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All Journal journal of internal medicine E-Jurnal Medika Udayana ISM (Intisari Sains Medis) : Jurnal Kedokteran Bali Dermatology and Venereology Journal Essential: Essence of Scientific Medical Journal Bali Dermatology Venereology and Aesthetic Journal
Made Swastika Adiguna
Dermatology And Venereology Departement, Faculty Of Medicine, Universitas Udayana, Sanglah General Hospital Denpasar, Bali, Indonesia
Biochemistry, Genetics & Molecular Biology Health Professions Immunology & microbiology Medicine & Pharmacology Neuroscience Public Health

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Positive correlation between psoriasis vulgaris severity degree with HbA1C level Made Swastika Adiguna; Made Wardhana; Fresa Nathania Rahardjo
Bali Dermatology and Venereology Journal Vol. 1 No. 2 (2018)
Publisher : DiscoverSys Inc

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15562/bdv.v1i2.11

Abstract

Introduction: Psoriasis is a skin abnormality based on chronic inflammation immune mediated. Inflammatory mediator roles (Th-1, TNF-α, IL-6,IL-7, IL-8, IL-17, and IL-23) in its pathogenesis proven to inhibit insulin receptor and glucose uptake from fat tissue and causing insulin resistance, then blood glucose level increased. Mean blood glucose level within 3 months can be represented by HbA1c (glycosylated haemoglobin) level. HbA1c is a bond between glucose and hemoglobin.           Objective: The aim of this study is to understanding correlation between psoriasis vulgaris severity degree with HbA1c.Material and methods: This study is using cross sectional method. HbA1c level examination done by drawing venous blood, then analyzed with chromatography method. Samples were selected by using inclusion and exclusion criteria and consecutive sampling method.Result: Study result shows subject consist of total 51 subjects consists of 33 subjects with psoriasis vulgaris (22 males and 11 females with youngest age of 15 and oldest age of 65 years old), and 18 subjects without psoriasis vulgaris. Psoriasis vulgaris severity degree measured with Psoriasis Area Severity Index (PASI), then grouped to 3 categories: mild PASI score <6, moderate PASI score  6 – 12, and severe PASI score> 12. Mostly  (15 subjects) including mild category. HbA1c level on this study subjects resulted minimum level of 4.6%, maximum 12.1 %, and median 5.4%.  Based on Perkeni consensus, normal HbA1c level is <5,7%, prediabetes 5,7-6,4%, and diabetes >6,5%. HbA1c level of psoriasis vulgaris subjects are higher than non psoriasis vulgaris subjects significantly (p=0,019). Psoriasis vulgaris causing increase of HbA1c level with Prevalence Ratio (PR) 6,55. Thus, Psoriasis vulgaris subjects have increased risk 6,5 times to increase HbA1c level compared with non psoriasis vulgaris subjects. Correlation between severity degree and HbA1c level found in positive course significantly with moderate strength of correlation (Spearman correlation; r = 0.580, p<0,001).Conclusion: HbA1c level on psoriasis vulgaris subjects are higher than non psoriasis vulgaris, and psoriasis vulgaris severity degree positively correlated with HbA1c increasing level. Every increase of  psoriasis vulgaris severity degree will cause increase level of  HbA1c.
Low plasma level of insulin-like growth factor-I (IGF-I) is a risk factor for multibacillary type of leprosy Luh Mas Rusyati; Made Swastika Adiguna; Indra Teguh Wiryo
Bali Dermatology and Venereology Journal Vol. 1 No. 2 (2018)
Publisher : DiscoverSys Inc

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15562/bdv.v1i2.12

Abstract

Introduction: Leprosy is one of infectious diseases with complex issues. Previous study showed poverty, malnutrition, lack of proper food and nutrient intake, as well as low income. Recently, many studies reported insulin-like growth factor-I (IGF-I) as excellent nutrient marker.Objective: This study aims to prove that low plasma level of insulin-like growth factor-I is a risk factor for multibacillary type of leprosy. Material and methods: This case-control study design involved 38 patients with leprosy subjects as cases and 38 control subjects. The sample collection is done by consecutive sampling and has fulfilled the inclusion and exclusion criteria which matched by age and gender in Dermatology and Venereology Outpatient clinic of Sanglah General Hosptital. The collected data was analyzed using SPSS version 23.0 with Pearson Chi square test to obtain Odds Ratio. Results: This study showed that IGF-I plasma levels in the case group were significantly lower than the control group (p<0.05) with Odds ratio for IGF-I plasma 34.61 (95% CI= 7.17-167.01, p<0.001)Conclusion: Low plasma level of insulin-like growth factor-I is a risk factor for multibacillary type of leprosy.
High plasma dopamine level as a risk factor for atopic dermatitis Made Swastika Adiguna; Made Wardhana; Ermon Naftali Limbara
Bali Dermatology and Venereology Journal Vol. 2 No. 1 (2019)
Publisher : DiscoverSys Inc

