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All Journal Folia Medica Indonesiana Jurnal Insan Farmasi Indonesia Eduvest - Journal of Universal Studies
Zulkarnain, Bambang Subakti
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Aerospace Engineering Biochemistry, Genetics & Molecular Biology Chemistry Computer Science & IT Health Professions Immunology & microbiology Medicine & Pharmacology Neuroscience Physics Social Sciences Other

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PENGARUH PELATIHAN TANGGAP TUBERKULOSIS DAN PENDAMPINGAN MINUM OBAT TERHADAP PENGETAHUAN KADER KESEHATAN DESA DI KECAMATAN BLUTO Rahem, Abdul; Wijaya, I Nyoman; Ifadotunnikmah, Farida; Rahmadi, Mahardian; Achmad, Gusti Noorrizka Veronika; Athiyah, Umi; Yuda, Ana; Zulkarnain, Bambang Subakti; Nugraheni, Gesnita; Ardianto, Chrismawan; Sumarno, Sumarno; Aryani, Toetik; Budiatin, Aniek Setiya; Hermansyah, Andi; Sulistyarini, Arie; Priyandani, Yuni; Sukorini, Anila Impian
Jurnal Insan Farmasi Indonesia Vol 7 No 3 (2024): Jurnal Insan Farmasi Indonesia
Publisher : Sekolah Tinggi Ilmu Kesehatan ISFI Banjarmasin

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36387/s8534m26

Abstract

Tuberculosis (TB) is one of the leading causes of death from infectious diseases worldwide. Indonesia ranks as the country with the second-highest number of TB cases after India. TB awareness training and medication adherence support for village health cadres are strategic steps to enhance their capacity in supporting TB treatment. This study aims to analyze the impact of TB awareness training and medication adherence support on improving the knowledge of village health cadres. A pre-experimental study with a pretest-posttest design was conducted involving 50 village health cadres in Bluto Subdistrict, Sumenep Regency. Data were collected using questionnaires administered before and after the training. Analysis was performed using the Mann-Whitney test. There was a significant increase in the knowledge scores of village health cadres regarding TB (pretest: 3.50 ± 1.65; posttest: 5.64 ± 2.70; p<0.05) and anti-TB drug side effects (pretest: 7.66 ± 4.07; posttest: 15.04 ± 3.11; p<0.05). The training also successfully enhanced the cadres' understanding of TB symptoms, prevention, and treatment, including drug side effects. TB awareness training and medication adherence support significantly improved the knowledge of village health cadres, making them more competent in supporting TB control efforts at the community level.
ANALYSIS OF CHANGES IN THE SERUM LEVEL NT-proBNP AFTER ACE INHIBITORS THERAPY IN PATIENTS WITH HEART FAILURE Hartoto, Halla Hisan; Zulkarnain, Bambang Subakti; Aminuddin, Muhammad
Folia Medica Indonesiana Vol. 52 No. 3 (2016): JULY - SEPTEMBER 2016
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (112.656 KB) | DOI: 10.20473/fmi.v52i3.5451

Abstract

BNP secreted by left ventricle as response to wall stress in patient with heart failure. Elevated concentration of NT-pro-BNP correlate with severity of heart failure across all stages of the condition and left ventricle ejection fraction in patient. Several clinical trials have demonstrated that neurohormonal modulation on the RAAS decreases NT-proBNP level and results in favorable outcomes. One of the drug used for blocked RAAS system is ACE inhibitor, decrease of NT-proBNP level show response to therapy include therapy with ACE inhibitors. To analize changes in the levels serum NT-proBNP levels after ace inhibitor therapy in patients with heart failure and monitoring creatinine serum. This study was a observational, prospective, non-randomized trial involving patient age 21-75 years, with NYHA class II-III HF, using ACE inhibitor therapy plus other therapy maximum 3 months before study without ARB or beta blocker. We compared serum NT-pro-BNP and creatinin serum parameters before and after two months treatment with ACE inhibitor. This study conducted in cardiovascular ambulatory patient dr. Soetomo hospital Surabaya. Between August-November 2015, 13 patient (38-63 years, 6 woman, 7 men) include in this study. The mean baseline level of NT-proBNP is 2166.92±1236.73 pg/ml, and creatinin serum 1.023±0.601 mg/dL. The NT-pro-BNP were significantly decreased after two months of treatment with ACE inhibitors 1508.23±651 pg/mL (p=0.025), there were no significant differences creatinin serum between two groups 0.951±0.0365 mg/dL (p=0.111). The results demonstrated the benefits of ACE inhibitor on the neurohormonal profile in patients with HF. If necessary we could measure NT-proBNP level to support prognosis data and monitoring effectivity therapy especially ACE inhibitor which had antiremodelling effect towards patients with HF.
ANALYSIS OF CHANGE IN NT-proBNP AFTER ANGIOTENSIN RECEPTOR BLOCKER (ARB) THERAPY IN PATIENT WITH HEART FAILURE Dewi, Intan Kusuma; Aminuddin, Muhammad; Zulkarnain, Bambang Subakti
Folia Medica Indonesiana Vol. 52 No. 4 (2016): OCTOBER - DECEMBER 2016
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (76.9 KB) | DOI: 10.20473/fmi.v52i4.5480

