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All Journal Narra J Media Dermato-Venereologica Indonesiana Journal of General Procedural Dermatology and Venereology Indonesia
Irawan, Yudo
Unknown Affiliation
Biochemistry, Genetics & Molecular Biology Health Professions Immunology & microbiology Medicine & Pharmacology Public Health

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Biomarkers for diagnosis, disease progression, and therapeutic response in psoriasis vulgaris: A mini-review Edwar, Sarah Q.; Irawan, Yudo; Budianti, Windy K.; Novianto, Endi; Fitri, Eyleny M.
Narra J Vol. 6 No. 1 (2026): April 2026
Publisher : Narra Sains Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52225/narra.v6i1.3017

Abstract

Psoriasis vulgaris is a chronic immune-mediated inflammatory disease with substantial clinical, psychosocial, and public health impact. Despite advances in therapeutic options, disease management continues to rely predominantly on clinical assessment, which remains limited in its ability to detect early disease, quantify subclinical inflammation, monitor disease progression, and anticipate long-term outcomes. These limitations are further compounded by marked interindividual heterogeneity in disease course, systemic inflammatory burden, comorbidity risk, and treatment response. Although a growing body of research has identified numerous candidate biomarkers related to genetic susceptibility, epidermal pathology, immune activation, and systemic inflammation, their clinical relevance and integration into routine practice remain unclear. A comprehensive synthesis that bridges molecular biomarkers with clinically meaningful applications is therefore needed. This review critically examines the current landscape of biomarkers in psoriasis vulgaris and explores their potential roles in diagnosis, assessment of disease progression, and prediction of therapeutic response. This review discusses genetic biomarkers associated with disease susceptibility and immune pathway regulation, tissue-associated biomarkers reflecting epidermal dysfunction and local inflammatory activity, and soluble biomarkers indicative of systemic inflammation and metabolic dysregulation. By organizing existing evidence across these biomarker domains, this review seeks to highlight conceptual frameworks, unresolved challenges, and future directions for biomarker-informed psoriasis management.
Co-Authors Adisasmito, Ayutika Saraswati Anggraini, Ika Azizah, Anggita Nur Bianti, Marsha Budianti, Windy K. Chelsea, Edelyne Edwar, Sarah Q. Endi Novianto Fitri, Eyleny M. Halim, Melissa Hanny Nilasari Krisanti, Roro Inge Ade Lili Legiawati Marissa, Melani Menaldi, Sri Linuwih SW Natasha, Joanne Nur Azizah, Anggita Rahadi Rihatmadja Santoso, Irene Dorthy SD, Emmy Soedarmi Shannaz Nadia Yusharyahya Sirait, Sondang Panjaitan Sjamsoe, Emmy Soedarmi Sri Adi Sularsito Sri L. Menaldi Windy Keumala Budianti Wresti Indriatmi B. Makes Yolanda, Lisda Zoulba, Erika