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All Journal JURNAL FARMASI DAN ILMU KEFARMASIAN INDONESIA Science and Technology Indonesia Jurnal Farmasi Galenika (Galenika Journal of Pharmacy) Jurnal Insan Farmasi Indonesia
Chrismawan Ardianto
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Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Education Environmental Science Health Professions Immunology & microbiology Materials Science & Nanotechnology Medicine & Pharmacology Physics Other

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The Effects of Beta-Ionone Addition in Perfume on Behavior and Serum Cortisol Level of Stress-Induced Mice Budiman, Clarissa; Miatmoko, Andang; Tyas, Veronika Earline Pudji Setianing; Ardianto, Chrismawan; Retnowati, Dini
Science and Technology Indonesia Vol. 9 No. 2 (2024): April
Publisher : Research Center of Inorganic Materials and Coordination Complexes, FMIPA Universitas Sriwijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.26554/sti.2024.9.2.470-479

Abstract

Stress is a condition that triggers a change in behavior and physiological state, affecting mental health. Beta-Ionone is a monocyclic terpenoid compound that can lower stress levels. However, there is a lack of studies about the anti-stress capability of Beta-Ionone inhalation, although Beta-Ionone is commonly used as a fragrance in perfumes. This study aimed to evaluate the effect of Beta-Ionone addition as the fragrance in perfumes on mice stress. The Beta-Ionone perfume was formulated with Bergamot Oil, Lavender Oil, Eucalyptus Oil, Tea Tree Oil, and Patchouli Oil to produce Fem, Fem-Ion (Fem + Beta-Ionone), Masc, and Masc-Ion (Fem + Beta-Ionone), which had different preferable odors. The anti-stress effectivity was then evaluated in stress induced mice, which were restrained for one hour every day for one week. The perfumes were then given by inhalation every alternate day. The stress level of the mice was evaluated using a tail suspension test and serum cortisol level assays. The results showed that inhalation of the perfumes lowered the immobility time of mice in the tail suspension test, albeit the addition of Beta Ionone did not give a significant difference. Based on the results of serum cortisol level, there was a substantial decrease in serum cortisol by inhaling the Fem and Fem-Ion, showing decreases in stress level. However, there were increases in serum cortisol levels for Masc and Masc-Ion, indicating stress induction, which was suggested to be caused by 1,8-cineole, a compound in the Eucalyptus oil as the perfume oil components.
Effects of Selective Serotonin Reuptake Inhibitors Exposure in Stressed Pregnant Mice on the Anxiety Behavior of the Offspring: Efek Pemberian SSRIs Prenatal pada Perilaku Kecemasan Offspring dari Model Maternal Stres Ardianto, Chrismawan; Aprilia, Pingkan; Rahmadi, Mahardian; Sumartha, I Nengah Budi
Jurnal Farmasi Galenika (Galenika Journal of Pharmacy) (e-Journal) Vol. 10 No. 1 (2024): (March 2024)
Publisher : Universitas Tadulako

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22487/j24428744.2024.v10.i1.16481

Abstract

Background: Stress hurts problem-solving abilities, while anxiety disorders and depression are associated with unpleasant feelings and impaired daily functioning. Open field test (OFT) is used to assess anxiety-like behavior in animals by observing their exploratory behavior. Pregnant women are vulnerable to stress, which increases the risk of premature birth and low birth weight. Stress during pregnancy can also lead to preeclampsia and behavioural problems in newborns. Selective serotonin reuptake inhibitors (SSRIs), commonly used antidepressants during pregnancy, help manage mental disorders by increasing serotonin levels and regulating the endocrine system. They reduce glucocorticoid levels, thereby alleviating anxiety and stress in pregnant women. Objectives: This research investigates the correlation between the administration of SSRIs to stress-induced expectant mothers, the manifestation of depression-like behaviour, and the expression of glucocorticoid receptors in the offspring's hippocampus. Material and Methods: This study included four mouse groups: control without stress, control with offspring stress, stress model with footshock on dams and o ffspring, and stress with fluvoxamine treatment. Depressive and stress-related behaviors were measured using OFT. Results: OFT was used to assess the behaviour of offspring mice. Significant differences were observed in the number of crossings in the centre area and behaviour. The SSRI treatment showed potential anxiolytic effects, while stress led to reduced behaviour. These findings contribute to understanding anxiety-related responses and the effects of stress and SSRI treatment in animal models. Conclusions: OFT revealed significant differences in anxiety behaviour, specifically in the number of crossing centres, the centre area, and behaviour. SSRI treatment exhibited anxiolytic effects, while stress-decreased behaviour findings enhanced our understanding of anxiety responses and the impact of stress and SSRI treatment in animal models.
PENGARUH PELATIHAN TANGGAP TUBERKULOSIS DAN PENDAMPINGAN MINUM OBAT TERHADAP PENGETAHUAN KADER KESEHATAN DESA DI KECAMATAN BLUTO Rahem, Abdul; Wijaya, I Nyoman; Ifadotunnikmah, Farida; Rahmadi, Mahardian; Achmad, Gusti Noorrizka Veronika; Athiyah, Umi; Yuda, Ana; Zulkarnain, Bambang Subakti; Nugraheni, Gesnita; Ardianto, Chrismawan; Sumarno, Sumarno; Aryani, Toetik; Budiatin, Aniek Setiya; Hermansyah, Andi; Sulistyarini, Arie; Priyandani, Yuni; Sukorini, Anila Impian
Jurnal Insan Farmasi Indonesia Vol 7 No 3 (2024): Jurnal Insan Farmasi Indonesia
Publisher : Sekolah Tinggi Ilmu Kesehatan ISFI Banjarmasin

