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All Journal Jurnal Kimia dan Kemasan Majalah Kedokteran Gigi Indonesia Metalurgi Makara Journal of Health Research
Basril Abbas
Pusat Aplikasi Isotop dan Radiasi (PAIR)-BATAN
Chemistry Dentistry Energy

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Pengaruh Iradiasi Gamma pada Sifat Fisik dan Mekanik Film Kitosan Erizal, Erizal; Abbas, Basril; Sudirman, Sudirman; Deswita, Deswita; Budianto, Emil
Jurnal Kimia dan Kemasan Vol. 34 No. 1 April 2012
Publisher : Balai Besar Kimia dan Kemasan

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (1050.802 KB)

Abstract

Aplikasi radiasi gamma untuk pengembangan bahan polimer yang berasal dari produk laut, banyak dikembangkan. Pada penelitian ini, pengaruh iradiasi gamma terhadap sifat fisik dan mekanik film kitosan dilakukan. Sifat fisik dan mekanik film kitosan yang diiradiasi pada dosis 10 kGy sampai 50 kGy dengan laju dosis 7 kGy/j dibandingkan dengan film yang tidak diiradiasi sebagai kontrol. Karakterisasi film kitosan dilakukan dengan Fourier Transform Infra Red spectroscopy (FTIR) untuk mempelajari perubahan derajat deasetilasi (DD) kitosan. Sifat mekanik dan perubahan warna film kitosan diinvestigasi menggunakan instron meter dan chromameter. Hasil evaluasi menunjukkan bahwa DD, perpanjangan putus, dan tegangan putus film kitosan cenderung menurun dengan meningkatnya dosis iradiasi yang disertai perubahan warna. Hal ini menunjukkan bahwa iradiasi gamma dapat digunakan sebagai cara alternatif untuk mengontrol berat molekul kitosan selain dengan reaksi enzimatis. 
PEMBUATAN KOMPOSIT POLIKAPROLAKTON-KITOSAN-HIDROKSIAPATIT IRADIASI UNTUK APLIKASI BIOMATERIAL[Preparation of Irradiated Polycaprolactone-Chitosan-Hydroxyapatite for Biomaterial Application] Warastuti, Yessy; Abbas, Basril; Suryani, Nani
Metalurgi Vol 28, No 2 (2013): Metalurgi Vol.28 No.2 Agustus 2013
Publisher : Pusat Penelitian Metalurgi dan Material - LIPI

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (659.921 KB) | DOI: 10.14203/metalurgi.v28i2.256

Abstract

PEMBUATAN KOMPOSIT POLIKAPROLAKTON-KITOSAN-HIDROKSIAPATIT IRADIASI UNTUK APLIKASI BIOMATERIAL. Biokompatibel komposit polikaprolakton-kitosan-hidroksiapatit dengan berbagai komposisi telah dibuat menggunakan pelarut asam asetat glasial dan menggunakan metode film casting pada suhu kamar. Dilakukan proses iradiasi dengan mesin berkas elektron pada dosis 10-50 kGy. Membran komposit tersebut diuji kemampuannya untuk mengabsorpsi air, uji sifat mekanik, identifikasi gugus fungsi dengan fourier transform infra red spectroscopy (FTIR) dan analisa pola difraksi dengan x-ray diffraction (XRD). Uji absorpsi air menunjukkan peningkatan seiring dengan bertambahnya konsentrasi kitosan dan hidroksiapatit karena sifat hidrofilisitas dari keduanya. Uji sifat mekanik menunjukkan kenaikan nilai kekuatan tarik maksimum dan penurunan elongasi seiring dengan kenaikan dosis iradiasi. Pita serapan FTIR dari membran komposit I - IV menunjukkan gabungan puncak-puncak yang khas dari bahan penyusunnya. Analisa pola difraksi dengan XRD menunjukkan tidak teramatinya perubahan struktur kristal pada membran komposit. Penelitian ini menghasilkan komposisi membran yang prospektif untuk dikembangkan lebih lanjut sebagai bahan biomaterial untuk aplikasi klinis. AbstractBiocompatible polycaprolactone-chitosan-hydroxyapatite composite with various composition were preparedusing glacial acetic acid solvent and film casting method at room temperature. Irradiation process was doneusing electron beam machine at the dose of 10-50 kGy. These membranes were investigated for its ability toabsorp water, mechanical properties, identification of functional group with fourier transform infra redspectroscopy (FTIR) and diffraction pattern analysis with x-ray diffraction (XRD). Water absorptionincreased with the increasing of chitosan and hydroxyapatite because of their hidrophilicity. Mechanicalproperties test shows the increased of tensile strength and decreased of elongation as the irradiation dose rises.FTIR absorbed bands composite membrane I to IV shows association of specific peaks of polycaprolactone,chitosan and hydroxyapatite. Diffraction pattern analysis by using XRD shows unchanged of crystalstructures in composite membranes. The results of this study show the composition of membranes isprospective for the further development of biomaterial for clinical application.
Effect of coral Goniopora Sp scaffold application on human osteoblast-like MG-63 cell activity in vitro Julia, Vera; Abbas, Basril; Bachtiar, Endang W; Latief, Benny S; Kuijpers-Jagtman, Anne M
Makara Journal of Health Research Vol. 23, No. 2
Publisher : UI Scholars Hub

