Article Per Year (5 Year)
p-Index From 2020 - 2025
1.452
P-Index
This Author published in this journals
All Journal Journal of Islamic Pharmacy Jurnal Farmasi Galenika (Galenika Journal of Pharmacy) Jurnal Abdimas PHB : Jurnal Pengabdian Masyarakat Progresif Humanis Brainstorming Health Sciences and Pharmacy Journal Jurnal Kefarmasian AKFARINDO Jurnal Ilmiah Medicamento Borneo Journal of Pharmacy
Imtihani, Hilya Nur
Unknown Affiliation
Automotive Engineering Biochemistry, Genetics & Molecular Biology Chemistry Computer Science & IT Health Professions Immunology & microbiology Mechanical Engineering Medicine & Pharmacology Nursing Public Health Social Sciences

Published : 7 Documents Claim Missing Document
Claim Missing Document
Check
Articles

Found 7 Documents
Search

 1 
Formulasi dan Evaluasi Suspensi Granul Effervescent Ekstrak Kitosan Cangkang Kepiting Bakau (Scylla serrata) Dengan Perbandingan Natrium Bikarbonat Oktavina, Windy Riyan; Imtihani, Hilya Nur
Journal of Islamic Pharmacy Vol 8, No 2 (2023): J. Islamic Pharm.
Publisher : Universitas Islam Negeri Maulana Malik Ibrahim Malang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18860/jip.v8i2.23533

Abstract

Ekstrak kitosan dari cangkang kepiting bakau (Scylla serrata) diketahui dapat menurunkan kolesterol. Formulasi ekstrak kitosan cangkang kepiting bakau dibuat dalam bentuk suspensi granul effervescent menggunakan variasi kadar komponen basa. Penelitian ini bertujuan untuk mengetahui pengaruh perbandingan natrium bikarbonat 25% (F1) dan natrium bikarbonat 30% (F2) terhadap sifat fisik granul effervescent sebelum dan sesudah rekonstitusi. Formulasi granul effervescent ekstrak kitosan cangkang kepiting bakau dilakukan dengan metode granulasi kering, yaitu tidak menggunakan air atau pelarut lain. Hasil penelitian menunjukkan granul effervescent yang dihasilkan memenuhi syarat dengan laju alir (F1 3,1 detik); (F2 7,1 detik), sudut diam (F1 23,9 ̊); (F2 24 ̊), kadar air (F1 1,6%); (F2 2%), persentase fines (F1 5,6%); (F2 34,31%), waktu dispersi (F1 01,49 menit); (F2 03,65 menit), tinggi buih (F1 3,5 cm); (F2 3,2 cm), pH (F1 4,23); (F2 5,15), viskositas (F1 2,22 mPa.s); (F2 1,91 mPa.s). Keseluruhan evaluasi memenuhi persyaratan kecuali pH pada F1, sehingga F2 merupakan formula terbaik karena menghasilkan pH yang tidak terlalu asam dibandingkan dengan F1 dan F2 menjadi granul effervescent yang paling banyak disukai karena memiliki rasa yang segar.
FORMULASI DAN EVALUASI GRANUL DISPERSI PADAT EKSTRAK KITOSAN CANGKANG KEPITING BAKAU (Scylla serrata) DENGAN PERBANDINGAN KITOSAN:PVP K-30 1:2 Abdullah, Hannah Savitri; Imtihani, Hilya Nur
Jurnal Kefarmasian Akfarindo Vol 7 No 1 (2022)
Publisher : Akademi Farmasi Indonesia Yogyakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37089/jofar.vi0.119

