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All Journal Indonesia Medicus Veterinus The Journal of Experimental Life Sciences (JELS) Jurnal Medik Veteriner Veterinary Biomedical and Clinical Journal JURNAL KAJIAN VETERINER
Setianingrum, Ani
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Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Education Health Professions Immunology & microbiology Medicine & Pharmacology Neuroscience Public Health Veterinary

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Umur Sangat Memengaruhi Kejadian Massa Abnormal Superfisial Nonneoplastik pada Mencit di Wilayah Malang Raya Adha, Essly Hervianingsih; Dewi, Sang Ayu Putri Aristya; Wukirani, Maulidi Robingi Mardiyani; Setianingrum, Ani; Hardian, Andreas Bandang
Indonesia Medicus Veterinus Vol 12 (4) 2023
Publisher : Faculty of Veterinary Medicine, Udayana University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.19087/imv.2023.12.4.506

Abstract

Massa abnormal superfisial sering ditemukan pada mencit yang dibudidayakan di Malang Raya. Massa abnormal superfisial dapat bersifat neoplastik ataupun nonneoplastik, terletak pada bagian superfisial tubuh, dan relatif mudah teramati secara visual. Massa nonneoplastik merupakan massa dengan pertumbuhan yang lambat dan tidak memiliki sel-sel neoplastik. Penelitian ini bertujuan untuk melihat hubungan faktor risiko umur dan kepadatan populasi di dalam kandang mencit terhadap kejadian massa nonneoplastik di Malang Raya. Spesimen diambil dengan metode koleksi secara purposif pada mencit dengan massa nonneoplastik pada delapan peternakan mencit di Malang Raya. Pemeriksaan histopatologi dilakukan untuk mengidentifikasi jenis massa nonneoplastik superfisial, sedangkan hasil wawancara dengan peternak digunakan sebagai data sekunder untuk mengetahui faktor risiko pada manajemen peternakan mencit. Proporsi kejadian divisualisasikan menggunakan QGIS 3.4.5 melalui peta sebaran proporsi temuan massa pada mencit di Malang Raya dan analisis faktor risiko menggunakan uji chi-square SPSS 26 untuk mengetahui ada tidaknya hubungan faktor risiko umur dan kepadatan kandang terhadap kejadian massa nonneoplastik superfisial pada mencit. Identifikasi histopatologi massa nonneoplastik superfisial menunjukkan setidaknya terdapat tiga variasi massa: abses subkutan, dermatitis, dan hematoma. Analisis faktor risiko dengan uji chi-square menunjukkan adanya hubungan antara umur mencit dengan tingkat kejadian massa nonneoplastik superfisial dan tidak ditemukan adanya hubungan dengan kepadatan populasi dalam kandang. Kalkulasi Odd Ratio (OR) menunjukkan mencit dengan umur di atas dua bulan berpeluang 8,21 kali lipat untuk mengalami kejadian massa nonneoplastik superfisial dibandingkan mencit dengan rentang umur 0-2 bulan.
Antioxidant Activity of Goat Milk Yogurt Casein on Dioxin Intoxicated Rat Liver Function Setianingrum, Ani; Padaga, Masdiana Chendrakasih
Veterinary Biomedical and Clinical Journal Vol. 1 No. 1 (2019)
Publisher : Faculty of Veterinary Medicine Universitas Brawijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (206.741 KB) | DOI: 10.21776/ub.VetBioClinJ.2019.001.01.4

