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All Journal Biosaintifika: Journal of Biology & Biology Education Biopendix: Jurnal Biologi, Pendidikan dan Terapan The International Journal of Tropical Veterinary and Biomedical Research
Fitriana, Rizky
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Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Education Immunology & microbiology Medicine & Pharmacology Public Health Veterinary

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Antidiabetic Potential of Methanol Extract of Flamboyant (Delonix regia) Flowers Eriani, Kartini; Hasanah, Uswatun; Fitriana, Rizky; Sari, Widya; Yunita, Yunita; Azhar, Al
Biosaintifika: Journal of Biology & Biology Education Vol 13, No 2 (2021): August 2021
Publisher : Department of Biology, Faculty of Mathematics and Sciences, Semarang State University . Ro

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15294/biosaintifika.v13i2.30080

Abstract

Providing scientific evidences for the medicinal benefits and possible toxic effects of the flamboyant flowers (Delonix regia (Bojer ex Hook.) Raf.) are very important to implementing the medicinal plant in this modern era. This study aimed to investigate antidiabetic potential of methanol extract of flamboyant flowers using a completely random design. Twenty-four male rats were randomly divided into 6 treatment groups with 4 replications: healthy rats (normal control, P1), diabetic rats treated with flamboyant flower extract of 0 (negative control, P2), 100 (P3), 200 (P4), and 400 mg/kg BW (P5), and rats which were induced by 0.45 mg/kg BW of Glibenclamide (positive control, P6). Diabetic condition was achieved by a single injection of alloxan 150 mg/kg BW. Treatments were given once a day for 14 days. On day 0, 3 and 18 blood samples were withdrawn from rats’ orbital vein for glucose measurement. All rats were sacrificed for liver, gastrocnemius muscles and pancreatic tissues collection. The liver and gastrocnemius muscle were subjected for glycogen measurement whereas pancreatic tissues were processed for histological examinations. Data was analyzed by ANOVA and followed by Duncan test. The results showed that flamboyant flowers extracts significantly (p<0.05) reduced blood glucose as well as degeneration and necrosis of pancreatic β cells. Optimal dose to decrease blood glucose and pancreatic cell degeneration was 200 mg/kg BW; whereas optimum dose to decrease pancreatic cell necrosis was 400 mg/kg BW. In conclusion, flamboyant flower extract can reduce blood glucose in rats. This is the first that shows antidiabetic potential of local Flamboyant flower extracts along its toxicity effect to pancreatic tissues. These information could become a basic consideration for the use of the plant extracts as a candidate to cure patients with diabetic problems.
Case report: clinical presentation and diagnostic findings in a cat with diabetes mellitus and hepatic-biliary disorders Hafizsha, Nabila Latifa; Agung, Nabilah Putroe; Nurfadhilah, Elvina; Fitriana, Rizky
The International Journal of Tropical Veterinary and Biomedical Research Vol 9, No 2 (2024): Vol. 9 (2) November 2024
Publisher : The Faculty of Veterinary Medicine of Syiah Kuala University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21157/ijtvbr.v9i2.43956

Abstract

Diabetes mellitus (DM) is a metabolic disorder and endocrinopathy characterized by hyperglycemia or a persistent increase in blood glucose levels. This case describes a male domestic cat exhibiting symptoms of vomiting, loss of appetite, and yellowish discoloration of the ears and oral mucosa, which was diagnosed with DM and hepatic-biliary disorders based on serum biochemistry and ultrasonographic examinations. The treatment included insulin injections, antibiotics, antiemetics, a liver supplement, and a specialized diabetic diet. After 14 days of insulin injection and a diabetic diet, the cats blood glucose levels returned to normal. A diabetic diet will be provided for the cat throughout its lifetime.
The effect of katuk leaf (Sauropus androgynous L. merr) extract administration on reducing blood triglyceride levels in male local rabbits induced with hypercholesterolemia Khalid, Idham; Ferasyi, Teuku Reza; Sugito, Sugito; Hafizsha, Nabila Latifa; Ulfa, Rasyida; Fitriana, Rizky; Makmur, Ali
The International Journal of Tropical Veterinary and Biomedical Research Vol 9, No 2 (2024): Vol. 9 (2) November 2024
Publisher : The Faculty of Veterinary Medicine of Syiah Kuala University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21157/ijtvbr.v9i2.44322

