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All Journal Jurnal Pengajaran MIPA Dimas: Jurnal Pemikiran Agama untuk Pemberdayaan Jurnal Kimia dan Kemasan Biology, Medicine, & Natural Product Chemistry Journal of Islamic Studies and Humanities JC-T (Journal Cis-Trans): Jurnal Kimia dan Terapannya Al-Kimia Walisongo Journal of Chemistry Jambura Journal of Chemistry Social, Humanities, and Educational Studies (SHEs): Conference Series Reswara: Jurnal Pengabdian Kepada Masyarakat Jurnal Kimia dan Kemasan Prosiding Seminar Nasional Pendidikan dan Agama Dinamika Sosial: Jurnal Pengabdian Masyarakat Dan Transformasi Kesejahteraan
Hafshah, Mutista
UIN Walisongo Semarang
Religion Agriculture, Biological Sciences & Forestry Humanities Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Computer Science & IT Economics, Econometrics & Finance Education Environmental Science Languange, Linguistic, Communication & Media Law, Crime, Criminology & Criminal Justice Materials Science & Nanotechnology Medicine & Pharmacology Public Health Social Sciences Other

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Antibacterial Activity Test of Secang Wood (Caesalpinia sappan L.) Ethanol Extract Against Streptococcus mutans Listiani, Febri Intan; Hafshah, Mutista; Latifah, Rais Nur
Al-Kimia Vol 11 No 1 (2023): JUNE
Publisher : Study Program of Chemistry - Alauddin State Islamic University of Makassar

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24252/al-kimia.v11i1.37136

Abstract

Dental caries is caused by the Streptococcus mutans bacteria, which causes a food deposit to harden and adhere to the tooth surface. Cavities will develop if food residue is not removed. Herbal plants, specifically sappan wood, can be used as an antibiotic. The purpose of this study was to look at the secondary metabolite content of sappan wood extract, antibacterial activity, and the minimum inhibitory concentration (MIC) and minimum bactericidal concentration (MBC) of sappan wood extract against Streptococcus mutans bacteria. This research method includes the maceration of sappan wood extract with 96% ethanol solvent, phytochemical screening of sappan wood extract, inhibition zone test with paper disc method, and MIC and MBC tests. Qualitative testing revealed that the sappan wood extract contained alkaloids, flavonoids, tannins, and saponins. Flavonoids, tannins, and saponins are all constituents of plants. Secang wood extract has antibacterial activity against Streptococcus mutans, as evidenced by the formation of inhibition zones at concentrations of 20%, 40%, 60%, 80%, and 100%, namely 8.75±0.354; 11±1.41;, 12.75±0.354; 16.25±0.354; and 17.5±0.000 mm. Sappan wood ethanol extract had a MIC of 12.5% against Streptococcus mutans and an MBC of 25%.
Modelling of QSAR Equations for Styryl Quinolone Compound Derivatives as HIV-1 Inhibitors Firdaus, Irvan Maulana; Hafshah, Mutista; Amin, Ahmad Faqih; Satriya, Daffa Faiq Aji
Walisongo Journal of Chemistry Vol 7, No 1 (2024): Walisongo Journal of Chemistry
Publisher : Department of Chemistry Faculty of Science and Technology Walisongo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21580/wjc.v7i1.22315

