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All Journal Journal of Tropical Life Science : International Journal of Theoretical, Experimental, and Applied Life Sciences Indonesian Journal of Cancer Chemoprevention Jurnal Riset Industri ANNALES BOGORIENSES Jurnal Ners Annales Bogorienses
Ahmad Randy
Polymer Chemistry Group, Research Center for Chemistry Indonesian Institute of Sciences (LIPI) Kawasan Puspiptek Serpong, Tangerang 15314 – Indonesia
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Environmental Science Health Professions Immunology & microbiology Industrial & Manufacturing Engineering Medicine & Pharmacology Nursing

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Determination of The Active Asiaticoside Content in Centella asiatica as Anti-Cellulite Agent Sondari, Dewi; Harmami, Sri Budi; Ghozali, M; Randy, Ahmad; S, Athanasia Amanda; Irawan, Yan
Indonesian Journal of Cancer Chemoprevention Vol 2, No 2 (2011)
Publisher : Indonesian Research Gateway

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (4.399 KB)

Abstract

Centella  asiatica  accumulates  large  quantities  of  pentacyclic  triterpenoid saponins,  collectively  known  as  centelloids.  These  terpenoids  include  asiaticoside, centelloside,  madecassoside,  brahmoside,  brahminoside,  thankuniside,  sceffoleoside, centellose, asiatic-, brahmic-, centellic- and madecassic acids. Preparations of C. asiatica are  used  in  traditional  and  alternative  medicine  due  to  the  wide  spectrum  of pharmacological  activities  associated  with  these  secondary  metabolites,  such  as anticellulite agent. Asiaticoside was found in Centella asiatica. In this present study, the asiaticoside was extracted using methanolic and ethanolic solvent. Determination of the asiaticoside  content  in  the  extract  was  conducted  with  High Performance  Liquid Chromatography (HPLC), Thin Layer Chromatography (TLC), and Fourier Transform Infra Red (FTIR). Samples of C.  asiatica used in this study came from three different plantation  areas,  Bogor,  Lembang  and  Solo.  Asiaticoside  content  in  the  methanolic extract  from  Bogor,  Lembang,  and  Solo  samples  were  2.82%;  2.68%;  and  2.8% respectively. Asiaticoside in ethanolic extract from Bogor, Lembang, and Solo samples were 2.79%; 2.75%; and 2.91% respectively. Two way ANOVA study showed that there was  significant  difference  between  types  of  solvent  used  in  extraction  and  the asiaticoside  content  in  the  obtained  extract,  significant  difference  between  varied plantation area and obtained asiaticoside content, and significant difference between interactions of different solvent with different plantation area.     Key words: Centella asiatica, asiaticoside, anticellulite, medicine, metabolites  
MODIFIKASI KARET ALAM MENJADI BAHAN ELASTOMER TERMOPLASTIK Suhardjo, Kuntari Adi; Basuki, Ariyadi; ., Surasno; Randy, Ahmad; Sondari, Dewi
Jurnal Riset Industri Vol 5, No 3 (2011): Peningkatan Nilai Tambah dan Produktivitas Industri
Publisher : Badan Penelitian dan Pengembangan Industri

