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Manihuruk, Fani Nuryana
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Gambaran imunohistokimia CD40 aorta jantung tikus wistar jantan (Rattus norvegicus) yang diinduksi minyak jelantah Fani Nuryana Manihuruk; Gusbakti Rusip; Esther R. D. Sitorus; M. Ichwan
Jurnal Kedokteran Syiah Kuala Vol 20, No 2 (2020): Volume 20 Nomor 2 Agustus 2020
Publisher : Universitas Syiah Kuala

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24815/jks.v20i2.18496

Abstract

Abstrak: Aterosklerosis adalah penyakit kronis yang dapat menyebabkan kematian diawali inflamasi pembuluh darah oleh hiperlipidemia.  Pemakaian minyak jelantah  menyebabkan peningkatan asam lemak trans, asam lemak bebas dan radikal bebas sehingga memicu terjadinya aterosklerosis. Salah satu biomarker aterosklerosis adalah CD40. Tujuan penelitian ini adalah untuk mengetahui gambaran imunohistokimia CD40 pada aorta jantung tikus Wistar jantan (Rattus norvegicus) yang diinduksi minyak jelantah. Penelitian ini adalah true experimental dengan rancangan randomize post-test only control group design. Jumlah sampel adalah 12 ekor tikus Wistar jantan sehat, umur 3-4 bulan dan berat 150-200 gram, dibagi menjadi 4 kelompok. K0(diet normal), K1(5 kali penggorengan),  K2(10 kali penggorengan), K3(15 kali penggorengan) selama 60 hari dan menghitung score CD40. Hasil uji Kruskal-Wallis diperoleh adanya perbedaan yang bermakna antara keempat kelompok perlakuan (p0,05). Gambaran imunohistokimia CD40 pada K3(15 kali penggorengan) lebih tinggi dibandingkan K1 (5 kali penggorengan) dan K2 (10 kali penggorengan). Minyak jelantah dapat meningkatkan CD40 yang memicu aterosklerosis.Kata kunci: Aterosklerosis, minyak jelantah, CD40Abstract: Atherosclerosis is a chronic disease that cause death and begins inflammation of blood vessel by hiperlipidemia. It is associated with increased trans fatty acids, free fatty acids, and free radical compounds due consumption of deep frying oil that can trigger atherocslerosis. One of the biomarkers of atherosclerosis is CD40. The purpose of this study was to determine immunohistochemical images of CD40 in aorta of male Wistar rat (Rattus norvegicus) induced by deep frying oil. This research is true experimental with randomize post-test only control group design. The experimental animals were 12 healthy male Wistar rats age 3-4 month and weight between 150-200g. Male wistar rat were randomly divided into 4 group. Group K0 (control) was given standart diet, group K1 was given orally  deep fried oil 5 times, group K2 was given orally deep fried oil 10 times, group K3 was given orally deep fried oil 15 times for 60 day. The Imunohistochemical examination assessed score of CD40. The Kruskal-Wallis test showed that imunohistochemical of CD40 were significantly different among the four groups (p0,05). Imunohistochemical of CD40 in group K3(deep fried 15 times) is higher than group K1(deep fried 5 times) and K2(deep fried 10 times). Deep frying oil inceased that mount of CD40 and induced risk of aterosclerosis.Keywords: Atherosclerosis, deep frying oil, CD40
Total Kadar Bilirubin Pada Pasien Tuberculosis (TB) Paru Setelah 5 Bulan Mengkonsumsi Obat Anti Tuberkulosis (OAT) di Rumah Sakit Tentara Kota Binjai Fani Nuryana Manihuruk; Sanna Kamisna Purba; Liber Napitupulu
Herbal Medicine Journal Vol 5 No 1 (2022): Herbal Medicine Journal
Publisher : Program Studi S1 Farmasi, STIKES Senior, Medan

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (426.808 KB) | DOI: 10.58996/hmj.v5i1.45