Abstract

Background: Mangrove crab shells (Scylla serrata) contain chitosan which functions as an anticholesterol. Chitosan is insoluble in water but soluble in acids such as acetic acid. In the process of increasing the solubility, a solid dispersion system is made. The solid dispersion is then formulated into granules. Objective: The purpose of this study was to determine the physical properties of the solid dispersion chitosan granules (FI) and the physical mixture granules (FII). Methods: The method used for the manufacture of solid dispersions is solvent evaporation using PVP K-30 (1:2) as a carrier. The solid dispersion will be made in the form of granules by wet granulation method which will then evaluate the quality of the granules. Results: From this study, the granule flow rate FI=12.89 g/second, and FII=24.58 g/second. The angle of repose of the granules FI=22,13o, and FII=9,46o. The compressibility and Hausner granule FI ratio were found to be 20% and 1.25; while FII obtained 9.90% and 1.11. The percentage of water content of FI granules is 6.38%, and FII is 2.04%. Conclusion: The formulation in this study was able to produce granules that met the requirements, and there was a significant difference between the physical properties of FI and FII granules.
Formulasi tablet kitosan cangkang kepiting bakau (Scylla serrata) dari co-processed excipient dengan PEG 4000 sebagai meltable binder Imtihani, Hilya Nur; Natarani, Mutia; Sandy, Yessy Kurnia
Health Sciences and Pharmacy Journal Vol. 6 No. 3 (2022)
Publisher : STIKes Surya Global Yogyakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32504/hspj.v6i3.741

Abstract

Chitosan has many functions in the health sector, one of which can be used as an anti cholesterol supplement. Co-processing is a technique carried out to obtain new additives by combining two or more existing additives, where the combinations of these materials will complement each other, so that new additives with better (superior) properties are obtained. The purpose of this study was to determine the formulation and evaluation of mud crab shell (Scylla serrata) chitosan tablets from co-processed excipients with PEG 4000 as a meltable binder with a ratio of 10% (F1) and 20% (F2). Co-processed excipients are made using the melt granulation method with additional ingredients, namely lactose as a filler and primogel as a disintegrant. Tablets were printed using the direct compression method with the addition of Mg Stearate as a lubricant. The results of the co-processed excipient evaluation showed that each granule met the requirements for the flow rate test, angle of repose test, compressibility test and Hausner's ratio. From the results of statistical tests using the Mann-whitney test method, there is a significant difference between co-processed excipient PEG 4000 10% and PEG 4000 20% as a meltable binder for the parameters of water content with F2 moisture content (1.67%) lower than in F1 (3.33%). In the evaluation of chitosan tablets, they produced tablets that met the test requirements for weight uniformity, tablet friability (F1), tablet hardness, disintegration time (F2) and did not meet the requirements for the tablet size uniformity test. The selected formula for this study was F2 with a PEG 4000 meltable binder of 20% because it produced tablets that met disintegration time with low water content.
Penyuluhan dan Pembudidayaan Tanaman Bunga Telang (Clitoria ternatea L.) di Krian, Sidoarjo Yuliarni, Floreta Fiska; Imtihani, Hilya Nur; Zulfa, Ilil Maidatuz; Permatasari, Intan Kurnia
Jurnal Pengabdian Masyarakat Progresif Humanis Brainstorming Vol 7, No 4 (2024): Jurnal Abdimas PHB : Jurnal Pengabdian Masyarakat Progresif Humanis Brainstormin
Publisher : Politeknik Harapan Bersama