Abstract

HIV-1 (Human Immunodeficiency Virus) inhibitor compounds have been designed using a QSAR analysis approach for 33 styryl quinolone derivative compounds, with descriptors calculated using semi-empirical methods. This research aims to determine the best semi-empirical method and to obtain the best QSAR equation by comparing the Principal Component Regression method with Multiple Linear Regression, as well as modifying the structure of new styryl quinolone derivative compounds to achieve higher predicted theoretical HIV-1 integrase protein inhibitor activity. The analysis results showed that the semi-empirical MINDO3 method was the best. The QSAR MINDO3 equation with Principal Component Regression is as follows: :  pIC50 = 5.046 + 0.515 VL1 with n = 33, r = 0.611, r2 = 0.374, SD = 0.677, Fcount/Ftable = 4.45, PRESS = 20.554, Sig = 0.01.  Meanwhile, with Multiple Linear Regression, the equation is as follows: pIC50 = -11.252 + 88.481 (qC3) + 26.667 (qC4) + 9.156 (qC5) – 1.443 (qC7) + 4.284 (qC8)-0.03 (Surface Area Approx) + 0.033 (Grid) - 0.195 (logP) – 0.007 (Mr) – 2.166 (HOMO) with n = 33; r = 0.870; r2 = 0.758; SD =0.500; Fcount/Ftable =2.995; PRESS =5.505; Sig. 0.01. The design of the new compound was carried out based on the best QSAR equation, namely Multiple Linear Regression. We obtained 10 structural modifications from the equation above with the best theoretical pIC50 values from the reference ligand.
In Vitro Anti-inflammatory Activity of Bamboo Tali Leaf (Gigantochloa apus) Ethanol Extract Hidayah, Nurul; Hafshah, Mutista
Biology, Medicine, & Natural Product Chemistry Vol 12, No 2 (2023)
Publisher : Sunan Kalijaga State Islamic University & Society for Indonesian Biodiversity

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14421/biomedich.2023.122.601-606

Abstract

Inflammation is a physiological process that serves as a defense mechanism for the body against foreign substances, bacteria, or irritants. Inflammation can be cured with anti-inflammatory drugs. One of the plants that has the potential to be an anti-inflammatory agent is the bamboo leaf. This research aims to analyze the content of secondary metabolites, determine the inhibition value and IC50 value of the anti-inflammatory activity of the ethanol extract of bamboo tali leaves. Bamboo tali leaves were macerated using 96% ethanol and subjected to phytochemical screening. The extract was then tested for anti-inflammatory activity in vitro with the Bovine Serum Albumin (BSA) protein denaturation inhibition method. Bamboo tali leaf ethanol extract contains flavonoids, alkaloids, saponins, and phenols. The anti-inflammatory activity of the ethanol extract of bamboo tali leaves with concentrations of 28, 42, 56, 70, and 84 ppm had an inhibition percentage value of 23.14 ± 0.008%; 34.30 0.026%; 54.51 0.060%; 69.07 ± 0.006%; and 87.02 ± 0.021% with an IC50 value of 52.991 ppm. These results indicate that the ethanol extract of bamboo tali leaves has the potential to be an anti-inflammatory with a strong IC50 value below 100 ppm.
Implementation of Educational Care Model for Orphans: Case Study in Kertomulyo Village Mutista Hafshah; Supitayanti Supitayanti; Eka Intansari; Muhammad Faza Nasrullah
PROSIDING SEMINAR NASIONAL PENDIDIKAN DAN AGAMA Vol. 5 No. 1 (2024): PROSIDING SEMINAR NASIONAL PENDIDIKAN DAN AGAMA
Publisher : Sekolah Tinggi Pastoral Kateketik (STPKat) Santo Fransiskus Assisi Semarang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55606/semnaspa.v5i1.2075

Abstract

The care and education of orphans is a shared responsibility of the community that requires a comprehensive approach. This study aims to analyze the implementation of an educational care model for orphans in Kertomulyo Village, Brangsong District, Kendal Regency, Central Java. The research method uses a qualitative approach with data collection techniques through participatory observation, in-depth interviews, and documentation studies. The results of the study indicate that the educational care model implemented combines formal education at SDN 1 Kertomulyo and non-formal education at TPQ Al Ittihad. The parenting pattern applied tends to be democratic with an emphasis on role models and local wisdom values. Supporting factors include social support from the community and high awareness of the importance of education, while inhibiting factors include limited human resources and psychological constraints of orphans. The implementation of this model plays an important role in meeting the educational needs and developing the potential of orphans in Kertomulyo Village.
Menghidupkan Nilai-Nilai Islami Berbasis Awesome Muharram Fest di TPQ Al Ittihad Desa Kertomulyo Mutista Hafshah; Supitayanti Supitayanti; Eka Intansari
Dinamika Sosial : Jurnal Pengabdian Masyarakat dan Transformasi Kesejahteraan Vol. 1 No. 4 (2024): Desember : Dinamika Sosial : Jurnal Pengabdian Masyarakat dan Transformasi Kese
Publisher : Lembaga Pengembangan Kinerja Dosen

