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All Journal Majalah Kedokteran Bandung Junior Medical Journal Jurnal Akademik Pengabdian Masyarakat
Sosiawan, Insan
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Religion Biochemistry, Genetics & Molecular Biology Computer Science & IT Economics, Econometrics & Finance Education Health Professions Industrial & Manufacturing Engineering Medicine & Pharmacology Public Health Social Sciences

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Antioxidant and Antiaging Properties of Ethanolic Ripe Sesoot Fruit Extract Utami, Sri; Sosiawan, Insan; Nurul, Dewi; Purnamasari, Endah; Batubara, Lilian; Sachrowardi, Qomariyah Romadhiyani; Damayanti, Ndaru Andri; Aryenti, Aryenti; Dewi, Intan Keumala; Nafik, Said; Arrahmani, Betharie Cendera; Kusuma, Hanna Sari Widya; Widowati, Wahyu; Utomo, Herry S
Majalah Kedokteran Bandung Vol 56, No 3 (2024)
Publisher : Faculty of Medicine, Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15395/mkb.v56.3472

Abstract

Skin aging can be characterized by changes in skin, such as the appearance of wrinkles and loss of skin moisture. Some elements that might lead to cell damages and aging are free radicals through the increase of the activities of hyaluronidase and tyrosinase. Bioactive compounds found in sesoot (Garcinia picrorhiza Miq.) are known for their antioxidant properties, which may reduce excessive amounts of free radicals in the body and act as an antiaging agent by inhibiting hyaluronidase and tyrosinase activities. This study aimed to examine the antioxidant, anti-hyaluronidase, and anti-tyrosinase properties found in Ethanolic Extract Ripe Sesoot (EERS). The ethanol extract of ripe sesoot fruit obtained from LIPI, Bogor Botanical Garden was used for the antioxidant and antiaging assays conducted at PT Aretha Medika Utama in December 2016. The activity of antioxidants was measured as the Ferric Reducing Antioxidant Power (FRAP) of the EERS, while the antiaging assays were performed through the inhibition activity of hyaluronidase and tyrosinase. Results indicated that the EERS has a higher FRAP activity (17.58 μM Fe (II)/μg) than xanthone (2.54 μM Fe (II)/μg) at the highest concentration of sample of 5,000 µg/mL. The anti-hyaluronidase of the EERS exhibited lower activity (IC50 of 619.21±12.15 µg/mL) than xanthone (IC50 of 365.55±25.10 µg/mL) and the tyrosinase inhibitory assay demonstrated a lower activity of EERS (IC50 of 1060.68±12.81 µg/mL) compared to xanthone (IC50 of 218.33±9.73 µg/mL). To conclude, EERS shows antioxidant and antiaging properties.
Sosialisasi Pengelolaan Limbah Medis B3 di RSUD Batara Guru Sosiawan, Insan; Zamli
JURNAL AKADEMIK PENGABDIAN MASYARAKAT Vol. 3 No. 4 (2025): Juli
Publisher : CV. KAMPUS AKADEMIK PUBLISING

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.61722/japm.v3i4.6027

Abstract

This community service activity aims to increase understanding and awareness of hazardous and toxic medical waste management (B3) at Batara Guru Regional Hospital, Luwu Regency. The main problem encountered was a lack of technical understanding and implementation of regulatory waste management standards. The activity was implemented through interactive outreach with pre- and post-tests to measure participants' knowledge. Results showed significant improvement, with knowledge in the good category increasing from 22.73% to 90.91%. This activity demonstrates the importance of regulation-based and participatory education in fostering a safe and healthy work culture in hospitals.
Hubungan Faktor Risiko dengan Kejadian Penyakit Rheumatoid Arthritis di RSUD Bangkinang Kampar Riau 2019 – 2020 dan Tinjauannya Menurut Pandangan Islam andani, rafika tasya; Sosiawan, Insan; Arsyad, Muhammad
Junior Medical Journal Vol. 3 No. 5 (2025): September 2025
Publisher : Fakultas Kedokteran Universitas YARSI

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33476/jmj.v3i5.4391

Abstract

Rheumatoid Arthritis (RA) adalah penyakit autoimun sistemik kronis yang menyerang lapisan sendi synovial dan dikaitkan dengan kecacatan progresif, kematian dini, dan beban sosial ekonomi. Faktor risiko yang dapat dimodifikasi diantaranya adalah obesitas, merokok, memakan daging merah, infeksi, inflamasi pada sendi dan selubung tendon. Faktor risiko yang tidak dapat dimodifikasi antara lain faktor genetik, usia dan jenis kelamin. Data Dinas Kesehatan Kabupaten Kampar 2019, penyakit RA berada di posisi ke-4 dengan jumlah penderita sebanyak 13.964 dari 10 penyakit yang paling banyak di Kabupaten Kampar. Penelitian ini dilakukan dengan pendekatan analitik crossectional yang menganalisa data sekunder berupa rekam medis. Populasi dalam penelitian ini adalah pasien yang mengeluh nyeri sendi dan berobat di RSUD Bangkinang Kampar periode 2019-2020. Pemilihan sampel menggunakan teknik simple random sampling, sehingga setiap pasien memiliki hak dan kesempatan yang sama untuk dijadikan sampel penelitian. Mayoritas responden berada pada usia pra-lansia (45-59 tahun) sebanyak 54% dengan jenis kelamin perempuan (58,7%) dan status gizi normal (50,7%). Analisa bivariat terdapat hubungan yang signifikan antara faktor resiko usia (P=0,039), jenis kelamin (P=0,000) dan status gizi (P=0,014) dengan kejadian rheumatoid arthritis pada pasien RSUD Bangkinang Kampar Riau periode 2019-2020. Terdapat hubungan antara faktor resiko usia, jenis kelamin dan IMT dengan kejadian rheumatoid arthritis pada pasien RSUD Bangkinang Kampar Riau periode 2019-2020.
Co-Authors andani, rafika tasya Arrahmani, Betharie Cendera Aryenti, Aryenti Batubara, Lilian Damayanti, Ndaru Andri Dewi Nurul, Dewi Dewi, Intan Keumala Endah Purnamasari Hanna Sari Widya Kusuma, Hanna Sari Widya Muhammad Arsyad Nafik, Said Sachrowardi, Qomariyah Romadhiyani Sri Utami Utomo, Herry S WAHYU WIDOWATI Zamli