannin, and vitamin C, have the ability to lower serum triglyceride levels. This research aims to determine the essential oil content in bay leaves using the steam distillation method and its potential as an antibacterial. The results of the research show that bay leaves contain essential oils which have antibacterial properties against the bacteria Helicobater pylori and Bacillus cereus. Bay leaf essential oil (Syzygium polyanthum (Wight.) Walp) with varying concentrations of 10%, 30%, 50%, 70% and 100% showed the highest inhibitory zone diameter for Helicobater pylori bacteria, namely at a concentration of 100% with a diameter of 5, 25 mm and in Bacillus cereus bacteria with a diameter of 7.95 mm.
Formulation Cream of Ethanol Patikan Kebo Weeds (Euphorbia hirta L.) Extract As An In Vitro Anti-Acne Barus, Lydia Br; Purba, Sanna Kamisna Royani; Br. Gultom, Sesilia Sri Susandri; Simanjuntak, Helen Anjelina; Purba, Hermawan; Singarimbun, Nurbaiti Br.; Zega, Defacto Firmawati
JURNAL PEMBELAJARAN DAN BIOLOGI NUKLEUS Vol 11, No 2: Jurnal Pembelajaran Dan Biologi Nukleus June 2025
Publisher : Universitas Labuhanbatu

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36987/jpbn.v11i2.6698

Abstract

Background: Acne is a skin inflammation that is prevalent in 80-100% of the population, particularly during adolescence.  The Patikan Kebo (Euphorbia hirta L.) weed plant is employed in a cream formulation to treat acne. Therefore, this study aims to determine the formula of the Patikan Kebo (E. hirta L.) weed cream preparation that is as effective as an in vitro anti-acne. Methodology: the research method was carried out experimentally with the stages of sample preparation, phytochemical screening, extraction, formulation, evaluation, and antibacterial activity test that caused acne using the well diffusion method. Findings: The results showed the Patikan Kebo (E. hirta L.) weed has secondary metabolites consisting of alkaloids, flavonoids, saponins, tannins, and steroids/triterpenoids. The evaluation of the cream preparation of each formula has met cosmetic standards. The diameter of the F4 inhibition zone has antibacterial activity against acne-causing Propionibacterium acnes (12.03 ± 0.81 mm), Staphylococcus epidermidis (11.48 ± 1.10 mm), S. aureus (12.07 ± 0.06 mm), and the F5 inhibition zone P. acnes (13.53 ± 0.15 mm), S. epidermidis (12.54 ± 0.75 mm), and S. aureus (13.03 ± 0.61 mm). Formulas F4 and F5 are more effective as anti-acne with a strong inhibition zone diameter. Contribution: These findings indicate that formulas F4 and F5 can be further developed as alternative natural active ingredients in cosmetic or pharmaceutical products for acne therapy, thus contributing to the development of safer, more economical, and more sustainable local herbal medicine
Analisis Paracetamol dalam Sediaan Sirup X dan W dengan Metode Spektrofotometri UV-Vis Genesis 10s Purba, Hermawan; Gresela, Paula; Manalu, Tiodora; Mayranti, Dwi; Zalukhu, Historis
Herbal Medicine Journal Vol 7 No 2 (2024): Herbal Medicine Journal
Publisher : Program Studi S1 Farmasi, STIKES Senior, Medan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.58996/hmj.v7i2.146

Abstract

Paracetamol is a medication that is safe for children to use to relieve pain and reduce fever, with minimal side effects. This medication is available in various forms, including syrup, which consists of a solution with a high sucrose content. Maximum Wavelength and Calibration Curve: In the study, the standard paracetamol was analyzed to determine that the obtained wavelength is at 246 nm. Several solutions with different concentrations (10, 15, 20, 25, and 30 ppm) were used to create a calibration curve, which shows the relationship between absorbance and concentration. Linear regression equation: Y = 0.0044x – 0.0166, R² = 0.9936. The absorbance of the syrup sample indicates a paracetamol concentration of approximately 24.23 ppm for sample X and 17.63 ppm for sample W, calculated using a calibration curve. Thus, the research shows an effective analytical method for determining the concentration of paracetamol in syrup preparations.
Analisis Asam Askobat dalam Sediaan Tablet A dan Minuman Suplemen B dengan Metode Spektrofotometri UV-Vis Genesis 10s Purba, Hermawan; Faneca, Egia; Anggreni, Wulan
Herbal Medicine Journal Vol 8 No 1 (2025): Herbal Medicine Journal
Publisher : Program Studi S1 Farmasi, STIKES Senior, Medan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.58996/hmj.v8i1.147

