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All Journal Journal Health & Science : Gorontalo Journal Health and Science Community Jurnal Prima Medika Sains Jurnal Kesehatan Tambusai JOURNAL LA MEDIHEALTICO Jurnal EduHealth Jurnal Locus Penelitian dan Pengabdian Nusantara Scientific Medical Research Journal PCJN Pharmaceutical and Clinical Journal of Nusantara Journal of Innovative and Creativity
Novriani, Erida
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Aerospace Engineering Automotive Engineering Decision Sciences, Operations Research & Management Dentistry Education Electrical & Electronics Engineering Health Professions Languange, Linguistic, Communication & Media Mathematics Medicine & Pharmacology Neuroscience Nursing Public Health Social Sciences Veterinary Other

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Antibiotics self-medication practices among students in Universitas Prima Indonesia Novriani, Erida; Neswita, Elfia; Razoki, Razoki
Jurnal Prima Medika Sains Vol. 5 No. 2 (2023): December
Publisher : Program Studi Magister Kesehatan Masyarakat Universitas Prima Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.34012/jpms.v5i2.4622

Abstract

The irrational use of antibiotics can endanger health by causing unwanted drug reactions, side effects, and drug resistance. This study aimed to analyze the patterns of antibiotic self-medication among university students. This descriptive cross-sectional study was conducted at Prima Indonesia University in October 2023. A total of 307 randomly selected students from various faculties (health science clumps and non-health science clumps) filled out questionnaires distributed via Google Forms. The collected data are then analyzed descriptively to obtain frequency and percentage data, which are then presented in the form of tables and narratives. The results showed that about 83.39% of respondents had used antibiotics before. Most respondents used antibiotics because they were easily available (43.36%) or because of their previous experience (36.72%). The most common conditions for antibiotic use were cough and cold (47.66%), and infections (23.05%). Most respondents used antibiotics based on doctor ’sor pharmacist’s recommendations (45.31%). The duration of antibiotic use was 1-3 days (61.72%), followed by 4-7 days (31.64%) and more than 7 days (6.64%). Antibiotics were purchased from pharmacies (83.20%). The most common reactions to the overuse of antibiotics were nausea and vomiting (40.23%) and headache (32.81%). Most respondents (53.13%) consulted a doctor or pharmacist if they experienced reactions to antibiotic overuse.
Antioxidant In Reducing MDA Conditions and Increasing SOD Conditions in White Rats (Rattus norvegicus) Wistar Strain Given a High Cholesterol Diet and Induced More Physical Activity Riana, Nova; Putri, Lenni Dianna; Novriani, Erida
Journal La Medihealtico Vol. 5 No. 2 (2024): Journal La Medihealtico
Publisher : Newinera Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37899/journallamedihealtico.v5i2.1101

Abstract

Sedentary lifestyles increase the risk of morbidity and infectious illnesses. Physical exercise can improve immune function but can lead to increased oxidants and reactive oxygen species (ROS), damaging cells and tissues. Crucial in mitigating the cellular damage caused by free radicals are antioxidants, including non-enzymatic antioxidants such as glutathione, vitamins C and E, and others. Moderate to high-intensity physical exercise can result in an increase in ROS and a reduction in SOD. Grape seeds are rich in antioxidants, which have been shown to neutralize free radicals and protect against inflammation, bacteria, ulcers, and cancer. These antioxidants, including phenols and proanthocyanidins, are beneficial to health and have applications in various industries, including energy production, cosmetics, and pharmaceuticals. Research is also being conducted to explore their antioxidant effects on MDA levels. Grape seed extract was tested for its impact on malondialdehyde (MDA) levels in the blood of male Wistar strain white rats. Rats' MDA levels decreased following four weeks of treatment. Rat cages, digital scales, an MDA test kit, and SPSS were some of the equipment used in the study. Grape seed extract effectively reduces MDA levels in rats with hypercholesterolemia, resulting in weight loss and a lee index below 0.3, and increases SOD levels, indicating potential for human use.
AKTIVITAS Lactobacillus casei SEBAGAI PENURUN KADAR KOLESTEROL SECARA In Vitro Ritonga, Lestina; Saragih, Ria Natalia; Novriani, Erida; Fachrial, Edy
Journal Health & Science : Gorontalo Journal Health and Science Community Vol 8, No 3 (2024): JULI: JOURNAL HEALTH AND SCIENCE : GORONTALO JOURNAL HEALTH AND SCIENCE COMMUNIT
Publisher : Gorontalo State University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35971/gojhes.v8i3.26191