Abstract

NT-proBNP is an inactive fragment of BNP secreted by stretched ventricle as response to wall stress in patients with heart failure. As a specific cardiac marker, elevated NT-proBNP correlates well with heart failure severity. The principle of heart failure therapy is modulation on neurohormonal activation. ARB can modulate neurohormon on RAA system, that result in decreasing NT-proBNP level and favorable outcomes. Reduction in NT-proBNP more than biologic variability (> 25%) shows a therapy response.This study was to analyze change of NT-proBNP after ARB therapy in ambulatory HF patients. This observational prospective study was carried from September to December 2015. Blood sampling was performed on patients who meet the inclusion criteria of the study at first visit and after 2 months therapy. NT-proBNP was measured by IMMULITE® as primary parameter and creatinin as secondary parameter. There are 14 patients met the inclusion criteria of the study (11 males and 3 females). ARB therapy used in patients were Valsartan (64%), Telmisartan (22%) and Candesartan (14%). After 2 months ARB therapy, a decrease in level of NT-proBNP with initial median 3092.5 (216 – 32112) pg/ml to 2135.5 (350 – 16172) pg/ml respectively were statistically significant (p=0.003). And the secondary parameter creatinin serum convert to eGFR shows a change in eGFR with initial median 73.33 (37.05 – 266.68) ml/minute to 81.04 (39.31 – 167.02) ml/minute respectively were statistically not significant (p=0.657). There were 7 patients (50%) have a decrease > 25%. In this study, we found that ARB therapy can change NT-proBNP level significantly after 2 months therapy.
Profile of Prophylactic Antibiotics in Cesarean Sections with Occurrence of Infection: Literature Review Asfarina, Hairunnisyah; Zulkarnain, Bambang Subakti
Eduvest - Journal of Universal Studies Vol. 5 No. 6 (2025): Eduvest - Journal of Universal Studies
Publisher : Green Publisher Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.59188/eduvest.v5i6.50136

Abstract

Caesarean section is a surgical procedure that requires the use of prophylactic antibiotics throughout its implementation. Providing prophylactic antibiotics before surgery can reduce the risk of postoperative infections. The most common short-term complications of a caesarean section are wound infections. This research aims to ascertain the profile of prophylactic antibiotic use in caesarean section patients and to review the incidence of infections. The method used is a literature review. A total of eleven papers met the inclusion criteria for review. Based on the results of the article review, all of the research conducted were randomised controlled trial (RCT) studies. Randomised controlled trials (RCTs) are the gold standard for assessing the benefits of a treatment. Cefazolin, the first-generation cephalosporin antibiotic, is the most commonly used antibiotic for patients undergoing caesarean section. This aligns with the recommendations in the guideline. The highest prevalence of post-cesarean section infections is wound infections, with a percentage of 11.8% or 437 caesarean section patients. The most common microbiological pattern causing these infections is Staphylococcus aureus.
Co-Authors Abdul Rahem, Abdul Ana Yuda Arie Sulistyarini Asfarina, Hairunnisyah Budiatin, Aniek Setiya Chrismawan Ardianto Farida Ifadotunnikmah Gesnita Nugraheni Gusti Noorrizka Veronika Ahmad Hartoto, Halla Hisan Hermansyah, Andi I NYOMAN WIJAYA Intan Kusuma Dewi Mahardian Rahmadi Muhammad Aminuddin, Muhammad Priyandani, Yuni Sukorini, Anila Impian Sumarno . Toetik Aryani Umi Athiyah, Umi