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.62951/dinsos.v1i4.633

Abstract

This research aims to revive Islamic values through the Awesome Muharram Fest activity at the Al-Quran Education Park (TPQ) Al Ittihad, Kertomulyo Village. Awesome Muharram Fest is an educational and recreative program designed to welcome the Islamic new year, as well as a means of learning and strengthening Islamic religious values for children. This activity involved various competitions, namely, there was a calligraphy coloring competition, a daily prayer memorization competition, an adhan competition, a short letters memorization competition, and a gharib competition, with the aim of deepening the understanding of TPQ Al-Ittihad students. In its implementation, ustadz and ustadzah also participated in supporting and assisting the committee in preparing for the competition. The Muharram Fest held by the KKN team went well and smoothly. It is hoped that this competition can be a means of learning and self-development for TPQ Al-Ittihad students of Kertomulyo Village and encourage their enthusiasm for learning and confidence. For the KKN Team, it is hoped that they can take lessons and experiences from various shortcomings that exist during the process of organizing the Awesome Muharram Fest by the KKN Posko 95 group.
PENGUATAN PERAN PEREMPUAN MELALUI PEMBUATAN ECOENZYME LINGKUNGAN RUMAH TANGGA Hafshah, Mutista; Wibowo, Teguh; Ismail, Amrizarois; Nida, Khoirin
Reswara: Jurnal Pengabdian Kepada Masyarakat Vol 4, No 2 (2023)
Publisher : Universitas Dharmawangsa

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.46576/rjpkm.v4i2.2839

Abstract

Limbah rumah tangga merupakan penyumbang limbah terbesar. Sebagian besar limbah rumah tangga adalah limbah organik yang jika tidak dikelola dengan baik dapat menimbulkan dampak negatif. Berdasarkan hal tersebut maka pengelolaan limbah organik perlu dilakukan secara komprehensif. Pelatihan pembuatan eco-enzyme bertujuan untuk menambah wawasan, pengetahuan, dan keterampilan masyarakat, khususnya ibu-ibu rumah tangga dalam mengolah sampah organik rumah tangga menjadi produk eco-enzyme. Metode pengabdian ini adalah sosialisasi dan diskusi terkait teknologi eco-enzyme, demonstrasi teknologi eco-enzyme, dan praktik langsung pembuatan eco-enzyme bersama peserta pelatihan. Eco-enzyme dapat dibuat dari campuran limbah organik, molase dan air dengan perbandingan 3:1:10. Kegiatan pelatihan tersebut mendapatkan respon yang baik dari peserta, diantaranya jumlah kehadiran peserta lebih dari 85%, antusias dan semangat peserta baik, tanggapan masyarakat terkait kegiatan pelatihan positif. Produk eco-enzyme yang dihasilkan oleh peserta baik dan sesuai indikator eco-enzyme, yaitu warna kecoklatan, bau khas buah dan sedikit beraroma alkohol, pH asam (3-4), dan tidak ditumbuhi jamur atau belatung
Training of Adding Turmeric and Curcuma as Food Additives for Laying Hens Fitriani, Ika Nur; Kholidah, Kholidah; Hafshah, Mutista; Hashona, Achmad Hasmy
Dimas: Jurnal Pemikiran Agama untuk Pemberdayaan Vol. 22 No. 2 (2022)
Publisher : LP2M of Institute for Research and Community Services - UIN Walisongo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21580/dms.2022.222.12997

