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All Journal Journal Of Vocational Health Studies Abdi Masyarakat Jurnal Farmasi dan Sains Indonesia (JFSI) Proceedings of the International Conference on Nursing and Health Sciences Media Farmasi Indonesia Prosiding Seminar Informasi Kesehatan Nasional Indonesian Journal of Medical and Pharmaceutical Science
Erikania, Susanti
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Humanities Biochemistry, Genetics & Molecular Biology Chemistry Economics, Econometrics & Finance Education Energy Health Professions Immunology & microbiology Languange, Linguistic, Communication & Media Medicine & Pharmacology Neuroscience Nursing Public Health Social Sciences Other

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Comparison of Antibiofilm Activities of Green Coffee Beans (Coffea Canephora P.) and Roasted Robusta Coffee (Coffea Canephora L.) Against Staphylococcus Aureus ATCC 25923 Wicahyo, Septian Maulid; Wardani, Tatiana Siska; Erikania, Susanti
Proceedings of the International Conference on Nursing and Health Sciences Vol 5 No 1 (2024): January-June 2024
Publisher : Global Health Science Group

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37287/picnhs.v5i1.2794

Abstract

Biofilm is a collection of microbial cells that are irreversibly attached to a surface and encased in an EPS matrix (Extracellular Polymeric Substances). One of the infectious bacteria that produce biofilms is Staphylococcus aureus. Coffee contains compounds that are responsible for antibacterial activity, including alkaloids, flavonoids, phenolics, terpenoids/steroids and saponins among others. The purpose of this study was to determine the activity of the antibiofilm between Green Coffee (Coffea canephora P.) and Robusta Coffee (Coffea canephora L.) against Staphylococcus aureus bacteria. Extraction of green coffee beans and robusta coffee beans was carried out by maceration method, fractionation was carried out by liquid-liquid extraction method using water, ethyl acetate and n-hexane as solvents. Inhibitory activity and biofilm degradation were carried out using the crystal violet staining method which was read at a wavelength of 595 nm. Obtained inhibition and degradation were analyzed using the ANOVA statistical test. The method for testing anti-biofilm activity was determined by testing the inhibition of biofilm formation and biofilm degradation using extracts and fractions robusta green coffee bean (Coffea canephora P.) and roasted robusta coffee beans (Coffea canephora L.) at various concentrations of 2, 4, 8 and 16 mg/ml. Robusta roasted coffee bean extract has the greatest anti-biofilm inhibition effectiveness with IC50 biofilm inhibition of 2.13 ppm. The ethyl acetate fraction from roasted robusta coffee beans has the greatest effectiveness in destroying (degrading) anti-biofilms with the EC50 biofilm degradation of 1.93 ppm.
Aktivitas Antioksidan Ekstrak, Fraksi dan Sub Fraksi Ekstrak Etanol Daun Manggis (Garcinea mangostana) dan Kuantifikasi Senyawa Aktif Dalam Kelompok Sub Fraksi Secara Densitometri erikania, susanti; Silfiana, Dita; Kurniawati, Nurrizka; Kristyanti, Yulia
Media Farmasi Indonesia Vol. 18 No. 2 (2023): Media Farmasi Indonesia
Publisher : SEKOLAH TINGGI ILMU FARMASI YAYASAN PHARMASI SEMARANG