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Abstract

Karet alam  bersifat elastomer dan termoseting, sehingga sulit  untuk dibentuk dan tidak dapat didaur ulang., Modifikasi karet alam menjadi bahan elastomer termoplastik dimaksudkan untuk memperoleh bahan yang mudah dicetak  menjadi  produk  jadi   dan  dapat  dapat  didaur  ulang  sehingga  tidak  merusak  lingkungan.   Untuk mendapatkan teknologi pembuatan elastomer termoplastik dari karet alam  telah dilakukan percobaan  dengan metoda pencangkokan (grafting)   secara polimerisasi emulsi antara karet alam lateks dengan monomer stirena dan metil metakrilat. Polimerisasi emulsi dilakukan pada suhu 65°C selama 6 jam. Perbandingan komposisi karet alam lateks dan monomer di variasi:  80:20; 70:30; 60:40; 50:50 (% berat) dengan komposisi monomer stirena dan metil metakrilat   1:1, menggunakan dua jenis inisiator yaitu potassium persulfat 2 % berat atau ammonium peroksodisulfat divariasi 2, 2,5, 5 % berat serta emulsifier sodium dodesil sulfat divariasi: 0, 1, 1,5,  2, 5 % berat. Dari hasil analisa 1 H NMR dan FTIR terlihat bahwa proses cangkok monomer stirena dan metil metakrilat telah terjadi pada tulang punggung karet alam. Puncak pada frekuensi 833 cm -1 menunjukkan pita RzC=CHR, frekuensi 1743 dan 1519 cm-1menunjukkan pita C=O (gugus karbonil dari metil metakrilat) dan pita C=C (cincin benzena dari stirena). Efisiensi cangkok maksimum sebesar 97,60% diperoleh  pada komposisi 70% karet alam lateks dan 30% monomer dimana komposisi monomer antara stirena dan metil metakrilat adalah 1: 1 menggunakan inisiator potasium persulfat 2% dan emulsifier sodium dodesil sulfat 1%.Kata  kunci: Elastomer termoplastik, kopolimer cangkok, karet alam lateks, stirena, metilmetakrilat.
MODIFIKASI KARET ALAM MENJADI BAHAN ELASTOMER TERMOPLASTIK Suhardjo, Kuntari Adi; Basuki, Ariyadi; ., Surasno; Randy, Ahmad; Sondari, Dewi
Jurnal Riset Industri Vol 5, No 3 (2011): Peningkatan Nilai Tambah dan Produktivitas Industri
Publisher : Badan Penelitian dan Pengembangan Industri

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (6742.063 KB)

Abstract

Karet alam  bersifat elastomer dan termoseting, sehingga sulit  untuk dibentuk dan tidak dapat didaur ulang., Modifikasi karet alam menjadi bahan elastomer termoplastik dimaksudkan untuk memperoleh bahan yang mudah dicetak  menjadi  produk  jadi   dan  dapat  dapat  didaur  ulang  sehingga  tidak  merusak  lingkungan.   Untuk mendapatkan teknologi pembuatan elastomer termoplastik dari karet alam  telah dilakukan percobaan  dengan metoda pencangkokan (grafting)   secara polimerisasi emulsi antara karet alam lateks dengan monomer stirena dan metil metakrilat. Polimerisasi emulsi dilakukan pada suhu 65°C selama 6 jam. Perbandingan komposisi karet alam lateks dan monomer di variasi:  80:20; 70:30; 60:40; 50:50 (% berat) dengan komposisi monomer stirena dan metil metakrilat   1:1, menggunakan dua jenis inisiator yaitu potassium persulfat 2 % berat atau ammonium peroksodisulfat divariasi 2, 2,5, 5 % berat serta emulsifier sodium dodesil sulfat divariasi: 0, 1, 1,5,  2, 5 % berat. Dari hasil analisa 1 H NMR dan FTIR terlihat bahwa proses cangkok monomer stirena dan metil metakrilat telah terjadi pada tulang punggung karet alam. Puncak pada frekuensi 833 cm -1 menunjukkan pita RzC=CHR, frekuensi 1743 dan 1519 cm-1menunjukkan pita C=O (gugus karbonil dari metil metakrilat) dan pita C=C (cincin benzena dari stirena). Efisiensi cangkok maksimum sebesar 97,60% diperoleh  pada komposisi 70% karet alam lateks dan 30% monomer dimana komposisi monomer antara stirena dan metil metakrilat adalah 1: 1 menggunakan inisiator potasium persulfat 2% dan emulsifier sodium dodesil sulfat 1%.Kata  kunci: Elastomer termoplastik, kopolimer cangkok, karet alam lateks, stirena, metilmetakrilat.
Control of Biodegradability of Polyurethane Foam Based on Palm Oil by Ratio of Soft Segment on the Polymer Backbone Haryono, Agus; Triwulandari, Evi; Sondari, Dewi; Randy, Ahmad; Ridwanuloh, Asep Muhamad
ANNALES BOGORIENSES Vol 14, No 1 (2010): Annales Bogorienses
Publisher : Research Center for Biotechnology - Indonesian Institute of Sciences (LIPI)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.1234/35

