Article Per Year (5 Year)
p-Index From 2020 - 2025
2.255
P-Index
This Author published in this journals
All Journal Jurnal Penelitian Kesehatan Suara Forikes Jurnal Farmasi dan Sains Indonesia (JFSI) Journal of Science and Technology Research for Pharmacy Benzena Pharmaceutical Scientific Journal Prosiding Seminar Nasional Unimus Science and Community Pharmacy Journal
Firstca Aulia Rachma
STIKES Telogorejo Semarang
Humanities Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Engineering Health Professions Immunology & microbiology Medicine & Pharmacology Neuroscience Nursing Public Health

Published : 9 Documents Claim Missing Document
Claim Missing Document
Check
Articles

Found 9 Documents
Search

 1 
Analysis Tolerance of Monosodium Glutamate (MSG) In instant noodles With Uv-Vis Spectrophotometry Rachma, Firstca Aulia; Saptawati, Tunik
Journal of Science and Technology Research for Pharmacy Vol 1 No 1 (2021)
Publisher : Universitas Negeri Semarang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15294/jstrp.v1i1.43568

Abstract

Background: MSG has become one of the most widely used food flavorings in the world, the FDA (Food and Drug Administration) reported an average per capita intake of MSG in the United States of 550 mg / day in 1973. The use of MSG as a food additive has been regulated by its use. WHO. This rule stipulates that daily consumption of MSG per person should not exceed the safe threshold of 120 mg / kg / day. MSG is proven to be a risk factor for obesity. The increase in body weight in mice occurred after MSG was given as much as 15-30 mg / kg or the equivalent of 1-2 g / person. Based on the description above, it is known that there is a significant influence of MSG in the health sector if consumed in excess. Therefore, researchers are interested in conducting further research related to MSG levels in instant noodle samples in the Semarang city area. Aim: The purpose of this study was to test the MSG levels in instant noodles with a spectrophotometer. Method: The tools used are a UV-Vis spectrophotometer (Shimadzu), NaCl and MSG salts. MSG used in instant noodles, 0.5% Ninhydrin Reagent. Result: MSG levels from each of the 10 samples of instant noodles that are traded in Semarang City, the highest levels are found in sample J of 4.70% and the lowest MSG levels are in sample G of 2.90%. Conclusion: Instant noodles sold in the city of Semarang are positive for Monosodium glutamate (MSG) and The results of quantitative analysis, where the MSG levels contained in each sample of instant noodles in Semarang City show that it is still below the standard for adults.
Profil Parameter Spesifik dan Non Spesifik Ekstrak Etanol Kulit dan Biji Terong Belanda (Solanum betaceum Cav.) Ida Sari Dewi; Tunik Saptawati; Firstca Aulia Rachma
Jurnal Penelitian Kesehatan SUARA FORIKES Vol 12 (2021): Nomor Khusus November 2021
Publisher : FORIKES

