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All Journal MKGK (Majalah Kedokteran Gigi Klinik) (Clinical Dental Journal) UGM Majalah Kedokteran Gigi Indonesia Journal Of Vocational Health Studies
Naim, Cantika Nadrotan
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Dentistry Health Professions

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Antimicrobial photodynamic therapy with erythrosine photosensitizer against immune response in chronic periodontitis model Rochmawati, Mutia; Kusuma, Maulidina Raihan; Maziyyah, Faiz; Naim, Cantika Nadrotan; Prihastuti, Christiana Cahyani; Satrio, Rinawati; Laksitasari, Anindita; Sari, Dwi Nur Indah; Ichsyani, Meylida
Majalah Kedokteran Gigi Indonesia Vol 9, No 2 (2023): August
Publisher : Faculty of Dentistry, Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/majkedgiind.77084

Abstract

Chronic periodontitis is a progressive inflammatory disease of the supporting tissues of the teeth caused by dental plaque bacteria with a clinical sign of periodontal pockets. A Gram-negative bacterium that can trigger this inflammatory disease is Porphyromonas gingivalis. Antimicrobial photodynamic therapy with blue LED light irradiation and photosensitizer erythrosine can reduce the survival rate of P. gingivalis. This study aimed to determine the effects of antimicrobial photodynamic therapy (APDT) exposure with blue LED light irradiation and PS erythrosine on the number of macrophages, lymphocytes, and gingival fibroblasts in gingival tissue of Sprague Dawley rats as chronic periodontitis models. This study used a posttest-only control group design to examine 27 Sprague Dawley rats which were divided into P group (healthy rats), N group (untreated chronic periodontitis rats), and PDT groups (chronic periodontitis model given 1 mg/ml PS erythrosine and irradiated with blue LED light for 60 seconds). Cell observation of histologic preparations of rat gingival tissue with hematoxylin-eosin (H&E) staining was carried out on the 1st, 3rd, and 5th days. Histological preparations of gingival tissue with H&E staining was carried out on the 1st, 3rd, and 5th days. Statistical analysis used a one-way ANOVA and the Kruskal-Wallis test, continued with LSD and the Mann-Whitney post-hoc tests. Results showed significant difference in the mean of macrophages in the PDT group compared to the untreated chronic periodontitis group on the 1st, 3rd, and 5th days (p < 0.05). The mean lymphocyte in the PDT group was significantly different from the untreated chronic periodontitis group on the 1st, 3rd, and 5th days (p < 0.05), and significantly lower than that in the healthy group (p < 0.05) but only on the 3rd and 5th days. The mean fibroblast in the PDT group was significantly different compared to the untreated chronic periodontitis group on the 1st, 3rd, and 5th days (p < 0.05). In conclusion, there were significant differences in the number of macrophages, lymphocytes, and fibroblasts in a chronic periodontitis rat model after treatment with APDT exposure with blue LED and erythrosine photosensitizer.
PROLIFERATION AND APOPTOSIS IN RAT MODELS OF ORAL SQUAMOUS CELL CARCINOMA INDUCED BY CAPSAICIN EXTRACT NANOPARTICLE GEL Widyaningsih, Pratiwi Nur; Aniowati, Fitri; Naim, Cantika Nadrotan; Anggraeni, Nova Dwi
Journal of Vocational Health Studies Vol. 7 No. 2 (2023): November 2023 | JOURNAL OF VOCATIONAL HEALTH STUDIES
Publisher : Faculty of Vocational Studies, Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/jvhs.V7.I2.2023.100-106