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15562/bdv.v2i1.15

Abstract

Background: Dopamine is responsible for inflammatory response and plays a role in the skin immune system by modulating T-cells, dendritic cells, and keratinocytes which increases skin inflammatory response in atopic dermatitis (AD). Elevation of dopamine level will affect IL-6, IL-8, IL-23, Th-17, and TNF-α, which promotes keratinocyte proliferation and differentiation, infiltration of inflammatory cells, angiogenesis, vasodilation, and skin barrier disruption on AD.Objective: This study aimed to establish whether the increase of plasma dopamine level contributes to a risk factor for AD occurrence.Methods: This is a matched-pair case-control observational analytical study which involves patients with AD and without AD as control. Samples were taken using a consecutive sampling method which fulfilled inclusion and exclusion criteria, matched for gender and age. Plasma dopamine level was measured from venous blood and processed using enzyme-linked immunosorbent assay (ELISA) method. The collected data were then analysed using SPSS version 20.0 with Pearson chi-square test for the odds ratio.Results: A total of 30 samples with AD (case group) and 30 samples without AD (control group) involved in this study. This study proves that plasma dopamine levels in the case group were significantly higher than the control group (p<0.05). Odds ratio for plasma dopamine was 42.2 (95%CI: 9.5-187.2, p < 0.001).Conclusion: This study concludes that high plasma dopamine level is a risk factor for AD.
Positive correlation of psoriasis vulgaris severity and HOMA-IR Made Wardhana; Made Swastika Adiguna; Putu Ayu Diah Nareswari
Bali Dermatology and Venereology Journal Vol. 2 No. 1 (2019)
Publisher : DiscoverSys Inc

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15562/bdv.v2i1.18

Abstract

Background: Psoriasis vulgaris is a chronic inflammatory skin disease that its aetiology is still not completely known. A chronic inflammation in psoriasis can cause organ dysfunctions. Elevation of proinflammatory cytokines gives rise to insulin resistance by inhibiting insulin and glucose transport mechanism signals. Insulin resistance is the underlying pathogenesis of metabolic syndrome.Objective: This study aimed to undestand any correlation in the severity of psoriasis vulgaris with HOMA-IR.Methods: A cross sectional research involving 35 subjects with psoriasis vulgaris and 15 subjects without who met the selection criteria. HOMA-IR is a formula used to measure insulin resistance which calculates the fasting insulin value in μU/ml x fasting glucose in mg/DL/405 taken from the blood veins of subjects. PASI score was used to determine psoriasis vulgaris severity.Results: This study shows that the HOMA-IR median value was higher in psoriasis subject than the subjects without psoriasis (p<0.05). The correlaton analysis shows a moderate positive correlation between psoriasis vulgaris severity and HOMA-IR (r= 0.427; p<0.05). The prevalence ratio was 8.57, which means psoriasis vulgaris subjects were 8.57 times more likely to have HOMA-IR compared to those without psoriasis vulgaris (p<0.05; 95%CI: 1.26-58.1).Conclusion: This study concludes that there is a moderate positive correlation between severity of psoriasis vulgaris and HOMA-IR values.
Negative correlation between interleukin-2 (IL-2) serum with bacterial index in leprosy Patricia Dian Putri; Luh Made Mas Rusyati; Made Swastika Adiguna
Bali Dermatology and Venereology Journal Vol. 3 No. 1 (2020)
Publisher : DiscoverSys Inc