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.53359/mfi.v18i2.220

Abstract

Tanaman manggis (Garcinia mangostana L.) banyak dilaporkan memiliki aktivitas farmakologi seperti antimikroba, antikanker, antiinflamasi, antidiabetes, dan antioksidan. Antioksidan merupakan suatu senyawa yang dapat menyerap atau menetralisir radikal bebas sehingga mampu mencegah penyakit degenaratif. Penelitian ini bertujuan untuk mengetahui aktivitas antioksidan ekstrak, fraksi dan sub fraksi ekstrak etanol daun manggis beserta kuantifikasi senyawa aktifnya. Ekstraksi dilakukan secara maserasi menggunakan etanol 96%. Ekstrak hasil maserasi di partisi secara ECC. Ekstrak dan fraksi hasil ECC dilakukan uji antioksidan menggunakan metode DPPH. Hasil antioksidan tertinggi selanjutnya difraksinasi secara KCV (kromatografi cair vakum). Fraksi dimonitoring menggunakan kromatografi lapis tipis (KLT) menghasilkan 3 kelompok sub fraksi yaitu A, B dan C. Pengujian antioksidan dilanjutkan pada 3 kelompok sub fraksi dengan metode DPPH. Kuantifikasi senyawa aktif dalam kelompok sub fraksi menggunakan metode KLT densitometri dengan fase diam silica gel F254 dan fase gerak etil asetat : toluen : metanol : asam format (6:6:3:2). Analisis data dan statistik menggunakan SPSS One way Anova. Hasil penelitian menunjukkan fraksi etanol hasil ECC memiliki nilai IC50 tertinggi yaitu 3,21 ppm dibandingkan ekstrak etanol 4,00 ppm, fraksi n heksan 4,59 ppm dan fraksi etil asetat 3,56 ppm. Kelompok sub fraksi C memiliki aktivitas antioksidan tertinggi dengan nilai IC50 yaitu 18,09 ppm dibandingkan A sebesar 311,81 ppm dan B sebesar 60,52 ppm. Kuantifikasi kelompok sub fraksi secara KLT densitometri diperoleh nilai kadar yaitu C sebesar 1,92 µg/ml, B sebesar 0,80 µg/ml dan A sebesar 1,84 µg/ml. Hasil uji SPSS One way Anova menunjukkan nilai signifikan (p<0,05) yang berarti terdapat perbedaan yang signifikan antara kelompok sub fraksi A, B, dan C. Sehingga dapat disimpulkan bahwa kelompok sub fraksi C memiliki aktivitas antioksidan tertinggi dengan IC50 sebesar 19,09 ppm dan memiliki kadar senyawa aktif tertinggi yaitu 1,92 µg/ml.
ANTI-BACTERIAL ACTIVITY TEST OF ETHANOL EXTRACTS AND ETHLACETATE FRACTION FROM THE EXTRACT OF JATROPHA CURCAS L. LEAVES AGAINST STAPHYLOCOCCUS AUREUS Wulandari, Sekar; Erikania, Susanti; Maritha, Vevi
Journal of Vocational Health Studies Vol. 5 No. 1 (2021): July 2021 | JOURNAL OF VOCATIONAL HEALTH STUDIES
Publisher : Faculty of Vocational Studies, Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/jvhs.V5.I1.2021.31-38

Abstract

Background: Staphylococcus aureus is a gram-positive bacteria that can cause infection. One of the plants that has antibacterial activity is jatropha leaves which contain flavonoids, saponins, tannins, alkaloids, steroids and polyphenols. Purpose: To determine the antibacterial activity of ethanol extract and ethyl acetate fraction with concentrations of 30%, 60% and 100% against Staphylococcus aureus bacteria. Method: The method for extracting jatropha leaves is maceration with 96% ethanol solvent and the fractionation method, namely liquid-liquid fractionation with ethyl acetate solvent. Antibacterial activity test was carried out in vitro with the disc diffusion method and compared the mean zone of inhibition of each treatment with a positive control (gentamicin 10 μg). Result: The results showed that the ethanol extract and ethyl acetate fraction of jatropha leaves had a strong resistance response, while the positive control gave a very strong inhibitory response to the growth of S. aureus bacteria. Based on the one way ANOVA test, ethanol extract and ethyl acetate fraction showed a significant difference from each treatment with a significant value (P=<0.05). Conclusion: The ethanol extract of Jatropha leaves can inhibit the growth of S. aureus bacteria at a concentration of 100% (18.28 ± 0.50 mm), 100% concentration of ethyl acetate fraction (15.10 ± 0.12 mm). The ethanol extract provided the best inhibition power, namely 18.28 ± 0.50 mm and a positive control 21.82 ± 0.092 mm.
ANTIBACTERIAL ACTIVITY OF MANGOSTEEN BARK FRACTION (GARCINIA MANGOSTANA L.) SALMONELLA TYPHI ATCC 13311 Anggraini, Salmah Wilujeng; Erikania, Susanti; Maritha, Vevi
Journal of Vocational Health Studies Vol. 5 No. 3 (2022): March 2022 | JOURNAL OF VOCATIONAL HEALTH STUDIES
Publisher : Faculty of Vocational Studies, Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/jvhs.V5.I3.2022.139-145

