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All Journal JOPS (Journal Of Pharmacy and Science) Journal Syifa Sciences and Clinical Research (JSSCR) Jurnal Abdimas PHB : Jurnal Pengabdian Masyarakat Progresif Humanis Brainstorming jurnal syntax admiration Kieraha Medical Journal Journal of Biotechnology and Natural Science Jurnal Farmasi Indonesia Jurna Beta Kimia
Sadik, Fahmi
Program Studi Farmasi, Fakultas Kedokteran, Universitas Khairun Jl. Jusuf Abdulrahman Kampus II Gambesi Ternate, Maluku Utara, 97719 Indonesia
Aerospace Engineering Agriculture, Biological Sciences & Forestry Automotive Engineering Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Computer Science & IT Education Electrical & Electronics Engineering Engineering Health Professions Immunology & microbiology Industrial & Manufacturing Engineering Languange, Linguistic, Communication & Media Law, Crime, Criminology & Criminal Justice Mathematics Mechanical Engineering Medicine & Pharmacology Nursing Public Health

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SKRINING FITOKIMIA SPONS LAUT (Forcepia Sp) SEBAGAI SUMBER POTENSIAL SENYAWA ANTIOKSIDAN ALAMI UNTUK KESEHATAN DAN KOSMETIK Febrianty, Marisca; Fiskia, Ermalyanti; A. Disi, Muhammad Zulfian; Sadik, Fahmi; Nur, Amran
Kieraha Medical Journal Vol 6, No 1 (2024): KIERAHA MEDICAL JOURNAL
Publisher : Fakultas Kedokteran, Universitas Khairun

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33387/kmj.v6i1.9090

Abstract

Indonesia, dikenal sebagai negara dengan banyak kepulauan dan juga sumber daya alam yang kaya, memiliki ekosistem terumbu karang yang mendukung keberagaman hayati laut. Spons laut, khususnya dari genus Forcepia, menjadi fokus penelitian ini karena potensi bioaktifnya yang belum dioptimalkan pemanfaatannya. Penelitian ini ditujukan guna mengidentifikasi senyawa bioaktif, khususnya senyawa antioksidan, melalui uji fitokimia. Metode yang diterapkan adalah ekstraksi maserasi bersama pelarut etanol 96%, diikuti dengan pengujian alkaloid, flavonoid, saponin, dan tanin. Hasil uji menunjukkan keberadaan alkaloid (ditandai dengan endapan positif pada pereaksi Mayer, Bouchardat, dan Dragendorf), flavonoid (perubahan warna ungu dengan pereaksi FeCl₃), saponin (terbentuknya busa stabil), dan tanin (warna biru-hitam dengan FeCl₃). Temuan ini mengindikasikan bahwa Spons laut (Forcepia sp) mengandung senyawa bioaktif yang dapat menjadi sumber antioksidan alami. Penelitian lebih lanjut diperlukan untuk mengeksplorasi aktivitas antioksidan dan mekanisme kerja senyawa- senyawa ini dalam sistem biologi.
Antioxidant Capacity and Phytochemical Profile of Jatropha curcas L. Leaf Extracts and Fractions Using the FRAP Method Sadik, Fahmi; Nur, Amran; S. Somadayo, Nur Asma; Hartina, Sitti
Journal of Biotechnology and Natural Science Vol. 5 No. 2 (2025): December
Publisher : Universitas Ahmad Dahlan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.12928/jbns.v5i2.14781

Abstract

This study explored the free radical scavenging potential of Jatropha curcas L. leaves, focusing on identifying active biochemical constituents and evaluating antioxidant efficacy through a series of extraction and chemical analysis procedures. Phytochemical screening confirmed the presence of several bioactive secondary metabolites, including alkaloids, saponins, triterpenoids, tannins, and flavonoids. In the Ferric Reducing Antioxidant Power (FRAP) assay, the ethyl-acetate fraction exhibited the highest level of antioxidant activity (9.19 ± 0.38 µmol TE/g), significantly higher than that of the ethanol extract (3.52 ± 0.71 µmol TE/g), as well as the aqueous and n-hexane fractions. This value corresponds to strong activity according to the TEAC classification, indicating that Jatropha curcas leaves are a promising source of natural antioxidants. The total phenolic content (TPC) was determined to be 6.78 ± 0.27% GAE, while the total flavonoid content (TFC) measured 1.35 ± 0.07% QE. These findings indicate that phenolic and flavonoid constituents play a primary role in the antioxidant activity of the extract. Variations significantly influenced the observed outcomes in the extraction methodology and solvent polarity. In summary, Jatropha curcas leaves possess substantial antioxidant potential, particularly within the ethyl-acetate fraction, supporting further development for nutraceutical and pharmaceutical applications.
Aktivitas Antioksidan Ekstrak Etanol Daun Jarak Pagar (Jatropha curcas L.) Melalui Metode FRAP dan Penambatan Molekuler Sadik, Fahmi; Marwati, Eri
JFIOnline | Print ISSN 1412-1107 | e-ISSN 2355-696X Vol. 16 No. 2 (2024): Jurnal Farmasi Indonesia
Publisher : Pengurus Pusat Ikatan Apoteker Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35617/jfionline.v16i2.294

Abstract

This study evaluated the antioxidant activity of Jatropha curcas L. leaf ethanol extract via Ferric Reducing Antioxidant Power (FRAP) assay and molecular docking against Superoxide Dismutase 1 (SOD1) enzyme. Extraction was performed by maceration using 96% ethanol. In vitro results showed the extract possessed moderate antioxidant capacity of 3.52 mg TE/g and contained flavonoids and tannins. In silico analysis revealed that Naringenin-7-O-β-D-glucopyranoside exhibited the highest binding affinity towards SOD1 with a Gibbs free energy of -10.41 kcal/mol, surpassing the co-crystal ligand (-9.05 kcal/mol). Stable interactions were formed through hydrogen bonds at key residues LYS175 and TRP109. This study concludes that J. curcas leaves have dual potential as electron donors and modulators of body defense enzymes for combating oxidative stress.
Co-Authors A. Rifqah Amalia Anwar Amran Nur Anwar, Mahgial Eri Marwati Ermalyanti Fiskia Febrianty, Marisca Hartina, Sitti Ismail Rahman Muh Nasir Muhammad Zulfian A. Disi Rahmiyati Hi Samang S. Somadayo, Nur Asma Somadayo, Nur Asma S