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All Journal Jurnal Ilmiah Kedokteran Wijaya Kusuma Jurnal Berkala Kesehatan Qanun Medika - Medical Journal Faculty of Medicine Muhammadiyah Surabaya Jurnal Biologi Tropis Al-Iqra Medical Journal : Jurnal Berkala Ilmiah Kedokteran Indonesian Journal of Pharmacy and Natural Product Academic Hospital Journal Indonesian Journal of Biomedicine and Clinical Sciences
Fuzianingsih, Eka Noviya
Universitas Airlangga
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Dentistry Health Professions Immunology & microbiology Medicine & Pharmacology Neuroscience Nursing Public Health

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Journal : Academic Hospital Journal

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The Role of TNF-α (Tumor Necrosis Factor-alpha) in Pulmonary Tuberculosis Sulistyasmi, Wiwit; Fuzianingsih, Eka Noviya; Kuncara, Rachmad Bayu
Academic Hospital Journal Vol 7, No 2 (2025)
Publisher : Rumah Sakit Akademik Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/ahj.v7i2.106190

Abstract

Background: Tuberculosis (TB) remains a primary global health concern, with Indonesia accounting for approximately 10% of international cases. Tumor necrosis factor-alpha (TNF-α) plays a crucial role in the immune response against Mycobacterium tuberculosis, particularly in pulmonary tuberculosis (TB).Method: This article is a narrative literature review that examines the role of tumor necrosis factor-alpha (TNF-α) in pulmonary tuberculosis.Result:  This pro-inflammatory cytokine is essential for activating macrophages, promoting phagolysosome fusion, and supporting the formation and maintenance of granulomas—immune structures critical for containing infection. However, dysregulated TNF-α expression can be detrimental: excessive levels contribute to inflammation and lung tissue damage, while insufficient production—such as that induced by TNF-α inhibitor therapy—can lead to reactivation of latent TB. This narrative review examines the biosynthesis, immunological functions, and regulatory mechanisms of TNF-α in the context of pulmonary tuberculosis, highlighting its dual role in protective immunity and immunopathology.Conclusion: A deeper understanding of TNF-α modulation may inform the development of targeted, host-directed therapies that improve treatment outcomes while minimizing tissue damage.
Co-Authors Ade Churie Tanjaya Ade Yahya Nasution Ade Yahya Nasution, Ade Yahya Adithya Stephana Mahendra Agung Ismanuworo Agung Ismanuworo Anggadha, Fernaldhi - Arif Santoso Choirul Huda Churie Tanjaya, Ade Cyuzuzo Callixte Dhelya Widasmara Dinda Eka Putri Fernaldhi - Anggadha Haidar Abror Firladi Hansel Hansel Heny Arwati Kuncara, Rachmad Bayu Lucia Tri Suwanti, Lucia Tri Marselaonety La’lang Melati Aprilliana Ramadhani Panji Sananta Panji Sananta Pera Amelia PUTRA, YUDHA ANANTHA KHAERUL Rahmawati, Ayu Sintya Citra Safitri, Yunita Diyah Sananta, Panji - SULASTRI vifta, rissa laila Wildan Faza Pratama Wiwit Sulistyasmi