Abstract

Polyurethane  is  polymer  synthetic  which  is  formed  by  reaction  between  polyols  and  polyisocyanates.polyols  are  compounds  which  contain  two or  more  hydroxyl  groups.  Polyurethane  can  be  applied  in  various forms,  such  as  foam,  elastomeric,  coating  and  adhesive.  In  this  work,  we  developed  pol yurethane  foams  by using polyols  based  on  palm  oil.  Palm  oil  based  polyols  as  soft  segments  in  the  polyurethane  backbone accelerate biodegradable process of the polyurethane. Biodegradability is the ability of material to be utilized as a carbon source by  microorganisms and converted safely into carbon dioxide, biomass and water. Commercially available  polyurethane  foams  are  usually  produced  from  petrochemical  based  polyols  that  they  are  not biodegradable. The biodegradability study was conducted by using  Aspergillus niger  (fungi) and  Pseudomonas aeruginosa(bacteria),  with  variation  of  method  and  media  for  biodegradation.  Rigid  polyurethane  foam  was synthesized by  using  one  shoot  process  method,  which  is  reaction  between  palm based polyol  mixture  and methylene diphenly diisocyanate (MDI) at room temperature. The effect of variation of ratio of polyisocyanates (NCO) as hard segment and polyols (OH) as soft segment to the properties of polyurethane foams were studied in detail. Study of the effect NCO/OH ratio   was conducted with variation ratio of 0.8,  1.0  and  1.2. Increasing hard segment (NCO) ratio to the soft segment (OH) affected in the decreasing of hydrophilicity of foam. Thus,the penetration of water into bulk of polymer decreased. The biodegradability  of foam was also affected by the soft segment ratio on the polymer backbone.   Keywords: biodegradable, polyurethane, palm oil, polyols, soft segment
Cytotoxic of Usnic Acid Isolated from Ramalina sp.: Cytotoxic of Usnic Acid Isolated from Ramalina sp. Darmawan, Akhmad; Maulidiyah; Megawati; Ariani, Novita; Aisya, Sitti; Sukirno; Randy, Ahmad; Primahana, Gian; Hendra, Medi; Nurdin, Muhammad
Journal of Tropical Life Science Vol. 14 No. 2 (2024)
Publisher : Journal of Tropical Life Science

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.11594/jtls.14.02.14

Abstract

Ramalina sp. (Ramalinaceae) is a type of lichen known to contain many active secondary metabolite compounds that have the potential to be used as medicine or medicinal raw materials. One of the biological activities possessed by Ramalina sp. lichen is its anticancer activity. This research aims to isolate and identify active secondary metabolite compounds from the methanol extract of the Ramalina sp. lichen and to find out the cytotoxic activity of the isolated compound against MCF7 breast cancer cells. Compound 1 (usnic acid) was successfully isolated from fraction A. The isolation and purification process was carried out starting with a maceration process using acetone solvent, followed by silica gel column chromatography using a gradient solvent system consisting of n-hexane, n-hexane:EtOAc, EtOAc, EtOAc:MeOH, and MeOH with 5% increment of polarity to obtain 17 fractions (F-1 to F-17). From the 17 fractions obtained, fraction 3 (F-3) and fraction 4 (F-4) (eluted with n-hexane:EtOAc 30%), which had the same TLC profile, were combined and named as fraction A. Compound 1 (50 mg) is a yellow needle crystal that was formed in a bottle of fraction A, which was obtained after the process of combining fractions F-3 and F-4 and solvent evaporation process. The crystals were then separated and purified with CHCl3 and MeOH. Compound 1 was then characterized based on spectroscopic data. Various spectroscopic analysis data, including FTIR, 1D- and 2D-NMR, and LC-ESI-MS, show that Compound 1 is a dibenzofuran derivative compound with 18 carbons (3 from carbonyl groups (C=O) and 3 from methyl groups) and 2 hydroxyl (-OH). Cytotoxicity assay showed that at a low concentration of 18.75 ug/mL, Compound 1 caused a 67.06% decrease in MCF7 viability
Cytotoxic of Usnic Acid Isolated from Ramalina sp.: Cytotoxic of Usnic Acid Isolated from Ramalina sp. Darmawan, Akhmad; Maulidiyah; Megawati; Ariani, Novita; Aisya, Sitti; Sukirno; Randy, Ahmad; Primahana, Gian; Hendra, Medi; Nurdin, Muhammad
Journal of Tropical Life Science Vol. 14 No. 2 (2024)
Publisher : Journal of Tropical Life Science