Abstract

Pulmonary tuberculosis (TB) is an infectious disease caused by Mycobacterium tuberculosis which attacks the lungs and bronchi. Anti-tuberculosis drugs consist of isoniazid, ethambutol, pyrazinamide, rifampicin and streptomycin which must be consumed for 6 months. OAT has side effects, especially disturbing liver function, one of which is bilirubin. Bilirubin is a yellow pigment derived from the heme reshuffle of hemoglobin in the process of erythrocyte breakdown by reticuloendothelial cells. This research is desktiptif. This study aims to describe the total bilirubin levels in pulmonary tuberculosis patients after 5 months of consuming anti-tuberculosis drugs in TK.IV.01.07.02 Binjai Army Hospital in May-June. This study was taken from 53 samples of total bilirubin levels in tuberculosis patients who had consumed OAT for 5 months. The results of the 53 samples found normal total bilirubin levels of (77.40%) and increased by (22.60%). Frequency distribution in male sex (56.6%) women (43.4%). Total bilirubin levels increased more in male patients (13.21%). The increase in total bilirubin occurred at> 56 years of age. Total bilirubin levels increased more in female patients (9.43%).
Gambaran Hasil Pemeriksaan Real-Time Polymerase Chain Reaction (RT-PCR) pada Pasien yang Sudah Terkonfirmasi Positif Swab Antigen dan Reaktif Rapid Test Antibodi Fani Nuryana Manihuruk
Herbal Medicine Journal Vol 4 No 2 (2021): Herbal Medicine Journal
Publisher : Program Studi S1 Farmasi, STIKES Senior, Medan

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (600.821 KB) | DOI: 10.58996/hmj.v4i2.48

Abstract

Corona virus are a large family of viruses that can cause disease in humans. Examination of Real-Time Polymerase Chain Reaction (RT-PCR) is an examination using in vitro techniques for determining or measuring the extent and nature of the template DNA (DNA chain) in real time. Antigen Swab a rapid diagnostic test for Covid-19 to detect the presence of antigens from the corona virus. antibody rapid test examination is an initial screening method for detecting IgM and IgG antibodies. This research is descriptive to get an overview of the result Real-Time Polymerase Chain Reaction (RT-PCR) examination in patients who have been confirmed positive on the antigen swab and reactive on the antibody rapid test. The population in this study were patients who were confirmed positive for swab antigens totaling 183 samples and confirmed antibody reactive totaling 117 samples who underwent a follow up examination of Real-Time Polymerase Chain Reaction (RT-PCR). There were positive RT-PCR results on the antigen swab examination as many as 162 samples (88.5%) and 21 (11.5%) negative results and positive RT-PCR results on the antibody rapid test examination as many as 34 samples (29.1 %) and obtained negative results as many as 83 (70.9%). The results of this study are expected to be a science for the public in knowing supporting laboratory tests in detecting the corona virus.
GAMBARAN CANDIDA ALBICAN DALAM URINE PADA WANITA PENDERITA DIABETES MELLITUS DI LINGKUNGAN PERUMAHAN RIVER PARK KELURAHAN MANGGA KECAMATAN MEDAN TUNTUNGAN Fani Nuryana Manihuruk; Liber Napitupulu
Jurnal Kesehatan Tambusai Vol. 4 No. 3 (2023): SEPTEMBER 2023
Publisher : Universitas Pahlawan Tuanku Tambusai

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31004/jkt.v4i3.15205

Abstract

Diabetes mellitus (DM) adalah penyakit yang ditandai dengan terjadinya hiperglikemia dengan kadar glukosa puasa lebih tinggi dari 110 mg/dl. Kadar glukosa yang tinggi akan keluar bersama urine disebut dengan glukosuria. Keadaan glukosuria dapat memicu terinfeksi jamur. Gula yang terdapat dalam urine menumpuk di vulva yang akan menjadi makanan untuk pertumbuhan Candida albicans. Tujuan dilakukan penelitian ini adalah untuk mengetahui gambaran Candida albicans dalam urine pada wanita penderita Diabetes Mellitus di Lingkungan Perumahan River Park Kelurahan Mangga Kecamatan Medan Tuntungan Kota Medan. Jenis Penelitian ini adalah deskriptif dengan metode mikroskopis, pemeriksaan glukosuria melalui darah kapiler dengan metode glukometer (strip glukosa) dan identifikasi Candida albicans menggunakan metode Germ-tube test. Hasil Penelitian Dari 10 penderita diabetes mellitus yang diperiksa, terdapat 4 orang  (40%) penderita diabetes mellitus di dalam urine nya mengandung Candida albicans dan terdapat 6 orang (60%) penderita diabetes mellitus di dalam urine nya tidak mengandung Candida albicans. Berdasarkan umur dari 3 penderita DM yang berumur ? 50 tahun sebanyak 1 orang  urinenya  mengandung Candida albicans dan dari 7 penderita DM yang berumur ? 50 tahun sebanyak 3 orang urinenya mengandung Candida albicans. Berdasarkan pengontrolan penyakit, dari 4 penderita DM tidak terkontrol sebanyak 2 (50%) urinenya mengandung Candida albicans dan dari 6 pasien penderita DM terkontrol sebanyak 2 (33,3%) urinenya mengandung Candida albicans. Diharapkan untuk penderita DM untuk tetap mengontrol secara rutin agar terhindar dari penyakit komplikasi dan selalu menjaga hygiene genitalianya agar tidak dalam kondisi lembab yang dapat memicu berkembangnya Candida di area genital.
Analisa Mycobacterium Tuberculosis Pada Penderita Diabetes Melitus Di RSUD Dr. R. M. Djoelham Binjai Purba, Sanna Kamisna Royani; Manihuruk , Fani Nuryana
Health Information : Jurnal Penelitian Content Digitized
Publisher : Poltekkes Kemenkes Kendari