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15562/bdv.v3i1.34

Abstract

Background: Leprosy is strongly influenced by the host immunity response. One of the cytokines that play a role in cellular immunity is IL-2. IL-2 will stimulate macrophages to activate phagocytosis and form granulomas, and this occurs in the tuberculoid type of leprosy.Objective: Aim of this study was to verify the IL-2 serum levels are negatively correlated or not with bacterial index in leprosy.Methods: This study was a cross-sectional observational analytic study involving 50 leprosy subjects (41 MB and 9 PB types). Study was conducted at Dermatolovenerology Polyclinic of Sanglah General Hospital from December 2019 to March 2020. Sample was taken using a consecutive sampling method. IL-2 serum levels were measured by ELISA. Result: The mean of IL-2 serum in PB was 75.53±10.32 pg/mL and in MB was 37.59±17.13 pg/mL. Strong negative correlation (r= -0.67; p<0.001) between serum IL-2 levels with bacterial index (CI 95%= 25.96–49.93; p<0.001) was found. Every 1 pg/mL increase in IL-2 serum levels will be accompanied by a decrease in the bacterial index of 0.039 and vice versa. Determinant coefficient shows that 42.2% of bacterial index affected by the IL-2 serum levels. Low IL-2 serum levels were the risk factor of high bacterial index 2.8 times (PR= 2.8; CI 95%= 1.444–5.519; p<0.001).Conclusion: IL-2 serum levels were found to be higher in PB than MB. There was a negative correlation between IL-2 serum levels with bacterial index. Low IL-2 serum levels were the risk factor of a high bacterial index in leprosy patients.
The characteristic of tinea capitis in children among dermato-venereology outpatients’ polyclinic at Sanglah General Hospital, Denpasar from 2014-2017: a preliminary study Velava Kumar Gopal; Made Swastika Adiguna; Prima Sanjiwani Saraswati Sudarsa
Intisari Sains Medis Vol. 10 No. 3 (2019): (Available online: 1 December 2019)
Publisher : DiscoverSys Inc.

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (536.078 KB) | DOI: 10.15562/ism.v10i3.462

Abstract

Background: Tinea capitis is a type of dermatophytosis (skin disease) caused by the infection of dermatophytes. It is generally caused by the dermatophyte species of Microsporum and Trichophyton. It has been known to be able to spread human to human and animal to human. It is also almost commonly found in the prepubertal age and very rare among the adults of either gender. This study aims to determine the prevalence of Tinea capitis in children by age, sex, clinical manifestation, laboratory tests, and treatments.Methods: A cross-sectional observational study from the medical records of patients with Tinea capitis was conducted at Dermato-Venereology Outpatient Clinic RSUP Sanglah from 2014 to 2017. A total of 5 research variables were identified for this study: age, sex, clinical manifestation, laboratory tests, and treatment. The data was then analyzed and interpreted and further presented in forms of description, tables and graphs in this study by using SPSS version 17 for WindowsResults: A total of 32 patients were identified as having Tinea capitis from the period of 2014–2017. There was a slightly higher prevalence in the male gender (56.25%) compared with female gender (43.75%). The highest prevalence of the disease was found in the age groups of 1 – 5 and 6 – 10 years old with 43.75% respectively. Majority of the patients showed the presence of grey patch on their scalp on examination (53.13%). The dermatophyte Trichophyton rubrum had the highest isolation in comparison with other dermatophytes at 25.00%. The patients were almost all treated with oral Griseofulvin.Conclusion: The majority diagnosis of Tinea capitis was found in group 1-5 and 6-10 years old and had a grey patch appearance, whereas Trichophyton rubrum as the highest isolation in comparison with other dermatophytes
Profil onikomikosis pada pasien lanjut usia di Rumah Sakit Umum Pusat Sanglah, Bali, Indonesia: studi retrospektif I Gusti Ayu Agung Dwi Karmila; Made Swastika Adiguna; Luh Made Mas Rusyati
Intisari Sains Medis Vol. 11 No. 1 (2020): (Available online: 1 April 2020)
Publisher : DiscoverSys Inc.

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (342.843 KB) | DOI: 10.15562/ism.v11i1.653