Abstract

Vitamin C is one of the nutrients that acts as an antioxidant and is effective in fighting free radicals that can potentially damage cells or tissues, including protecting the lens of the eye from oxidative damage caused by radiation. Additionally, Vitamin C can also help reduce the risk of cancer and prevent damage caused by free radicals that can trigger cancer development. The purpose of this research is to determine the vitamin C content in tablet A and drink B using the UV-Vis spectrophotometry method with the Genesis 10S. This study is descriptive in nature, focusing on the determination of vitamin C levels in tablet A and drink B using the UV-Vis spectrophotometry method with the Genesis 10S. To prepare a concentration series of 2; 4; 6; 8; 10 ppm, pipette from the stock solution of Chloramphenicol at 1000 mg/L. Each sample is placed into a 10 ml volumetric flask and diluted with distilled water up to the mark.Then, an examination was conducted on each concentration using UV-Vis spectrophotometry. After the curve appeared, the calibration curve was obtained by examining the relationship between concentration (X) and the area under the chromatogram (Y) and determining its regression equation (y= ax + b). The results of the analysis of ascorbic acid in tablet preparation A and drink B using the UV-Vis Genesis 10s spectrophotometry method yielded a linear equation for the calibration curve between absorbance and the concentration of the standard solution, resulting in the equation Y = 0.0395x- 0.0443 with an r² value of 0.9853.
Uji Aktivitas Antibakteri Krim Ekstrak Etanol Daun Kitolod (Isotoma longiflora)(L).C.Presl Terhadap Staphylococcus epidermidis dan Pseudomonas aeruginosa Simanjuntak, Helen Anjelina; Nahampun, Laura Yunita; Purba, Hermawan; Simanjuntak, Herlina; Sinaga, Suharni Pintamas; Sembiring, Mahral Effendi; Rahmiati, Rahmiati; Situmorang, Toberni S
Herbal Medicine Journal Vol 8 No 2 (2025): Herbal Medicine Journal
Publisher : Program Studi S1 Farmasi, STIKES Senior, Medan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.58996/hmj.v8i2.186

Abstract

Kitolod plants are used to treat various types of diseases, such as eye pain, wound healing, asthma, bronchitis, rheumatism and others. This study aims to determine the antibacterial activity test of kitolod leaf ethanol extract cream (Isotoma longiflora) (L).C.Presl against Staphylococcus epidermidis and Pseudomonas aeruginosa bacteria. This research stage includes determination, preparation of simplicia, extraction, phytochemical screening, cream formulation F0 (0%), F1 (4%), F2 (6%) F3 (8%), and antibacterial test. The results of the phytochemical screening showed that alkaloids, flavonoids, tannins, saponins and steroids were obtained. The results of the antibacterial activity test of the formula against Staphylococcus epidermidis in sequence F0 (0%), F1 (4%), F2 (6%) and F3 (8%) were 11.315 mm; 15.205 mm; 18.843 mm; 23.698 mm. Meanwhile, against Pseudomonas aeruginosa bacteria, the measurements were 6.04 mm, 8.19 mm, 12.46 mm, and 17.24 mm, respectively. In conclusion, all variations of the cream formula showed antibacterial activity in inhibiting the growth of Staphylococcus epidermidis and Pseudomonas aeruginosa bacteria. The cream formulation was more sensitive to Staphylococcus epidermidis bacteria than Pseudomonas aeruginosa bacteria.
PENYULUHAN TENTANG PENYAKIT KECACINGAN PADA ANAK DI DESA UJUNG LABUHAN KECAMATAN NAMORAMBE Sinaga, Sahat; Sihombing, Ismadi; Kemala, Sarma Dewi; Barus, Syafril; Ginting, Junius Gian; Purba, Hermawan
Community Development Journal : Jurnal Pengabdian Masyarakat Vol. 5 No. 4 (2024): Volume 5 No. 4 Tahun 2024
Publisher : Universitas Pahlawan Tuanku Tambusai

