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Sosiawan, Insan
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Computer Science & IT Economics, Econometrics & Finance Education Industrial & Manufacturing Engineering Medicine & Pharmacology Social Sciences

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Antioxidant and Antiaging Properties of Ethanolic Ripe Sesoot Fruit Extract Utami, Sri; Sosiawan, Insan; Nurul, Dewi; Purnamasari, Endah; Batubara, Lilian; Sachrowardi, Qomariyah Romadhiyani; Damayanti, Ndaru Andri; Aryenti, Aryenti; Dewi, Intan Keumala; Nafik, Said; Arrahmani, Betharie Cendera; Kusuma, Hanna Sari Widya; Widowati, Wahyu; Utomo, Herry S
Majalah Kedokteran Bandung Vol 56, No 3 (2024)
Publisher : Faculty of Medicine, Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15395/mkb.v56.3472

Abstract

Skin aging can be characterized by changes in skin, such as the appearance of wrinkles and loss of skin moisture. Some elements that might lead to cell damages and aging are free radicals through the increase of the activities of hyaluronidase and tyrosinase. Bioactive compounds found in sesoot (Garcinia picrorhiza Miq.) are known for their antioxidant properties, which may reduce excessive amounts of free radicals in the body and act as an antiaging agent by inhibiting hyaluronidase and tyrosinase activities. This study aimed to examine the antioxidant, anti-hyaluronidase, and anti-tyrosinase properties found in Ethanolic Extract Ripe Sesoot (EERS). The ethanol extract of ripe sesoot fruit obtained from LIPI, Bogor Botanical Garden was used for the antioxidant and antiaging assays conducted at PT Aretha Medika Utama in December 2016. The activity of antioxidants was measured as the Ferric Reducing Antioxidant Power (FRAP) of the EERS, while the antiaging assays were performed through the inhibition activity of hyaluronidase and tyrosinase. Results indicated that the EERS has a higher FRAP activity (17.58 μM Fe (II)/μg) than xanthone (2.54 μM Fe (II)/μg) at the highest concentration of sample of 5,000 µg/mL. The anti-hyaluronidase of the EERS exhibited lower activity (IC50 of 619.21±12.15 µg/mL) than xanthone (IC50 of 365.55±25.10 µg/mL) and the tyrosinase inhibitory assay demonstrated a lower activity of EERS (IC50 of 1060.68±12.81 µg/mL) compared to xanthone (IC50 of 218.33±9.73 µg/mL). To conclude, EERS shows antioxidant and antiaging properties.
Sosialisasi Pengelolaan Limbah Medis B3 di RSUD Batara Guru Sosiawan, Insan; Zamli
JURNAL AKADEMIK PENGABDIAN MASYARAKAT Vol. 3 No. 4 (2025): Juli
Publisher : CV. KAMPUS AKADEMIK PUBLISING

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.61722/japm.v3i4.6027

Abstract

This community service activity aims to increase understanding and awareness of hazardous and toxic medical waste management (B3) at Batara Guru Regional Hospital, Luwu Regency. The main problem encountered was a lack of technical understanding and implementation of regulatory waste management standards. The activity was implemented through interactive outreach with pre- and post-tests to measure participants' knowledge. Results showed significant improvement, with knowledge in the good category increasing from 22.73% to 90.91%. This activity demonstrates the importance of regulation-based and participatory education in fostering a safe and healthy work culture in hospitals.
Co-Authors Arrahmani, Betharie Cendera Aryenti, Aryenti Batubara, Lilian Damayanti, Ndaru Andri Dewi Nurul, Dewi Dewi, Intan Keumala Endah Purnamasari Hanna Sari Widya Kusuma, Hanna Sari Widya Nafik, Said Sachrowardi, Qomariyah Romadhiyani Sri Utami Utomo, Herry S WAHYU WIDOWATI Zamli