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36387/s8534m26

Abstract

Tuberculosis (TB) is one of the leading causes of death from infectious diseases worldwide. Indonesia ranks as the country with the second-highest number of TB cases after India. TB awareness training and medication adherence support for village health cadres are strategic steps to enhance their capacity in supporting TB treatment. This study aims to analyze the impact of TB awareness training and medication adherence support on improving the knowledge of village health cadres. A pre-experimental study with a pretest-posttest design was conducted involving 50 village health cadres in Bluto Subdistrict, Sumenep Regency. Data were collected using questionnaires administered before and after the training. Analysis was performed using the Mann-Whitney test. There was a significant increase in the knowledge scores of village health cadres regarding TB (pretest: 3.50 ± 1.65; posttest: 5.64 ± 2.70; p<0.05) and anti-TB drug side effects (pretest: 7.66 ± 4.07; posttest: 15.04 ± 3.11; p<0.05). The training also successfully enhanced the cadres' understanding of TB symptoms, prevention, and treatment, including drug side effects. TB awareness training and medication adherence support significantly improved the knowledge of village health cadres, making them more competent in supporting TB control efforts at the community level.
The Effect of Quercetin on Coenzyme HMG-CoAR, ABCA1 Transporter, Dyslipidemia Profile and Hepatic Function in Rats Dyslipidemia Model Ignasius Agyo Palmado; Sulistyanaengci Winarto; Honey Dzikri Marhaeny; Yusuf Alif Pratama; Chrismawan Ardianto; Khotib, Junaidi
JURNAL FARMASI DAN ILMU KEFARMASIAN INDONESIA Vol. 11 No. 3 (2024): JURNAL FARMASI DAN ILMU KEFARMASIAN INDONESIA
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/jfiki.v11i32024.274-290

Abstract

Background: Dyslipidemia is a lipid metabolic disorder that increases the risk of cardiovascular disease, typically marked by abnormalities in triglycerides (TG), low-density lipoprotein (LDL), and total cholesterol (TC), along with decreased high-density lipoprotein (HDL) levels. This study explored the potential of quercetin, a natural substance, as a preventive agent against dyslipidemia induced by high-fat diet (HFD) in a rat model. Simvastatin, a standard cholesterol-lowering drug, was used for the comparison. Objective: The main objective of this research was to evaluate the potential of quercetin in lipid metabolism for dyslipidemia caused by HFD and compare its effects with the first-line drug therapy simvastatin, which has a similar mechanism. Methods: Rats fed a HFD were treated with quercetin and simvastatin, and their lipid profiles, liver enzyme activities, and molecular markers related to cholesterol metabolism were analyzed. Results: Quercetin markedly decreased cholesterol levels by inhibiting the enzyme 3-Hydroxy-3-Methylglutaryl-CoA Reductase (HMG CoAR). Cellular observation revealed that it also prevented liver damage and showed a protective effect on liver enzyme activity. Quercetin enhanced the expression of the Adenosine Triphosphate Binding Cassette subfamily A member 1 (ABCA1) protein, showing a protective effect against dyslipidemia akin to simvastatin, yet with a reduced likelihood of liver toxicity. Conclusion: Quercetin may serve as an effective and safer alternative to simvastatin for treating dyslipidemia, offering cholesterol-lowering benefits without hepatotoxic risks associated with long-term statin therapy.
Co-Authors Abdul Rahem, Abdul Aprilia, Pingkan Arie Sulistyarini Budiatin, Aniek Setiya Budiman, Clarissa Dini Retnowati Farida Ifadotunnikmah Gesnita Nugraheni Gusti Noorrizka Veronika Ahmad Hermansyah, Andi Honey Dzikri Marhaeny I NYOMAN WIJAYA Ignasius Agyo Palmado Junaidi Khotib Mahardian Rahmadi Miatmoko, Andang Priyandani, Yuni Sukorini, Anila Impian Sulistyanaengci Winarto Sumarno . Sumartha, I Nengah Budi Toetik Aryani Tyas, Veronika Earline Pudji Setianing Umi Athiyah, Umi Yuda, Ana Yusuf Alif Pratama Zulkarnain, Bambang Subakti