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

Latar Belakang : Diabetes melitus (DM) merupakan salah satu faktor risiko paling penting dalam terjadinya perburukan TB. Sejak permulaan abad ke 20, para klinisi telah mengamati adanya hubungan antara DM dengan TB, meskipun masih sulit untuk ditentukan apakah DM yang mendahului TB atau TB yang menimbulkan manifestasi klinis DM. Istilah DM menggambarkan suatu kelainan metabolik dengan berbagai etiologi yang ditandai oleh hiperglikemia kronis dengan gangguan metabolisme karbohidrat, protein, dan lemak, sebagai akibat defek pada sekresi insulin, kerja insulin, atau keduanya. Penyakit Tuberculosis (TB) Paru merupakan suatu penyakit infeksi yang disebabkan bakteri berbentuk batang (basil) yang dikenal dengan nama Mycobacterium tuberculosis. Penularan penyakit ini melalui perantaraan dahak atau droplet penderita yang mengandung bakteri Mycobacterium tuberculosis yang positif masuk ke dalam tubuh manusia melalui saluran pernafasan. Tujuan : Untuk mengetahui analisa terjadinya Mycobacterium Tuberculosis (TB) paru pada penderita diabetes melitus di RSUD Dr. R.M Djoelham Binjai. Metode : Penelitian ini menggunakan jenis penelitian dengan metode deskriptif dengan rancangan bangun penelitian cross sectional, yang digunakan untuk mengetahui Pravelensi Terjadinya Tuberculosis (TB) Paru pada Penderita Diabetes Melitus di RSUD Dr. R.M Djoelham Binjai. Hasil Penelitian: Berdasarkan pemeriksaan terhadap 36 sampel, diketahui sebanyak 16 orang (44,4%) penderita diabetes melitus menderita tuberculosis (TB). Sedangkan sisanya sebanyak 20 orang (55,6%) diketahui negatif TB. Hal ini menunjukkan persentasi yang tidak besar karena tidak melebihi angka 50%. Dari 36 sampel yang diperiksa 16 orang diantaranya merupakan perempuan (44,4%) dan 20 lainnya adalah laki – laki(55,6%).
The Utilisation of Coconut Water Waste into Nanocellulose and Potential Synergistic Effect of Asthma Plant (Euphorbia hirta L.) Extract as an Antibacterial Agent Barus, Lydia Br; Manihuruk, Fani Nuryana; Sari, Mesi Puspita; Simanjuntak, Helen Anjelina; Ginting, Junius Gian; Purba, Hermawan
JURNAL PEMBELAJARAN DAN BIOLOGI NUKLEUS Vol 9, No 3: Jurnal Pembelajaran Dan Biologi Nukleus November 2023
Publisher : Universitas Labuhanbatu