Abstract

The use of bioactive plants to replace antibiotics is now widely used. The program's purpose is to provide a solution for natural feed additives to laying hens in Ngaliyan as a substitute for Antibiotics Growth Promotor (AGP), which is prohibited by the government, and provide knowledge to farmers about the use of medicinal plants to improve the productivity of livestock. The target was laying hens farmers in Ngaliyan. The problem was chicken feed is made without AGP and egg prices fell while feed prices had risen. The solution offered to the partner was adding food additives from turmeric and Curcuma. Turmeric and Curcuma will improve immunity to increase livestock productivity, feed efficiency, and egg quality. Based on this reason, we conducted community services for laying hens farmers in Ngaliyan. Community service activities were carried out using the PAR method for two months through socialization, training, assistance in providing additional natural feed, and evaluation. Giving turmeric and Curcuma flour can improve the quality of eggs. The result of the community service showed an understanding of partners to formulate and produce feed additives in raising laying hens was improved. In addition, farmers were able to formulate and produce herbal feed based on requirements.
Analisis Fitokimia dan Uji Aktivitas Antioksidan Ekstrak Etanol Kulit Batang Alpukat Mentega (Persea Americana Mill) Chusnah, Hudallil; Hafshah, Mutista
Jambura Journal of Chemistry Vol 7, No 1 (2025): February
Publisher : Universitas Negeri Gorontalo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37905/jambchem.v7i1.21182

Abstract

Lack of physical activity, fast food products, and increased stress due to work pressures are all dangers that might induce unnoticed changes in the body that can lead to degenerative diseases. The existence of free radicals, which can cause cancer and damage cells in the body, might trigger the emergence of degenerative disorders. Antioxidants can help to prevent degenerative disorders caused by the presence of free radicals. The purpose of this study is to investigate the yield percentage, secondary metabolite chemicals, and the IC50 value of the antioxidant activity of butter avocado stem bark (Persea americana Mill). The maceration method is used in the extraction of avocado butter bark. The obtained extraction results give as much as. Flavonoids, tannins, saponins, and alkaloids are among the secondary metabolites found in butter avocado stem bark. The antioxidant activity was then determined using the DPPH (2,2-diphenyl-1-picryhidrazil) technique. The ethanol extract of avocado butter stem bark exhibited an IC50 value of 137.81 ppm, indicating that it was a natural product with moderate antioxidant activity that may be exploited as a natural antioxidant source.
Modelling of QSAR Equations for Styryl Quinolone Compound Derivatives as HIV-1 Inhibitors Firdaus, Irvan Maulana; Hafshah, Mutista; Amin, Ahmad Faqih; Satriya, Daffa Faiq Aji
Walisongo Journal of Chemistry Vol. 7 No. 1 (2024): Walisongo Journal of Chemistry
Publisher : Department of Chemistry Faculty of Science and Technology UIN Walisongo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21580/wjc.v7i1.22315

Abstract

HIV-1 (Human Immunodeficiency Virus) inhibitor compounds have been designed using a QSAR analysis approach for 33 styryl quinolone derivative compounds, with descriptors calculated using semi-empirical methods. This research aims to determine the best semi-empirical method and to obtain the best QSAR equation by comparing the Principal Component Regression method with Multiple Linear Regression, as well as modifying the structure of new styryl quinolone derivative compounds to achieve higher predicted theoretical HIV-1 integrase protein inhibitor activity. The analysis results showed that the semi-empirical MINDO3 method was the best. The QSAR MINDO3 equation with Principal Component Regression is as follows: :  pIC50 = 5.046 + 0.515 VL1 with n = 33, r = 0.611, r2 = 0.374, SD = 0.677, Fcount/Ftable = 4.45, PRESS = 20.554, Sig = <0.01.  Meanwhile, with Multiple Linear Regression, the equation is as follows: pIC50 = -11.252 + 88.481 (qC3) + 26.667 (qC4) + 9.156 (qC5) – 1.443 (qC7) + 4.284 (qC8)-0.03 (Surface Area Approx) + 0.033 (Grid) - 0.195 (logP) – 0.007 (Mr) – 2.166 (HOMO) with n = 33; r = 0.870; r2 = 0.758; SD =0.500; Fcount/Ftable =2.995; PRESS =5.505; Sig. <0.01. The design of the new compound was carried out based on the best QSAR equation, namely Multiple Linear Regression. We obtained 10 structural modifications from the equation above with the best theoretical pIC50 values from the reference ligand.
THE POTENTIAL OF CALANONE DERIVATIVES AS ANTILEUKEMIA AGENTS VIA AN IN SILICO APPROACH: MOLECULAR DOCKING AND MOLECULAR DYNAMICS ANALYSIS Firdaus, Irvan Maulana; Hafshah, Mutista; Akbar, Achmad; Faiz, Rijal Akhmad; Iswanto, Ponco; Chasani, Mochammad; Hanafi, Muhammad; Delsy, Eva Vaulina Yulistia
Walisongo Journal of Chemistry Vol. 8 No. 2 (2025): Walisongo Journal of Chemistry
Publisher : Department of Chemistry Faculty of Science and Technology UIN Walisongo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21580/wjc.v8i2.26105