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Abstract

Background: Coral is an osteo-conductive biomaterial that can act as an alternative scaffold for osteogenesis. In this in vitro study we analyzed the activity of osteoblast-like cells after treatment with the coral Goniopora. Methods: Human osteoblast-like MG-63 cells were incubated in α-minimal essential medium supplemented with 10% fetal bovine serum and 300 ng/mL amphotericin B plus 1% penicillin-streptomycin and stored in a 5% CO2 incubator at 37°C. The Goniopora were smashed into size A (20 mesh), B (1–2 mm), and C (200 mesh) particles, sterilized using gamma radiation and applied to cells. Protein and alkaline phosphatase (ALP) concentrations were evaluated after incubation for 24 and 48 h. Results: The protein assay of 24 h and 48 h cultured osteoblasts illustrated that treated cells, whether with coral size A, B and C exhibited a lower mean value compared to the untreated cells. For ALP levels there were statistically significant differences at 48 h between B and C (p = 0.004), and A and C (p = 0.09). Conclusions: No significant differences in total protein concentrations were found among all groups after 24 and 48 h. Smaller coral size and longer incubation time tended to facilitate osteogenesis. These results require further empirical validation.
Polyvinyl alcohol–collagen–hydroxyapatite composite membrane derived from Lates calcarifer for alveolar socket preservation Ariesanti, Yessy; Dewi, Imanda Vyatri; Abbas, Basril
Majalah Kedokteran Gigi Indonesia Vol 11, No 3 (2025): December
Publisher : Faculty of Dentistry, Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/majkedgiind.106147

Abstract

Alveolar socket preservation (ASP) requires an ideal barrier membrane that provides anti-bacterial activity, water contact angle (WCA) and swelling behavior to support bone regeneration. This study evaluated these characteristics in a Polyvinyl Alcohol-Collagen-Hydroxyapatite composite membranes derived from the scales of Lates calcarifer.L. The PVA-Col-HA CM was produced from the scales of Lates calcarifer through mixing, homogenization, casting, and drying and then divided into three groups: non-irradiated, 15 kGy irradiation, and 25 kGy irradiation. Antibacterial activity was assessed by disk-diffusion test and inhibition zone diameters were measured. Water contact angle was determined using a contact angle goniometer on both membrane surfaces. Swelling behavior was evaluated by immersing samples in phosphate-buffered saline for 60 minutes, followed by periodic weighing and calculation using a swelling formula. The anti-bacterial activity test showed a larger zone of inhibition in the 25 kGy group by 2mm on Escherichia coli and Staphylococcus aureus. One-way ANOVA test of WCA values showed significant differences (p < 0.05) among groups, with the 25 kGy group exhibiting the highest hydrophilicity. Analysis of swelling behavior using ANOVA and Kruskal-wallis test showed no significant differences (p > 0.05) among groups, but the linear graph shows that the 25kGy group displayed the lowest and most stable swelling profile. These findings suggest that the PVA-Col-HA CM exhibited favorable anti-bacterial activity, WCA, and swelling behavior, with optimal performance observed in the 25 kGy irradiation group.
Co-Authors Ariesanti, Yessy Benny S Latief Deswita Deswita Dewi, Imanda Vyatri Emil Budianto Endang W Bachtiar Erizal Erizal Kuijpers-Jagtman, Anne M Nani Suryani Sembiring, Rinawati Vera Julia Yessy Warastuti