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All Journal International Journal of Advances in Applied Sciences Acta Pharmaceutica Indonesia Jurnal Fitofarmaka Indonesia Current Research on Biosciences and Biotechnology
Andi Rifki Rosandy
Bandung Institute Of Technology
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Earth & Planetary Sciences Environmental Science Materials Science & Nanotechnology Mathematics Medicine & Pharmacology Physics

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Journal : Current Research on Biosciences and Biotechnology

 1 
Phenazine-1-carboxylic acid (PCA) from cold-adapted yeast Glaciozyma antarctica PI12 Andi Rifki Rosandy; Rozida Mohd. Khalid
Current Research on Bioscences and Biotechnology Vol. 2 No. 1 (2020)
Publisher : Institut Teknologi Bandung

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.5614/crbb.2020.2.1/TLCY1641

Abstract

A phenazine alkaloid, phenazine-1-carboxylic acid (PCA) was isolated from the ethyl acetate extract of cold-adapted yeast Glaciozyma antarctica PI12 (Kriegeriales). The compounds were isolated by several chromatography techniques i.e. radial chromatography (RC) and thin-layer chromatography (TLC). The chemical structure was elucidated by ultraviolet (UV), infrared (IR), nuclear magnetic resonance (1D and 2D NMR) spectroscopy and mass spectrometry.
Antibacterial activity of lupeol from the bark of Dehaasia cuneate (Lauraceae) Andi Rifki Rosandy; Sumail Sidik Ode Ishak; Noor Aziiraa Sabri; Wan Yaacob Wan Ahmad; Laode Muhammad Ramadhan Al Muqarrabun
Current Research on Bioscences and Biotechnology Vol. 2 No. 2 (2021)
Publisher : Institut Teknologi Bandung

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.5614/crbb.2021.2.2/BOFY6724

Abstract

Dehaasia cuneata, locally known in Malaysia as ‘gajus hutan or pekan’, belongs to family Lauraceae. From its bark, A triterpenoid, lupeol was isolated and characterized. The chemical structure of the isolated compound was determined using spectroscopic methods, such as UV–vis, FT-IR, 1D & 2D-NMR, and ESIMS spectrometer. The isolated compound was tested against Gram-negative and positive bacteria using agar disc diffusion technique. The results showed that lupeol had a moderate inhibition zone value of 10.0±0.00 mm against Gram-negative Serratia marcescens ATCC 14756 whereas low inhibition which is 7.0±0.00 mm against Escherichia coli ATCC 25922, Vibrio fluvialis ATCC 33809, Bacillus subtilis ATCC 6633, and Methicillin-resistant Staphylococcus aureus (MRSA) ATCC 43300.
Isolation of bioactive compounds with tyrosinase inhibitory activity from the methanol extract of meniran herb (Phyllanthus niruri Linn.) Syefira Salsabila; Rika Hartati; Laode M.R. Al Muqarrabun; Nurinanda Prisky Qomaladewi; Ariranur Haniffadli; Andi Rifki Rosandy; Agus Chahyadi; Elfahmi
Current Research on Bioscences and Biotechnology Vol. 3 No. 2 (2022)
Publisher : Institut Teknologi Bandung

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.5614/crbb.2022.3.2/GOO6ZULV

Abstract

Meniran (Phyllanthus niruri L.) is a wild plant in the Euphorbiaceae family which grows in tropical climates. The plant is known to possess antioxidant activity and is rich in phenolic compounds. Since plants with high phenolic content and high antioxidant activity are known to exhibit high tyrosinase inhibitory activity, the purpose of this study is to determine the inhibitory activity of the tyrosinase enzyme by the methanol extract of meniran (P. niruri L.) and to isolate secondary metabolites from the extract and fractions which exhibit inhibitory activity against tyrosinase. The in vitro tyrosinase inhibitory activity assay was conducted using the 96-well microplate method with kojic acid as the positive control, while the separation and purification of compounds were carried out using chromatography techniques. The methanol extract and n-hexane fraction showed tyrosinase inhibitory activity with IC50 of 11.05±0.16 and 2.57±0.08 mg/ml, respectively. Three bioactive compounds were succesfully isolated from the n-hexane fraction. Based on the UV and NMR spectra, compounds 1, 2, and 3 were identified as phyllanthin, phyltetralin, and hypophyllanthin, respectively. Furthermore, phyllanthin (1) was shown to demonstrate inhibitory activity against tyrosinase with IC50 of 0.6322 mM. In conclusion, both meniran extract and phyllanthin (1) were found to exhibit inhibitory acitivity against the tyrosinase enzyme. In the future they can be candidates for the treatment against hyperpigmentation and also as an active ingredient in skincare formulations.
Co-Authors Adi Permadi, Adi Agus Chahyadi Agus Chahyadi Ariranur Haniffadli Budiastuti, Pramudita Elfahmi Elfahmi, Elfahmi Fatma Nuraisyah, Fatma Hasnaeni hasnaeni, Hasnaeni Laode M.R. Al Muqarrabun Laode Muhammad Ramadhan Al Muqarrabun Noor Aziiraa Sabri Novitasari, Putri Rachma Nurinanda Prisky Qomaladewi Nurul Nadiah Binti Abdul Rahman Pratiwi Apridamayanti, Pratiwi Ramadhan, Muhammad Kaisar Sutomo Rika Hartati Rozida Khalid Rozida Mohd. Khalid Rumaisha, Sanda Salsabila, Syefira Setyanto, Barry Nur Sumail Sidik Ode Ishak Syamsuddin, Arief Wan Yaacob Wan Ahmad Wulandana, Rachmadian