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All Journal Jurnal Agronomi Indonesia (Indonesian Journal of Agronomy) Jurnal Fitopatologi Indonesia Journal of Tropical Life Science : International Journal of Theoretical, Experimental, and Applied Life Sciences Biotropika MPI (Media Pharmaceutica Indonesiana) JURNAL FARMASI DAN ILMU KEFARMASIAN INDONESIA Window of Health : Jurnal Kesehatan Keteg : Jurnal Pengetahuan, Pemikiran dan Kajian Tentang Bunyi Pharmacon: Jurnal Farmasi Indonesia
Suharjono
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Agriculture, Biological Sciences & Forestry Arts Biochemistry, Genetics & Molecular Biology Chemistry Economics, Econometrics & Finance Education Environmental Science Health Professions Immunology & microbiology Materials Science & Nanotechnology Medicine & Pharmacology Nursing Public Health Other

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Hypoxia-inducible Factor-2α Probably Mediated the Toxicities of Intravenous Beta-Cyclodextrin in Normal and Diabetic Rats’ Kidneys Anita Purnamayanti; Suharjono; Mahardian Rahmadi
JURNAL FARMASI DAN ILMU KEFARMASIAN INDONESIA Vol. 12 No. 3 (2025): JURNAL FARMASI DAN ILMU KEFARMASIAN INDONESIA
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/jfiki.v12i32025.372-381

Abstract

Background: Intravenous β-cyclodextrin administration poses an increased risk of toxicity. Objective: This study aimed to determine the nephrotoxicity of intravenous beta-cyclodextrin (BCD) and its underlying molecular mechanism. Methods: Sixteen Wistar rats were randomly assigned to the healthy or diabetic test group, which received a daily intravenous injection of water for injection or a 6% beta-cyclodextrin solution, respectively, for 28 days. Histopathology was analyzed semi-quantitatively on a 0-5 score basis, and RT-PCR was used to quantify the mRNA expression of HIF-1, HIF-2, IL-1, IL-6, IL-18, and eNOS. Results: There were no deaths in any of the groups, and renal function declined in the test groups. Histopathological findings revealed abnormalities in vascular integrity, cellular infiltration/damage, and necrosis in the kidney, while the relative expression of mRNA for hypoxia-inducible factors (HIFs), a marker of regional renal hypoxia, was upregulated. Conclusion:  Intravenous administration of beta-cyclodextrin increases the risk of nephrotoxicity, and the molecular mechanisms underlying kidney injury are probably mediated by hypoxia inducible factors-2α (HIF-2α). We strongly suggest that future research should be conducted with an adequate sample size.
Co-Authors Agustina, Nensi Alsagaff, M. Yusuf Anita Purnamayanti Ardiana, Shafira muti Ardianty, Nonie Asparita, Yulia Dwi Budi Suprapti Bulqiah, Andi Didik Hasmono Eko Handayanto Listiadewi, Afifah Luqman Qurata Aini Mahardian Rahmadi Mutia Erti Dwiastuti NUR AINI Oktavia, Maria Santosa Nugroho, Aji Shofia Ummu, Lathifa Siswati Siswati Triwiratno , Anang Ustiatik, Reni Virdiyanti, Windi Yulia Nuraini