Abstract

Hiperkolesterolemia adalah di mana keadaan tingkat kolesterol dalam darah melebihi batas normal yang ditetapkan, yaitu melebihi 200 mg/dL. Bakteri asam laktat dapat digunakan sebagai terapi alternatif kemampuan untuk menurunkan kadar kolesterol. Kebaruan dari penelitian ini probiotik bakteri asam laktat memiliki manfaat terapeutik seperti kadar kolesterol dalam darah menurun dan mencegah terjadinya kanker usus. Tujuan dari penelitian ini adalah untuk mengetahui apakah Lactobacillus casei dapat menurunkan kolesterol secara in vitro. Metode penelitian aktivitas antimikroba dilakukan dengan metode disc paper, uji ketahanan terhadap pH asam, garam empedu dan pengurangan kolesterol dilakukan dengan metode spektrofotometer. Hasil penelitian uji aktivitas antimikroba isolat Lactobacillus casei menunjukkan aktivitas zona hambat terhadap bakteri E. coli sebesar 28,5 mm dan S. aureus sebesar 33,2 mm. Uji ketahanan terhadap pH asam sebesar 45,42%. Uji ketahanan terhadap garam empedu yaitu 55,39%, penurunan kadar kolesterol secara in vitro cukup baik yaitu 82,20%. Kontrol positif pengurangan kolesterol oleh simvastatin adalah 56,89%. Kesimpulan yang diperoleh dari penelitian ini adalah probiotik isolat Lactobacillus casei dapat menurunkan kadar kolesterol secara In Vitro.
Study of Administrative, Pharmaceutical, and Clinical Aspects of Hypertension Patient Prescriptions at Advent Hospital, Medan Saragih, Maria Lady; Simanjuntak, Nerly Juli Pranita; Novriani, Erida
PCJN: Pharmaceutical and Clinical Journal of Nusantara Vol. 3 No. 02 (2025): PCJN: Pharmaceutical and Clinical Journal of Nusantara
Publisher : CV. Nusantara Scientific Medical

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.58549/pcjn.v3i02.111

Abstract

Hypertension is a common chronic disease requiring precise pharmacological management to prevent complications. Inappropriate prescriptions may lead to treatment failure or adverse events. This study aimed to evaluate the completeness of prescriptions for hypertensive outpatients at Advent Hospital Medan based on administrative, pharmaceutical, and clinical aspects. This descriptive retrospective study analyzed 303 prescriptions collected from January to March 2024. Evaluation criteria included patient and prescriber identity, dosage form, drug strength, usage instructions, indication accuracy, dosage accuracy, and potential drug interactions. Results showed administrative completeness was high, with 100% inclusion of most identity elements, but 0% for weight and height. Pharmaceutical completeness was suboptimal, with only 25.08% including dosage form. Clinically, all prescriptions were appropriate in terms of indication, dose, and timing, and showed no duplication. However, 88.11% of prescriptions contained potential drug interactions, with 68 major interactions identified. The most frequent were Amlodipine–Simvastatin and Spironolactone–Candesartan combinations. These findings indicate that while clinical accuracy was excellent, pharmaceutical documentation and interaction screening need improvement. Collaboration between prescribers and pharmacists is essential to enhance medication safety.
Effect of Garlic (Allium sativum) and Turmeric (Curcuma domestica Val.) Extract Combination in Type 2 Diabetic Rats. Ndruru, Titi Marlina; Simanjuntak, Nerly Juli Pranita; Novriani, Erida
PCJN: Pharmaceutical and Clinical Journal of Nusantara Vol. 3 No. 02 (2025): PCJN: Pharmaceutical and Clinical Journal of Nusantara
Publisher : CV. Nusantara Scientific Medical

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.58549/pcjn.v3i02.112

Abstract

Type 2 diabetes mellitus (T2DM) often leads to kidney damage due to chronic hyperglycemia and oxidative stress. Garlic (Allium sativum) and turmeric (Curcuma domestica Val.) are traditional medicinal plants with known antioxidant and anti-inflammatory properties. This study evaluated the nephroprotective effect of their combined extracts in streptozotocin (STZ)-induced diabetic rats. Twenty-five male rats were divided into five groups: negative control, positive control (metformin 500 mg/kg BW), and three treatment groups receiving extract combinations at doses of 100, 200, and 300 mg/kg BW. Blood glucose, urea, and creatinine levels were measured, followed by histopathological examination. Phytochemical analysis confirmed the presence of alkaloids, flavonoids, and other secondary metabolites. Although statistical analysis showed no significant difference in glucose, urea, and creatinine levels among groups (p > 0.05), the 200 mg/kg BW group exhibited the most favorable trends in reduced blood glucose (226.70 ± 89.70 mg/dL) and kidney biomarkers. These results suggest the combination extract may offer protective effects on kidney function in diabetic conditions, warranting further investigation.
Histopathological Features of the Pancreas in Alloxan-Induced Diabetic White Rats Treated with Bandotan (Ageratum conyzoides L.) Extract Hasibuan, Fitriah Parmadami; Novriani, Erida; Simanjuntak, Nerly Juli Pranita
NSMRJ: Nusantara Scientific Medical Research Journal Vol. 3 No. 01 (2025): NSMRJ: Nusantara Scientific Medical Research Journal
Publisher : CV. Nusantara Scientific Medical