Abstract

Dioxin is toxic contaminant which persistent in the environment. This compound bio-accumulate through food chain and generate adverse effect in human health. Oxidative stress due to dioxin exposure can interfere metabolism process and leads to the development of hepatotoxicity.The aim of this study was to asses the role of casein derived from goat milk yogurt in dioxin-intoxicated rat based on liver function parameters. Substances used were: 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) diluted in corn oil and casein from goat milk yogurt. The study included 24 Wistar rats divided into 6 groups: (1) control group, (2) placebo group which given casein 600 mg/kg BW, (3) TCDD group given with TCDD 100 ng/kg BW, (4) group P1 given casein 300 mg/kg BW and TCDD, (5) group P2 given casein 600 mg/kg BW and TCDD, (6) group P3 given casein 900 mg/kg BW and TCDD. The respective dose were given orally for 21 days. Blood serum was collected for transaminases (ALT, AST) and γ-glutamyl transferase (GGT) analysis. Based on serum transaminases activity, there were no significant change on AST and ALT level. Casein yogurt supplementation has significant effect on serum GGT level (p<0,05) and optimum dose was 600 mg/kg BW/day
Prevalence and Predisposing factors of Subclinical Mastitis in Dairy Cows in Bakir, Sukomulyo Village, Batu Regency Fatmawati, Mira; Setianingrum, Ani; Haskito, Ajeng Erika Prihastuti; Dameanti, Fidi Nur Aini Eka Puji
Veterinary Biomedical and Clinical Journal Vol. 1 No. 2 (2019)
Publisher : Faculty of Veterinary Medicine Universitas Brawijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (195.291 KB) | DOI: 10.21776/ub.VetBioClinJ.2019.001.02.5

Abstract

Peradangan ambing pada sapi perah yang lebih dikenal sebagai mastitis masih menjadi masalah utama dalam industri susu. Kerugian peternak karena mastitis disebabkan oleh penurunan produksi susu dan penurunan kualitas susu yang dihasilkan. Pada umumnya pengetahuan peternak rakyat akan mastitis sebatas pada mastitis klinis karena gejala klinis yang dapat teramati. Mastitis yang sifatnya subklinis sulit dideteksi dan apabila dibiarkan tanpa penanganan dapat menjadi sumber penularan ke sapi perah lainnya. Deteksi mastitis subklinis pada sapi perah menggunakan uji tidak langsung yaitu california mastitis test (CMT) atau menggunakan uji langsung dengan penghitungan jumlah sel somatis (JSS). Penelitian ini merupakan studi lintas seksional dengan menggunakan sampel susu kwartir pada peternakan sapi perah rakyat di dusun Bakir, desa Sukomulyo, kabupaten Batu. Pengujian mastitis dilakukan di lapangan dengan uji CMT dan di laboratorium untuk penghitungan JSS. Pengambilan data dengan kuesioner untuk mengetahui faktor predisposisi mastitis. Prevalensi mastitis subklinis berdasarkan JSS adalah 60,22% dan berdasarkan uji CMT di lapangan adalah 18,20% dari total sampel kwartir. Faktor predisposisi yang mempengaruhi masih adanya kejadian mastitis pada peternakan antara lain kebersihan sapi, kandang, dan sanitasi sebelum dan sesudah pemerahan.
Yolk Binding Treatment for Reticulated Python in House of Pet Clinic: Penanganan Kasus Yolk Binding Pada Ular Sanca batik (Python reticulatus) di Klinik House of Pet Isnaeni, Intan Kirana; Setianingrum, Ani; Hardian, Andreas Bandang; Yesica, Reza; Herlambang, Anugrah Niki
Veterinary Biomedical and Clinical Journal Vol. 4 No. 1 (2022)
Publisher : Faculty of Veterinary Medicine Universitas Brawijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21776/ub.VetBioClinJ.2022.004.01.6

Abstract

Yolk binding is a condition where the egg yolk as food reserves while the snake still in the egg phase is notcompletely absorbed in the snake’s body when the snake has become neonatal. This study aims todetermine the handling of cases of yolk binding in Python reticulatus. A 3-month-old female Pythonreticulatus was brought by the owner to the vet with complaints of not defecating after ten days from thelast feeding on and the presence of a ¼ lump from the caudal. The results of the stool examinationshowed the number of protozoa. The x-ray results, show the air-filled medial with radiolucent colorintensity and a mass with radioopaque color intensity. Based on the signals, history, physical examination,and investigations, a diagnosis of yolk binding was obtained. The treatment given is surgery, drug therapy,and post-operative care. After being brought home, five days after surgery snake died.
Teratogenic of 2,3,7,8-Tetrachlorodibenzo-P-Dioxin (TCDD) on Eye Diameters and Body Weight in Chicken Embryo Firdaus, Muhammad Aviv; Pratiwi, Herlina; Setianingrum, Ani; Airlangga, Gegana Wimaldy
Jurnal Medik Veteriner Vol. 4 No. 2 (2021): October
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/jmv.vol4.iss2.2021.180-188

