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All Journal Ilmiah Manajemen Bisnis Nusantara Medical Science Journal Jurnal Biomedika Sasambo Journal of Pharmacy Jurnal Ilmiah Ibnu Sina (JIIS): Ilmu Farmasi dan Kesehatan Majalah Ilmiah Inspiratif Bandung Conference Series: Accountancy Gunung Djati Conference Series Indonesian Journal of Pharmacy and Natural Product Neraca Manajemen, Akuntansi, dan Ekonomi Bilangan: Jurnal Ilmiah Matematika, Kebumian dan Angkasa Algoritma: Jurnal Matematika, Ilmu Pengetahuan Alam, Kebumian dan Angkasa
Arif Santoso
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Religion Agriculture, Biological Sciences & Forestry Astronomy Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Computer Science & IT Decision Sciences, Operations Research & Management Earth & Planetary Sciences Economics, Econometrics & Finance Education Energy Engineering Environmental Science Health Professions Immunology & microbiology Industrial & Manufacturing Engineering Languange, Linguistic, Communication & Media Law, Crime, Criminology & Criminal Justice Library & Information Science Materials Science & Nanotechnology Mathematics Medicine & Pharmacology Neuroscience Public Health Social Sciences Other

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Prevalence of Listeria spp. with PRS Genes in Fresh Vegetables from Traditional Markets A. Kaisar Adiwijaya Putra; Rizalinda Sjahril; Arif Santoso; Dianawaty Amiruddin; Andi Alfian Zainuddin; Firdaus Hamid
Biomedika Vol 13 No 2 (2020): Jurnal Biomedika
Publisher : Fakultas Ilmu Kesehatan Universitas Setia Budi Surakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31001/biomedika.v13i2.842

Abstract

Listeriosis is a foodborne infectious disease caused by Listeria monocytogenes and is considered a serious health problem, due to the severity of symptoms and a high mortality rate in worldwide This study aims to identify and determine the prevalence of Listeria species through prs gene screening of fresh vegetables distributed in several markets of Makassar City. A total of 57 fresh vegetable samples were collected from February to May 2019 in four traditional markets Makassar. The isolates is examines to phenotypically and genotypically Vitek and Multiplex PCR with prs and lmo1030 primer. Phenotype analysis did not show the presence of Listeria species, but the results of genotypic was found 8 positive prs gene samples (14.03%), consisting of 31.2% long beans, 18.2% cabbage, and 9.1% cucumber and. All Listeria species found in this study is Listeria monocytogenes. This study also provide information and additional data that prs genes can be used as screening genotype for identify Listeria species in fresh vegetables.
Pendekatan Pengawasan Internal dalam Pencegahan Fraud: Peran Moderator Audit Intern Iman Kadarman; Meiliani Meiliani; Arif Santoso
Ilmiah Manajemen Bisnis VOL. 19, NO. 2 JULI - DESEMBER 2019
Publisher : Ilmiah Manajemen Bisnis

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Abstract

Abstract — The phenomenon of fraud in the government becomes a challenge for the effectiveness of internal control to reduce the risk of the threat. Since COSO identifes informal and formal aspects within the framework of the internal control, soft control and hard control are two internal control approaches that need to be applied. The presence of the internal audit is a function that cannot be ignored in strengthening the internal control system. This study aimed to investigate the role of internal audit of the effect of soft control and hard control on the fraud prevention of fnancial statements in the Local Government of Bengkulu City. One hundred and forty-fve fnancial management offcials at OPD Bengkulu City were surveyed. The results of data analysis show that (1) the soft control partly has a signifcant effect on the fraud prevention, only on the commitment on competence, and the responsibility and authority delegation; (2) the hard control partly and signifcantly influences the fraud prevention only on the performance review, the information system control, and the documenting; (3) the internal audit moderates partly the effect of the soft control on the fraud prevention only on the commitment on competence, the responsibility and authority delegation; the assurance activity, the consulting activity, the commitment on competence and assurance activity, and positive leadership and the assurance activity; and (4) the internal audit partly moderates the effect of the hard control on the fraud prevention on the performance review, the information system control, and the. Discussion and implication are discussed. Keywords— Financial statement, Fraud, Hard control, Internal audit, Soft control
Case Reports on Severe Antituberculosis-Drug Induced Hepatotoxicity in Tuberculosis Patients: The Post-Incidence Therapy Nasrawati Basir; Yulia Yusrini Djabir; Arif Santoso
Nusantara Medical Science Journal Volume 5 No. 1 Januari - Juni 2020
Publisher : Faculty of Medicine, Hasanuddin University.

