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All Journal Universa Medicina Indonesian Journal of Medicine
Putro, Prasetyo Sarwono
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Health Professions Immunology & microbiology Medicine & Pharmacology Public Health

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The diagnostic value of apparent diffusion coefficient to differentiate benign and malignant meningiomas Marissa, Risa; Rahayu, Rachmi Fauziah; Wujoso, Hari; Subandi, Subandi; Putro, Prasetyo Sarwono; Soewondo, Widiastuti
Universa Medicina Vol. 40 No. 2 (2021)
Publisher : Faculty of Medicine, Universitas Trisakti

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18051/UnivMed.2021.v40.141-150

Abstract

BACKGROUNDMeningiomas are the most common primary extra-axial non-glial intracranial tumors. The severe grade of meningioma, according to WHO, has the highest recurrence rate accompanied by high morbidity and mortality rates. Therefore, it is imperative to perform pre-operative assessments so the clinician can give prompt treatment to gain a better prognosis. It is a novel alternative way of predicting meningioma’s malignancy by calculating the tumor’s apparent diffusion coefficient (ADC) value. The objective of the study was to determine the value of ADC for differentiating benign and malignant meningiomas. METHODSThis cross-sectional study involved 32 subjects with clinically diagnosed or histologically verified meningioma (21 benign and 11 malignant). They underwent a head-magnetic resonance imaging (MRI) examination and biopsy. We calculated the ADC value by creating regions of interest (ROIs) on the solid part of the tumor, guided by contrast and fluid-attenuated inversion recovery (FLAIR) sequence. We analyzed the ADC value with independent t-test and Bland-Altman graphs, calculated the average difference, CI 95%, limit of agreement between observers, and ROC. RESULTSMean ADC of malignant meningiomas (0.877 ± 0.167 x 10-3 mm2/s) was significantly lower than that of benign meningiomas (0.990 ± 0.105 x 10-3 mm2/s) (p<0.05). The ADC threshold is 0.886 x 10-3 mm2/s with sensitivity 63.6%, specificity 85.7%, positive predictive value 70% and negative predictive value 81.8%. CONCLUSIONThe ADC value measurement provides a discriminative feature to differentiate between benign and malignant meningiomas. However, the clinical applicability still needs to be elucidated, as histopathological confirmation remains the mainstay of definitive diagnosis.
Differences in Post-Operative Complaints between Patients with and without Anatomical Variations of Ostiomeatal Complex Based on CT Scan of Chronic Rhinosinusitis at Dr. Moewardi Hospital Putro, Prasetyo Sarwono; Duswanto, Yudo; Wujoso, Hari; Soewondo, Widiastuti
Indonesian Journal of Medicine Vol. 6 No. 2 (2021)
Publisher : Masters Program in Public Health, Universitas Sebelas Maret, Indonesia

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Abstract

Background: The ostiomeatal complex has various anomalous variants that can vary in type and number for each person. These ano­malies can contribute to the development of chronic rhinosinusitis and the accompanying symptoms. This study aims to determine the differences in post-treatment complaints between patients with and without anatomical variations of the ostiomeatal complex in chro­nic rhinosinusitis at RSUD Dr. Moewardi.Subjects and Method: A cross-sectional study was conducted in Dr. Moewardi hospital, Surakarta. A sample of 30 of chronic rhino­sinusitis patients who were subjected to a CT scan in the radiology department and surgery by an ENT-KL specialist at Dr. Moewardi, from January 2019 to June 2020, was selected for this study. The study variables were anatomical variations of ostimeatal complex and post-operative complaints. Difference of post-opera­tive complaints between chronic rhino­sinusitis patients with and without anatomical variations of ostiomeatal complex were described in frequency (n) and percent (%).Results: This study indicated that there is no difference in post-operative complaints between patients with and without anatomical variations of the ostiomeatal complex based on CT Scan of chronic rhinosinusitis (p= 0.856).Conclusion: There is no difference in post-operative complaints between patients with and without anatomical variations of the ostio­meatal complex based on CT Scans of chronic rhinosinusitis.Keywords: ostiomeatal complex, CT scan, post-operative complaintsCorrespondence: Yudo Duswanto. Department of Radiology, Dr. Moewardi Hospital, Surakarta, Indonesia. Email: yudoduswanto7@gmail.com.Indonesian Journal of Medicine (2021), 06(02): 212-219https://doi.org/10.26911/theijmed.2021.06.02.10 
The Relationship between Tumor Size and Carcinoembryonic Antigen (CEA) Levels in Stage IV Colorectal Adenocarcinoma Patients at Dr. Moewardi Hospital, Indonesia Eri, Rakhmawati Susetyaning; Kusumaningrum, Sulistyani; Widiastuti, Widiastuti; Wujoso, Hari; Adnyana, Ida Bagus Budhi Surya; Putro, Prasetyo Sarwono
Indonesian Journal of Medicine Vol. 6 No. 3 (2021)
Publisher : Masters Program in Public Health, Universitas Sebelas Maret, Indonesia