Abstract

2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) is a chemical compound resulting from the burning effect that is very dangerous for humans, plants, or animals which can cause skin damage, immunotoxic, hepatotoxic, carcinogenic, teratogenic, effects on reproduction, growth processes, neurobehavioral, and endocrine effects that are specific In addition, this compound can also reduce embryo weight and increase embryo mortality. This study aimed to determine the teratogenic of TCDD administration on eye diameters and body weight of chicken embryo. In this study there were 2 treatment groups, i.e: 1) P1 as a normal group without the addition of TCDD, and 2) P2 as a group with the addition of TCDD of 5 ng / egg with dissolved in 5 µL corn oil. The treatment was carried out for 7 days. The measurement data of eye diameters and body weight of chicken embryo were analyzed by the unpaired sample T test. The analysis showed that the teratogenic of TCDD had a significant effect on eye diameters and body weight of chicken embryos, where the teratogenic of TCDD caused a decrease in eye diameters and body weight loss in chicken embryos.
The Association of Age and Number of Parturition with Mammary Gland Tumor Case Rate in Mice in Malang Raya Wukirani, Maulidi Robingi Mardiyani; Adha, Essly Hervianingsih; Dewi, Sang Ayu Putri Aristya; Setianingrum, Ani; Pratama, Dyah Ayu Oktavianie Ardhiana; Hardian, Andreas Bandang
Jurnal Medik Veteriner Vol. 5 No. 1 (2022): April
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/jmv.vol5.iss1.2022.9-15

Abstract

Mammary gland tumours are frequently reported in adult female mice. It broadly affects the productivity and breeding performance of mice in breeding centres. The tumours might occur spontaneously due to internal factors such as genetic mutation and hormonal disturbance, however, external causes such as Mouse Mammary Tumour Virus (MMTV) infection was also reported. This study aimed to prove that age and number of parturition associate with mammary gland tumour case rate in female mice in Malang Raya. Chi-square tests were employed to analyse the association between risk factors and mammary gland tumour case rate in this study. Histopathologic analysis described three subtypes of mammary gland tumours in mice which were adenoma, adenocarcinoma type A and adenocarcinoma type B. Chi-square tests results of tumour case rate toward age and number of parturitions were consecutively 0,004 and 0,0025 which indicated that age and number of parturitions were associated with mammary gland tumours case rate in mice in Malang Raya. The mapping of tumour case distribution visually showed a trend that higher disease proportions were spotted in higher altitude of sampling location. This might relate to the geographical breeding characteristics or temperature which needs further study to explore the association of spatial factors with the mammary tumour incidence in mice.
SUPLEMENTASI YOGURT FORTIFIKASI KONSENTRASI BERTINGKAT EKSTRAK ROSELLA UNGU TERHADAP KADAR MALONDIALDEHIDA (MDA) DAN GAMBARAN HISTOLOGI GINJAL MENCIT Ratna, Novia Kumala Dian Nur; Setianingrum, Ani; Nugroho, Widi; Haskito, Ajeng Erika Prihastuti; Noviatri, Aldila
JURNAL KAJIAN VETERINER Vol 10 No 1 (2022): Jurnal Kajian Veteriner
Publisher : FAKULTAS KEDOKTERAN HEWAN UNIVERSITAS NUSA CENDANA

