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All Journal Buletin Farmatera Indonesian Journal of Cardiology Sumatera Medical Journal Heart Science Journal Cardiovascular and Cardiometabolic Journal (CCJ) Journal of Endocrinology, Tropical Medicine, and Infectious Disease (JETROMI) The Journal of Society Medicine (JSOCMED) Medistra Medical Journal (MMJ)
Sitepu, Andika
Departemen Jantung Dan Pembuluh Darah, Fakultas Kedokteran Universitas Sumatera Utara
Biochemistry, Genetics & Molecular Biology Health Professions Immunology & microbiology Medicine & Pharmacology Neuroscience Public Health

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Journal : Heart Science Journal

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Association between frontal QRS-T angle and thrombus burden in patients with ST-elevation myocardial infarction: A single-center cross-sectional study Azmi, Muhammad; Nasution, Ali Nafiah; Lubis, Hilfan Ade Putra; Siregar, Abdullah Afif; Habib, Faisal; Sitepu, Andika
Heart Science Journal Vol. 6 No. 4 (2025): The Pursuit of Precision: Navigating Risks, Refining Diagnosis, and Securing Lo
Publisher : Universitas Brawijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21776/ub.hsj.2025.006.04.13

Abstract

BACKGROUND: ST-Elevation Myocardial Infarction (STEMI) is one of the leading causes of global morbidity and mortality, with burden of thrombus as an influential factor of clinical outcomes. OBJECTIVES: The purpose of this study was to evaluate the relationship between frontal QRS-T (fQRST) angle and thrombus burden in STEMI patients. METHODS: A cross-sectional study was carried out at Haji Adam Malik General Hospital, Medan, between January 2024 and July 2024. STEMI patients who underwent coronary angiography were included. The fQRST angle was measured using a 12-lead electrocardiogram (ECG), the thrombus burden was graded according to the Thrombolysis in Myocardial Infarction (TIMI) grading system. Statistical analysis included Spearman's correlation and Receiver Operating Characteristic (ROC) curve analysis. RESULTS: 108 STEMI patients were included in the study. The fQRST angle was strongly positively correlated with thrombus burden (r = 0.61–0.80, p < 0.05). Patients with more thrombus burden had larger fQRST angles compared to patients with less thrombus burden. Additionally, diabetes mellitus and symptom delay exceeding 12 hours were highly correlated with higher thrombus burden (p < 0.05), whereas infarct-related artery (IRA) location was not significantly associated (p > 0.05). ROC curve demonstrated that the fQRST angle had an AUC of 0.88 (p = 0.001) At the optimal cut-off value of 61°, the sensitivity and specificity were 88.3% and 87.5% (95% CI of 88.5%–98.2).
Correlation between iron profile and severity of coronary artery lesion in patients with non-ST segment elevation myocardial infarction Syarifuddin, Fairuz; Andika Sitepu; Abdullah Afif Siregar; Zulfikri Mukhtar; Cut Aryfa Andra; Teuku Bob Haykal; Harris Hasan
Heart Science Journal Vol. 6 No. 4 (2025): The Pursuit of Precision: Navigating Risks, Refining Diagnosis, and Securing Lo
Publisher : Universitas Brawijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21776/ub.hsj.2025.006.04.12

Abstract

BACKGROUND: Excessive iron has been shown to increase the atherosclerosis process through the help of non-transferrin-bound iron (NTBI). OBJECTIVE: This study aimed to ascertain the association between iron profile and the severity of coronary artery lesions in patients with acute non-ST segment elevation myocardial infarction (NSTEMI).  METHOD: This observational analytical study with a cross-sectional design was conducted from February to September 2024 at Adam Malik General Hospital. NSTEMI patients planned for coronary angiography were examined for iron profile, including serum iron, total iron binding capacity (TIBC), and transferrin saturation. Coronary artery lesion severity was evaluated using the synergy between percutaneous coronary intervention with taxus and cardiac surgery (SYNTAX) score.  RESULTS: This study involved 72 subjects. The results showed there were no correlations between serum iron levels and SYNTAX scores (p = 0.891) and transferrin saturation with SYNTAX scores (p = 0.545). Nevertheless, TIBC and SYNTAX score were negatively correlated (p = 0.004) with a weak correlation coefficient (r = -0.334).  CONCLUSION: TIBC levels are inversely correlated with the severity of coronary artery lesions. However, transferrin saturation and serum iron have not been shown to correlate with the severity of coronary artery lesions.
Co-Authors Abdullah Afif Siregar Abdullah Afif Siregar Abimanyu, Roni Ahmad Handayani Aldino Satria Adhitya Alfuadi, T. Rifki Mirza Ali Nafiah Nasution Andra, Cut Aryfa Andra, Cut Aryfa Br Ginting, Kristivani Chan, Muhammad Ikhsan Cut Aryfa Andra Dhilion, Har Rawishwar Singh dr Nicholas Prananda Sembiring Faisal Habib FAPSC FASCC FIHA Habib, Faisal Harris Hasan Harris Hasan Hasan, Harris Hasan, Refli Haykal, T. Bob Ilyas, Kamal Kharrazi Intan, Tengku Kemala Jaya Suganti Ketaren, Andre Pasha Lubis, Ainil Wardah Lubis, Anggia Chairuddin Lubis, Hilfan Ade Putra Muhammad Azmi, Muhammad Mukhtar, Zulfikri Nasution, Ali Nafiah Putra, Muhammad Hafiz Mahruzza Ratna Mariana Tamba Raynaldo, Abdul Halim Sarastri, Yuke Setia Putra Tarigan Shafira Pramesi Putri Sinulingga, Brigitta Olivia Siregar, Abdullah Afif Steven Winardi Syarifuddin, Fairuz Tamba, Ratna Mariana Tanjung, Ika Citra Dewi Teuku Bob Haykal Wirtanto, Ardy Putra Yuke Sarastri Zulfikri Mukhtar