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31004/cdj.v5i4.33282

Abstract

Kecacingan adalah infeksi cacing usus yang sering disebabkan oleh cacing gelang, cacing cambuk dan cacing tambang. Penyebaran infeksi cacing dapat disebabkan oleh masuknya makanan, minuman yang terkontaminasi dengan telur cacing kemudian masukkan cacing dari permukaan kulit melalui vektor cacing yang terdapat pada tanah. Infeksi cacing dapat memberikan dampak terhadap pertumbuhan dan perkembangan anak, anemia, lemas, mengantuk, malas belajar, IQ menurun, prestasi dan produktivitas menurun, terganggunya perkembangan fisik dan mental serta kekurangan gizi. Kegiatan pengabdian berupa penyuluhan tentang penyakit kecacingan pada anak di desa ujung labuhan kecamatan namorambe yang dilaksanakan pada hari senin, 03 Juni 2024. Peserta yang hadir terdiri dari 30 anak yang didampingi oleh ibunya. Kesimpulan kegiatan menunjukkan adanya pemahaman pada ibu tentang pentingnya menjaga kebersihan diri dan lingkungan yang dapat dilihat dari antusias para ibu dalam sesi tanya jawab. Selain itu, kegiatan ini memberikan manfaat secara langsung maupun tidak langsung karena telah menambah wawasan terkait dampak buruk akibat penyakit kecacingan sehingga para ibu berupaya untuk mencegah penyakit kecacingan memalui Tindakan kebersihan diri dan lingkungan.
Uji Aktivitas Antibakteri Ekstrak Etanol Daun Sirih Cina (Peperomia pellucida (L.) Kunth). Terhadap Bakteri Propionibacterium acnes, Staphylococcus epidermidis dan Staphylococcus aureus Purba, Hermawan; Hilleri Damanik, Geby
Herbal Medicine Journal Vol 9 No 1 (2026): Herbal Medicine Journal
Publisher : Program Studi S1 Farmasi, STIKES Senior, Medan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.58996/hmj.v9i1.209

Abstract

Pathogenic bacteria have negative impacts if exposed to the human body for a certain period of time. It is necessary to inhibit bacterial growth from natural materials because they generally have non-toxic, environmentally friendly, and biodegradable properties. This study used Chinese betel leaf extract (Peperomia pellucida (L.) Kunth) as an antibacterial material against Propionibacterium acnes, Staphylococcus epidermidis and Staphylococcus aureus. The results of the phytochemical screening analysis showed that there were secondary metabolites in the extract and simplicia such as tannins, alkaloids, and flavonoids. The antibacterial test pad with the largest concentration variation has a strong and very strong category on the three types of bacteria, namely against Staphylococcus epidermidis (diameter 19.9 mm) at a concentration of 5%, Staphylococcus aureus (diameter 22.92 mm) at a concentration of 7%, Propionibacterium acnes. (diameter 19.63 mm) at a concentration of 7%.
Co-Authors Afrida Yelni Anggreni, Wulan Barus, Syafril Bonar Sinaga Br. Gultom, Sesilia Sri Susandri Cander Pasaribu Daeli, Mestika Clemesiya Yulianti Dame Meldaria sipahutar Dame Meldaria Sipahutar Defacto Firmawai Zega Defacto Firmawati Zega Faneca, Egia Ginting, Junius Gian Gresela, Paula Helen Anjelina Simanjuntak Hilleri Damanik, Geby Iksen, Iksen Ismadi Sihombing Kemala, Sarma Dewi Lydia Br Barus Manalu, Tiodora Manihuruk, Fani Nuryana Mayranti, Dwi Nahampun, Laura Yunita Purba, Sanna Kamisna Royani Rahmiati Rahmiati Risanti Situmorang Sahat Sinaga Sahat Sinaga Sahat Sinaga Sari, Mesi Puspita Sarma Dewi Kemala Sembiring, Mahral Effendi Sihotang, Santyria Simanjuntak, Herlina Sinaga, Sahat Sinaga, Suharni Pintamas Singarimbun, Nurbaiti Br Suharni Sinaga Toberni S Situmorang Toberni S Situmorang Toberni S Situmorang Wahyuni, Sri Wan Yuli Anjani Yanti Yanti Zalukhu, Historis Zega, Defcato Firmawati