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.58549/nsmrj.v3i01.99

Abstract

Damage to pancreatic β-cells can lead to hyperglycemia, a hallmark of diabetes mellitus. Ageratum conyzoides L. (bandotan), a plant from the Asteraceae family, is traditionally used in herbal medicine due to its rich content of secondary metabolites. This study aimed to evaluate the histopathological profile of pancreatic tissue in alloxan-induced diabetic rats following treatment with ethanol extract of bandotan leaves. The research employed a true experimental design with a posttest-only control group. A total of 24 white rats were randomly divided into six groups: normal, negative control (aquadest + alloxan), positive control (glibenclamide 0.65 mg/kg BW), and three treatment groups receiving bandotan extract at doses of 100, 200, and 400 mg/kg BW, respectively. Bandotan leaves (4–5 kg) were extracted using ethanol, and histopathological observations were performed under a light microscope at 100x and 400x magnification. Pancreatic damage was scored and analyzed using descriptive statistics. The mean pancreatic damage scores were as follows: negative control group = 1.25; positive control group = 1.00; 100 mg/kg BW group = 1.00; 200 mg/kg BW group = 0.25; 400 mg/kg BW group = 0.00; and normal group = 0.00. The results indicate that the 400 mg/kg BW dose of Ageratum conyzoides L. extract was the most effective in preventing pancreatic damage, with histological features comparable to those of the normal group.
Analysis of the Relationship Between Attitude and Motivation and Medication Adherence Among Hypertensive Patients at Royal Prima General Hospital Medan Natalia, Desi; Novriani, Erida; Lubis, Razoki
PCJN: Pharmaceutical and Clinical Journal of Nusantara Vol. 3 No. 02 (2025): PCJN: Pharmaceutical and Clinical Journal of Nusantara
Publisher : CV. Nusantara Scientific Medical

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.58549/pcjn.v3i02.115

Abstract

Hypertension remains one of the leading causes of morbidity and mortality globally, with poor medication adherence being a key barrier to effective management. This study aimed to analyze the relationship between attitude and motivation with medication adherence in hypertensive patients at Royal Prima General Hospital Medan. A quantitative, cross-sectional approach was employed, involving 150 respondents selected via purposive sampling. Primary data were collected using validated questionnaires covering demographics, attitude, motivation, and medication adherence. Data were analyzed using SPSS version 25 through univariate and bivariate (Chi-square) methods. Results showed that 59.3% of respondents had a fair attitude, 44.0% had moderate motivation, and 75.3% adhered to their medication. Bivariate analysis revealed a significant relationship between attitude and adherence (p = 0.000), and between motivation and adherence (p = 0.016). Patients with better attitudes and higher motivation demonstrated higher compliance with antihypertensive therapy. These findings highlight that psychosocial factors like attitude and motivation play critical roles in influencing patient behavior. Interventions targeting these behavioral dimensions could substantially improve treatment adherence and long-term health outcomes in hypertensive patients. Healthcare professionals should incorporate patient education and motivational strategies into hypertension management to foster sustained adherence.
Potensi Antioksidan dan Total Fenol Ekstrak Etanol Kunyit Putih dengan Metode DPPH-FRAP Sitorus, Christina Berliana; Razoki, Razoki; Syahputra, Hariyadi Dharmawan; Novriani, Erida
Jurnal Locus Penelitian dan Pengabdian Vol. 4 No. 6 (2025): JURNAL LOCUS: Penelitian & Pengabdian
Publisher : Riviera Publishing

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.58344/locus.v4i6.4301

Abstract

Stres oksidatif akibat radikal bebas beperan dalam patogenesis penyakit degeneratif, mendorong pemanfaatan antioksidan alami seperti kunyit putih yang kayak fenolik sebagai alternatif yang lebih aman dari sintetis. Penelitian ini mengevaluassi hubungan antara kandungan fenolik dan kapasitas antioksidan kunyit putih menggunakan metode DPPH dan FRAP. Aktivitas antioksidan dan kadar total fenol ekstrak etanol kunyit putih dianalisis menggunakan metode DPPH, FRAP, dan Folin-Ciocalteu. Ekstrak etanol kunyit putih mengandung total fenol 189,21 mg GAE/g dan menunjukkan aktivitas antioksidan sangat kuat dalam menangkal radikal bebas dengan nilai IC50 5,30 ppm (DPPH) dan 24,02 ppm (FRAP).
Test of Stevia Leaf Ethanol Extract (Stevia Rebaudiana) Administered Orally to Female Wistar Rats (Rattus Norvegicus) on a High-Fat Diet to Prevent Dyslipidemia Randy Suryadinata, Emmanuel; Hendriani Djuang, Michelle; Novriani, Erida; Merry Cisca, Anita
Jurnal EduHealth Vol. 14 No. 04 (2023): Jurnal eduHealt, 2023, December
Publisher : Sean Institute