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33846/sf.v12i0.1544

Abstract

One of the plants that has medicinal properties is Tamarillo (Solanum betaceum Cav.). Tamarillo peel is useful as an antioxidant and can lower blood sugar levels, while seeds are useful as a natural dye because of the anthocyanin contents. This study aims to determine the values of specific parameters (SP) and non-specific parameters (NSP) contained in the ethanol extract of the peel and seeds of Tamarillo. Tamarillo peel and seeds were extracted using the maceration method using 96% ethanol as a solvent to obtain a thick extract. SP tested consisted of identity and organoleptic. NSP tested consisted of drying shrinkage, moisture content, total ash content, acid insoluble ash content and cadmium content. The results of the identity test showed that the name of the plant was Tamarillo. Organoleptic testing showed that the extract was viscous in the form of Tamarillo peel extract (TPE), MFSE and SSE. The results of the NSP test showed that drying shrinkage of the TPE was 3.79%±1.39%, MFSE 3.76%±0.54%, SSE 2.09%±0 0.07%. Water content of the TPE was 0.93%±0.11% (v/w), MFSE 3.46%±0.09% (w/w), SSE 1.86%±0.07% (w/w). Total ash content of the TPE was 1.36%±0.57% (w/w), MFSE 1.55%±0.08% (w/w), SSE 4.27%±0.24% (w/w). Acid insoluble ash content test of TPE was 0.09%±0.03% (w/w), MFSE 0.22%±0.02% (w/w), SSE 0.30%±0.02% (w/w). Cadmium content of TPE, MFSE and the SSE was 0.0±0.0 (ppm).Keywords: tamarillo (Solanum betaceum Cav.); specific parameters; non-specific parameters; color test; thin layer chromatography (TLC)ABSTRAKSalah satu tanaman yang memiliki khasiat dalam pengobatan adalah terong belanda (Solanum betaceum Cav.). Kulit terong belanda bermanfaat sebagai antioksidan dan dapat menurunkan kadar gula darah. Bagian bijinya bermanfaat sebagai pewarna alami karena adanya kandungan antosianin. Penelitian bertujuan untuk mengetahui nilai parameter spesifik (PS) dan non spesifik (PNS) yang terdapat dalam ekstrak etanol kulit dan biji terong belanda. Ekstrasi kulit dan biji terong belanda dengan metode maserasi menggunakan pelarut etanol 96% hingga diperoleh ekstrak kental. PS terdiri dari identitas dan organoleptis. PNS terdiri dari susut pengeringan, kadar air, kadar abu total, kadar abu tidak larut asam dan kadar kadmium. Hasil uji identitas menunjukkan bahwa nama daerah tanaman adalah terong belanda. Pengujian organoleptis didapatkan hasil ekstrak berbentuk kental baik pada ekstrak kulit terong belanda (KTB), ekstrak biji tanpa lendir (BTL) dan ekstrak biji berlendir (BB). Hasil uji susut pengeringan KTB adalah 3.79%±1.39%, BTL 3.76%±0.54%, BB 2.09%±0.07%. Hasil uji kadar air KTB adalah 0.93%±0.11% (v/b), BTL 3.46%±0.09% (b/b), BB 1.86%±0.07% (b/b). Hasil uji kadar abu total KTB adalah 1.36%±0.57% (b/b), BTL 1.55%±0.08% (b/b), BB 4.27%±0.24% (b/b). Hasil uji kadar abu tidak larut asam KTB adalah 0.09%±0.03% (b/b), BTL 0.22%±0.02% (b/b), BB 0.30%±0.02% (b/b). Hasil uji kadar kadmium KTB, BTL dan BB adalah 0.0±0.0 (ppm).Kata kunci: terong belanda (Solanum betaceum Cav.); parameter spesifik; parameter non spesifik; uji warna; kromatografi lapis tipis (KLT)
Karakteristik Anatomi, Skrining Fitokimia dan Uji Aktivitas Antioksidan Herba Drosera capillaris dengan Metode FRAP Dwi Martha Septy; Tunik Saptawati; Firstca Aulia Rachma
Prosiding Seminar Nasional Unimus Vol 4 (2021): Inovasi Riset dan Pengabdian Masyarakat Post Pandemi Covid-19 Menuju Indonesia Tangguh
Publisher : Universitas Muhammadiyah Semarang