Abstract

Cancer, particularly leukemia, remains a major global health concern with a high mortality rate, necessitating the development of more effective and selective therapeutic agents. This study evaluated the potential of calanone derivatives as antileukemia agents using an in silico approach. The objectives were to (1) analyze the molecular docking interactions between predicted calanone derivatives and commercial leukemia drugs targeting the Bruton’s Tyrosine Kinase (BTK) receptor (PDB ID: 5P9J); (2) predict the ADMET properties (Absorption, Distribution, Metabolism, Excretion, and Toxicity) of the calanone derivatives; and (3) compare the molecular dynamics analysis results of the predicted compounds with those of commercial drugs. The findings revealed that the predicted molecules, including Vaulina2 ((5-hydroxy-2,2-dimethyl-8-oxo-10-phenyl-2H,8H-pyrano[2,3-f]chromen-6-yl)(phenyl)methyl 2-amino-3-(4-hydroxyphenyl)-3-oxopropanoate)), Prediction1 ((8-amino-5-hydroxy-2,2-dimethyl-10-phenyl-2H,8H-pyrano[2,3-f]chromen-6-yl)(phenyl)methanediol)), Prediction2 (6-(dihydroxy(phenyl)methyl)-2,2-dimethyl-10-phenyl-2H,8H-pyrano[2,3-f]chromene-5,8-diol)), Prediction3 (2-amino-9,9-dimethyl-3,7-diphenyl-2,3-dihydro-5H,9H-furo[2,3-f]pyrano[2,3-h]chromen-5-ol)), and Prediction4 (4-(dihydroxy(8-hydroxy-2,2-dimethyl-5-oxo-10-phenyl-6,8-dihydro-2H,5H-pyrano[2,3-f]chromen-6-yl)methyl)benzoic acid)), demonstrated greater stability compared to the reference drug ibrutinib, with Gibbs free energy (ΔG) values of −11.25, −12.50, −10.83, −10.74, and −10.63 kcal/mol, respectively. All compounds also conformed to the predicted ADMET profiles. Molecular dynamics simulations indicated that Vaulina2, Prediction1, and Prediction2 exhibited superior performance based on Root-Mean-Square Deviation (RMSD), Root-Mean-Square Fluctuation (RMSF), Solvent-Accessible Surface Area (SASA), hydrogen bond occupancy, and Molecular Mechanics–Generalized Born Surface Area (MM-GBSA) parameters.
Co-Authors Ahmad Zubaeri Akbar, Achmad Amin, Ahmad Faqih Amrizarois Ismail Ana Mardliyah Azza Lathifah Chusnah, Hudallil Eka Intansari Eva Vaulina Yulistia Delsy Faiz, Rijal Akhmad Firdaus, Irvan Maulana Hashona, Achmad Hasmy Ika Nur Fitriani Ismail, Amrizarois Khoirin Nida Kholidah Kholidah, Kholidah Lilis Karlina Lilis karlina, Lilis Listiani, Febri Intan Mochammad Chasani Muhammad Faza Nasrullah Muhammad Hanafi Nana Misrochah Niamul Faza Assauqi NIDA, KHOIRIN NURUL HIDAYAH Ponco Iswanto Rais Nur Latifah Rohmah, Alfiatu Satriya, Daffa Faiq Aji Sri Mulyanti Supitayanti Supitayanti Teguh Wibowo Tika Rahmawati Titin Kartin