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36987/jpbn.v9i3.5060

Abstract

Skin infections contribute to one of the most significant global health issues. Acne, blisters, and abscesses are examples of skin infections that can be induced by Propionibacterium acnes, Staphylococcus aureus, and Staphylococcus epidermidis. Treatment can be attempted through the development of nanotechnology in the form of nanocellulose. Nanocellulose, an organic substance, can be produced through the conversion of coconut water waste and Acetobacter xylinum bacteria. Future applications of nanocellulose formulated with a blend of extracts derived from natural sources, including Patikan Kebo (Euphorbia hirta L.), are anticipated to include the treatment of wound dressings (patches). Determining the antibacterial potential of nanocellulose was the objective of this study. The experimental research technique is implemented in phases. The extraction process was conducted by means of maceration, while the parallel streak method was utilized for antibacterial testing. The findings of the study indicated that the mean zone of inhibition for each treatment variable was as follows: 0 mm, 15.1 mm, 23.53 mm, and 23.06 mm for nanocellulose (serving as the negative control), nanocellulose and 0.5% extract, 1% extract, 1.5% extract, and clindamycin, respectively. Conclusion: Antibacterial activity was observed in nanocellulose extracts containing 1% and 1.5%
Identification Of Candida Albicans In Saliva Patients With Type 2 Diabetes Mellitus At The Simalingkar Health Center Medan City Fani Nuryana Manihuruk; Gultom , Atri Gustiana
Jurnal EduHealth Vol. 15 No. 04 (2024): Jurnal EduHealt (inpres), Year 2024
Publisher : Sean Institute

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Abstract

Diabetes mellitus is a predisposing factor for the emergence of oral candidiasis. Increased blood glucose levels can also increase glucose levels in saliva. Excessive blood sugar levels in saliva stimulate the growth of Candida albicans on the mucosal surface, as a result, Candida albicans will be found in the saliva of DM patients. Oral candidiasis can attack mucosal tissues such as the mouth and pharynx and can be a complication of cancer. Purpose of this study was to identify candida albicans in the saliva of patients with type 2 diabetes mellitus at the Simalingkar Health Center, Medan City. Method This study is a descriptive study with a cross-sectional approach. The sampling technique was random. The number of samples identified in this study was 25 respondents, macroscopic and microscopic examinations were carried out, then the data were analyzed descriptively. The result of the descriptive analysis of the examination obtained the results of the study 56% positive Candida albicans, and 44% of respondents were negative for Candida albicans fungus. Conclusion The percentage value shows that most saliva samples from type 2 diabetes mellitus patients contain Candida albicans. These results emphasize the importance of routine monitoring of blood glucose levels to prevent the occurrence of oral candidiasis more effectively in type 2 diabetes melitus.
Hubungan Trombosit Dengan IgG IgM pada Pasien Suspek Demam Berdarah Dengue di Rs Universitas Sumatera Manihuruk, Fani Nuryana; Gultom, Atri Gustiana
Jurnal Ners Vol. 9 No. 3 (2025): JULI 2025
Publisher : Universitas Pahlawan Tuanku Tambusai

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31004/jn.v9i3.46476

Abstract

Penelitian ini bertujuan untuk mengetahui hubungan antara kadar trombosit dengan IgG dan IgM pada pasien DBD di RS Universitas Sumatera Utara. Penelitian ini merupakan penelitian observasional dengan desain cross-sectional. Sampel penelitian terdiri dari 20 pasien DBD yang memenuhi kriteria inklusi. Data yang dikumpulkan meliputi hasil pemeriksaan trombosit, IgG, dan IgM. Analisis data dilakukan menggunakan uji korelasi Pearson dan uji regresi linear. Hasil analisis korelasi menunjukkan bahwa tidak terdapat hubungan yang signifikan antara trombosit dengan IgG pada pasien DBD (Pearson Correlation = -0.074, p = 0.755). Sebaliknya, terdapat korelasi positif antara trombosit dengan IgM, namun hubungan ini tidak signifikan secara statistik (Pearson Correlation = 0.356, p = 0.123). Hasil uji regresi menunjukkan bahwa baik IgG maupun IgM tidak berpengaruh signifikan terhadap jumlah trombosit (R Square untuk IgG = 0.006, p= 0.755; R Square untuk IgM = 0.127, p = 0.123). Penelitian ini menunjukkan bahwa tidak terdapat hubungan yang signifikan antara kadar trombosit dengan IgG pada pasien DBD, dan meskipun terdapat korelasi positif antara trombosit dengan IgM, hubungan ini tidak signifikan secara statistik. Hasil ini mengindikasikan kompleksitas hubungan antara parameter imunologis dan jumlah trombosit pada pasien DBD. Penelitian lebih lanjut dengan sampel yang lebih besar diperlukan untuk memperkuat hasil ini.Program Studi Manajemen Keuangan, Fakultas Ekonomi, Universitas Methodist Indonesia, Indonesia
Gambaran Kadar Hb Pada Penderita Malaria Tropika di UPTD Puskesmas Kuala Makmur Manihuruk, Fani Nuryana; Akrama, Nurul
Herbal Medicine Journal Vol 7 No 2 (2024): Herbal Medicine Journal
Publisher : Program Studi S1 Farmasi, STIKES Senior, Medan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.58996/hmj.v7i2.148