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

Pendahuluan: Drosera capillaris merupakan tanaman karnivora/pemakan serangga yang umumnyadapat ditemukan di Meksiko dan di seluruh bagian Tenggara Amerika Serikat. Tujuan penelitianadalah untuk mengetahui aktivitas antioksidan dari ekstrak etanol herba Drosera capillaris denganmenggunakan metode Ferric Reducing Antioxidant Power (FRAP). Metode: Pengamatan terhadapanatomi Drosera capillarisdilakukan dengan menggunakan mikroskop binokuler pada bagianakar,batang/peduncle dan daun. Metode maserasi pada proses ekstraksi, Skrining fitokimia uji warna danKromatografi Lapis Tipis (KLT) untuk mengetahui golongan senyawa dan uji aktivitas antioksidandengan metode FRAP yang absorbansinya diukur pada Spektofotometer UV-Vis. Hasil: Pengamatananatomi pada bagian akar, batang, dan daun terdapat korteks, cork, xylem, floem, sel parenkim steledan pith/intisari, epidermis, hipodermis, sklerenkim dan vascular bundle, stomata spesifik tipecylocytic, trikomata, glandular head, vascular tissue dan stalk yang terdapat vessel spiral thickening.Skrining fitokimia dari ekstrak etanol Drosera capillaris pada uji warna positif fenol, tanin,flavonoidd, dan saponin, uji KLTmengandung senyawa fenol, tanin,  flavonoid, alkaloid,antrakuinon dan saponin. Nilai IC50 dari ekstrak etanol sebesar 15,83µg/mL. Kesimpulan:Padapengamatan anatomi ditemukan tipe stomata cylocytic yang spesifik. Senyawa yang terdapatdalam herba Drosera capillarispositif mengandung senyawa fenol, tanin,  flavonoid, alkaloid,antrakuinon dan saponin dengan Rf yang baik dengan rentang 0,2-0,8..Ekstrak etanol Droseracapillaris memiliki aktivitas antioksidan sangat kuat (IC50< 50µg/mL). Kata Kunci: Drosera capillaris, Antioksidan, Skrining Fitokimia, FRAP, Spektrofotometer UV-Vis
Skrining Fitokimia Ekstrak Etanol Kulit dan Biji Terong Belanda (Solanum betaceum Cav.) Ida Sari Dew; Tunik Saptawati; Firstca Aulia Rachma
Prosiding Seminar Nasional Unimus Vol 4 (2021): Inovasi Riset dan Pengabdian Masyarakat Post Pandemi Covid-19 Menuju Indonesia Tangguh
Publisher : Universitas Muhammadiyah Semarang

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

Salah satu tanaman yang memiliki khasiat dalam pengobatan adalah terong belanda (Solanumbetaceum Cav.). Kulit terong belanda berguna sebagai antioksidan dan dapat menurunkan kadar guladarah, sedangkan bijinya berguna sebagai pewarna alami. Penelitian bertujuan untuk mengetahuigolongan senyawa kimia yang terkandung dalam ekstrak etanol kulit terong belanda, biji tanpa lendirdan biji berlendir. Data hasil penelitian yang diperoleh dianalisis secara deskriptif. Ekstrasi kulit terong belanda, biji tanpa lendir, dan biji berlendir dilakukan dengan metode maserasimenggunakan pelarut etanol 96% sampai diperoleh ekstrak kental. Skrining fitokimia yang dilakukanmeliputi uji warna dan Kromatografi Lapis Tipis (KLT) yang dideteksi dengan menggunakan sinarUV254nm dan sinar UV366nm, serta penampak bercak yang sesuai dengan golongan kimianya. Hasil skrining fitokimia dan KLT menunjukkan bahwa dalam ekstrak etanol kulit terong belandamengandung senyawa golongan alkaloid, flavonoid, saponin, tanin, dan triterpenoid. Ekstrak etanolbiji tanpa lendir dan ekstrak etanol biji berlendir mengandung senyawa golongan flavonoid, saponin,dan triterpenoid. Kata Kunci : Terong belanda, skrining fitokimia, Kromatografi Lapis Tipis (KLT).
UJI EFEKTIFITAS SITOTOKSIK EKSTRAK ETANOL KULIT BATANG SIRSAK TERHADAP SEL T47D Firstca Aulia Rachma; Haryoto; Peni Indrayudha
Jurnal Farmasi & Sains Indonesia Vol 3 No 2 (2020)
Publisher : LPPM Sekolah Tinggi Ilmu Farmasi Nusaputera

