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Sawiji, Repining Tiyas
Sekolah Tinggi Farmasi Mahaganesha
Agriculture, Biological Sciences & Forestry Humanities Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Education Environmental Science Health Professions Immunology & microbiology Materials Science & Nanotechnology Medicine & Pharmacology Nursing Public Health Social Sciences Other

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Antipyretic Activity Test of 70% Ethanol Extract of Red Andong Leaves (Cordyline fruticosa (L) A. Chev) in Male Wistar Rats (Rattus norvegicus) Jawa La, Elisabeth Oriana; Salma, Cut Asyifa Baezura Mangkurat; Ni Ketut Esati; Repining Tiyas Sawiji
Jurnal FARMASIMED (JFM) Vol 8 No 2 (2026): Jurnal Farmasimed (JFM)
Publisher : Fakultas Farmasi Institut Kesehatan Medistra Lubuk Pakam

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35451/cjzzj881

Abstract

Introduction: Fever is a common health problem that can cause discomfort and may lead to serious complications. One alternative treatment for fever is the use of herbal plants that have been proven to possess antipyretic effects, such as red to plant leaves (Cordyline fruticosa (L.) A. Chev). Objective: To evaluate the secondary metabolite content and assess the antipyretic activity of 70% ethanol extract of red ti plant leaves in male Wistar rats induced with fever using 5% peptone. Methodology: This research used a completely randomized design (CRD) with five treatment groups: a negative control group (1% Na-CMC), a positive control group (paracetamol at a dose of 500 mg/kgBW), and three test groups receiving 70% ethanol extract of red ti plant leaves at doses of 1,200 mg/kgBW, 1,800 mg/kgBW, and 2,400 mg/kgBW. Antipyretic activity was assessed by measuring the reduction in body temperature of the test animals, expressed as a percentage of antipyretic power, and statistically analyzed to evaluate the antipyretic effect of the extract. Results: The study showed that the 70% ethanol extract of red to plant leaves tested positive for flavonoids, tannins, and saponins, which are potential antipyretic compounds. Additionally, the extract demonstrated significant antipyretic activity, as indicated by a notable reduction in the body temperature of the test animals. All three doses of the extract resulted in a temperature decrease, with the 2,400 mg/kgBW dose showing the most optimal antipyretic effect, approaching the effectiveness of paracetamol as the positive control. Conclusion: The 70% ethanol extract of red ti plant leaves has been proven to exhibit antipyretic activity, with the 2,400 mg/kgBW dose demonstrating an effect comparable to paracetamol. The extract also contains secondary metabolites such as flavonoids, tannins, phenol, terpenoids and saponins.
Co-Authors Adityawan, Putu Agus Rama Agustina Nila Yuliawati Darmawan, Gede Agus Dewi, Ni Made Ayu Sukma Esati, Ni Ketut Fitriyani I Gusti Ayu Dwi Gangga Pratiwi I Komang Tri Musthika Jawa La, Elisabeth Oriana Kadek Duwi Cahyadi Kadek Duwi Cahyadi Kumanireng, Maria Ariyani Da Costa Ni Ketut Sukarmini Ni Made Rai Yuliani Ni Wayan Ari Sukmadiani Nurjana, Novia Hayyu Pande Made Desy Ratnasari Pramana, I Gede Komang Aditya Purnamasari, I Gusti Ayu Putu Prima Putra, Kadek Ria Dwitya Putri, Kadek Mita Wulandari Putu Dian Marani Kurnianta Salma, Cut Asyifa Baezura Mangkurat Sujayanti, Luh Gede Tina Sukarya, Dewa Ayu Kade Devina Krisyanti Dewi Valtina, Ni Putu Wikayanti, Ni Putu Ayu Putri Yani, Ketut Tia Pran Anggar