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All Journal As-syifaa Jurnal Farmasi Jurnal Farmasi Klinik dan Sains
Intiyani, Rafila
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Biochemistry, Genetics & Molecular Biology Chemistry Health Professions Immunology & microbiology Materials Science & Nanotechnology Medicine & Pharmacology

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EFEK ANALGETIK EKSTRAK AKUADES DAUN MELINJO (Gnetum gnemon L.) PADA MENCIT PUTIH (Mus musculus L.) JANTAN DENGAN METODE INDUKSI ASAM ASETAT 1% Dewi, Evelyne Citra; Sodik, Anwar; Khuluq, Husnul; Intiyani, Rafila
As-Syifaa Jurnal Farmasi Vol 15, No 2 (2023): AS-SYIFAA JURNAL FARMASI
Publisher : Fakultas Farmasi UMI

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.56711/jifa.v15i2.1055

Abstract

Pain is an unpleasant sensory and emotional feeling, associated with tissue damage. Melinjo leaves (Gnetum gnemon L.) are a plant that is useful as a traditional medicine for reducing and treating diseases, one of which is pain. The use of traditional medicine has fewer side effects than chemical medicine. This study aims to determine the analgesic activity and best dose of melinjo leaf distilled water extract in male white mice induced by 1% acetic acid. This research is experimental research. The subjects of this research were 25 male white mice. Mice were divided into 5 treatment groups with each group consisting of 5 mice. The treatment groups consisted of negative control CMC-Na 1%, positive control, melinjo leaf aqueous extract group at doses of 50, 100, and 150 mg/kgBW. The pain inducer was given 1% acetic acid. Observations were made by observing the movements of mice to calculate the % of analgesic protection. The data that has been obtained is then tested using One Way Anova and Post Hoc LSD or Games-Howell statistical tests. The results obtained by melinjo leaf aqueous extract at a dose of 150 mg/kgBW had the best analgesic effect because it had the largest % protection, namely 66.89%, and provided a significant effect (p<0.05) in mice induced by 1% acetic acid. Melinjo leaf aqueous extract at a dose of 150 mg/kgBW had the best analgesic effect on male white mice which was declared significant (p<0.05) and the mean difference value was greater.
EVALUASI KEPATUHAN PENGGUNAAN OBAT ANTIDIABETES PADA PASIEN DIABETES MELITUS TIPE 2 DI INSTALASI RAWAT JALAN RUMAH SAKIT PKU MUHAMMADIYAH GOMBONG Mulyani, Ayu Achiriyah; Widiastuti, Tri Cahyani; Intiyani, Rafila
Jurnal Farmasi Klinik dan Sains Vol 4, No 2 (2024): Jurnal Farmasi Klinik dan Sains
Publisher : Lembaga Penelitian dan Pengabdian Masyarakat Universitas Muhammadiyah Gombong

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.26753/jfks.v4i2.1459

Abstract

Diabetes Melitus (DM) adalah penyakit metabolik ditandai dengan kenaikan gula darah yang disebabkan karena kelainan produksi insulin, kerja insulin atau kedua-duanya. Ketidakpatuhan penggunaan obat antidiabetes dapat dipengaruhi oleh beberapa faktor. Dampak karena ketidakpatuhan pengobatan dapat terjadi resiko komplikasi, kualitas hidup penderita yang buruk. Penelitian ini bertujuan untuk mengetahui tingkat kepatuhan minum obat antidiabetes pada pasien diabetes melitus tipe 2. Metode penelitian ini observasional dengan menggunakan metode pendekatan cross sectional. Instrumen penelitian menggunakan kuesioner MMAS-8. Jumlah responden 90 orang dilakukan bulan Mei-Juni dengan metode purposive sampling. Data diolah menggunakan SPSS-26 dan dianalisis dengan uji chi-square.Hasil penelitian menunjukkan pasien tidak patuh sebesar 42,2%, cukup patuh 43,3%, dan patuh sebesar 14,4%. Tingkat kepatuhan minum obat berdasarkan karakteristik pasien, yaitu mayoritas pasien perempuan, berusia 46-60 tahun, pendidikan terakhir SMA, pasien bekerja sebagai petani dan karyawan, berpenghasilan <1-4 juta, menderita <1 tahun, kombinasi obat, pengobatan <6 bulan, dan tidak dengan penyakit penyerta.Tingkat kepatuhan pasien dalam mengkonsumsi obat sedang (43,3%).
Co-Authors Anwar Sodik, Anwar Dewi, Evelyne Citra Khuluq, Husnul Mulyani, Ayu Achiriyah Widiastuti, Tri Cahyani