Abstract

Background: Typhoid fever is caused by Salmonella typhi bacterial infection which spreads via the faecal-oral route and has epidemic potential. Salmonella typhi is a Gram-negative bacterium in the Enterobacteriaceae family. Currently, the use of natural ingredients can be an alternative treatment for typhoid fever, one of which is the mangosteen stem skin (Garcinia mangostana L.). Purpose: To determine the antibacterial activity of mangosteen stem skin fraction against Salmonella typhi ATCC 13311. Method:The maceration method was selected using methanol solvent and fractionation by ECC using ethyl acetate and n-hexane as solvents. This study used five treatments (fraction with a concentration of 20%, 40%, 80%, chloramphenicol 30µg as a positive control, and DMSO as a negative control) which tested their antibacterial activity against Salmonella typhi ATCC 13311 by disc diffusion. Result: The results showed that the ethyl acetate fraction of mangosteen stem skin had the greatest average inhibition zone, that is 13.86 ± 0.72 mm compared to the n-hexane fraction of mangosteen stem skin with an inhibition zone of 10.43 ± 0.73 mm. The data obtained were then analyzed with One-way ANOVA. Conclusion: The results obtained were p=0.000 (sig <0.05), indicating that there was a significant difference between the ethyl acetate fraction and the n-hexane fraction with 20%, 60%, and 80% concentrations with positive control
Validasi Metode Penetapan Kadar Etanol pada Parfum Isi Ulang yang Dijual di Kota Madiun menggunakan Metode Kromatografi Gas Detektor FID (Flame Ionization Detection) Wigyaningrum, Amelia Ike; Kurniawati, Nurrizka; Erikania, Susanti
Indonesian Journal of Medical and Pharmaceutical Science Vol. 3 No. 2 (2024)
Publisher : Sultan Agung Islamic University of Semarang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30659/ijmps.v3i2.202

Abstract

Background: Perfume and fragrance oils are among the thousands of industrial products that are in demand by the public. The general public uses fragrance oils as body fresheners, for clothing and for rooms. Perfume is a mixture of essential oils and aromatic compounds, binders and solvents used to provide fragrance to the human body, objects or rooms. The purpose of this study was to analyze the ethanol content in refill perfume products. Method: This study used gas chromatography, gas chromatography is a dynamic method for the separation and detection of volatile compounds in a mixture. Gas chromatography can be used to determine the concentration of ethanol. This method has been improved and shows a significant increase in determining the concentration of ethanol. The tests carried out include qualitative and quantitative tests. Results: The results of the qualitative test showed that all perfume samples were positive for ethanol. While the results of the quantitative test to determine the ethanol content in perfume samples showed results of 1.9%; 2.04%; 2.03%; 1.83% and 1.84%. According to BPOM, the safe ethanol content in perfume is 5% calculated as % of ethanol and isopropanol. Conclusion: The FID detector gas chromatography method is efficiently used in determining the ethanol content in perfume. The results of the calculation of the content values contained in sequence from samples 1,2,3,4, and 5 are 1.9%; 1.49%; 2.03%; 1.83% and 1.84%. All refill perfume samples sold in perfume shops in Madiun City meet BPOM standards.
Uji Aktivitas Antioksidan Ekstrak Terpurifikasi dari Selada Laut (Ulva lactuca L.) dari Perairan Pantai Pidakan Pacitan dengan Metode DPPH (1,1-Diphenyl-2-picrylhydrazyl) Ainiyah, Nur; Erikania, Susanti; Nurmaulawati, Rina
Jurnal Farmasi & Sains Indonesia Vol 6 No 2 (2023)
Publisher : LPPM Sekolah Tinggi Ilmu Farmasi Nusaputera

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52216/jfsi.vol6no2p61-70

Abstract

Free radicals in the absence of antioxidants can damage important cells in the body so that they can cause degenerative diseases. Natural antioxidants can be found from plants that contain phenolic compounds throughout plant parts such as wood, seeds, fruits, roots, flowers, and leaves. One plant that has antioxidant activity is sea lettuce. This study aims to determine the antioxidant activity of purified sealettuce extract results expressed with IC50. The method chosen to make lettuce ethanol extract was the maceration used 96% ethanol solvent, then purified with a split funnel using 96% ethanol solvent and n-hexane. Purified extracts was screened for phytochemicals. Furthermore, antioxidant testing was carried out with the DPPH method by UV-Vis spectrophotometry. After antioxidant testing, data and statistics were analyzed using the SPSS Independent Samples T-Test. The results of this study showed that purified extracts contained flavonoids, alkaloids, saponins, phenols and tannins. In purified extracts of sea lettuce, an average IC50 value of 47.99 ppm was obtained and an average IC50 value of 4,38 ppm was obtained. Based on the Independent Samples T-Test of purified sea lettuce extract and vitamin C showed a significant difference from each treatment as evidenced by a significance value (p < 0.05).
Training on Processing Used Cooking Waste into Solid Soap and Liquid Soap at the Karang Taruna of Palur Village. Wardani, Tatiana siska; Suhatmi, Erna Chotidjah; Artini, Kusumaningtyas Siwi; Dewi, Belinda Arbitya; Erikania, Susanti
Abdi Masyarakat Vol 7, No 1 (2025): Abdi Masyarakat
Publisher : Lembaga Penelitian dan Pendidikan (LPP) Mandala

