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DEKOLORISASI SENYAWA AZO LIMBAH REMAZOL GOLDEN YELLOW OLEH BIOADSORBEN ECENG GONDOK (EICHHORNIA CRASSIPES) Fitriani, Ika Nur; Puspitasari, Anggi Ristiyana; Amelia, Rizki Nor
Walisongo Journal of Chemistry Vol 2, No 2 (2019): Walisongo Journal of Chemistry
Publisher : Department of Chemistry Faculty of Science and Technology Walisongo

Telah dilakukan penelitian tentang adsorbsi senyawa azo Remazol Golden Yellow dari limbah cair zat warna sintetis menggunakan adsorben dari eceng gondok (Eichhornia crassipes). Penelitian ini bertujuan untuk mengetahui kondisi optimal eceng gondok (Eichhornia crassipes) sebagai bioadsorben limbah zat warna Remazol Golden Yellow dan mengetahui kadar ppm Remazol Golden Yellow maksimum dalam limbah zat warna sintetis yang dapat diserap oleh bioadsorben eceng gondok (Eichhornia crassipes). Subyek penelitian adalah eceng gondok yang teraktivasi NaOH 2% dengan waktu perendaman 24 jam. Obyek penelitian adalah efisiensi adsorpsi eceng gondok (Eichhornia crassipes) terhadap zat warna sintetis-reaktif Remazol Golden Yellow. Variabel bebas yang dipakai adalah variasi massa. Daya adsorbsi ditentukan dengan dengan membandingkan konsentrasi Remazol Golden Yellow sebelum dan setelah adsorbsi. Hasil penelitian menunjukkan bahwa semakin besar massa bioadsorben, efisiensi adsorbsi juga akan semakin besar dan adsorbsi optimum variasi massa Remazol Golden Yellow diperoleh pada massa adsorben 2,5 gram/100 mL dengan efisiensi adsorbsi 74,767%

Molecular Docking Study of Nutmeg (Myristica Fragrans) Constituents as Anti-Skin Cancer Agents Fitriani, Ika Nur; Ansory, Hery Muhamad
JKPK (Jurnal Kimia dan Pendidikan Kimia) Vol 6, No 1 (2021): JKPK (Jurnal Kimia dan Pendidikan Kimia)
Publisher : Program Studi Pendidikan Kimia FKIP Universitas Sebelas Maret

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20961/jkpk.v6i1.47223

Molecular docking analysis was carried out to understand better the interaction between DHODH and inhibitor from nutmeg in this series. The nutmeg constituent binding orientations in the active site of DHODH was seen in a molecular docking analysis and helped design a potentially new inhibitor. This work aimed to study the molecular docking of nutmeg constituents with the DHODH inhibitor using a computer-aided drug design. Molecular docking using AutoDock 4.2 was done to explore the models of binding complexes. The 3D structure was derived using Discovery Studio to investigate the essential chemical interaction of complex structures. Dihydroguaiaretic acid was the most potent ligand having a docking score of -9.3 kcal/mol. This value was better than the standard drug 5-FU. The dihydroguaiaretic acid structure interacted with Tyr365 and Thr63 through a hydrogen bond similar to the native ligand. These results suggest that nutmeg seed could serve as the lead compound for potent DHODH inhibitors against skin.

“SWEET PAPAYA SEED CANDY” ANTIBACTERIAL ESCHERICHIA COLI CANDYWITH PAPAYA SEED (CARICA PAPAYA L.) Tika Pangesti; Ika Nur Fitriani; Firdiawan Ekaputra; Andi Hermawan
Pelita - Jurnal Penelitian Mahasiswa UNY Volume VIII, Nomor 2, Agustus 2013
Publisher : Pelita - Jurnal Penelitian Mahasiswa UNY

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (173.809 KB)

This research is experimental research aims to knowing how to made papayaseed candy as antibacterial in Escherichia coli and knowing inhibition zone of sweetpapaya seed candy against bacteria E. coli. This research give alternative new productof healthy food and improve economic value of papaya seed (Carica papaya L.)The process in this research has for ways: making papaya seed powder, makingjelly candy, making solution candy, and testing the bacterial growth inhibition zone ofEscherichia coli bacteria. This proses was held for two days in “Balai LaboratoriumKesehatan Yogyakarta”Result of this research is papaya seed can be processed to made papaya seedcandy by dried and refined. Beside on the bacterial growth inhibition testing, papayaseed candy didn’t have inhibition zone against Escherichia coli bacteria.