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

Kanker adalah penyakit akibat pertumbuhan tidak normal dari sel-sel jaringan tubuh yang berubah menjadi sel kanker. Tanaman sirsak (Annona muricata L.) merupakan bahan alam yang berpotensi untuk dikembangkan sebagai obat antikanker. Penelitian ini bertujuan untuk mengetahui efek sitotoksik dari simplisia kulit batang sirsak (Annona muricata L.) terhadap sel T47D. Uji sitotoksik dilakukan dengan metode MTT dengan menggunakan 4 seri konsentrasi, yaitu 250; 125; 62,50; 31,25 dan 15,63 µg/mL dengan kepadatan sel 10.000 sel/sumuran. Identifikasi golongan senyawa kimia menggunakan metode kromatografi lapis tipis dengan fase diam silika GF254 dan fase gerak etil asetat : n-heksan 8:2 menggunakan beberapa pereaksi semprot yaitu FeCl3, Lieberman Burchard, Vanilin, Sitroborat, dan Dragendorff. Hasil uji sitotoksik menunjukkan bahwa ekstrak etanol kulit batang sirsak (Annona muricata L.) kurang poten dalam menghambat sel kanker payudara dengan nilai IC50 sebesar 221,81 µg/mL.
PHYTOCHEMICAL SCREENING OF ETHANOL EXTRACT OF TREMBESI FRUIT SEEDS (Samanea saman) Saptawati, Tunik; Dayanti, Ema; Rachma, Firstca Aulia; Ovikariani
Science and Community Pharmacy Journal Vol. 1 No. 2 (2022): Science and Community Pharmacy
Publisher : STIKES Telogorejo Semarang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.63520/scpj.v1i2.325

Abstract

Trembesi (Samanea saman) is a fast-growing plant from Central America and Northern South America. the Trembesi Tree is an easily recognize tree because it has an umbrella-shaped canopy with a canopy diameter greater than its height, the trembesi fruit is blackish-brown when ripe, with seeds embedded in the flesh of the fruit. This study aims to determine the class of compounds contained in the ethanol extract of trembesi fruit seeds extraction by maceration method using 70% ethanol solvent. The analysis uses univariates that present data with calculation results. The extract results were obtained by weight of 91% with an amendment value of 18.20%. The phytochemical screening were carried out with color tests and emphasized by the TLC test. The trembesi fruit seed ethanol extract containing alkaloid, flavonoids, saponins, and tannins compounds.
The Effect of the Addition of Virgin Coconut Oil (Vco) on the Physical Stability of Carrot Sunscreen Preparations (Daucus carota L.) Kalsum, Ummi; Nihlatunnaja, Nadiya; Firstca Aulia Rachma
Science and Community Pharmacy Journal Vol. 2 No. 1 (2023): Science and Community Pharmacy
Publisher : STIKES Telogorejo Semarang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.63520/scpj.v2i1.354

Abstract

UV rays have harmful side effects of free radicals, dry skin can reduce the body's defenses against the effects of free radicals, antioxidants have activity as a free antiradical, Carrots have antioxidant activity due to the presence of carotenoid compounds, Fatty acid content from VCO which has the function of softening and moisturizing the skin.This study aims to determine the effect of the addition of Virgin Coconut Oil (VCO) on physical stability in the formulation of carrot sunscreen cream preparations. As well as Knowing the effectiveness of antioxidants on carrot tubers. Research methods test the physical characteristics of the preparation (organoleptic, pH, homogeneity, adhesion and dispersion), Cycling test cream stability test and in the onewayanova test.The results of the study obtained the influence of the stability of oily texture and rancid odor in formula III (21%) and based on data analysis, the higher the concentration, the wider the distribution power of the preparation and the decrease in the adhesion of the preparation. Conclusion The addition of Virgin Coconut Oil (VCO) affects the stability of texture and smell in formula III (21%) and based on data analysis the addition of Virgin Coconut Oil (VCO) to carrot sunscreen cream (Daucus carota L.) the higher the concentration the wider the dispersal power of the preparation and the decrease in adhesion of the preparation.
AN ANALYSIS OF FLAVONOID COMPOUNDS FROM ETHANOL EXTRACT OF MORINGA LEAVES (MORINGA OLEIFERA L.) USING FTIR AND HPLC Puruhita, Ranatri; Sulistyoningsih, Danik; Kristiyanti, Winnie; Aulia Rachma, Firstca
Science and Community Pharmacy Journal Vol. 3 No. 2 (2024): Science and Community Pharmacy
Publisher : STIKES Telogorejo Semarang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.63520/scpj.v3i2.583