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20956/nmsj.v5i1.13450

Abstract

Introduction:  The first-line regimen for tuberculosis (TB) treatment comprises Isoniazid, Rifampicin, Pyrazinamide, and Ethambutol. However, these drugs are known to potentially cause hepatotoxicity. This study aimed to evaluate hepatotoxicity incidence in patients during intensive phase of anti-tuberculosis treatment focusing on post-incidence therapy. Methods:  The study involved pulmonary TB patients who were admitted to the National Lung Health Center due to hepatotoxicity after receiving fixed-dose combination of antituberculosis drugs (FDC-AT) in September-October 2019. Drug-related hepatotoxicity is defined as an increase in serum alanine aminotransferase (ALT) or aspartate aminotransferase (AST) levels greater than 2.5 times of the normal upper limit (ULN) with an increase in bilirubin level. Results:  There were 8 patients admitted to the center due to hepatotoxicity, 4 of them experienced grade 3 (severe) hepatotoxicity, during which the ALT, AST, bilirubin levels increased 5-10 times of the ULN. The post-hepatotoxicity treatment includes the cessation of FDC-AT treatment followed by hepatoprotective supplements. Following two weeks of treatments, the biomarker levels of two out of four patients went back to normal and the AT therapy was resumed. Meanwhile, the other two patients continued to receive the hepatoprotective therapy for up to 8 weeks. However, when the treatment failed to bring the transaminase level back to normal, a different AT regimen was prescribed. Conclusions: The cessation of FDC-AT and the use of hepatoprotective supplements for two to eight weeks were able to alleviate the AT-induced severe hepatotoxicity. A close monitoring of liver biomarkers is warranted to prevent the incidence of hepatotoxicity in patients receiving antituberculosis
The survival rate comparison of non small cell lung carcinoma patients who are given by epidermal growth factor receptor-tyrosin kinase inhibitor and those given by first-line chemotherapy treatment Hasan Nyambe; Arif Santoso; Nur Ahmad Tabri; Harun Iskandar; Muh Ilyas; Edward Pandu Wiriyansyah
Nusantara Medical Science Journal Volume 6 Issue 2, July - December 2021
Publisher : Faculty of Medicine, Hasanuddin University.