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Abstract

Background: Colorectal adenocarcinoma is one of the most common types of colorectal cancer based on histopathology, accounting for about 10% of cancer cases diagnosed worldwide each year. Tumor size and levels of carcinoembryonic antigen (CEA) are used to determine the presence and evaluation of colorectal cancer. However, studies on the correlation between the size of colorectal cancer based on CT scan abdominal with contrast and the CEA levels are still very minimal in the Indonesian population. This study aimed to analyze the relationship between tumor size examined by abdominal CT scan with contrast and carcinoembryonic antigen (CEA) levels in stage IV colorectal adenocarcinoma patients.Subjects and Method: A cross-sectional study was conducted at the radiology department, Dr. Moewardi hospital, Surakarta, from February 2021 to July 2021. A total of 40 patients with stage IV colorectal adenocarcinoma were selected in this study. The patient already had the examination results of blood CEA levels and performed an abdominal CT scan with contrast. The dependent variable was blood CEA levels. The independent variable was tumor size. Data were collected from medical records and analyzed by the Spearman test.Results: There was a positive and significant relationship between tumor size and CEA levels (r= 0.47; p= 0.003).Conclusion: Tumor size is positively correlated to blood CEA levels in patients with stage IV colorectal adenocarcinoma.Keywords: colorectal adenocarcinoma, contrast abdominal CT scan, carcinoembryonic antigen (CEA).Correspondence: Sulistyani Kusumaningrum. Department of Radiology Dr. Moewardi Hospital/ Faculty of Medicine of Universitas Sebelas Maret, Surakarta. Email: sulistyani_sprad@staff.uns.ac.idIndonesian Journal of Medicine (2021), 06(03): 285-290https://doi.­org/10.26911/theijmed.2021.06.03.05
Long Covid-19, Radiological Findings, and Its Management: A Systematic Review Soewondo, Widiastuti; Putro, Prasetyo Sarwono; Hermansah, Muhamad Lukman; Lestari, Lilik; Reviono, Reviono; Harsini, Harsini; Adhiputri, Artrien
Indonesian Journal of Medicine Vol. 6 No. 4 (2021)
Publisher : Masters Program in Public Health, Universitas Sebelas Maret, Indonesia

