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All Journal ANIMA Indonesian Psychological Journal Jurnal Psikiatri Surabaya (Surabaya Psychiatry Journal) Jurnal Pengabdian kepada Masyarakat Nusantara Indian Journal of Forensic Medicine & Toxicology Journal of Scientific Research, Education, and Technology
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Journal : Indian Journal of Forensic Medicine

 1 
Time-dependent Expression of Caspase-3 and Degeneration of Lateral Rectus Muscle on Experimental Esotropia in Rabbits Luki Indriaswati; Nurwasis; Gatut Suhendro; Soetjipto; Retno Handajani
Indian Journal of Forensic Medicine & Toxicology Vol. 15 No. 2 (2021): Indian Journal of Forensic Medicine & Toxicology
Publisher : Institute of Medico-legal Publications Pvt Ltd

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37506/ijfmt.v15i2.14785

Abstract

Background: To identify correlation between caspase-3 expression and degeneration of lateral rectus muscleon experimental esotropia in rabbits by using time dependent analysis. Methods: Twenty four rabbits weredivided into 4 groups, first month sham (S1); second month sham (S2); first month esotropia (E1); andsecond month esotropia (E2) model groups. Immunohistochemical and haematoxyllin eosin staining wereperformed. Results: In first month observation no significant difference in caspase-3 expression between S1(1.56 ± 1.03) and E1 (3.93 ± 1.66) groups (p >0.05) and in the degeneration score of lateral rectus musclebetween S1 (1.33 ± 1.36) and E1 (3.83 ± 2.04) groups (p> 0.05). In second month observation no significantdifference in caspase-3 expression between S2 (1.80 ±1.08) and E2 (6.50 ± 3.26) groups (p >0.05); butthere was significant difference in the degeneration score of lateral rectus muscle between S2 (1.16 ± 1.16)and E2 (4.50 ± 1.04) groups (p <0.05). There was a significant correlation between caspase-3 expressionand the degeneration score of lateral rectus muscle (p=0.020; r=0.471). Conclusion: On the experimentalesotropia with prolonged lateral muscle contraction in rabbits, the increasing trend of caspase-3 expressionhas a correlation with the increasing degeneration score of lateral rectus muscle.
Effect of Cacao on Plasma F2-Isoprostane Level, CD34 and ICAM-1 Expression of Coronary Arteries in Cigarette Smoking Exposed Rats Dina Helianti; Soetjipto; Widjiati; I Ketut Sudiana
Indian Journal of Forensic Medicine & Toxicology Vol. 15 No. 3 (2021): Indian Journal of Forensic Medicine & Toxicology
Publisher : Institute of Medico-legal Publications Pvt Ltd

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37506/ijfmt.v15i3.15729

Abstract

This research aimed to evaluate cardioprotective effects of cacao in smoking exposure condition that the effects were mediated through the anti-oxidant pathway by measure plasma F2-isoprostane level, Endothelial Progenitor Cell (EPC) enhancement by expression of CD34, while dysfunction endothelial condition was measured by expression of ICAM-1 in coronary arteries. This study subjected rats, divided into four groups: the normal control group (2 ml of aqua bidest, air exposure); the cigarette control group (2 ml of aqua bidest, cigarette smoke); cacao group 1 (1205 mg/kg BW/day, cigarette smoke); cocoa group 2 (2410 mg/kg BW/day, cigarette smoke). The oxidant biomarker, F2-isoprostane level was assessed using ELISA; CD34, and ICAM-1 expression in coronary arteries by immunohistochemistry. Cacao 1205 mg/kg BW/day significantly decreases plasma F2-isoprostane level, and ICAM-1 expression of coronary arteries in cigarette smoking exposed rat (p < 0.05) but there was not a significant increases CD34 (p < 0.05). Cocoa in cigarette smoke-exposed rats can prevent endothelial dysfunction through decrease F2-isoprostane but not increase CD34. The results of this study can be used as a basis for preventing endothelial dysfunction due to cigarette smoke by using cacao.
Associations between P53, Transforming Growth Factor Beta-1, and Interleukin-10 Serum Levels with Advanced Liver Disease and Hepatitis B Virus Infection Citrawatidyahkencono Wungu; Mochamad Amin; Ulfa Kholili; Gwennyichsan Prabowo; Poernomoboedi Setiawan; Soetjipto; Retno Handajan
Indian Journal of Forensic Medicine & Toxicology Vol. 15 No. 3 (2021): Indian Journal of Forensic Medicine & Toxicology
Publisher : Institute of Medico-legal Publications Pvt Ltd

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37506/ijfmt.v15i3.15736

Abstract

Co-Authors Abdul Khairul Rizki Purba Mustofa Indwiani Astuti Adhilah, Nindy Adila Taufik Syamlan Agustina Sjenny Andyani Pratiwi Bin Patawari, Anwar Mohamad Budi Kristiano Christopher Aditya Purba Deviyana Soetjipto Dina Faizatur Rahmah Dina Helianti Eden Febria Rike Erliana Feytie Magda Mawey Gatut Suhendro Hendy Muagiri Margono Indriani Astin Pulanga Izzatul Fithriyah Karimah, Azimatul Khoe Teguh Konginan, Agustina Lia Jessica Linda Dewi Terserani Lase Luki Indriaswati Marlina S. Mahajuddin Mochamad Amin Mulyantono Novelita Mesah Nurwasis Nurwasis Pemilda Dian Catur Ayu Wisnu Putri Poernomoboedi Setiawan Prabowo, Gwenny Ichsan Putra, Patria Yudha Putriana, Maria Magdalena Greda Retno Handajan Retno Handajani Rifat Nurwita Kusumaningtyas Rizka Solehah Robert Simare Mare S.Pd. M Kes I Ketut Sudiana . Samsriyaningsih Handayani Sang Putra Duha Sheila Maryam Gautama Teisha Jediya Videlia Marantika Ulfa Kholili Viki Rizki Virzi Aliyyah Rahma Waruwu, Septerianus Widjiati Williana Suwirman Wungu, Citrawati Dyah Kencono Yariama Zendrato Yulianti, Erikavitri