Article Per Year (5 Year)
p-Index From 2021 - 2026
0.408
P-Index
This Author published in this journals
All Journal Journal of Tropical Life Science : International Journal of Theoretical, Experimental, and Applied Life Sciences Indonesian Journal of Cancer Chemoprevention Jurnal Riset Industri
Ahmad Randy
Polymer Chemistry Group, Research Center for Chemistry Indonesian Institute of Sciences (LIPI) Kawasan Puspiptek Serpong, Tangerang 15314 – Indonesia
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Environmental Science Industrial & Manufacturing Engineering Medicine & Pharmacology

Published : 5 Documents Claim Missing Document
Claim Missing Document
Check
Articles

Found 5 Documents
Search

 1 
Determination of The Active Asiaticoside Content in Centella asiatica as Anti-Cellulite Agent Sondari, Dewi; Harmami, Sri Budi; Ghozali, M; Randy, Ahmad; S, Athanasia Amanda; Irawan, Yan
Indonesian Journal of Cancer Chemoprevention Vol 2, No 2 (2011)
Publisher : Indonesian Research Gateway

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (4.399 KB)

Abstract

Centella  asiatica  accumulates  large  quantities  of  pentacyclic  triterpenoid saponins,  collectively  known  as  centelloids.  These  terpenoids  include  asiaticoside, centelloside,  madecassoside,  brahmoside,  brahminoside,  thankuniside,  sceffoleoside, centellose, asiatic-, brahmic-, centellic- and madecassic acids. Preparations of C. asiatica are  used  in  traditional  and  alternative  medicine  due  to  the  wide  spectrum  of pharmacological  activities  associated  with  these  secondary  metabolites,  such  as anticellulite agent. Asiaticoside was found in Centella asiatica. In this present study, the asiaticoside was extracted using methanolic and ethanolic solvent. Determination of the asiaticoside  content  in  the  extract  was  conducted  with  High Performance  Liquid Chromatography (HPLC), Thin Layer Chromatography (TLC), and Fourier Transform Infra Red (FTIR). Samples of C.  asiatica used in this study came from three different plantation  areas,  Bogor,  Lembang  and  Solo.  Asiaticoside  content  in  the  methanolic extract  from  Bogor,  Lembang,  and  Solo  samples  were  2.82%;  2.68%;  and  2.8% respectively. Asiaticoside in ethanolic extract from Bogor, Lembang, and Solo samples were 2.79%; 2.75%; and 2.91% respectively. Two way ANOVA study showed that there was  significant  difference  between  types  of  solvent  used  in  extraction  and  the asiaticoside  content  in  the  obtained  extract,  significant  difference  between  varied plantation area and obtained asiaticoside content, and significant difference between interactions of different solvent with different plantation area.     Key words: Centella asiatica, asiaticoside, anticellulite, medicine, metabolites  
MODIFIKASI KARET ALAM MENJADI BAHAN ELASTOMER TERMOPLASTIK Suhardjo, Kuntari Adi; Basuki, Ariyadi; ., Surasno; Randy, Ahmad; Sondari, Dewi
Jurnal Riset Industri Vol 5, No 3 (2011): Peningkatan Nilai Tambah dan Produktivitas Industri
Publisher : Badan Penelitian dan Pengembangan Industri

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (6742.063 KB)