Abstract

This research aimed to study the effectiveness of katuk leaf extract in lowering blood triglyceride levels in male local rabbits treated with hypercholesterolemia. The research was done at the Laboratory of Veterinary Public Health and the Animal Experimental Unit of the Faculty of Veterinary Medicine, Universitas Syiah Kual. This experiment used the Split Plot design, comprising two factors. The first factor was treatment (P1, P2, and P3) that gives katuk leaf extract 2.5 cc, 5 cc, and 10 cc, whereas the second factor was the sampling time (I, II, III, IV, and V). The results of this research showed that the treatment did not significantly (P0.05) on levels of triglycerides in the blood of local rabbits. Still, different sampling times were very significant (P 0.01) on levels of triglycerides in the blood of local rabbits. After doing Duncan tests, the results test showed that the sampling time between a decrease of local rabbit blood triglyceride levels was not significant (P0.05) by giving katuk leaf extract. The treatment of katuk leaf extracts of 2.5 cc, 5cc, and 10cc has not been able to reduce levels of triglycerides in the blood of male local rabbits treated with hypercholesterolemia.
Serum IL-6 AS A marker of immuno-inflammatory response to Zn-Mg alloy implants in porcine (Sus scrofa) Hafizsha, Nabila Latifa; Safitri, Jessica Anggun; Ulfa, Rasyida; Khalid, Idham; Agung, Nabilah Putroe; Makmur, Ali; Fitriana, Rizky
The International Journal of Tropical Veterinary and Biomedical Research Vol 10, No 1 (2025): Vol 10 (1) May 2025
Publisher : The Faculty of Veterinary Medicine of Syiah Kuala University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21157/ijtvbr.v10i1.45637

Abstract

Background and Aim: The present study aimed to evaluate the immune-inflammatory response induced by ZnMg(3x) and ZnMg(4x) alloy implants in the porcine urinary bladder by measuring serum interleukin-6 (IL-6) levels.Materials and Methods: Nine porcines, aged 2-3 months old with 25-30 kg body weight, were divided into three groups: ZnMg(3x), ZnMg(4x), and control, while the observation time was performed on days 0, 14, and 28. Implantation was performed on the urinary bladder using cystotomy techniques. Measurement of IL-6 levels is done using enzyme-linked immunosorbent assay (ELISA). Data were analyzed statistically using analysis of variance (ANOVA).Results : The results showed that at day 0 for the ZnMg(3x) and ZnMg(4x) implants were 0.53 0.92 pg/mL and 0.10 0.17 pg/mL, respectively. On day 14, IL-6 levels in both implants decreased, although not significantly. On day 28, a slight increase was observed in ZnMg(3x) compared to ZnMg(4x), but this was also not significant (P0.05).Conclusion: Based on the results, Zn-Mg materials are suitable to be used as urinary stent base materials.
Phytoestrogenic Activity of Fresh Bitter Melon (Momordica charantia L.) Fruit Extract on Ovarian Folliculogenesis in Female Mice Ulfa, Rasyida; Agung, Nabilah Putroe; Fitriana, Rizky; Makmur, Ali; Hafizsha, Nabila Latifa
BIOPENDIX: Jurnal Biologi, Pendidikan dan Terapan Vol 12 No 2 (2025): Biopendix: Jurnal Biologi, Pendidikan & Terapan
Publisher : Program Studi Pendidikan Biologi FKIP Unpatti

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30598/biopendixvol12issue2page102-109

Abstract

Momordica charantia L., commonly known as bitter melon, is a medicinal plant that contains various bioactive compounds such as flavonoids, saponins, tannins, triterpenoids, and alkaloids. These compounds have potential antifertility properties. This study aimed to evaluate the potential of bitter melon extract as an antifertility agent in female animals. A total of 18 female mice (Mus musculus L.) were divided into three groups: a control group (K0), treatment group 1 (P1) received 5% bitter melon extract, and treatment group 2 (P2) received 10% extract. The mice (Mus musculus L.) were orally administered the extract for 16 consecutive days using the gavage method. On the final day of treatment, the mice were dissected to isolate the ovaries. The ovaries were weighed and processed for histological examination using the paraffin method and Hematoxylin-Eosin staining. The observed parameters included the number of primary, secondary, tertiary, and Graafian follicles. Data were analyzed using one-way analysis of variance (ANOVA) followed by Duncan’s post hoc test to determine statistical differences among groups. The results showed that administration of 5% bitter melon extract significantly increased the number of primary and secondary follicles. However, at the 10% concentration, a reduction was observed in the number of all follicle types, including Graafian follicles. These findings indicate that low-dose bitter melon extract may promote ovarian follicle development, whereas high-dose administration exhibits antifertility potential through a phytoestrogen mechanism that inhibits follicular maturation.
Co-Authors Agung, Nabilah Putroe Al Azhar Idham Khalid Jessica Anggun Safitri KARTINI ERIANI Makmur, Ali Nabila Latifa Hafizsha Nurfadhilah, Elvina Rasyida Ulfa Sembiring, Rinawati Sugito - Teuku Reza Ferasyi Uswatun Hasanah Widya Sari Yunita Yunita