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

This study aims to analyze and test the effect of Stevia Rebaudiana ethanol extract in preventing dyslipidemia in female Wistar rats (Rattus Norvegicus) fed a high-fat diet. The results showed that giving Stevia Rebaudiana ethanol extract at 40 mg / 200 gr BW of female Wistar rats given a high-fat diet orally prevented a decrease in HDL cholesterol levels. However, it will increase total cholesterol, LDL cholesterol, and triglycerides. This study demonstrated that the ethanol extract of Stevia Rebaudiana has beneficial properties in controlling hyperlipidemia, which is presumably due to the antioxidant and glycoside effects of the ethanol extract of Stevia Rebaudiana, which overall contributes to the development profile lipid rats were given a high-cholesterol diet.
IDENTIFIKASI RESIKO DRUG RELATED PROBLEMs (DRPs) PADA PASIEN GERIATRI DENGAN PENYAKIT HIPERTENSI DI INSTALASI RAWAT JALAN RUMAH SAKIT ROYAL PRIMA MEDAN Alwin, Nicholas; Novriani, Erida; Pratama, Irza Haicha
Jurnal Kesehatan Tambusai Vol. 5 No. 3 (2024): SEPTEMBER 2024
Publisher : Universitas Pahlawan Tuanku Tambusai

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31004/jkt.v5i3.32723

Abstract

Penelitian ini menyoroti pentingnya mengidentifikasi Drug Related Problems (DRPs) pada pasien geriatri dengan penyakit hipertensi di instalasi rawat jalan Rumah Sakit Umum Royal Prima Medan. Mengingat populasi geriatri rentan terhadap komplikasi obat, identifikasi DRPs menjadi krusial untuk meningkatkan keselamatan dan efektivitas terapi. Penelitian ini merupakan penelitian yang menggunakan metode crosssectional untuk menyajikan data deskriptif periode April - Juni 2024. Data yang digunakan adalah 247 pasien rawat jalan yang berusia di atas 60 tahun dan menderita didiagnosis dengan hipertensi baik dengan atau tanpa komplikasi. Data menunjukkan bahwa obat antihipertensi yang paling sering digunakan adalah candesartan (golongan Angiotensin Receptor Blocker) sebanyak 139 kasus. Obat antihipertensi terbanyak kedua adalah amlodipine (golongan Calcium Channel Blocker) sebanyak 91 kasus, diikuti oleh bisoprolol (golongan Beta Blocker) sebanyak 48 kasus. Identifikasi DRPs dalam penelitian ini meliputi tiga kategori yaitu interaksi obat, duplikasi pengobatan dan reaksi obat yang merugikan. Hasil menunjukkan bahwa persentase DRPs terbesar berasal dari interaksi obat sebesar 76,1% sementara duplikasi pengobatan hanya 0,8% dan reaksi obat yang merugikan tidak ditemukan. Interaksi obat yang paling sering terjadi antara obat hipertensi dan obat penyakit penyerta adalah golongan Angiotensin Receptor Blocker (ARB) dengan tingkat keparahan moderate sebanyak 25.85%.Duplikasi pengobatan teridentifikasi pada 2 resep,yaitu alprazolam dan diazepam, berdasarkan kesamaan mekanisme obat, efek samping yang mirip, serta ketidakadaan manfaat tambahan ketika dikonsumsi bersamaan. Penelitian ini menggaris bawahi pentingnya pemantauan penggunaan obat pada pasien geriatri dengan hipertensi untuk mengurangi risiko DRPs dan meningkatkan kualitas pengobatan.  
Co-Authors Alwin, Nicholas DESI NATALIA, DESI Edy Fachrial Hasibuan, Fitriah Parmadami Hendriani Djuang, Michelle irza Haicha Pratama Lubis, Razoki Merry Cisca, Anita Ndruru, Titi Marlina Neswita, Elfia Nova Riana Putri, Lenni Dianna Randy Suryadinata, Emmanuel Razoki, Razoki Ritonga, Lestina Sabira, Khansa Saragih, Maria Lady Saragih, Ria Natalia Simanjuntak, Nerly Juli Pranita Sitorus, Christina Berliana Syahputra, Hariyadi Dharmawan