Abstract

Karet alam  bersifat elastomer dan termoseting, sehingga sulit  untuk dibentuk dan tidak dapat didaur ulang., Modifikasi karet alam menjadi bahan elastomer termoplastik dimaksudkan untuk memperoleh bahan yang mudah dicetak  menjadi  produk  jadi   dan  dapat  dapat  didaur  ulang  sehingga  tidak  merusak  lingkungan.   Untuk mendapatkan teknologi pembuatan elastomer termoplastik dari karet alam  telah dilakukan percobaan  dengan metoda pencangkokan (grafting)   secara polimerisasi emulsi antara karet alam lateks dengan monomer stirena dan metil metakrilat. Polimerisasi emulsi dilakukan pada suhu 65°C selama 6 jam. Perbandingan komposisi karet alam lateks dan monomer di variasi:  80:20; 70:30; 60:40; 50:50 (% berat) dengan komposisi monomer stirena dan metil metakrilat   1:1, menggunakan dua jenis inisiator yaitu potassium persulfat 2 % berat atau ammonium peroksodisulfat divariasi 2, 2,5, 5 % berat serta emulsifier sodium dodesil sulfat divariasi: 0, 1, 1,5,  2, 5 % berat. Dari hasil analisa 1 H NMR dan FTIR terlihat bahwa proses cangkok monomer stirena dan metil metakrilat telah terjadi pada tulang punggung karet alam. Puncak pada frekuensi 833 cm -1 menunjukkan pita RzC=CHR, frekuensi 1743 dan 1519 cm-1menunjukkan pita C=O (gugus karbonil dari metil metakrilat) dan pita C=C (cincin benzena dari stirena). Efisiensi cangkok maksimum sebesar 97,60% diperoleh  pada komposisi 70% karet alam lateks dan 30% monomer dimana komposisi monomer antara stirena dan metil metakrilat adalah 1: 1 menggunakan inisiator potasium persulfat 2% dan emulsifier sodium dodesil sulfat 1%.Kata  kunci: Elastomer termoplastik, kopolimer cangkok, karet alam lateks, stirena, metilmetakrilat.
MODIFIKASI KARET ALAM MENJADI BAHAN ELASTOMER TERMOPLASTIK Suhardjo, Kuntari Adi; Basuki, Ariyadi; ., Surasno; Randy, Ahmad; Sondari, Dewi
Jurnal Riset Industri Vol 5, No 3 (2011): Peningkatan Nilai Tambah dan Produktivitas Industri
Publisher : Badan Penelitian dan Pengembangan Industri

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (6742.063 KB)

Abstract

Karet alam  bersifat elastomer dan termoseting, sehingga sulit  untuk dibentuk dan tidak dapat didaur ulang., Modifikasi karet alam menjadi bahan elastomer termoplastik dimaksudkan untuk memperoleh bahan yang mudah dicetak  menjadi  produk  jadi   dan  dapat  dapat  didaur  ulang  sehingga  tidak  merusak  lingkungan.   Untuk mendapatkan teknologi pembuatan elastomer termoplastik dari karet alam  telah dilakukan percobaan  dengan metoda pencangkokan (grafting)   secara polimerisasi emulsi antara karet alam lateks dengan monomer stirena dan metil metakrilat. Polimerisasi emulsi dilakukan pada suhu 65°C selama 6 jam. Perbandingan komposisi karet alam lateks dan monomer di variasi:  80:20; 70:30; 60:40; 50:50 (% berat) dengan komposisi monomer stirena dan metil metakrilat   1:1, menggunakan dua jenis inisiator yaitu potassium persulfat 2 % berat atau ammonium peroksodisulfat divariasi 2, 2,5, 5 % berat serta emulsifier sodium dodesil sulfat divariasi: 0, 1, 1,5,  2, 5 % berat. Dari hasil analisa 1 H NMR dan FTIR terlihat bahwa proses cangkok monomer stirena dan metil metakrilat telah terjadi pada tulang punggung karet alam. Puncak pada frekuensi 833 cm -1 menunjukkan pita RzC=CHR, frekuensi 1743 dan 1519 cm-1menunjukkan pita C=O (gugus karbonil dari metil metakrilat) dan pita C=C (cincin benzena dari stirena). Efisiensi cangkok maksimum sebesar 97,60% diperoleh  pada komposisi 70% karet alam lateks dan 30% monomer dimana komposisi monomer antara stirena dan metil metakrilat adalah 1: 1 menggunakan inisiator potasium persulfat 2% dan emulsifier sodium dodesil sulfat 1%.Kata  kunci: Elastomer termoplastik, kopolimer cangkok, karet alam lateks, stirena, metilmetakrilat.
Cytotoxic of Usnic Acid Isolated from Ramalina sp.: Cytotoxic of Usnic Acid Isolated from Ramalina sp. Darmawan, Akhmad; Maulidiyah; Megawati; Ariani, Novita; Aisya, Sitti; Sukirno; Randy, Ahmad; Primahana, Gian; Hendra, Medi; Nurdin, Muhammad
Journal of Tropical Life Science Vol. 14 No. 2 (2024)
Publisher : Journal of Tropical Life Science

