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All Journal Jurnal Riset Kesehatan Biology, Medicine, & Natural Product Chemistry GANEC SWARA Bioscientist : Jurnal Ilmiah Biologi Nutriology: Jurnal Pangan, Gizi, Kesehatan ADMA: Jurnal Pengabdian dan Pemberdayaan Masyarakat Jurnal Kolaboratif Sains JAPI: Jurnal Akses Pengabdian Indonesia Alamtana
Sukanty, Ni Made Wiasty
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Journal : GANEC SWARA

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PROTEIN RAS-LIKE PROTEINS FROM RAT BRAIN SEBAGAI TARGET PENGHAMBATAN PERKEMBANGAN SEL KANKER SUKANTY, NI MADE WIASTY; SAPUTRA, I PUTU BAYU AGUS; ARIANI, FARIDA; YUNITA, LINA; DEWI, NOVIANTI TYSMALA
GANEC SWARA Vol 17, No 4 (2023): Desember 2023
Publisher : Universitas Mahasaraswati K. Mataram

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35327/gara.v17i4.661

Abstract

Ras-like proteins from rat brain (Rab) is one of the crucial proteins in the process of intracellular transport. Rab plays a role in delivering vesicles from the donor membrane to the acceptor membrane. Vesicles contain various molecules that are important in cell growth and development. These molecules are generally involved in some signaling pathways. In carrying out its functions, Rab needs to be activated first. The activation process of Rab involves various proteins. Thus, Rab activation and deactivation control are critical to regulating the movement of the transferred molecules. In cancer, there is an uncontrolled activation and deactivation of Rab. Rab's involvement in various signaling pathways by providing molecules needed for growth and development is a basis for increasing the speed of growth and development of cancer cells. Although Rab is not the main factor causing cancer, it can help the development of cancer. So, it can be one of the keys to controlling the transfer of molecules involved in the growth and development of cancer cells. There are several methods related to the activation of Rab for molecular transport. Rab activation inhibition by Rab inhibitors and inhibitors of Rab activating proteins and the use of miRNAs can prevent molecule transport. Thus, control of Rab activation can be an alternative to suppress the growth and development of cancer cells.
EFEKTIVITAS EKSTRAK ETANOL TAUGE (VIGNA RADIATA) DALAM MENINGKATKAN KADAR GLUTATION PEROKSIDASE PADA TIKUS PUTIH (RATTUS NORVEGICUS) YANG DIINDUKSI TOLUENA SUKANTY, NI MADE WIASTY; SAPUTRA, I PUTU BAYU AGUS
GANEC SWARA Vol 17, No 4 (2023): Desember 2023
Publisher : Universitas Mahasaraswati K. Mataram

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35327/gara.v17i4.673

Abstract

Toluene is an industrial volatile compound that is easily inhalable. Excessive exposure to toluene causes health problems because it can increase ROS and cause oxidative stress. Bean sprouts are a plant rich in antioxidants to ward off ROS. The known effectiveness of bean sprout ethanol in increasing antioxidants is uncertain. This study aims to determine the potency of ethanol extract from bean sprouts in increasing the GPX antioxidant levels of white rats induced by toluene. The sample consisted of 30 mice divided into groups K-, K+, P1, P2, and P3. Ethanol extract of bean sprouts is given orally at a dose of 50 mg/200 g BW (P1), 100 mg/200 g BW (P2), and 200 mg/200 g BW (P3) in samples that have been induced before by 0.2 mL toluene/200 g BB for 30 days. MDA and GPX levels were measured using ELISA and tested statistically using the One Way Anova test with α = 0.05. The test results showed that there were no significant differences in MDA levels in all groups (p > 0.05), and there were outstanding differences in GPX levels between the K+ and K- groups (p = 0.001) and P2 (p = 0.009). Based on these results, administering ethanol extract of bean sprouts at 100 mg/200 g BW can increase GPX levels in rats induced by toluene.
Co-Authors Aditya, I Ketut Agus Yura Anggriany, Nissa ANISAH Anisah Anwariah, Jukhairiatun Ariki, Iptan Astawan, Wanda Januar Azani, Anggun Sukma DarmaIsasih, Widani Defel Septian Dewi, Novianti Tysmala Dewi, Novianty Tysmala Erna Sari, Erna Falindri, Jumania Farida Ariani Febriani, Esya Mariska I Putu Bayu Agus Saputra Jauhari, M. Thonthowi Laksmi Nur Fajriani Naktiany, Wayan Canny Novia Zuriatun Solehah Putri, Baiq Amelia Eka Helvyana Putri, Dea Pratiwi Silpia Rahmiati, Baiq Fitria Santika, I Gede Panji Siti Ulfatun Najiyyah, Siti Ulfatun Utami, Syintia Widani Darma Isasih Yunita, Lina