Abstract

Background: Fungal infections are one of the most common dermatologic conditions affecting elderly population. Elderly population is susceptible to all of the superficial mycoses such as tinea pedis, candidiasis, and onychomycosis in geriatric populations compared to other age groups.Objective:  To determine the profile of onychomycosis among elderly patients over a period of 1 years (January 2018–August 2019) at Dermatology and Venereology outpatient clinic, Sanglah General HospitalMethods:  Retrospective study was performed at Department of Dermatology and Venereology, Sanglah General Hospital, Denpasar, Bali. The data collected from patient’s register data of outpatient clinic.Result:  A total of 11 patients were diagnosed with onychomycosis, consist of 5 women and 6 men. From these, 4 (36,3%) was reported with chronic systemic diseases and 7 (63,6%) reported with no concomitant diseases. The most common clinical sign were onychodystrophy, hyperkeratotic subungual and dyschromia (6 patients, 54,54%). Potassium hydroxide examination reveal positive results in all patient. From 5 patients, on culture examination, Candida (2 patients, 40%), Trichophyton rubrum (2 patients, 40%), and Trychophyton mentagrophytes (1 patient, 20%) were found. For therapy, there were 7 patients got combination therapy (fluconazole 150 mg and ciclopirox lacquer 8%) and 4 patients with single therapy (ciclopirox lacquer 8%).Conclusion: Onychomycosis is more common in the elderly or geriatric patients, this occurs because old age can change the body's immune function, including decreased immune response to fight infections against viruses, bacteria, and fungi.  Pendahuluan: Infeksi jamur adalah salah satu kondisi dermatologis paling umum yang mempengaruhi populasi lansia. Populasi lansia rentan terhadap semua mikosis superfisial seperti tinea pedis, kandidiasis, dan onikomikosis pada populasi geriatri dibandingkan dengan kelompok usia lainnya.Tujuan:  Untuk menentukan profil onikomikosis pada pasien usia lanjut selama 1 tahun (Januari 2018 - Agustus 2019) di poliklinik rawat jalan Dermatologi dan Venereologi, Rumah Sakit Umum Pusat Sanglah.Metode:  Studi retrospektif dilakukan di Departemen Dermatologi dan Venereologi, Rumah Sakit Umum Pusat Sanglah, Denpasar, Bali. Data dikumpulkan dari data pendaftaran pasien di klinik rawat jalan.Hasil:  Sebanyak 11 pasien didiagnosis menderita onikomikosis, terdiri dari 5 wanita dan 6 pria. Dari hasil ini, sebanyak 4 orang (36,3%) dilaporkan dengan penyakit sistemik kronis dan 7 orang (63,6%) dilaporkan tanpa penyakit bersamaan. Tanda klinis yang paling umum adalah onikodistrofi, hiperkeratotik subungual dan dischromia (6 pasien, 54,54%). Pemeriksaan kalium hidroksida mengungkapkan hasil positif pada semua pasien. Dari 5 pasien pada hasil pemeriksaan kultur ditemukan adanya infeksi Candida (2 pasien, 40%), Trichophyton rubrum (2 pasien, 40%), dan Trychophyton mentagrophytes (1 pasien, 20%). Untuk penatalaksanaan, terdapat sejumlah 7 orang pasien mendapatkan terapi kombinasi (fluconazol 150 mg dan ciclopirox lacquer 8%) dan 4 orang pasien dengan terapi tunggal (ciclopirox lacquer 8%).Simpulan: Onikomikosis lebih sering terjadi pada pasien usia lanjut atau usia lanjut dimana hal ini terjadi karena usia tua dapat mengubah fungsi kekebalan tubuh, termasuk penurunan respons imun untuk melawan infeksi terhadap virus, bakteri, dan jamur.
The positive correlation between psoriasis vulgaris severity degree with HbA1C level Made Swastika Adiguna; Made Wardhana; Fresa Nathania Rahardjo
Bali Dermatology Venereology and Aesthetic Journal BDVJ - Vol. 1 No. 2 (December 2018)
Publisher : Explorer Front

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.51559/w3yp6214

Abstract

Introduction: Psoriasis is a skin abnormality based on chronic inflammation immune-mediated. Insulin resistance and psoriasis seem to have a connection, but it has not been explained clearly. HbA1c describe the glucose concentration and demonstrate the insulin resistance condition indirectly. Objective: This study aims to understand the correlation between psoriasis vulgaris severity degree with HbA1c. Material and methods: This study was using a cross sectional method. Psoriasis vulgaris diagnosed clinically and assessed with the PASI score. The HbA1c level examination done by drawing venous blood then analyzed with chromatography method. Samples were selected by using inclusion and exclusion criteria and a consecutive sampling method. Results: Total 51 subjects (33 subjects with psoriasis vulgaris and 18 subjects without psoriasis vulgaris) were included in this study. Mostly (57.6%) of the subject was mild, 24.2% moderate, and 18.2% severe psoriasis. HbA1c level of psoriasis vulgaris subjects is significantly higher than non-psoriasis vulgaris subjects (p=0.019, PR=6.545). Correlation between severity degree and HbA1c level found in positive course significantly with moderate strength of correlation (r = 0.580, p<0.001). Conclusion: HbA1c level on psoriasis vulgaris subjects are higher than non-psoriasis vulgaris. Psoriasis vulgaris severity degree positively correlated with HbA1c.
Low plasma level of insulin-like growth factor – I (IGF-I) is a risk factor for multibacillary type of leprosy Luh Made Mas Rusyati; Made Swastika Adiguna; Indra Teguh Wiryo
Bali Dermatology Venereology and Aesthetic Journal BDVJ - Vol. 1 No. 2 (December 2018)
Publisher : Explorer Front