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.58258/abdi.v7i1.8714

Abstract

Karang Taruna Saras Muda Palur Village in creating a clean environment, one of which is collecting used cooking oil so that it does not pollute the environment and can have a bad impact on health. One of the uses of used cooking oil that can be turned into a product that has a selling value is soap. The purpose of this PKM is to increase understanding and training in liquid soap and solid soap that can be sold to increase the income of Karang Taruna Saras Muda Palur Village. The methods used are socialization, soap making training and entrepreneurship training. This PKM produces a processed product from used cooking oil waste and increases partner understanding after the pretest and posttest. From the activities above, it can be concluded that the results of the PKM related to the utilization of used cooking oil waste carried out by Karang Taruna Saras Muda Palur Mojolaban Sukoharjo have been carried out well and smoothly.
UJI IN SILICO SENYAWA DAUN BELIMBING WULUH (Averrhoa bilimbi L.) SEBAGAI ANTIKANKER KOLOREKTAL SERTA PREDIKSI PROFIL FARMAKOKINETIK DAN TOKSISITAS Pratama, Jayanti Putri; Kurniawati, Nurrizka; Erikania, Susanti
Prosiding Seminar Informasi Kesehatan Nasional 2023 : SIKesNas 2023
Publisher : Fakultas Ilmu Kesehatan Universitas Duta Bangsa Surakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.47701/sikenas.vi.2823

Abstract

Kanker merupakan penyakit yang menjadi ancaman terhadap kesehatan manusia yang ditandai dengan ploriferasi sel atau pembelahan sel yang tidak terkendali. Terapi perawatan kanker kolorektal menggunakan obat 5-Fluorouracil (5-FU) sebagai kontrol positif atau ligan standar pembanding yang dapat membantu meningkatkan kelangsungan hidup pasien pada berbagai jenis kanker. Berdasarkan efek samping yang di timbulkan, hal ini kemudian mendorong masyarakat untuk beralih pengobatan ke bahan alam atau obat tradisional. Daun belimbing wuluh (Averrhoa bilimbi L) merupakan salah satu jenis tanaman yang dikenal oleh masyarakat sebagai salah satu sumber pengobatan tradisional. Penelitian ini bertujuan untuk mengetahui potensi senyawa kimia yang terkandung dalam daun belimbing wuluh (Averrhoa bilimbi L) sebagai antikanker kolorektal dengan metode in silico, serta prediksi profil farmakokinetik (ADME) dan nilai toksisitas. Hasil penelitian ini adalah senyawa 7 (1,4-Dimethylnaphthalene) memiliki nilai ΔGbinding paling rendah terhadap 3 protein yaitu Chk1:-6,2 (Kkal/mol), Cyclin A:-3,6 (Kkal/mol), Apoptosis Regulator Bcl-2:-6,2 (Kkal/mol). Prediksi profil farmakokinetik dengan hasil yaitu senyawa 3 (1,4-Diethylbenzene) yang memenuhi parameter ADME. Prediksi toksisitas menunjukkan 6 senyawa uji termasuk dalam kategori 1 yaitu toksisitas rendah (Low Class), dan 13 senyawa memiliki hasil negatif terhadap genotoksik maupun nongenotoksik karsinogen sehingga tidak bersifat karsinogenik
UJI AKTIVITAS ANTIBAKTERI GETAH JARAK PAGAR (Jatropha curcas L.) TERHADAP BAKTERI ISOLAT ULKUS DIABETIKUM MENGGUNAKAN METODE DIFUSI CAKRAM Suryani, Hidayatullah Putri; Erikania, Susanti; Natawaskita, Kuncara
Prosiding Seminar Informasi Kesehatan Nasional 2023 : SIKesNas 2023
Publisher : Fakultas Ilmu Kesehatan Universitas Duta Bangsa Surakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.47701/sikenas.vi.2850