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Abstract

Background: COVID-19 is a disease caused by SARS-CoV-2 and has numerous clinical spectrums. Mild respiratory infection is the common clinical manifestation of COVID-19, and the less common is pneumonia accompanied by fever, cough, and breathing difficulty. Long COVID can be defined as prolonged signs and symptoms which cannot be explained for other reasons 4 weeks after being diagnosed with SARS-CoV-2. This study aimed to describe the cause of illness is confirmed or suspected COVID-19 patients, specifically on long COVID.Subjects and Method: We performed literature searches of the latest articles with Medline, CINAHL (EBSCO), Global Health (Ovid), WHO Global Research on COVID-19 database, LitCovid and Google Scholar databases published from 2019 to 2020. Two reviewers searched all articles independently (P and W, with 7 and 10 years of experience, respectively). We conducted a systematic review to provide recent evidence of symptoms and complications in long COVID. We followed PRISMA guidelines.Results: A total of 22 papers was identified and screened for eligibility from medical databases. There were 15 papers included in this review. Reason for the continuous symptoms covid an extent of organ destruction, continuous response of chronic inflammation or immunology reaction, non-specific effect of hospital admission, some critical disease, post ICU syndrome, complications from COVID-19 infection,  morbidities and adverse effects of medications used. Common symptoms are fatigue, shortness of breath, cough, chest pain, palpitations, dizziness, arthralgia, myalgia and weakness, sleep problems, sharp pain, gastrointestinal problems, rash and hair loss, impaired balance and ataxia, neurologic problems such as dementia, concentration disorders and poor quality of life.Conclusion: The incidence of long-term manifestations of COVID-19 has been increasing and systemic clinical symptoms affect many organs and systems. This can be due to numerous reasons like post-ICU syndrome, post-viral fatigue syndrome, permanent organ deterioration or others. Correspondence: Widiastuti Soewondo. Department of Radiology, Dr. Moewardi General Hospital/ Faculty of Medicine, Universitas Sebelas Maret. Jl. Ir. Sutami 36A, Surakarta 57126, Indonesia. Email: widiastuti.sprad56@staff.uns.ac.idIndonesian Journal of Medicine (2021), 06(04): 387-392https://doi.org/10.26911/theijmed.2021.06.04.04
Correlation between Mortality of COVID-19 Patients with Hypertension and Thorax Radiography Treated in the Intensive Care Unit of Dr. Moewardi Hospital Nurhidayati, Faiza Salsabila; Soewondo, Widiastuti; Dewi, Ratih Tri Kusuma; Putro, Prasetyo Sarwono
Indonesian Journal of Medicine Vol. 7 No. 3 (2022)
Publisher : Masters Program in Public Health, Universitas Sebelas Maret, Indonesia

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Abstract

Background: Coronavirus 2019 or COVID-19, caused by the new SARS-CoV2 virus, has become a pandemic and attacked more than 200 countries, including Indonesia. The most comorbid disease in COVID-19 patients was hypertension. Chest radiography can predict prognosis and mortality in COVID-19 cases and one of the methods that can be used for chest radiographic assessment is the Brixia Score, specifically designed for COVID-19 patients to measure and analyze the severity of lung abnormalities in patients with COVID-19. This study aimed to find the correlation between the mortality of COVID-19 patients with hypertension and chest radiography using the Brixia Score treated in the intensive care unit (ICU) of Dr. Moewardi Hospital.Subjects and Method: This study used an analytic observational study with a cross-sectional approach. The subjects were 84 COVID-19 patients with hypertension who met the exclusion and inclusion criteria. The independent variable is chest radiography and dependent variable is mortality. Sampling was collected by purposive sampling and the data obtained were analyzed using the contingency coefficient test.Results: There was a significant correlation between the mortality of COVID-19 patients with hypertension and chest radiography as assessed using the Brixia Score (p<0.001). The youngest patient was 20 years old and the oldest was 87 years old.Conclusion: There was a correlation between the mortality of COVID-19 patients with hypertension and chest radiography treated in the ICU RSUD Dr. Moewardi, Surakarta.Keywords: COVID-19, mortality, hypertension, chest radiography, Brixia Score, intensive care unitCorrespondence: Widiastuti Soewondo. Faculty of Medicine Universitas Sebelas Maret Surakarta. Jl. Ir. Sutami 36A, Surakarta 57126, Indonesia. Email: Widiastuti.sprad56@staff.uns.ac.id. Mobile: 082134368592.Indonesian Journal of Medicine (2022), 07(03): 269-277https://doi.org/10.26911/theijmed.2022.07.03.03 
Co-Authors Adhiputri, Artrien Adnyana, Ida Bagus Budhi Surya Duswanto, Yudo Eri, Rakhmawati Susetyaning Hari Wujoso Hermansah, Muhamad Lukman Kusumaningrum, Sulistyani Lilik Lestari Marissa, Risa Mochammad Imron Awalludin Nurhidayati, Faiza Salsabila Rachmi Fauziah Rahayu Ratih Tri Kusuma Dewi, Ratih Tri Kusuma Reviono Reviono Soewondo, Widiastuti Subandi Subandi WIDIASTUTI -