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20956/nmsj.v6i2.18857

Abstract

Introduction. Lung cancer is the type of non-small cell carcinoma (NSCLC) consists of non-squamous and squamous. Non-small cell lung cancer of non squamous types consist of adenocarcinoma and large cell carcinoma. Currently, lung cancer therapy is highly developed of chemotherapeutic agents to targeted therapy especially EGFR-TKI. This study aims to assess the survival rate of NSCLC patients who receive first line chemotherapy and those who recieve EGFR-TKI therapy at Wahidin Sudirohusodo hospital. Methods. This study is a retrospective study between 2017 to 2019 from the medical records of NSCLC patients who receive first-line chemotherapy and thise who recieve EGFR-TKI. Patients with platinum-based chemotherapy and EGFR-TKI with gefitinib therapy 1x250 mg/day or erlotinib 1x150mg/day and or afatinib 1x40 mg/day. Survival rate assessed from start to erect the diagnosis until the patient dies or when the  study is     discontinued. Result. From 239 subject of NSCLC patients consisted of 135 patients who receive first-line chemotherapy, and 104 patients are treate with EGFR-TKI. Based on the characteristics of the patients, most are more than 40 years old (chemotherapy 124 (91.9%) and EGFR-TKI 101 (97.1%) with the male gender that dominates (chemotherapy 98 (72.6%), EGFR-TKI 64 (61.5%). Smoking patients who received first-line chemotherapy are 65.2% and 61.5% of EGFR-TKIs with chemotherapy highest IB (severe IB 28.9%) and for EGFR-TKI (moderate IB are 26.9%). 73.2% of adenocarcinoma histology type with a predominance of stage IV 86.6% (83.7% for chemotherapy and EGFR-TKI 90.4%). Survival rate of patients are 98,7% for 6 months survival, 1 year survival rate is 94.1% and 2 years survival rate of 24.3%. Median survival patients who receiving EGFR-TKI longer than they received first- line chemotherapy (21 months versus 20 months). The 18 months PFS showed that patients treated with EGFR-TKI were 15 months, while patients receiving chemotherapy was 11 months. (P 0.000). Conclusion. Survival rates in NSCLC patients with EGFR-TKI therapy had significantly the highest survival rates compared with all other chemotherapy. Progression was faster in patients with first-line chemotherapy than EGFR-TKI. The factors that most influence the survival rate is type of therapy with p value<0.05.
PENGARUH PEMBERIAN MINYAK BIJI JINTEN HITAM TERHADAP KADAR INTERLEUKIN-6 PADA PEROKOK AKTIF SEHAT Arif Santoso; Akrom Akrom; Laela Hayu Nuraini; Titiek Hidayati
Jurnal Ilmiah Ibnu Sina (JIIS): Ilmu Farmasi dan Kesehatan Vol 7 No 1 (2022): JIIS
Publisher : Sekolah Tinggi Ilmu Kesehatan ISFI Banjarmasin

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (230.385 KB) | DOI: 10.36387/jiis.v7i1.861

Abstract

Exposure to cigarette smoke causes cellular oxidative stress and is the key to the inflammatory process in the lungs. Black cumin seed oil (MBJH) is one of the traditional medicines that is proven to contain the active substances timoquinone, nigelon and negelin which have antioxidant and immunomodulatory effects. Interleukin-6 (IL-6) is a proinflammatory cytokine and a multifunctional cytokine that is very important for determining the immune response, cell survival, apoptosis and proliferation and is a protumorogenic agent in many cancers. The purpose of this study was to determine the levels of IL-6 in healthy active smokers after being given MBJH at a dose of 0.5 ml/capsule. The research design used was a single blind Randomized Controlled Trial (RCT). A total of 39 healthy healthy active smokers were divided into 4 groups: Group 1 was given a placebo 3x1 capsules/day, group 2 was given MBJH 3x1 capsules/day, group 3 was given MBJH 3x2 capsules/day and group 4 was given MBJH 3x3 capsules/day. The placebo and MBJH interventions were administered for 30 days. Statistical analysis obtained showed that there was no significant difference in the mean levels of IL-6 between the treatment group and the placebo group with p>0.05. The results showed that the use of MBJH for 30 days can reduce the average level of Interleukin-6 but not significantly in healthy active smokers.
Correlation of low body mass index and albumin level with the presence of liver dysfunction in newly diagnosed tuberculosis patients Sriyanty Sadsyam; Yulia Yusrini Djabir; Arif Santoso
Sasambo Journal of Pharmacy Vol. 2 No. 2 (2021): September
Publisher : Universitas Mataram

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (226.49 KB) | DOI: 10.29303/sjp.v2i2.105