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.11594/jtls.14.02.14

Abstract

Ramalina sp. (Ramalinaceae) is a type of lichen known to contain many active secondary metabolite compounds that have the potential to be used as medicine or medicinal raw materials. One of the biological activities possessed by Ramalina sp. lichen is its anticancer activity. This research aims to isolate and identify active secondary metabolite compounds from the methanol extract of the Ramalina sp. lichen and to find out the cytotoxic activity of the isolated compound against MCF7 breast cancer cells. Compound 1 (usnic acid) was successfully isolated from fraction A. The isolation and purification process was carried out starting with a maceration process using acetone solvent, followed by silica gel column chromatography using a gradient solvent system consisting of n-hexane, n-hexane:EtOAc, EtOAc, EtOAc:MeOH, and MeOH with 5% increment of polarity to obtain 17 fractions (F-1 to F-17). From the 17 fractions obtained, fraction 3 (F-3) and fraction 4 (F-4) (eluted with n-hexane:EtOAc 30%), which had the same TLC profile, were combined and named as fraction A. Compound 1 (50 mg) is a yellow needle crystal that was formed in a bottle of fraction A, which was obtained after the process of combining fractions F-3 and F-4 and solvent evaporation process. The crystals were then separated and purified with CHCl3 and MeOH. Compound 1 was then characterized based on spectroscopic data. Various spectroscopic analysis data, including FTIR, 1D- and 2D-NMR, and LC-ESI-MS, show that Compound 1 is a dibenzofuran derivative compound with 18 carbons (3 from carbonyl groups (C=O) and 3 from methyl groups) and 2 hydroxyl (-OH). Cytotoxicity assay showed that at a low concentration of 18.75 ug/mL, Compound 1 caused a 67.06% decrease in MCF7 viability
Control of Biodegradability of Polyurethane Foam Based on Palm Oil by Ratio of Soft Segment on the Polymer Backbone Haryono, Agus; Triwulandari, Evi; Sondari, Dewi; Randy, Ahmad; Ridwanuloh, Asep Muhamad
Annales Bogorienses Vol. 14 No. 1 (2010): Annales Bogorienses
Publisher : BRIN

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

Polyurethane is polymer synthetic which is formed by reaction between polyols and polyisocyanates. Polyols are compounds which contain two or more hydroxyl groups. Polyurethane can be applied in various forms, such as foam, elastomeric, coating and adhesive. In this work, we developed polyurethane foams by using polyols based on palm oil. Palm oil based polyols as soft segments in the polyurethane backbone accelerate biodegradable process of the polyurethane. Biodegradability is the ability of material to be utilized as a carbon source by microorganisms and converted safely into carbon dioxide, biomass and water. Commercially available polyurethane foams are usually produced from petrochemical based polyols that they are not biodegradable. The biodegradability study was conducted by using Aspergillus niger (fungi) and Pseudomonas aeruginosa (bacteria), with variation of method and media for biodegradation. Rigid polyurethane foam was synthesized by using one shoot process method, which is reaction between palm-based polyol mixture and methylene diphenyl diisocyanate (MDI) at room temperature. The effect of variation of ratio of polyisocyanates (NCO) as hard segment and polyols (OH) as soft segment to the properties of polyurethane foams were studied in detail. Study of the effect NCO/OH ratio was conducted with variation ratio of 0.8, 1.0 and 1.2. Increasing hard segment (NCO) ratio to the soft segment (OH) affected in the decreasing of hydrophilicity of foam. Thus, the penetration of water into bulk of polymer decreased. The biodegradability of foam was also affected by the soft segment ratio on the polymer backbone.
Pengaruh Efek Ekstrak Kayu Bajakah Merah (Sphatolobus littoralis) Terhadap Kadar Protein mTOR pada Sel Kanker Payudara MCF-7 Siskowati, Ratu Salia; Harliansyah, Harliansyah; Rahmah, Nunung Ainur; Randy, Ahmad; Pendrianto, Pendrianto
Jurnal Ners Vol. 10 No. 1 (2026): JANUARI 2026
Publisher : Universitas Pahlawan Tuanku Tambusai

