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All Journal JBIO: jurnal biosains (the journal of biosciences) JURNAL FARMASIMED (JFM) Jurnal Penelitian Farmasi dan Herbal JURNAL INOVASI KESEHTAN MASYARAKAT Mejuajua Jurnal Farmanesia Jurnal Pengabdian Masyarakat Putri Hijau Jurnal Pengmas Kestra (JPK) Jurnal Kedokteran Hewan
Barus, Bunga Rimta
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Optimization and Evaluation of Noni Leaf Skin Softening Lotion Preparation (Morinda Citrifolia L.) barus, bunga rimta; Ilsanna Surbakti, Christica; Salman, Salman
JURNAL BIOSAINS Vol. 11 No. 2 (2025): JURNAL BIOSAINS
Publisher : Universitas Negeri Medan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24114/jbio.v11i2.68012

Abstract

The premature aging process is usually characterized by visible wrinkles or wrinkles on the face, dry and rough skin, age spots and decreased skin elasticity. Noni leaves (Morinda citrifolia L.) are one type of herbal plant that can potentially act as an antioxidant. The purpose of this study was to see Optimizing the Formulation of Lotion Preparations and Evaluating the Physical Properties of Lotion Preparations. Noni leaves were macerated with 96% ethanol solvent and then rotary with an evaporator. Hand and body lotion preparations were made by adding ethanol extract of noni leaves with several concentrations of 2.5% (F1), 5% (F2), and 7.5% (F3) to the base of hand and body lotion. As a blank (F0) the base of hand and body lotion without ethanol extract of noni leaves. Testing on the preparation was an evaluation of stability for 4 weeks at room temperature (odor, color, pH, emulsion type, homogeneity), irritation test and anti- aging skin activity test using a skin analyzer on hand skin. The parameters measured included water content, pore size, number of blemishes and number of wrinkles. Treatment was carried out using hand and body lotion every day for 4 weeks. Ethanol extract concentrations of 2.5%, 5% and 7.5% were homogeneous preparations with an oil-in-water emulsion type, pH 6.3-6.8, stable in storage for 4 weeks, and did not irritate the skin. Anti- aging skin hand and body lotion preparations containing ethanol extract of noni leaves can increase water content, reduce pore size, reduce the number of blemishes, reduce the number of wrinkles on the skin of the back of the hand and are stable in storage for 4 weeks. Hand and body lotion preparations with ethanol extract at a concentration of 7.5% had better skin antiaging activity compared to concentrations of 2.5%, 5% and blank.
EFFECT OF HESPERETIN TREATMENT ON BLOOD GLUCOSE LEVEL, SPERMATOZOA QUALITY, AND SPERMATOZOA QUANTITY IN ALLOXAN-INDUCED DIABETIC MICE Nerdy, Nerdy; Meliala, Linta; Barus, Bunga Rimta; Lestari, Puji; Ginting, Selamat; Ariani, Peny; Mierza, Vriezka; Bakri, Tedy Kurniawan
Jurnal Kedokteran Hewan Vol 15, No 1 (2021): March
Publisher : Universitas Syiah Kuala

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21157/j.ked.hewan.v15i1.18406

Abstract

Male infertility has occurred rapidly in the last few decades, primarily in developing countries. An antioxidant, hesperetin is a flavonoid that is found in abundance in orange peels. The aims of this research were to determine the effect of hesperetin on blood sugar levels, spermatozoaquality, and spermatozoa quantity. The research structure included induction of diabetes mellitus and treatment for 8 weeks, followed bydetermination of blood sugar levels, spermatozoa quality, and spermatozoa quantity. Hesperetin has the ability to restore blood sugar levels, spermatozoa quantity, seminiferous tubules diameter, and testicular weight, volume, and germinal epithelial layer thickness with significant difference from the normal control group. Hesperetin did not fully restore spermatozoa motility, viability, and morphology with significant difference from the normal control group, nor from the positive control group. However, overall, hesperetin decreased blood glucose levels, increased spermatozoa quantity, and improved the spermatozoa quality in alloxan-induced diabetes mellitus mice. Dose-dependent activity was observed with the optimum dose at 200 mg/kg body weight.
Co-Authors Aminuyati Ariani, Peny BAKRI, TEDY KURNIAWAN Berkat Waruwu, Syukur Estevania Kaban, Vera Faldha, Asri Ginting, Ernawati GINTING, SELAMAT Hariati Hariati Ilsanna Surbakti, Christica Indah Lestari, Indah Marbun, Novarianti Meliala, Linta Mierza, Vriezka Muflihah Fujiko Nerdy, Nerdy Octavia Aitonang, Jessi PUJI LESTARI Salman Salman Sitorus, Friska Ernita Surbakti, Christica Tambunan, Pravil Mistryanto Vera Estefania Kaban