Abstract

Background: Oral Squamous Cell Carcinoma (OSCC) is highly invasive neoplasm of oral epithelial tissue that is moderately differentiated and tends to metastasize rapidly. Capsaicin, a pungent phytochemical in red peppers, exhibits both anti-proliferative and potential pro-cancer effects on human cancer cell lines. Purpose: Determine the proliferation and apoptosis between five groups of rats induced OSCC. Method: 5 groups of treatment; C- (untreated rats), C+ (induced by DMBA), E1 (exposed to DMBA and given cisplatin), E2 (induced by DMBA and Capsaicin extract nanoparticle gel with 1% concentration), and E3 (induced by DMBA and Capsaicin extract nanoparticle gel with a concentration of 3.3%). Maceration method was used to obtain Capsaicin extract from green cayenne pepper, then made into nanoparticle gel. Tissue samples were taken after the treatment was completed, then they were pathologicallyobserved histopathological using IHC to assess apoptic activity via the TUNEL method and proliferative activity using PCNA. Result: The proliferative activity in the E1 group had a significant difference compared to the E2 and E3 groups. E2 and E3 were not significantly different (p-value ≥0.05). Apoptotic activity in Group E1 indicated a significant difference from the E2 group and was not significantly different from the E3 group, whereas the E2 and E3 groups were significantly different from each other (p-value ≤0.05). Conclusion: The research showed that Capsaicin nanoparticle gel increased apoptotic activity while decreasing proliferative activity in different treatment groups of the OSCC rat model.
Manifestasi oral pada pasien gagal ginjal kronis di Rumah Sakit Umum Daerah Prof. Dr. Margono Soekarjo, Banyumas Djati, Fanni Kusuma; Naim, Cantika Nadrotan; Ramadhanti, Dian Praba; Kinasih, Amelia Sekar; Berlianza, Activira; Nugroho, Yunanto Dwi
MKGK (Majalah Kedokteran Gigi Klinik) (Clinical Dental Journal) UGM Vol 11, No 2 (2025)
Publisher : Fakultas Kedokteran Gigi, Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/mkgk.106128

Abstract

Gagal ginjal kronis (GGK) adalah suatu kondisi penurunan fungsi ginjal secara bertahap yang disebabkan karena terjadinya kerusakan pada ginjal. Gagal ginjal kronis biasanya terjadi dalam waktu lama (tahunan) yang ditandai dengan penurunan nilai glomerular filtration rate (GFR) <60 mL/menit per 1,73 m2. Prevalensi GGK di Indonesia mengalami peningkatan dari tahun 2013 yaitu 0,2% menjadi 0,38% pada tahun 2018. Etiologi GGK tergolong sangat bervariasi seperti diabetes, glomerulonefritis, hipertensi, dan penyakit ginjal kistik. Laporan ini bertujuan untuk mengidentifikasi berbagai manifestasi oral pada pasien GGK dengan mempertimbangkan keterkaitan klinisnya sebagai bahan refleksi diagnostik pada praktik kedokteran gigi. Laporan ini menunjukkan variasi manifestasi oral pada pasien GGK mencakup periodontitis uremik, hiperpigmentasi, oral hairy leukoplakia, cheilitis, stomatitis nekrotikan, coated tongue, dan kandidiasis kronis. Beberapa manifestasi oral pada kasus GGK kemungkinan berkaitan langsung dengan kondisi uremik, sementara manifestasi oral lainnya dipengaruhi oleh faktor xerostomia, gangguan imun, nutrisi, dan penggunaan obat-obatan. Kompleksitas sistemik pada GGK dapat memperburuk kesehatan rongga mulutsecara umum. Temuan pada laporan kasus ini menegaskan pentingnya peran dokter gigi untuk mengenali tanda sistemik yang tampak di rongga mulut serta perlunya pendekatan multidisipliner pada manajemen pasien GGK.
Co-Authors Anggraeni, Nova Dwi Aniowati, Fitri Berlianza, Activira Dwi Nur Indah Sari Fanni Kusuma Djati Kinasih, Amelia Sekar Kusuma, Maulidina Raihan Laksitasari, Anindita Maziyyah, Faiz Meylida Ichsyani Mutia Rochmawati Nugroho, Yunanto Dwi Prihastuti, Christiana Cahyani Ramadhanti, Dian Praba Satrio, Rinawati Widyaningsih, Pratiwi Nur