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.51559/yk1gk812

Abstract

Introduction: Leprosy is one of infectious diseases with complex issues. The previous study showed poverty, malnutrition, lack of proper food and nutrient intake, as well as low income. Recently, many studies reported insulin-like growth factor-I (IGF-I) as an excellent nutrient marker. Objective: This study aims to prove that low plasma level of insulin-like growth factor-I is a risk factor for the multibacillary type of leprosy. Material and methods: This case-control study design involved 38 patients with leprosy subjects as cases and 38 control subjects. The sample collection is done by consecutive sampling and has fulfilled the inclusion and exclusion criteria, which matched by age and gender in Dermatovenereology Polyclinic of Sanglah Hospital. The collected data was analyzed using SPSS version 23.0 with Pearson Chi-square test to obtain the odds ratio. Results: This study showed that IGF-I plasma levels in the case group were significantly lower than the control group (p<0,05) with Odds ratio for IGF-I plasma 34,61 (95% CI= 7,17-167,01, p<0,001) Conclusion: Low plasma level of insulin-like growth factor-I is a risk factor for the multibacillary type of leprosy.
High plasma dopamine level as a risk factor for atopic dermatitis Made Swastika Adiguna; Made Wardhana; Ermon Naftali Limbara
Bali Dermatology Venereology and Aesthetic Journal BDVJ - Vol. 2 No. 1 (June 2019)
Publisher : Explorer Front

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.51559/pnkrda77

Abstract

Background: Dopamine is responsible for inflammatory response and plays a role in the skin immune system by modulating T-cells, dendritic cells, and keratinocytes which increases skin inflammatory response in atopic dermatitis (AD). Elevation of dopamine level will affect IL-6, IL-8, IL-23, Th-17, and TNF-α, which promotes keratinocyte proliferation and differentiation, infiltration of inflammatory cells, angiogenesis, vasodilation, and skin barrier disruption on AD. Objective: This study aimed to establish whether the increase of plasma dopamine level contributes to a risk factor for AD occurrence. Methods: This is a matched-pair case-control observational analytical study which involves patients with AD and without AD as control. Samples were taken using a consecutive sampling method which fulfilled inclusion and exclusion criteria, matched for gender and age. Plasma dopamine level was measured from venous blood and processed using enzyme-linked immunosorbent assay (ELISA) method. The collected data were then analysed using SPSS version 20.0 with Pearson chi-square test for the odds ratio. Results: A total of 30 samples with AD (case group) and 30 samples without AD (control group) involved in this study. This study proves that plasma dopamine levels in the case group were significantly higher than the control group (p<0.05). Odds ratio for plasma dopamine was 42.2 (95%CI: 9.5-187.2, p < 0.001). Conclusion: This study concludes that high plasma dopamine level is a risk factor for AD.
Co-Authors Agung Bagus S. Satyarsa Ermon Naftali Limbara Ermon Naftali Limbara Fresa Nathania Rahardjo Fresa Nathania Rahardjo I Gusti Ayu Agung Dwi Karmila I Gusti Ayu Agung Elis Indira I Gusti Ayu Tika Indriani Indra Teguh Wiryo Indra Teguh Wiryo Jason Jonathan Joanne Roxanne Ketut Suryana Limbara, Ermon Naftali Luh Made Mas Rusyati Made Wardhana Nareswari, Putu Ayu Diah Ni Made Dwi Puspawati Ni Putu Candra Nirmalasari P Nyoman Suryawati Patricia Dian Putri Prima Saraswati Sanjiwani Sudarsa Putri, Patricia Dian Putu Ayu Diah Nareswari Putu Ayu Diah Nareswari Rahardjo, Fresa Nathania Velava Kumar Gopal Wiryo, Indra Teguh