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All Journal Medula Juke Jambura Journal of Health Sciences and Research JK Unila (Jurnal Kedokteran Universitas Lampung) Indian Journal of Forensic Medicine & Toxicology Jurnal Agromedicine Unila: Jurnal Kesehatan dan Agromedicine
Hendra Tarigan Sibero
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Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Dentistry Education Environmental Science Health Professions Immunology & microbiology Medicine & Pharmacology Neuroscience Nursing Public Health

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Journal : Medula

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Terapi Gabapentin pada Pasien Herpes Zoster Oftalmikus Fase Akut: Neuralgia Paska Herpetika Iffat Taqiyah; Hendra Tarigan Sibero
Medula Vol 9 No 4 (2020): Medula
Publisher : CV. Jasa Sukses Abadi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.53089/medula.v9i4.240

Abstract

Herpes zoster (HZ) is one of skin disease caused by viral infection, characterized by rash and pain, developed within unilateral dermatome consequence by Varicella Zoster Virus (VZV) reactivation in infected nerve. One of complication of HZ is pain that persists after the rash dissappears called postherpetic neuralgia (PHN). Postherpetic neuralgia can be predicted by people aged more than 50 years, severe prodromal symptoms, and severe acute pain of HZ. No treatment of prevention therapy for PHN has been shown but early therapy for reducing pain is expected for better outcome. Theory of early therapy of PHN has been still questionable. A 73-years old- women presenting with multiple blisters on her right forehead and eyelid accompanied by pain since 4 days ago. Dermatological status region of orbitalis and frontalis dextra, ophtalmic division of trigeminal nerve level appears pustules with erythematous base, circumscript, multiple, regular, lenticular, confluence, zoosteriform. Diagnosis of this case is herpes zoster ophtalmicus dextra. Management of this case is Acyclovir 5x800 mg for 7 days, Gabapentin 2x300 mg for 7 days, and compress with NaCl 0,9%. Patient has better outcome and patient has PHN that persist 5 months after rash dissappears. In this case, Gabapentin therapy in the acute phase can not prevent PHN but has a good outcome for reducing pain.
Polusi Udara dan Permasalahan terhadap Kulit Marcella Dena Fernanda; Hendra Tarigan Sibero; Hanna Mutiara
Medula Vol 13 No 1 (2023): Medula
Publisher : CV. Jasa Sukses Abadi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.53089/medula.v13i1.590

Abstract

Pollution has been shown to increasingly play a role in several common ailments, and the effects on the skin are no exception. Indoor and outdoor pollutants are widely distributed in urban and rural environments. WHO defines air pollution as contamination of the outdoor (ambient) and indoor (household) environment by any chemical, physical or biological agent that alters the natural characteristics of the atmosphere. Inhaled or ingested pollutants can be distributed throughout the body through the systemic circulation, making the exposed air a target for contaminants in the superficial and deep layers of the skin. The mechanisms by which pollutants may interact with human skin may differ based on each agent and its specific characteristics. Basic and clinical studies have provided growing evidence of the interaction of pollutants with the skin. Pollutants can activate skin metabolic and inflammatory pathways and induce oxidative stress by lowering antioxidant levels in particular. The skin is also a target for another known source of oxidative stress, namely UV radiation. The interaction of pollutants with UV light or the human skin microbiota requires further clinical investigation to evaluate their specific impact on skin health. Both outdoor and indoor pollution were found to increase signs of skin aging such as facial lentigines and wrinkles. Living in a polluted environment can also reduce skin moisture, increase the rate of sebum excretion and possibly worsen symptoms of chronic inflammatory skin diseases in both children and adults. Home location, type of work and diet all lead to internal and external exposure to a variety of pollutants, with clinical consequences that can accumulate or synergize. Pollutants are only one component of exposure which means that both internal and external factors must be considered when establishing pollution protection measures, which necessitates the development of standard methods for their evaluation. This literature review provides an overview of how pollutants affect the health of the skin.
Diagnosis dan Tatalaksana Psoriasis Muhammad Rafi Eka Putra; Dwi Indria Anggraini; Syahrul Hamidi Nasution; Hendra Tarigan Sibero
Medula Vol 13 No 2 (2023): Medula
Publisher : CV. Jasa Sukses Abadi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.53089/medula.v13i2.656

Abstract

Psoriasis is a chronic skin inflammation characterized by clear erythematous plaques, rough scales, and layered silvery white plaques, especially on the elbows, knees, scalp, back, umbilicus, and lumbar region. 125 million people worldwide have psoriasis, with prevalence varying in different countries. Psoriasis has a prevalence of 1% to 3% in Europe and the United States. Psoriasis is a disease caused by an autoimmune condition. The diagnosis of psoriasis can be made based on the clinical picture. The physical examination should include examination of the primary lesion and other common areas affected by psoriasis including the scalp. A family history should be asked to support the diagnosis. The diagnosis can also be established by the presence of candle drip phenomenon, auspitz and kobner (isomorphic) which are symptoms of psoriasis. In addition, a histopathological examination can also be performed with a picture of hyperkeratosis, parakeratosis, acanthosis, Munro's abscess, papillomatosis and vasodilatation subepidermis. Psoriasis therapy is given topically in mild degrees and systemic therapy and phototherapy are given in moderate to severe psoriasis. Topical therapy that can be given is corticosteroids, vitamin D analogues, retinoids, TAR (LCD 3-10%), keratolytics (salicylic acid), and emollients. Systemic therapy used in moderate to severe cases includes acitretin, methotrexate, cyclosporin. Commonly used autotherapy in the treatment of psoriasis are narrowband ultraviolet B (NB-UVB), broadband ultraviolet B (BB-UVB), and topical 8-methoxypsoralen and UVA (PUVA).
Co-Authors Ahmad Fauzi Ahmad Sirajudin Dwi Indria Anggraini Eryati Darwin Fifa Argentina Hanna Mutiara Iffat Taqiyah Marcella Dena Fernanda Marlintan Sukma Ambarwati Muhammad Rafi Eka Putra Muhammad Yusran Rika Lukas Satya Wydya Yenny Suharmanto Suharmanto Syahrul Hamidi Nasution Yan Wirasati