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30591/japhb.v7i4.7437

Abstract

Clitoria ternatea L. memiliki bunga berwarna biru, ungu, dan putih. Tanaman tersebut mengandung metabolit sekunder diantaranya fenol, flavonoid, tanin, alkaloid, terpenoid, steroid, dan cardiac glycosides. Bunga telang memiliki potensi farmakologis diantaranya sebagai antikanker, antidiabetes, antiparasit, anti-inflamasi, antibakteri, dan antioksidan. Tanaman telang relatif mudah ditanam dan tidak memerlukan perawatan yang rumit sehingga mudah dipelihara. Kegiatan pengabdian masyarakat memiliki tujuan untuk mengenalkan, memberi pengetahuan dan mempraktekkan cara budidaya tanaman bunga telang pada santri dan santriwati Madrasah Aliyah di Pondok Pesantren Modern Al-Amanah Junwangi. Metode pada kegiatan ini terdiri dari tiga tahap. Tahap pertama adalah tahap perencanaan yang meliputi survei lokasi dan permohonan izin. Tahap kedua adalah tahap pelaksanaan yang meliputi penyuluhan dan praktek penanaman tanaman bunga telang. Tahap ketiga evaluasi dengan memberikan soal pre-test kepada peserta. Kegiatan ini dilaksanakan oleh dosen dan tim mahasiswa (9 orang). Kegiatan tersebut dihadiri oleh 157 orang. Peserta antusias dengan memberikan pertanyaan ketika penyuluhan dan praktek langsung untuk menanam tanaman bunga telang. Kesimpulan dalam kegiatan ini adalah terjadi peningkatan pemahaman dan pengetahuan mengenai tanaman bunga telang dan cara pembudidayaannya. Rata-rata nilai pre-test yang didapatkan sebesar20,95 dan rata-rata nilai post-test sebesar 57,14. Persentase peningkatan sebesar 36,19%.
Uji In-Vitro Penurunan Kadar Kolesterol dengan Perbandingan Tiga Dosis Kitosan Cangkang Kepiting Bakau (Scylla serrata) pada Suspensi Granul Effervescent Novyanti, Erna Sri; Andina, Fateha Rizka; Subekti, Laura Andrea; Imtihani, Hilya Nur
Jurnal Ilmiah Medicamento Vol 11 No 1 (2025): Jurnal Ilmiah Medicamento
Publisher : Fakultas Farmasi Universitas Mahasaraswati Denpasar

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36733/medicamento.v11i1.9914

Abstract

Changes in human lifestyle—such as smoking, lack of physical activity, and poor dietary habits—have contributed significantly to the increasing incidence of hypercholesterolemia. Most cholesterol-lowering drugs currently available are chemically synthesized and may be associated with undesirable side effects. Consequently, there is growing interest in developing safer, natural alternatives. Indonesia produces a large volume of crab shell waste, which presents an opportunity for the sustainable production of chitosan, a biopolymer known for its cholesterol-lowering potential. However, chitosan has limited solubility in water, which can hinder its absorption and usability. To address this limitation, chitosan was formulated into an effervescent granule suspension to enhance solubility and improve patient compliance through easier consumption in liquid form. The effervescent granule suspensions were prepared using the wet granulation method. This study aimed to evaluate their cholesterol-lowering effects using the in vitro Lieberman–Burchard method, employing three different chitosan doses: F1 (45 mg), F2 (55 mg), and F3 (75 mg), in order to determine the optimal dosage. The average cholesterol reduction percentages were F1 = 14.66% ± 2.12, F2 = 22.39% ± 6.06, F3 = 13.37% ± 2.99, and simvastatin = 19.02% ± 0.74. Although F2 exhibited the highest cholesterol-lowering activity, the differences among the three formulations were not statistically significant (p = 0.156).
In Vitro Evaluation of Cholesterol-Reducing Ability of Chitosan from Mangrove Crab (Scylla serrata) Shell Solid Dispersion using PVP K-30 as a Carrier: Uji In Vitro Penurunan Kadar Kolesterol Sistem Dispersi Padat Kitosan dari Cangkang Kepiting Bakau (Scylla serrata) Menggunakan PVP K-30 Sebagai Pembawa Imtihani, Hilya Nur; Permatasari, Silfiana Nisa; Prasetya, Rahmad Aji
Jurnal Farmasi Galenika (Galenika Journal of Pharmacy) (e-Journal) Vol. 7 No. 2 (2021): (October 2021)
Publisher : Universitas Tadulako

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22487/j24428744.2021.v7.i2.15597