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35508/jkv.v10i1.5504

Abstract

Purple roselle has ingredients such as organic acids, anthocyanins, polysaccharides, and flavonoids. The antioxidant content in purple roselle has benefits in preventing cell damage due to free radicals. This study was conducted to discoverthe effect of supplementation yogurt fortified with a graded concentration of purple roselle extract on MDA levels and histology of the kidney organs of mice. Laboratory experimental study using 16 male Balb-C mice divided into four groups. The control (C) group was not given any treatment. The treatment groups 1,2, and 3 (T1, T2, T3) were given fortified purple roselle yogurt with concentrations of 5%, 10%, and 15%, respectively. The treatment was carried out for 14 days with a volume of 0.4 ml/day. Kidney organs were collected for histological analysis. Kidney malondialdehydelevels were assayed using the TBARS test and statistically analyzed with a 95% confidence level by one-way ANOVA analysis. Histology score analyzed using the Kruskal-Wallis test followed by the Mann- Whitney test. This study showedthat at concentrations of 10% and 15%, MDA levels of the mice kidneys reduce significantly compared to the control group. The kidney histology score results show some changes in treatment groups compares to control group. The average score decreasing from different treatment group, and the lowest score was group given yogurt fortified roselle extract 15%. The administration of fortified yogurt with purple roselle extract at a concentration of 15% can reduce MDA levels in the kidneys of mice, and the higher the concentration can reduce kidney damage in mice.
Purple Roselle Fortified Yogurt Supplementation Prevents Dioxin-Induced Oxidative Testicular Impairment in Rats Setianingrum, Ani; Nindhyasari, Shintya; Pratiwi, Herlina; Haskito, Ajeng Erika Prihastuti; Noviatri, Aldila
The Journal of Experimental Life Science Vol. 14 No. 2 (2024)
Publisher : Graduate School, Universitas Brawijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21776/ub.jels.2024.014.02.03

Abstract

Dioxins are highly toxic and hurt multiple organs and systems, including the reproductive organs. This study determined the supplementation of purple roselle (Hibiscus sabdariffa var. altissima) extract into yogurt to prevent testicular deterioration induced by 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD). The fortification of purple roselle extract into yogurt (RY) was used as a supplement because bioactive components are known to be efficacious in preventing cell damage. Five groups of male Wistar rats were group as follows: 1) negative control (C), 2) TCDD (T), 3) TCDD and 0.5% RY (P1), 4) TCDD and 1% RY (P2), 5) TCDD and 1.5% RY (P3). All treatments were carried out orally for 12 days. Testicular Malondialdehyde (MDA) level and histopathological changes were described quantitatively by one-way ANOVA. The study's results showed that treatment groups P1 (0.5% RY) and P2 (1% RY) had significantly (P<0,05)  lower MDA levels than the T group, while group P3 had no significant decrease in MDA level. It proved that supplementation of purple roselle yogurt reduced the formation of MDA in testicular tissue. Histopathology changes show that all groups exposed to TCDD have depleted spermatogenic, Sertoli, and Leydig cells compared to the C group. Suggests that dioxin exposure can have adverse effects on male reproductive organs. This research concludes that supplementing yogurt fortified with purple roselle extract can prevent increased testicular MDA levels. The decrease in testicular cells due to TCDD toxicity was inevitable. However, antioxidant activity from roselle yogurt supplementation can prevent further damage in rat testicular cells. Keywords: Histopathology, MDA, Purple Roselle, Testis, TCDD, Yogurt.
Co-Authors Adha, Essly Hervianingsih Airlangga, Gegana Wimaldy Dameanti, Fidi Nur Aini Eka Puji Dewi, Sang Ayu Putri Aristya Fatmawati, Mira Firdaus, Muhammad Aviv Hardian, Andreas Bandang Haskito, Ajeng Erika Prihastuti Herlambang, Anugrah Niki Isnaeni, Intan Kirana Nindhyasari, Shintya Noviatri, Aldila Padaga, Masdiana Chendrakasih Pratama, Dyah Ayu Oktavianie Ardhiana Pratiwi, Herlina Ratna, Novia Kumala Dian Nur Widi Nugroho Wukirani, Maulidi Robingi Mardiyani Yesica, Reza