ANALISIS KADAR NITROGEN (N) DALAM PUPUK NPK REAKSI PT. PETROKIMIA GRESIK MENGGUNAKAN METODE IN HOUSE DAN SNI-INOVASI Nida Awalia; Ika Nur Fitriani
Jurnal Inovasi Teknik Kimia Vol 5, No 2 (2020)
Publisher : Fakultas Teknik Universitas Wahid Hasyim

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31942/inteka.v5i2.3813

Potential Phytochemical Inhibitor from Allium cepa for the Medication of COVID-19 using In-Silico Approach Fitriani, Ika Nur; Utami, Wiji
ALKIMIA Vol 4 No 2 (2020): ALKIMIA
Publisher : SCIENCE AND TECHNOLOGY FACULTY OF UNIVERSITAS ISLAM NEGERI RADEN FATAH PALEMBANG

Infection of extreme acute respiratory syndrome coronavirus 2 triggers Coronavirus disease 2019 (COVID-19). COVID-19 has adverse consequences on persons and is getting worse in all nations. The aim of this research is to investigate the development of in-silico approach of phytochemical inhibitor used to fight COVID-19 pathway inhibition. In medicinal plants, there are many phytochemicals, however the bioactive mechanism remains uncertain. In-silico experiments offer additional evidence to confirm the inhibition of medicinal plants. Molecular docking was used to evaluate phytoconstituents from Allium cepa as COVID-19 M-pro inhibitor, compared to remdesivir (standard drug). STITCH database used to predict the interaction network process of the most potential compound. The most potential compound was oleanolic acid. Oleanolic acid with a docking score of -9.20 kcal/mol was reported as anti-COVID-19 activity. This docking score was higher than remdesivir. Oleanolic acid interacted with GLU166, CYS44, HIS41, and THR25 via the hydrogen bond. From STITCH Database, oleanolic acid interact with CASP-9, XIAP, CASP-3 signalling pathway. Oleanolic acid from Allium cepa has been reported as a possible COVID-19 M-pro inhibitor and should be studied in future studies. The experiment indicates that phytochemical inhibitor can be helpful in the medication of COVID-19.

Uji Analisis Kadar Sulfur (S) Pupuk SP-36 PT Petrokimia Menggunakan Metode In-House dan Inovasi Fitrani, Salsa; Fitriani, Ika Nur
ALKIMIA Vol 4 No 2 (2020): ALKIMIA
Publisher : SCIENCE AND TECHNOLOGY FACULTY OF UNIVERSITAS ISLAM NEGERI RADEN FATAH PALEMBANG

Fertilizer is an essential component in increasing food self-sufficiency in Indonesia. PT Petrokimia Gresik is one of the fourth-largest fertilizer producers in Indonesia and produces various kinds of fertilizers. One of the fertilizer is SP-36, contains sulphur and phosphate. This study investigated the sulphur (S) content in SP-36 fertilizer using the in-house and innovation method. The difference between the two methods is BaCl2; the in house method used BaCl2 powder, while the Innovation method used liquid BaCl2. Different used of BaCl2 were based on their colloid formation. This study used a UV-Vis spectrophotometer instrument to calculate the sulphur content of SP-36 fertilizer. The results obtained from the research show that the two methods tested can be used to measure the sulphur content in SP-36 fertilizer. The most accurate result was In house method. The average value of sulphur content in SP-36 fertilizer using the in house method is 4,83%, while the average value of sulphur content in SP-36 fertilizer using the innovation method is 5,22%.