Abstract

Tuberculosis (TB) patients often experience reduced appetite or nutritional malabsorption leading to malnutrition, which manifests in excessive loss of muscle mass and low body mass index (BMI). Patients with protein malnutrition is associated with increased risk of drug-induced liver injury and may require a close monitoring during the course of antituberculosis (AT) treatment. The purpose of this study was to determine the correlation of low body mass index and albumin level with liver dysfunction in patients newly diagnosed with TB prior to receiving AT drugs. This study is a nonexperimental observational study with consecutive sampling technique by following a descriptive analytic design (cohort study). The subjects were patients in the National Lung Health Center Makassar who are newly diagnosed with TB and have not received any AT drug. The BMI data and blood samples were collected and analyzed to obtain Alanine aminotransferase (ALT), Aspartat aminotransferase (AST), and Albumin levels. It was found that out of 22 total patients, 3 (14%) of the TB patients experienced liver dysfunction characterized by high level of ALT and AST levels. Both patients had normal levels of albumin despite one of them had a low BMI. The statistical showed no correlation between the low BMI or albumin level with the presence of liver dysfunction. It is concluded that the presence of liver dysfunction is not correlated with low BMI or albumin level in newly diagnosed TB patients, and hence, are not considered as independent risk factors of liver dysfunction in this population.
PENGARUH PAJAK DAERAH DAN RETRIBUSI DAERAH TERHADAP TINGKAT KEMANDIRIAN KEUANGAN DAERAH DENGAN BELANJA MODAL SEBAGAI VARIABEL Mulkan Teguh Sutrisno; Arif Santoso
Majalah Ilmiah Inspiratif Vol 7, No 13 (2021): Majalah Inspiratif Vol.7 No.13 Juli 2021
Publisher : Universitas Pandanaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (497.359 KB)

Abstract

Tujuan penelitian ini adalah  untuk memberikan bukti empiris pengaruh  Pajak Daerah dan Retribusi Daerah terhadap Tingkat Kemandirian Keuangan Daerah dengan Belanja Modal sebagai variabel intervening pada Kabupaten/Kota di Jawa Timur. Metode analisis yang digunakan dalam penelitian ini adalah metode kuantitaitif dengan pengujian regresi berganda dengan melakukan uji asumsi klasik sebelum mendapatkan model penelitian terbaik. Variabel dalam penelitian ini adalah Pajak Daerah dan Retribusi daerah sebagai variabel independen dan Belanja Modal sebagai variabel dependen. Jumlah populasi penelitian ini seluruh Laporan Realisasi Anggaran (LRA) Kabupaten/kota di Provinsi Jawa Timur yang berjumlah 38 kabupaten dan kota, dengan menggunakan teknik sensus sebagai sampel dari tahun 2015 sampai dengan tahun 2019. Hasil dari penelitian ini adalah : Pajak Daerah dan Retribusi Daerah  berpengaruh positif signifikan terhadap Belanja Modal, Pajak Daerah berpengaruh positif signifikan terhadap Tingkat Kemandirian Keuangan Daerah dan Retribusi daerah dan Belanja Modal tidak berpengaruh signifikan terhadap Tingkat Kemandirian Keuangan Daerah pada kabupaten/kota di Propinsi Jawa Timur.  Kata Kunci : Pajak Daerah, Retribusi Daerah, Belanja Modal dan Tingkat Kemandirian Keuangan Daerah
Pengaruh Tingkat Kompensasi dan Motivasi Kerja terhadap Kinerja Karyawan Arif Santoso; Nurleli
Bandung Conference Series: Accountancy Vol. 4 No. 1 (2024): Bandung Conference Series: Accountancy
Publisher : UNISBA Press

