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All Journal Jurnal Biologi Tropis Cendana Medical Journal
Damanik, Efrisca M. Br.
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Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Health Professions Immunology & microbiology Medicine & Pharmacology Public Health

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Effect of Bay Leaf Extract (Syzygium polyanthum) on The Histopathological Appearance of Large Intestine of White Rats (Rattus novergicus) Induced by Ibuprofen Balbesi, Patrick David Altissimo; Damanik, Efrisca M. Br.; Koamesah, Sangguana Marthen Jacobus; Hutasoit, Regina M.
Jurnal Biologi Tropis Vol. 26 No. 1 (2026): Januari-Maret
Publisher : Biology Education Study Program, Faculty of Teacher Training and Education, University of Mataram, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29303/jbt.v26i1.11206

Abstract

Nonsteroidal anti-inflammatory drugs (NSAIDs), particularly Ibuprofen, are widely used for their analgesic and anti-inflammatory properties. However, irrational or prolonged use may lead to gastrointestinal injury, including NSAID-induced colitis, due to the inhibition of protective prostaglandins in the mucosa. Syzygium polyanthum (bay leaf) extract contains flavonoids, tannins, saponins, and essential oils with antioxidant and anti-inflammatory properties, making it a potential agent for improving mucosal damage in the colon. Objective to determine the effect of bay leaf (Syzygium polyanthum) extract on the histopathological features of the colon in Sprague Dawley rats induced with Ibuprofen. This study was an experimental laboratory research using a posttest-only control group design. Thirty male Sprague Histopathological assessment of the colon was performed across five fields of view using the scoring system. Data were analyzed using the Kruskal–Wallis test followed by the Mann–Whitney test. The positive control group exhibited severe mucosal damage with extensive epithelial erosion and inflammatory infiltration. The P1 group (50 mg/kgBW) showed moderate improvements, while the P2 group (150 mg/kgBW) demonstrated reduced inflammation and ulceration. The highest dose group, P3 (250 mg/kgBW), showed the most prominent mucosal recovery, with significantly milder lesions compared to other groups. Bay leaf extract significantly improves the histopathological condition of the colon in Ibuprofen-induced rats. Higher doses of the extract result in better mucosal healing and reduced tissue damage.
Effect of Bay Leaf Extract (Syzygium polyanthum) on Renal Histopathology in Ibuprofen-Induced White Rats (Rattus norvegicus) Butar, Angel Tiurma; Damanik, Efrisca M. Br.; Hutasoit, Regina M.; Dean, Muhajirin
Jurnal Biologi Tropis Vol. 26 No. 1 (2026): Januari-Maret
Publisher : Biology Education Study Program, Faculty of Teacher Training and Education, University of Mataram, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29303/jbt.v26i1.11217

Abstract

Excessive use of nonsteroidal anti-inflammatory drugs (NSAIDs), especially ibuprofen, can cause Acute Kidney Injury (AKI) through oxidative stress and prostaglandin inhibition. Syzygium polyanthum leaves contain bioactive compounds such as flavonoids and tannins, which have antioxidant and antiinflammatory properties that may protect the kidneys. This study aimed to evaluate the nephroprotective effect and determine the optimal dose of ethanol extract of Syzygium polyanthum leaves on ibuprofeninduced renal damage in rats. Thirty-six male Sprague Dawley rats were divided into six groups: Negative Control (K-), Acute Positive Control (K+A), Recovery Positive Control (K+B), and three treatment groups (P1, P2, P3). Kidney damage was assessed using the EGTI scoring system (Endothelial, Glomerular, Tubular, Interstitial). Data were analyzed with the Kruskal-Wallis test followed by Dunn’s Post Hoc test. The analysis revealed significant differences in renal damage scores among the groups. The acute positive control group exhibited the highest level of renal injury. Among the treatment groups, the 150 mg/kgBW dose (P2) demonstrated the most optimal improvement, even exceeding spontaneous recovery. At the highest dose (P3), the protective effect did not increase and instead showed a tendency toward reduced efficacy, reflecting a hormetic phenomenon. The ethanol extract of Syzygium polyanthum leaves exerts significant nephroprotective effects against ibuprofen-induced histopathological damage to the renal epithelium, tubules, glomeruli, and interstitial tissue, with an optimal dose of 150 mg/kgBW.
Co-Authors Anita Lidesna Shinta Amat Balbesi, Patrick David Altissimo Bessie, Vinsensius Apolonaris Buntoro, Ika F. Butar, Angel Tiurma Dewanti, Intan Putri Go, Dinsella Handoyo, Nicholas E. Hutasoit, Regina M. Ika Febianti Buntoro Jojor Sihotang Kareri, Dyah Gita Rambu Koamesah, Sangguana Marthen Jacobus Liu, Cynthia Candra Dinawati Lokat, Rambu Bangi Masu, Vinsensius Idelfonsus Fence Nababan, Ezra Harun Florentino Nicholas Edwin Handoyo Nurina, Rr. Listyawati PAKAN, PRISCA DEVIANI Pratiwi, Lingga M. Qurrota’ayun, Aisyah Rante, Su Djie To Rante Riwu, Magdarita Sare, Maria Claudya Nere Sasputra, I Nyoman Setianingrum, Elisabeth Levina Sari Sunbanu, Vanda Melinda Sunbanu Melinda Woda, Rahel Rara