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.11594/jtls.14.02.14

Abstract

Ramalina sp. (Ramalinaceae) is a type of lichen known to contain many active secondary metabolite compounds that have the potential to be used as medicine or medicinal raw materials. One of the biological activities possessed by Ramalina sp. lichen is its anticancer activity. This research aims to isolate and identify active secondary metabolite compounds from the methanol extract of the Ramalina sp. lichen and to find out the cytotoxic activity of the isolated compound against MCF7 breast cancer cells. Compound 1 (usnic acid) was successfully isolated from fraction A. The isolation and purification process was carried out starting with a maceration process using acetone solvent, followed by silica gel column chromatography using a gradient solvent system consisting of n-hexane, n-hexane:EtOAc, EtOAc, EtOAc:MeOH, and MeOH with 5% increment of polarity to obtain 17 fractions (F-1 to F-17). From the 17 fractions obtained, fraction 3 (F-3) and fraction 4 (F-4) (eluted with n-hexane:EtOAc 30%), which had the same TLC profile, were combined and named as fraction A. Compound 1 (50 mg) is a yellow needle crystal that was formed in a bottle of fraction A, which was obtained after the process of combining fractions F-3 and F-4 and solvent evaporation process. The crystals were then separated and purified with CHCl3 and MeOH. Compound 1 was then characterized based on spectroscopic data. Various spectroscopic analysis data, including FTIR, 1D- and 2D-NMR, and LC-ESI-MS, show that Compound 1 is a dibenzofuran derivative compound with 18 carbons (3 from carbonyl groups (C=O) and 3 from methyl groups) and 2 hydroxyl (-OH). Cytotoxicity assay showed that at a low concentration of 18.75 ug/mL, Compound 1 caused a 67.06% decrease in MCF7 viability
Cytotoxic of Usnic Acid Isolated from Ramalina sp.: Cytotoxic of Usnic Acid Isolated from Ramalina sp. Darmawan, Akhmad; Maulidiyah; Megawati; Ariani, Novita; Aisya, Sitti; Sukirno; Randy, Ahmad; Primahana, Gian; Hendra, Medi; Nurdin, Muhammad
Journal of Tropical Life Science Vol. 14 No. 2 (2024)
Publisher : Journal of Tropical Life Science

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.11594/jtls.14.02.14

Abstract

Ramalina sp. (Ramalinaceae) is a type of lichen known to contain many active secondary metabolite compounds that have the potential to be used as medicine or medicinal raw materials. One of the biological activities possessed by Ramalina sp. lichen is its anticancer activity. This research aims to isolate and identify active secondary metabolite compounds from the methanol extract of the Ramalina sp. lichen and to find out the cytotoxic activity of the isolated compound against MCF7 breast cancer cells. Compound 1 (usnic acid) was successfully isolated from fraction A. The isolation and purification process was carried out starting with a maceration process using acetone solvent, followed by silica gel column chromatography using a gradient solvent system consisting of n-hexane, n-hexane:EtOAc, EtOAc, EtOAc:MeOH, and MeOH with 5% increment of polarity to obtain 17 fractions (F-1 to F-17). From the 17 fractions obtained, fraction 3 (F-3) and fraction 4 (F-4) (eluted with n-hexane:EtOAc 30%), which had the same TLC profile, were combined and named as fraction A. Compound 1 (50 mg) is a yellow needle crystal that was formed in a bottle of fraction A, which was obtained after the process of combining fractions F-3 and F-4 and solvent evaporation process. The crystals were then separated and purified with CHCl3 and MeOH. Compound 1 was then characterized based on spectroscopic data. Various spectroscopic analysis data, including FTIR, 1D- and 2D-NMR, and LC-ESI-MS, show that Compound 1 is a dibenzofuran derivative compound with 18 carbons (3 from carbonyl groups (C=O) and 3 from methyl groups) and 2 hydroxyl (-OH). Cytotoxicity assay showed that at a low concentration of 18.75 ug/mL, Compound 1 caused a 67.06% decrease in MCF7 viability
Co-Authors AGUS HARYONO Aisya, Sitti Akhmad Darmawan Ariani, Novita Ariyadi Basuki, Ariyadi Athanasia Amanda S Dewi Sondari Evi Triwulandari M Ghozali Maulidiyah Medi Hendra Megawati Muhammad Nurdin Primahana, Gian Ridwanuloh, Asep Muhamad Sri Budi Harmami Suhardjo, Kuntari Adi SUKIRNO Surasno . Yan Irawan