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29313/bcsa.v4i1.12363

Abstract

Abstract. This research aims to investigate and examine the influence of compensation and work motivation on employee performance. The study utilizes a quantitative research method approach. The researcher designated the sample for data collection in this study, consisting of employees at PT. Usaha Prima. The sample selected comprises 50 employees from PT. Usaha Prima. The research results indicate that the responses from 50 respondents to each statement on employee performance resulted in a total average service quality score of 215.7, falling within the interval of 214-254. This value represents a high criterion based on the interval scale table. Therefore, it can be concluded that PT. Usaha Prima has a relatively good performance. The research findings show that compensation and work motivation have a positive and significant impact on employee performance. Judging from the correlation coefficient between compensation and employee performance, the significance level is smaller than the predetermined significance level. Abstrak. Penelitian ini bertujuan untuk menyelidiki dan menguji pengaruh kompensasi dan motivasi kerja terhadap kinerja karyawan. Penelitian ini menggunakan pendekatan metode kuantitatif. Sampel ditunjuk peneliti sebagai sumber data yang diperlukan pada penelitian ini ialah para karyawan yang berada pada PT. Usaha Prima. Sampel yang diambil yaitu karyawan PT. Usaha Prima yang berjumlah 50 orang. 3Hasil penelitian menunjukan bahwa jawaban dari 50 responden terhadap masing-masing pernyataan kinerja karyawan, menghasilkan resume total skor nilai kualitas pelayanan rata-rata 215,7 yang berada pada interval 214- 254, dan nilai tersebut menunjukan kriteria tinggi berdasarkan table skala interval. Dengan demikian dapat disimpulkan bahwa PT. Usaha Prima mempunyai kinerja yang cukup baik. Hasil penelitian ini menunjukan kompensasi dan motivasi kerja berpengaruh postif dan signifikan terhadap kinerja karyawan. Dilihat dari besarnya koefisien korelasi kompensasi terhadap kinerja karyawan dengan tingkat signifikan lebih kecil dari tingkat signifikansi yang telah ditetapkan.
PENGARUH BRAND AMBASSADOR TERHADAP KEPUTUSAN PEMBELI KONSUMEN TOKOPEDIA Arif Santoso; Is Fadhillah
Musytari : Neraca Manajemen, Akuntansi, dan Ekonomi Vol. 8 No. 2 (2024): Musytari : Neraca Manajemen, Akuntansi, dan Ekonomi
Publisher : Cahaya Ilmu Bangsa

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.8734/musytari.v8i2.5507

Abstract

Saat ini, kemajuan teknologi telah membuat orang lebih mudah menggunakan berbagai hal, salah satunya adalah berbelanja online. Ketika mereka memilih untuk membeli sesuatu, pelanggan akan mempertimbangkan beberapa hal. Demikian juga, saat berbelanja online, banyak e-commerce yang menawarkan berbagai keuntungan untuk menarik pelanggan. Tujuan dari penelitian ini adalah untuk mengetahui bagaimana duta merek memengaruhi keputusan konsumen Kota Surabaya dalam hal pembelian di Tokopedia. Sebanyak 36 orang yang disurvei adalah warga Surabaya yang pernah berbelanja di Tokopedia. Data primer diperoleh dari jawaban responden pada kuesioner yang disebarkan secara online melalui formulir Google Forms. Mereka dianalisis menggunakan teknik regresi linear berganda. Hasil penelitian menunjukkan bahwa variabel brand ambassador tidak secara signifikan memengaruhi keputusan pembelian di Tokopedia, dengan nilai signifikansi 0,085 lebih besar dari 0,05. Kesimpulan Variabel brand ambassador tidak memengaruhi keputusan pembelian responden, tetapi variabel lain yang tidak disebutkan memengaruhi keputusan mereka. Variabel duta merek berdampak pada keputusan konsumen untuk membeli barang di Tokopedia secara bersamaan. Kata Kunci : Tokopedia, Brand Ambassador, Purchase Decision
Perbandingan Efektivitas Profilaksis Intermiten Klobazam Versus Diazepam pada Kejang Demam Sederhana (KDS): Systematic Review: Comparison Effectiveness of the Intermittent Prophylaxis of Clobazam Versus Diazepam in Simple Febrile Seizures (SFS): Systematic Review Sulastri; Nurjanah, Mutia Hariani; Ramadhani, Melati Apriliana; Arif Santoso; Rahma Diyan Martha; Vifta, Rissa Laila; Annisah Mahanani
Indonesian Journal of Pharmacy and Natural Product Vol. 7 No. 02 (2024): Indonesian Journal of Pharmacy and Natural Product
Publisher : Universitas Ngudi Waluyo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35473/ijpnp.v7i02.3308

