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All Journal Molecular and Cellular Biomedical Sciences (MCBS) Jurnal Respirologi Indonesia Jurnal Respirasi (JR) Sumatera Medical Journal AVERROUS: Jurnal Kedokteran dan Kesehatan Malikussaleh Respiratory Science Jurnal Impresi Indonesia The Journal of Society Medicine (JSOCMED)
Tarigan, Setia Putra
Division Of Thoracic Oncology, Department Of Pulmonology And Respiratory Medicine, Faculty Of Medicine, Universitas Sumatera Utara/Haji Adam Malik General Hospital, Medan, Indonesia.
Religion Biochemistry, Genetics & Molecular Biology Dentistry Economics, Econometrics & Finance Education Health Professions Immunology & microbiology Law, Crime, Criminology & Criminal Justice Medicine & Pharmacology Neuroscience Nursing Public Health Social Sciences

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Journal : Sumatera Medical Journal

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Levels of Squamous Cell Carcinoma Antigen and Interleukin-6 as Biomarkers in NSCLC Patients Arieta, Lydia; Soeroso, Noni Novisari; Tarigan, Setia Putra; Eyanoer, Putri Chairani
Sumatera Medical Journal Vol. 8 No. 2 (2025): Sumatera Medical Journal (SUMEJ)
Publisher : Talenta Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32734/sumej.v8i2.20027

Abstract

Background: Squamous Cell Carcinoma Antigen (SCC-Ag) and Interleukin-6 (IL‐6) has been widely used for monitoring Non-Small Cell Lung Cancer (NSCLC). Objective: This concentration also known to be higher in Non Small Cell Lung Cancer. Methods: This research used descriptive study among NSCLC patients. Blood sampling was used with serum. ELISA platform was used to rate SCC-Ag and IL-6 serum. Results: From 20 samples NSCLC, we found 20 males (100%), active smokers (80%). From histology type, Adenocarcinoma 12 cases (60%). The most of subjects were in stage IVA (70%). The Squamous Cell Carcinoma Antigen levels of NSCLC patients showed that as many as 20 samples (100%) were within normal limits and did not show an increased. Conclusion: Levels of IL-6 increased as many as 15 samples (75%), and IL-6 levels were still within the normal range sample (25%). Tumor marker are not meant to detect marker growth, but only as a marker that found in lung cancer,but IL-6 as the one of the pro-inflammation cytokines that shows an increased in patients NSCLC.
Protein Programmed Death-Ligand 1 Expression in Non-Small Cell Lung Cancer (NSCLC) and Its Correlation to Smoking Status in North Sumatera Population Soeroso, Noni Novisari; Tarigan, Setia Putra; Rahmat Hidayat; Elisna Syahruddin; Evlin Suzanna; Dian Chayadi
Sumatera Medical Journal Vol. 7 No. 2 (2024): Sumatera Medical Journal (SUMEJ)
Publisher : Talenta Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32734/sumej.v7i2.15289

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Background: Tobacco smoking is associated to the increase risk of lung cancer, and smoking could also trigger the tumour proportion score from programmed death ligand (PD-L1). Objective: This study aims to identify the correlation of non-small cell lung cancer (NSCLC) with the PD-L1 expression and smoking profile on the North Sumatra Population. Methods: This research implemented a descriptive study with cross-sectional design. Results: This study was carried out from August 2019 to September 2020. Results: Characteristics of patients with NSCLC to the PD-L1 expression were found more in male patients with percentage of 88.6%, whereas the most common type of cancer is adenocarcinoma, accounting for 97.14% of cases with mild degree smoking index for 45.7% (Brinkman index) and IV-stage of clinical status for 68.6%. The tumour proportion score with 1-49% was 51.4% with high expression of PD-L1 (positive) for 74.28%, while lower expression of PD-L1 accounted for 45%. Conclusion: There is a correlation between PD-L1 expression and smoking status in NSCLC patients, with p-value of 0.037 (<0.05).
Risk Factors for Lung Cancer in Non-smoking Women, North Sumatera, Indonesia Buana, Indra; Soeroso, Noni Novisari; Tarigan, Setia Putra; Syahruddin, Elisna
Sumatera Medical Journal Vol. 8 No. 1 (2025): Sumatera Medical Journal (SUMEJ)
Publisher : Talenta Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32734/sumej.v8i1.18763

Abstract

Background: Basic Health Research Data in 2018 reported that lung cancer in women in Indonesia ranked third after breast cancer. A person's risk of developing lung cancer can be evaluated by looking at age, genetic predisposition, tobacco use, and exposure to toxic agents. Objective: To obtain data on several risk factors associated with the incidence of lung cancer in non-smoking women at Adam Malik General Hospital and Santa Elisabeth General Hospital. Methods: This case-control matching study involved 224 research subjects through medical record data collection from January 2019 to December 2020. All subjects were confirmed by questionnaires related to risk factors: age, exposure to cigarette smoke (passive smokers), genetics, exposure to firewood, and air pollution. Data were analyzed by logistic regression test. Results: The average age in the case group was 57.86 years; in the control group, 47.4 years. Five risk factors influenced lung cancer incidence: age (p = 0.008), passive smokers (p = 0.043), genetic factors (p < 0.001), exposure to firewood (p = 0.007), and air pollution (p = 0.041). Conclusion: Risk factors that significantly influence lung cancer incidence in non-smoking women are age over 40 years, genetic factors, passive smoking, and exposure to firewood.
Co-Authors Arieta, Lydia Azizah Ghanie Icksan Buana, Indra Darren Wan-Teck Lim Dedy Dwi Putra, Dedy Dwi Dian Chayadi Elisna Syahruddin Elisna Syahruddin Elizabeth Napitupulu Erna Mutiara Erna Mutiara Erna Mutiara Evlin Suzanna Febiyanti, Mica Fotarisman Zalukhu Harahap, Putri Wulandari Hendra Taufik Hidayat Hidayat Lokman, Yovita Belva Lucia Aktalina Malisie, Ririe Fachrina Muhammad Harbi Praditya Muhammad Harbi Praditya Muntasir Abdullah Netty Delvrita Lubis Noni Novisari Soeroso Noni Novisari Soeroso Noni Novisari Soeroso Noni Novisari Soeroso Noni Novisari Soeroso Novia Nurul Faizah Novita Margaretta Ambarita Nurul Ramadhani Pinem, Agung Haganta Putri Chairani Eyanoer, Putri Chairani R.A Henny Anggriani Rahmat Hidayat Ritonga, Adewita Rosidah Hanum Hasibuan Rosita Juwita Sembiring Stephen Johan Prasetyo Tarigan, Amira P. Taufik Ashar Wan Betty Pratiwi Yahwardiah Siregar