PENERAPAN MODEL PEMBELAJARAN TGT UNTUK MENINGKATKAN HASIL BELAJAR PADA PELAJARAN IPAS DI KELAS V SD Fitriani, Ika Nur; Kurniawati, Rissa Prima; Komaladewi, Ratih
JS (JURNAL SEKOLAH) Vol 8, No 4 (2024): SEPTEMBER 2024
Publisher : Universitas Negeri Medan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24114/js.v8i4.61712

Abstract: In 2024, fifth grade students at SDN 03 Madiun Lor participated in two literacy collaborative learning projects. Information was collected from end-of-cycle tests, classroom observations, and surveys asking students' opinions about implementing TGT. To describe learning outcomes, increased student activity, and student responses to the learning process, data was examined descriptively using the TGT type. Student performance in class V of SDN Madiun Lor increased both before and after the introduction of the TGT learning paradigm, in accordance with the research results. In the pre-cycle the average student score was 52.19%, which then increased after applying the TGT model in cycle 1 to 69.84%, at the end of cycle 2 this figure increased to 76.41%. This research found that fifth grade students at SDN 03 Madiun Lor responded well to the use of TGT and were actively involved in the learning process. Keywords: Learning Outcomes, Team Games Tournament (TGT) Abstrak: Pada tahun 2024, siswa kelas V di SDN 03 Madiun Lor berpartisipasi dalam dua literasi proyek pembelajaran kolaboratif ini. Informasi dikumpulkan dari tes akhir siklus, observasi kelas, dan survei yang menanyakan pendapat siswa tentang penerapan TGT. Untuk menggambarkan hasil pembelajaran, peningkatan aktivitas siswa, dan tanggapan siswa terhadap proses pembelajaran, data diperiksa secara deskriptif menggunakan tipe TGT. Kinerja siswa di kelas V SDN Madiun Lor meningkat baik sebelum dan sesudah pengenalan paradigma pembelajaran TGT, sesuai dengan hasil penelitian. Pada prasiklus nilai rata-rata siswa adalah 52,19%, yang kemudian meningkat setelah menerapkan model TGT siklus 1 sebesar 69,84%, pada akhir siklus 2 angka tersebut meningkat menjadi 76,41%. Penelitian ini menemukan bahwa siswa kelas V SDN 03 Madiun Lor merespon dengan baik terhadap penggunaan TGT dan secara aktif terlibat dalam proses pembelajaran. Kata kunci: Hasil Belajar, Team Games Tournament (TGT)

Comparison of The Use of Glycerol and Sorbitol as Plasticizers on The Quality of Bioplastics Based on Cellulose-Chitosan Qolbi, Nur Nisa Aeni; Zidni Azizati; Ika Nur Fitriani
Walisongo Journal of Chemistry Vol. 7 No. 2 (2024): Walisongo Journal of Chemistry
Publisher : Department of Chemistry Faculty of Science and Technology Walisongo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21580/wjc.v7i2.24175

The accumulation of plastic waste poses significant environmental and health problems. One effort to mitigate this issue is the development of bioplastics. Correspondingly, the primary materials used in this research were cellulose from teak (Tectona grandis) wood powder, chitosan, glycerol, and sorbitol. This study aimed to compare the effectiveness of glycerol and sorbitol as plasticizers. Glycerol is considered cost-effective, renewable, biodegradable, and environmentally friendly, while sorbitol, which is also non-toxic and naturally abundant, can enhance product durability by inhibiting water evaporation. Both materials exhibit good potential as plasticizers; therefore, their comparison is necessary. The research stages included extracting cellulose from teak wood powder, synthesizing cellulose-chitosan-glycerol and cellulose-chitosan-sorbitol bioplastics, and characterizing the resulting materials. The results exhibited the presence of functional groups such as –OH, C-H, and C-O, which were typical of cellulose, as well as N-H groups, characteristic of chitosan. The best quality for glycerol-based bioplastics was achieved with the addition of 0.5 mL of glycerol, yielding a tensile strength of 5.79 MPa, elongation of 10.3%, water absorption of 43.43%, and a degradation time of 17 days. For sorbitol-based bioplastics, the best quality was obtained with the addition of 1 mL of sorbitol, resulting in a tensile strength of 6.23 MPa, elongation of 13.7%, water absorption of 67.46%, and a degradation time of 14 days. Based on these results, sorbitol is more recommended than glycerol as a plasticizer in this study.