Abstract

Febrile seizures are seizures that occur when body temperature rises (rectal temperature > 38o C). Each seizure can possibly cause epilepsy and trauma to the brain. The next priority is efforts to stop acute seizure attacks which can usually be treated with anti-seizure medication. Intermittent prophylaxis with clobazam at the onset of the first febrile seizure provides better results. This systematic review aims to review articles related to the use of intermittent prophylaxis of clobazam vs diazepam for children suffering from simple febrile seizures. The literature search method uses Google Scholar, PubMed and BMJ databases based on keywords. The selected articles were articles published between 2009-2023, full text in English, were original articles comparing the effectiveness of intermittent prophylaxis use of clobazam vs diazepam in febrile seizures in children. The results obtained were 4 articles that were relevant to the objectives of this systematic review. Data is homogeneous with RR of 0.44 (95% CI: 0.32-0.60) so that the therapeutic effectiveness of administering clobazam compared with diazepam is not significantly different even though there is a chance that the effectiveness of clobazam is 0.44 times compared with administering diazepam. The efficacy of clobazam compared to diazepam, clobazam has better advantages than diazepam in preventing recurrence of febrile seizures. Apart from that, the side effects that occur with clobazam are significantly lower, for example drowsiness and sedation. ABSTRAK Kejang demam merupakan bangkitan kejang yang terjadi pada kenaikan suhu tubuh (suhu rektal > 38o C). Setiap kejang kemungkinan dapat menimbulkan epilepsi dan trauma pada otak. Prioritas selanjutnya berupa usaha untuk menghentikan serangan kejang akut yang biasanya dapat ditangani dengan pemberian obat anti kejang. Pemberian profilaksis intermiten dengan klobazam pada permulaan terjadinya kejang demam pertama memberikan hasil yang lebih baik. Systematic review  ini bertujuan untuk mereview artikel-artikel terkait adanya penggunaan profilaksis intermiten klobazam vs diazepam untuk anak penderita kejang demam sederhana. Pencarian literatur menggunakan metode berupa database Google scholar,  PubMed dan BMJ berdasarkan keywords. Artikel yang dipilih adalah artikel yang dipublikasikan antara tahun 2009-2023, fulltext dalam inggris, merupakan original article yang membandingkan efektivitas antara penggunaan profilaksis intermiten klobazam vs diazepam pada kejang demam pada anak. Hasil diperoleh 4 artikel yang relevan terhadap tujuan systematic review ini. Data bersifat homogen dengan RR 0,44 (CI 95%: 0,32-0,60) sehingga efektivitas terapi pemberian klobazam dibandingkan dengan diazepam tidak berbeda bermakna meskipun terdapat peluang efektivitas klobazam sebesar 0,44 kali dibandingkan dengan pemberian diazepam. Kemanjuran klobazam dibandingkan dengan diazepam, klobazam memiliki keunggulan lebih baik dibandingkan diazepam dalam mencegah kekambuhan kejang demam. Selain itu efek samping yang timbul pada klobazam secara signifikan jauh lebih rendah misalnya seperti mengantuk dan sedasi.
Co-Authors A. Kaisar Adiwijaya Putra Akrom, Akrom Andi Alfian Zainuddin Annisah Mahanani Choirul Huda Dianawaty Amiruddin Edward Pandu Wiriyansyah Elen Vikelavianis Fatkul Anam Firdaus Hamid Fuzianingsih, Eka Noviya Harun Iskandar Hasan Nyambe Iman Kadarman Is Fadhillah Laela Hayu Nurani Meiliani Meiliani Melati Aprilliana Ramadhani Muh Ilyas Mulkan Teguh Sutrisno Nada Haristiani Barida Nasrawati Basir Nur Ahmad Tabri Nur Layli Indah Puspita Nurjanah, Mutia Hariani Nurleli Pera Amelia Rahma Diyan Martha Rahma Diyan Martha Ramadhani, Melati Apriliana Rizalinda Sjahril Sriyanty Sadsyam SULASTRI Titiek Suhardi Haripurnomo Kushadiwijaya Hidayati vifta, rissa laila Yulia Yusrini Djabir