Abstract

Moringa leaves contain flavonoids, phenols, tannins, alkaloids, saponins, terpenoids, and steroids. The flavonoid and phenol content has antioxidant activity. This research aimed to determine compounds in the ethanol extract of Moringa leaves To determine the type of flavonoid content using FTIR and HPLC. FTIR analysis shows that Moringa leaves possibly contain compounds from quercetin derivatives, which is supported by HPLC analysis. This quercetin compound is a group of flavonols that are characterized by the presence of a hydroxyl group and a carbonyl group. HPLC analysis was carried out by making a quercetin standard with a concentration of 200 ppm. The resulting wavelength is 254 nm. The results of the quercetin standard chromatogram which contains one main peak obtained from the quercetin standard. This peak shows the retention time at 3 minutes. The results of the standard chromatogram, quercetin has an outer area of ​​44763473 and a sample area of ​​17455781 with 2 times dilution, so the % purity of fraction 9 for quercetin is 77.99 ppm. This HPLC analysis shows that Moringa leaves probably contain quercetin derivatives which are characterized by the same retention time between the sample and the quercetin standard, namely at a retention time of 3 minutes, and have a peak pattern that is almost the same as the quercetin standard.
PENETAPAN PARAMETER SPESIFIK DAN NON SPESIFIK EKSTRAK ETANOL BIJI BUAH TREMBESI (samanea saman) Dayanti, Ema; Rachma, Firstca Aulia; Saptawati, Tunik; Ovikariani, Ovikariani
BENZENA Pharmaceutical Scientific Journal Vol 1 No 02 (2022): BENZENA PHARMACEUTICAL SCIENTIFIC JOURNAL
Publisher : Universitas Pekalongan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31941/benzena.v1i2.2390

Abstract

Trembesi (Samanea saman) merupakan tanaman cepat tumbuh asal Amerika Tengah dan Amerika Selatan Utara, Pohon Trembesi termasuk pohon yang mudah dikenali karena mem punyai kanopi yang berbentuk payung dengan diameter kanopi lebih besar dari tingginya. Penelitian ini bertujuan untuk mengetahui nilai parameter spesifik dan non spesifik pada ekstrak etanol biji buah trembesi. Ekstraksi dengan metode maserasi menggunakan pelarut etanol 70 %. Jenis penelitian deskriptif. Analisis menggunakan univariat dengan menyajikan data yang diperoleh dari perhitungan. Hasil ekstrak didapatkan berat 91 % dengan nilai rendemen yaitu 18,20 %. Parameter spesifik yang dilakukan yaitu identitas, organoleptik, senyawa yang terlarut dalam pelarut tertentu. Parameter spesifik yang dilakukan yaitu susut pengeringan, kadar air, kadar abu, cemaran logam berat. Pada hasil penetapan parameter spesifik dan non spesifik menunjukkan bahwa ekstrak etanol biji buah trembesi pada pengujian organoleptik didapatkan hasil berbentuk kental, warna coklat, bau khas, rasa kelat manis. Senyawa terlarut dalam etanol 51,66 %. Senyawa yang terlarut dalam air 40,00 %. susut pengeringan 7,66 %. Kadar air 5,28 %. Kadar abu total 9,16 %. Kadar abu tidak larut asam 1,83 %. Cemaran logam berat 0,020 mg/L. Hasil dari parameter spesifik dalam penelitian ini memenuhi persyatan.
Co-Authors Dayanti, Ema Dwi Martha Septy Ema Dayanti Haryoto Haryoto Haryoto Ida Sari Dew Ida Sari Dewi Kristiyanti, Winnie Nihlatunnaja, Nadiya Ovikariani Ovikariani Ovikariani Ovikariani, Ovikariani Peni Indrayudha Puruhita, Ranatri Sulistyoningsih, Danik Tunik Saptawati Ummi Kalsum