Abstract

Diabetes Melitus (DM) merupakan penyakit tidak menular yang disebabkan oleh gangguan metabolisme pada pagkreas yang ditandai dengan meningkatnya kadar gula darah. Penyakit ini dapat menyebakan berbagai komplikasi apabila tidak dikelola dengan baik Ulkus diabetikum merupakan salah satu komplikasi yang paling sering dialami oleh penderita diabtes melitus, keadaan ini dapat diperparah dengan adanya kontaminasi bakteri. Baktei yang terdapat didalam ulkus diabetikum merupakan bakteri aerob dan anaerob. Pengobatan ulkus diabetikum dapat dialakukan menggunakan antibiotik. Penggunaan antibotik yang berkepanjangan dapat menyebakan resisten, hal ini mendorong masyarakat beralih dari pengobatan kimia menjadi pengobatan menggunakan bahan alam. Getah jarak pagar dapat digunakan masyarakat sebagai alternatif membunuh bakteri yang terdapat didalam ulkus dibetikum. Penelitian ini bertujuan untuk mengetahui uji aktivitas antibakteri getah jarak pagar(Jatropha curcas L.) pada konsentrasi 25%,50%,100%dengan menggunakan kontrol negatif aqua pro injeksi dan kontrol positif antibiotik. Pengujian antibakteri dilakukan dengan menggunakan metode difusi cakram disk terhadap bakteri isolat ulkus diabetikum dilakukan inkubasi selama 24 jam dan diinkubasi pada suhu 37˚c kemudian dilakukan pengukuran zona hambat (mm) Hasil dari penelitian ini menunjukan bahwa getah jarak pagar dapat menghambat pertumbuhan bakteri isolat ulkus diabetikum yang di tunjukan dengan adanya zona hambat, zona hambat pada konsentrasi 25% = 13,71 ± 0,45 mm, pada konsentasi 50%=16,71 ± 0,44 mm, dan pada konsentrasi 100% =18,70 0,44 mm.
FORMULASI DAN EVALUASI UJI SEDIAAN TRANSDERMAL PATCH EKSTRAK ETANOL DAUN MANGGIS (Garcinia mangostana L.) TERHADAP LUKA SAYAT PADA MENCIT PUTIH (Mus musculus) Lailaturrofi, Retno; Erikania, Susanti; Cahya, Yanuar Ashari
Prosiding Seminar Informasi Kesehatan Nasional 2023 : SIKesNas 2023
Publisher : Fakultas Ilmu Kesehatan Universitas Duta Bangsa Surakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.47701/sikenas.vi.2853

Abstract

Luka merupakan jenis cedera atau hilangnya jaringan tubuh dari benda tajam yang dapat menyebabkan perdarahan, menganggu keseimbangan dan menyebabkan peradangan. Salah satu tanaman tradisional adalah daun manggis (Garcinia mangostana L.). Daun manggis mempunyai senyawa metabolit sekunder di antaranya yaitu triterpenoid, flavonoid, tanin dan saponin. Transdermal patch merupakan sediaan drug delivery system yang dirancang untuk menghantarkan zat obat dari permukaan kulit, melalui berbagai lapisannya dan kedalam sirkulasi sistemik Tujuan penelitian ini untuk mengetahui efektivitas transdermal patch ekstrak etanol daun manggis (Garcinia mangostana L.) terhadap luka sayat pada mencit (Mus musculus). Metode penelitian yaitu eksperimental laboratorium menggunakan mencit putih (Mus musculus) sebagai hewan uji, transdermal patch ekstrak daun manggis diujikan terhadap luka sayat pada mencit. Ekstrak etanol daun manggis diperoleh dengan metode maserasi menggunakan pelarut etanol 96%. Evaluasi fisik transdermal patch meliputi organoleptis, keseragaman bobot, pH, ketebalan patch, dan ketahanan lipat. Kelompok perlakuan terdiri dari kontrol positif, konsentrasi ekstrak 15%, 20% dan 25%. Data dianalisis dengan Program SPSS versi 25 menggunakan One Way ANOVA dan Post Hoc Test-LSD. Hasil analisis menunjukkan tidak adanya perbedaan signifikan (p≥0,05) antara kelompok perlakuan transdermal patch ekstrak etanol daun manggis dengan kelompok kontrol positif. Kesimpulan dari penelitian ini yaitu transdermal patch ekstrak etanol daun manggis (Garcinia mamgostana L.) memiliki efektivitas terhadap penyembuhan luka sayat pada mencit (Mus musculus ).
Co-Authors Anggraini, Salmah Wilujeng Artini, Kusumaningtyas Siwi Cahya, Yanuar Ashari Kristyanti, Yulia Kurniawati, Nurrizka Lailaturrofi, Retno Maritha, Vevi Natawaskita, Kuncara Nur Ainiyah Nurmaulawati, Rina Pratama, Jayanti Putri Sekar Wulandari Septian Maulid Wicahyo Silfiana, Dita Suhatmi, Erna Chotidjah Suryani, Hidayatullah Putri Umi Kalsum Wardani, Tatiana Siska Wigyaningrum, Amelia Ike