Abstract

Malaria is an infectious disease caused by Plasmodium falciparum. In people with malaria, Plasmodium attacks red blood cells. Malaria parasite infection destroys red blood cells, so the blood of malaria sufferers is always much lower than normal hemoglobin levels. Parasitic red blood cells can be destroyed by phagocytes trying to overcome this parasitic infection. The degree of anemia in malaria patients can affect the severity of the disease and also affect treatment efforts. This study used the POCT method or strip test with the Easy Touch device. This study aims to determine hemoglobin levels in malaria patients at the Kuala Makmur Public Health Center, Simeulue Regency in 2022 based on age, gender, and degree of anemia. The number of samples examined as many as 25 were taken by accidental sampling. The type of research used is quantitative research, that is, the type of research conducted with the aim of looking at the description of hemoglobin levels in patients with tropical malaria caused by Plasmodium falciparum. The results showed that the highest incidence of tropical malaria occurred in patients aged 21-30, female sex with normal degree of anemia 40%, mild 28%, moderate 12% and severe 20%. The average hemoglobin level in malaria patients is below normal with a percentage of 68%. From the results of the study, it can be concluded that hemoglobin levels in tropical malaria patients in the working area of ​​UPTD Puskesmas Kuala Makmur are below normal. Suggestions for health workers are expected to provide more frequent counseling about malaria about the meaning, symptoms, methods of prevention, modes of transmission, and treatment. For patients, so that patients check themselves more quickly if they have a fever and take anti-malarial drugs according to the instructions recommended by health workers.
Identifikasi Escherichia Coli Pada Suspek Diabetes Melitus Penyebab Infeksi Saluran Kemih Di Desa Pematang Lalang Kecamatan Percut Sei Tuan Manihuruk, Fani Nuryana; Gultom, Atri Gustiana
Innovative: Journal Of Social Science Research Vol. 4 No. 3 (2024): Innovative: Journal Of Social Science Research
Publisher : Universitas Pahlawan Tuanku Tambusai

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31004/innovative.v4i3.10418

Abstract

Identifikasi bakteri untuk mengetahui jenis bakteri penyebab ISK. Escherecia coli merupakan bakteri penyebab infeksi saluran kemih pada penderita DM yang ditemukan pada 80-90% kasus. Bakteri ini dapat berasal dari flora usus yang keluar sewaktu buang air besar, dan jika bakteri berkembang biak akan menjalar ke saluran genitalia dan naik ke kandung kemih dan ginjal, inilah yang menyebabkan infeksi saluran kemih. Jenis penelitian yang digunakan adalah kualitataif yang bersifat deskriptif. Untuk mengidentifikasi Escherichia Coli pada sampel urin suspek Diabetes Melitus penyebab infeksi saluran kemih di Desa Pematang Lalang. Escherichia Coli pada sampel urin suspek Diabetes Melitus penyebab Infeksi Saluran Kemih di Desa Pematang Lalang dari 24 reponden yang dilakukan pemeriksaan urin sebanyak 4(16,6%) reponden yang positif Escerichia Coli dan 20 (83,3) reponden yang negatif Escherichia Coli.
Co-Authors Akrama, Nurul Butar, Mastiur Julianti Butar- Esther R. D. Sitorus Ginting, Junius Gian Ginting, Radina Yuni Mahesa Gultom , Atri Gustiana Gultom, Atri Gustiana Gusbakti Rusip Helen Anjelina Simanjuntak Ismadi Sihombing Liber Napitupulu Liber Napitupulu Lydia Br Barus M. Ichwan Napitupulu, Liber Purba, Hermawan Purba, Sanna Kamisna Royani Ringo, Esther Siringo- Sanna Kamisna Purba Sari, Mesi Puspita Tambunan, Indah Yani Br.