Inhibition of Human Acetylcholinesterase (4EY7) using Bioactive Compound from Moringa oleifera: Molecular Docking and Dynamic Studies Utami, Wiji; Apriyanto, Apriyanto; Antari, Laila; Rasyid, Herlina; Fitriani, Ika Nur
Jurnal Kimia Valensi Jurnal Kimia VALENSI, Volume 10, No. 2, November 2024
Publisher : Syarif Hidayatullah State Islamic University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15408/jkv.v10i2.39840

Alzheimer's disease is a neurodegenerative disorder caused by acetylcholine hydrolysis that impairs cognitive brain function. This research aims to determine the interaction and dynamic of ligands from Moringa oleifera on AChE through Lipinski's Rule, ADMET properties, molecular docking calculations, and molecular dynamic simulations. Lipinski's Rule calculation provided ligand limits that adhere to druglikeness properties. ADMET results also showed that several ligands satisfy ADMET properties. Pterygospermine has lower binding energy than the ligand control (-10.28 kcal mol-1) with amino acid residues of TYR133 and GLU202. It indicates a favorable interaction between the AChE receptor and ligand in the inhibition process. Based on molecular docking calculations, pterygospermine inhibits the AChE receptor at the Long, narrow aromatic gorge active site. According to molecular dynamic simulations, the MMPBSA energy for pterygospermine is 37.377 kJ mol-1. The samples showed a total average RMSD of 2 Å, suggesting no significant conformational changes throughout the simulation. The sample's average RMSF value is around 2 Å, suggesting favorable interactions with the receptor during simulation. However, this data is different from the ligand control interaction mode. Molecular dynamic investigations of the pterygospermine ligand in the complex revealed the stability and unfolded effect on the protein. The results of this study propose a candidate anti-Alzheimer's ligand from Moringa oleifera against the AChE receptor. In practice, these results can contribute to research studies exploring natural ingredients from plants with medicinal potential in drug discovery. These results can be validated using further research in vitro and in vivo.

Comparison of The Use of Glycerol and Sorbitol as Plasticizers on The Quality of Bioplastics Based on Cellulose-Chitosan Qolbi, Nur Nisa Aeni; Zidni Azizati; Ika Nur Fitriani
Walisongo Journal of Chemistry Vol. 7 No. 2 (2024): Walisongo Journal of Chemistry
Publisher : Department of Chemistry Faculty of Science and Technology UIN Walisongo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21580/wjc.v7i2.24175

The accumulation of plastic waste poses significant environmental and health problems. One effort to mitigate this issue is the development of bioplastics. Correspondingly, the primary materials used in this research were cellulose from teak (Tectona grandis) wood powder, chitosan, glycerol, and sorbitol. This study aimed to compare the effectiveness of glycerol and sorbitol as plasticizers. Glycerol is considered cost-effective, renewable, biodegradable, and environmentally friendly, while sorbitol, which is also non-toxic and naturally abundant, can enhance product durability by inhibiting water evaporation. Both materials exhibit good potential as plasticizers; therefore, their comparison is necessary. The research stages included extracting cellulose from teak wood powder, synthesizing cellulose-chitosan-glycerol and cellulose-chitosan-sorbitol bioplastics, and characterizing the resulting materials. The results exhibited the presence of functional groups such as –OH, C-H, and C-O, which were typical of cellulose, as well as N-H groups, characteristic of chitosan. The best quality for glycerol-based bioplastics was achieved with the addition of 0.5 mL of glycerol, yielding a tensile strength of 5.79 MPa, elongation of 10.3%, water absorption of 43.43%, and a degradation time of 17 days. For sorbitol-based bioplastics, the best quality was obtained with the addition of 1 mL of sorbitol, resulting in a tensile strength of 6.23 MPa, elongation of 13.7%, water absorption of 67.46%, and a degradation time of 14 days. Based on these results, sorbitol is more recommended than glycerol as a plasticizer in this study.

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