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All Journal journal of internal medicine E-Jurnal Medika Udayana ISM (Intisari Sains Medis) : Jurnal Kedokteran Bali Dermatology and Venereology Journal Essential: Essence of Scientific Medical Journal Bali Dermatology Venereology and Aesthetic Journal
Made Swastika Adiguna
Dermatology And Venereology Departement, Faculty Of Medicine, Universitas Udayana, Sanglah General Hospital Denpasar, Bali, Indonesia
Biochemistry, Genetics & Molecular Biology Health Professions Immunology & microbiology Medicine & Pharmacology Neuroscience Public Health

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Positive correlation of psoriasis vulgaris severity and HOMA-IR Made Wardhana; Made Swastika Adiguna; Putu Ayu Diah Nareswari
Bali Dermatology Venereology and Aesthetic Journal BDVJ - Vol. 2 No. 1 (June 2019)
Publisher : Explorer Front

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.51559/0x8dn445

Abstract

Background: Psoriasis vulgaris is a chronic inflammatory skin disease that its aetiology is still not completely known. A chronic inflammation in psoriasis can cause organ dysfunctions. Elevation of proinflammatory cytokines gives rise to insulin resistance by inhibiting insulin and glucose transport mechanism signals. Insulin resistance is the underlying pathogenesis of metabolic syndrome. Objective: This study aimed to undestand any correlation in the severity of psoriasis vulgaris with HOMA-IR. Methods: A cross sectional research involving 35 subjects with psoriasis vulgaris and 15 subjects without who met the selection criteria. HOMA-IR is a formula used to measure insulin resistance which calculates the fasting insulin value in μU/ml x fasting glucose in mg/DL/405 taken from the blood veins of subjects. PASI score was used to determine psoriasis vulgaris severity. Results: This study shows that the HOMA-IR median value was higher in psoriasis subject than the subjects without psoriasis (p<0.05). The correlaton analysis shows a moderate positive correlation between psoriasis vulgaris severity and HOMA-IR (r= 0.427; p<0.05). The prevalence ratio was 8.57, which means psoriasis vulgaris subjects were 8.57 times more likely to have HOMA-IR compared to those without psoriasis vulgaris (p<0.05; 95%CI: 1.26-58.1). Conclusion: This study concludes that there is a moderate positive correlation between severity of psoriasis vulgaris and HOMA-IR values.
Negative correlation between interleukin-2 (IL-2) serum with bacterial index in leprosy Patricia Dian Putri; Luh Made Mas Rusyati; Made Swastika Adiguna
Bali Dermatology Venereology and Aesthetic Journal BDVJ - Vol. 3 No. 1 (June 2020)
Publisher : Explorer Front

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.51559/zngnct18

Abstract

Background: Leprosy is strongly influenced by the host immunity response. One of the cytokines that play a role in cellular immunity is IL-2. IL-2 will stimulate macrophages to activate phagocytosis and form granulomas, and this occurs in the leprosy tuberculoid type. Aim of this study was to verify the IL-2 serum levels are negatively correlated or not with bacterial index in leprosy. Methods: This study was a cross-sectional observational analytic study involving 50 leprosy subjects (41 MB and 9 PB types). Study was conducted at Dermatolovenerology Polyclinic of Sanglah General Hospital from December 2019 to March 2020. Ridley’s scale was used to determine bacterial index (BI). IL-2 serum levels were measured by ELISA. Result: The mean of IL-2 serum in PB was 75.53±10.32 pg/mL and in MB was 37.59±17.13 pg/mL. Strong negative correlation (r= -0.67; p<0.001) between serum IL-2 levels with bacterial index (CI 95%= 25.96–49.93; p<0.001) was found. Every 1 pg/mL increase in IL-2 serum levels will be accompanied by a decrease in the bacterial index of 0.039 and vice versa. Determinant coefficient shows that 42.2% of the BI is affected by the IL-2 serum levels. Low IL-2 serum levels were the risk factor of high BI 2.8 times (PR= 2.8; CI 95%= 1.444–5.519; p<0.001). Conclusion: IL-2 serum levels were found to be higher in PB than MB. There was a negative correlation between IL-2 serum levels with bacterial index. Low IL-2 serum levels were the risk factor of a high bacterial index in leprosy patients.
Co-Authors Agung Bagus S. Satyarsa Ermon Naftali Limbara Ermon Naftali Limbara Fresa Nathania Rahardjo Fresa Nathania Rahardjo I Gusti Ayu Agung Dwi Karmila I Gusti Ayu Agung Elis Indira I Gusti Ayu Tika Indriani Indra Teguh Wiryo Indra Teguh Wiryo Jason Jonathan Joanne Roxanne Ketut Suryana Limbara, Ermon Naftali Luh Made Mas Rusyati Made Wardhana Nareswari, Putu Ayu Diah Ni Made Dwi Puspawati Ni Putu Candra Nirmalasari P Nyoman Suryawati Patricia Dian Putri Prima Saraswati Sanjiwani Sudarsa Putri, Patricia Dian Putu Ayu Diah Nareswari Putu Ayu Diah Nareswari Rahardjo, Fresa Nathania Velava Kumar Gopal Wiryo, Indra Teguh