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31004/jn.v10i1.54258

Abstract

Abstrak Salah satu penyakit yang paling umum terjadi pada wanita adalah kanker payudara, yang terkait dengan pembelahan sel yang tidak terkendali melalui jalur sinyal mTORC. Studi ini bertujuan untuk menentukan bagaimana ekstrak Kayu Bajakah Merah (Spatholobus littoralis) mempengaruhi ekspresi protein mTORC secara in vitro pada sel kanker payudara MCF-7. Penelitian menggunakan desain true experimental dengan post-test only control group, melibatkan enam kelompok perlakuan, termasuk kontrol negatif, kontrol positif (Tamoxifen), dan perlakuan ekstrak Bajakah Merah pada konsentrasi IC₅ 72 jam. Sel dikultur, diolah, dan viabilitas sel diukur menggunakan CCK-8 untuk menentukan IC₅, sedangkan kadar protein mTORC dianalisis menggunakan ELISA. Hasil penelitian menunjukkan bahwa ekstrak Bajakah Merah menurunkan viabilitas sel secara dosis- dan waktu-dependen, dengan IC₅ terendah pada inkubasi 72 jam. Kadar mTORC meningkat signifikan pada kelompok perlakuan ekstrak dibanding kontrol negatif, menunjukkan pengaruh ekstrak terhadap jalur pensinyalan mTORC. Meskipun efek sitotoksik masih lebih rendah dibanding Tamoxifen, ekstrak kayu Bajakah Merah memiliki potensi sebagai agen kemopreventif berbasis bahan alam.. Kata Kunci: kanker payudara, MCF-7, ekstrak kayu Bajakah Merah, mTORC, sitotoksik, kemoprevensi. Abstract One of the most prevalent diseases in women is breast cancer, which is linked to unchecked cell division via the mTORC signaling pathway. This study sought to determine how Red Bajakah Wood (Spatholobus littoralis) extract affected the in vitro expression of the mTORC protein in MCF-7 breast cancer cells. A true experimental design with post-test only control group was employed, including six treatment groups: negative control, positive control (Tamoxifen), and Red Bajakah Wood extract at IC₅₀ 72-hour concentration. Cells were cultured, treated, and viability assessed using CCK-8 to determine IC₅₀, while mTORC protein levels were measured via ELISA. Results showed that Red Bajakah Wood extract reduced cell viability in a dose- and time-dependent manner, with the lowest IC₅₀ at 72 hours incubation. mTORC levels increased significantly in extract-treated cells compared to negative control, indicating the extract’s effect on the mTORC signaling pathway. Although its cytotoxicity was lower than Tamoxifen, Red Bajakah Wood extract demonstrated potential as a natural-based chemopreventive agent.. Keywords: breast cancer, MCF-7, Red Bajakah Wood extract, mTORC, cytotoxicity, chemoprevention.
Co-Authors AGUS HARYONO Aisya, Sitti Akhmad Darmawan Ariani, Novita Ariyadi Basuki, Ariyadi Athanasia Amanda S Dewi Sondari Evi Triwulandari Harliansyah, Harliansyah M Ghozali Maulidiyah Medi Hendra, Medi Megawati Muhammad Nurdin Nunung Ainur Rahmah Pendrianto Pendrianto, Pendrianto Primahana, Gian Ridwanuloh, Asep Muhamad Ridwanuloh, Asep Muhamad Siskowati, Ratu Salia Sri Budi Harmami Suhardjo, Kuntari Adi SUKIRNO Surasno . Yan Irawan