Abstract

Background: Chitosan is a compound that can be synthesized from nature which can reduce the total serum cholesterol levels between 5.8−42.6% and decrease LDL (Low-Density Lipoprotein) between 15.1-35.1%. One of the natural resources containing chitosan derivative compounds is the shell of mud crab. Chitosan is insoluble in water but soluble in acidic solutions such as acetic acid. With such chitosan solubility, it is necessary to increase the solubility by making a solid dispersion system so that drug absorption can be faster. Objectives: The aims of this study is to determine the potential of chitosan solid dispersion system for reducing cholesterol. Material and Methods: The reduction of cholesterol levels was carried out by in vitro tests using UV-Vis spectrophotometer at a wavelength of 405 nm with Lieberman-Burchad reagent. The positive control used was simvastatin. There are 4 formulas, namely SD1, PM1, SD2, and PM2. This solid dispersion system uses polyvinyl pyrrolidone K-30 (PVP K-30) as carrier. Results: The characterization of chitosan has fulfilled all the characterization requirements that is organoleptic (shape and color) was creamy white, moisture content was 2.15%, ash content was 1.14%, ninhydrin test was positive purple, and deacetylation degree was 70.57%. The results of in vitro evaluation were obtained a dark green solution. The reducing percentage in cholesterol levels are SD1: 18.44%; PM1 : 18.11%; SD2 : 29.57%; and PM2 :12.01%. Simvastatin as a positive control has a percentage reduction in cholesterol levels of 30.07%. Conclusion: Chitosan has an activity as anticholesterol agent. SD2 (Solid Dispersion Chitosan: PVP K-30 = 1:2) has the higher percentage than other formulas for reducing cholesterol level comparable with the positive control.
Granulation Methods Dependent Physical Characteristics of Chitosan Effervescent Granule Suspension from Mangrove Crab (Scylla serrata) Shell Imtihani, Hilya Nur; Isbandyah, Nimas Ajeng; Susanti, Endah; Aristyawan, Andhika Dwi
Borneo Journal of Pharmacy Vol. 8 No. 4 (2025): Borneo Journal of Pharmacy
Publisher : Institute for Research and Community Services Universitas Muhammadiyah Palangkaraya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33084/bjop.v8i4.7334

Abstract

The mangrove crab (Scylla serrata), a prevalent resource in coastal mangrove ecosystems, is widely utilized for consumption. Its shell offers a valuable source of chitosan, a biopolymer readily synthesized and recognized for its potential health benefits. Chitosan's unique structure, characterized by the presence of amine groups, imparts a strong positive charge, enabling it to effectively bind with negatively charged molecules such as oils and fats. This property makes chitosan a promising natural compound for managing cholesterol levels. Developing a palatable and convenient dosage form, such as an effervescent granule suspension, is crucial to enhance its public acceptance as a health supplement. This study investigated how different granulation methods (wet and dry) influence the physical properties of effervescent granules containing chitosan, both before and after reconstitution. Four distinct formulations were prepared: F1 and F2 employed dry and wet granulation, respectively, with a citric acid : tartaric acid ratio of 10% : 20%; while F3 and F4 utilized the same granulation methods but with a higher acid ratio of 13% : 26%. Comprehensive evaluation revealed that all formulations generally met quality requirements, except F3's pH (4.38 ± 0.57). Statistical analysis using an independent sample t-test indicated that the granulation method significantly affected parameters such as flow time, percentage of fines, dispersion time, and pH. Ultimately, the dry granulation method yielded the most favorable characteristics, with Formula I (F1) exhibiting superior flow properties, optimal pH, and desired viscosity.
Co-Authors Abdullah, Hannah Savitri Andina, Fateha Rizka Aristyawan, Andhika Dwi Endah Susanti, Endah Isbandyah, Nimas Ajeng Natarani, Mutia Novyanti, Erna Sri Oktavina, Windy Riyan Permatasari, Intan Kurnia Permatasari, Silfiana Nisa Prasetya, Rahmad Aji Sandy, Yessy Kurnia Subekti, Laura Andrea Yuliarni, Floreta Fiska Zulfa, Ilil Maidatuz