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All Journal Jurnal Biologi Tropis Buletin Farmatera Journal of Epidemiology and Public Health Oto Rhino Laryngologica Indonesiana International Journal of Nasopharyngeal Carcinoma eJournal Kedokteran Indonesia Kesmas: Jurnal Kesehatan Masyarakat Nasional (National Public Health Journal)
Adlin Adnan
Departemen Ilmu Kesehatan Telinga Hidung Tenggorok - Bedah Kepala Dan Leher Fakultas Kedokteran Universitas Sumatera Utara/Rumah Sakit Haji Adam Malik Medan
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Health Professions Immunology & microbiology Medicine & Pharmacology Neuroscience Public Health

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The Role of Manuka Honey in Protecting Against Cochlear Hair Cell Damage Caused by Diabetes Mellitus in Rats, Assessed Through Otoacoustic Emission Simatupang, Sholahuddin Adlan; Adnan, Adlin; Harahap, M. Pahala H.
Jurnal Biologi Tropis Vol. 25 No. 3 (2025): Juli-September
Publisher : Biology Education Study Program, Faculty of Teacher Training and Education, University of Mataram, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29303/jbt.v25i3.9599

Abstract

Diabetes mellitus is an escalating public health concern worldwide, with Indonesia being one of the countries heavily affected and facing a projected increase in cases. This condition is known to cause a range of complications, including hearing loss, which is frequently observed in diabetic individuals. This study aims to investigate the potential protective effect of honey against cochlear damage induced by diabetes mellitus. This ex-vivo experimental study applied a pretest-posttest control group design. Conducted over five months at the FMIPA USU Animal Laboratory, the study involved 25 healthy adult male Rattus norvegicus Wistar rats (150–250 grams, aged 2–3 months). The rats were divided into three treatment groups and assessed before and after honey administration on days 0, 3, 6, 9, and 12. SNR value differences were analyzed using Repeated Measures ANOVA or the Friedman test. Administration of honey at a dose of 1 g/kg body weight was more effective in preventing the decline of SNR values in diabetic rat models compared to the 2 g/kg dose. Honey demonstrates a protective effect against cochlear hair cell damage in diabetic Rattus norvegicus, as evidenced by SNR values from OAE assessments.
Gangguan Pendengaran dan Keseimbangan pada Penderita Tuberkulosis yang Mendapat Pengobatan Antituberkulosis Kategori 1 dan 2 Adriztina, Indri; Adnan, Adlin; Haryuna, Siti Hajar; Siagian, Parluhutan; Sarumpaet, Sorimuda
Kesmas Vol. 8, No. 8
Publisher : UI Scholars Hub

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Abstract

Tuberkulosis merupakan masalah yang serius di masyarakat. Pada tahun 2010, World Health Organization mencatat jumlah penderita tuberkulosis di Indonesia menurun ke posisi empat dengan meningkatnya keberhasilan pengobatan obat antituberkulosis (OAT). Namun, pemberian OAT jangka panjang dapat menyebabkan efek samping ototoksik berupa gangguan pendengaran dan keseimbangan. Penelitian ini dilakukan untuk mengetahui efek ototoksik pada penderita tuberkulosis paru dengan pemberian OAT di RSUP H. Adam Malik Medan. Penelitian ini bersifat deskriptif dengan pendekatan potong lintang. Analisis univariat dilakukan dengan tabel frekuensi distribusi sedangkan analisis bivariat dilakukan dengan menggunakan uji t dan Fisher’s exact test. Didapatkan 35 penderita tuberkulosis yang memenuhi kriteria inklusi, 22 orang dengan pengobatan tuberkulosis kategori 1 dan 13 orang tuberkulosis kategori 2. Dilakukan pemeriksaan audiometri nada murni dan tes keseimbangan. Tiga orang (33,3%) penderita tuberkulosis kategori 1 dan 6 orang (66,7%) penderita tuberkulosis kategori 2 mengalami gangguan pendengaran (p < 0,05). Hasil tes keseimbangan menunjukkan perbedaan yang signifikan yaitu 7 orang (100%) tuberkulosis kategori 2 dengan positif tes Romberg dan 11 orang (100%) tuberkulosis kategori 2 positif tes tandem Romberg. Gangguan pendengaran dan keseimbangan pada penderita tuberkulosis paru dengan OAT ditemukan lebih tinggi pada kategori 2 dibandingkan dengan kategori 1 dengan perbedaan yang signifikan. Tuberculosis remains a serious problem in the community. In 2010, World Health Organization report that Indonesia’s ranking decrease to fourth position due to success of antituberculosis treatment. But the long term administration of antituberculosis treatment may cause ototoxic effect like hearing and balance impairment. The aim of this study was to describe ototoxic effect of subjects who were given tuberculosis treatment in H. Adam Artikel Penelitian Gangguan Pendengaran dan Keseimbangan pada Penderita Tuberkulosis yang Mendapat Pengobatan Antituberkulosis Kategori 1 dan 2 Hearing and Balance Impairment in Tuberculosis Patient with Category 1st and 2nd Antituberculosis Treatment Indri Adriztina* Adlin Adnan* Siti Hajar Haryuna* Parluhutan Siagian** Sorimuda Sarumpaet*** 430 Malik General Hospital. This is a descriptive study with cross sectional approach. Univariat analysis was done by frequency distribution table, meanwhile bivariat analysis was done by t-test and Fisher’s exact test. Thirty five pulmonary tuberculosis patients met the inclusion criteria. Twenty two patients with 1st category, and 13 patients with 2nd category tuberculosis treatment. Pure tone audiometric and balance examination was evaluated. Three patients (33.3%) of 1st category tuberculosis and 6 (66.7%) patients of 2nd category tuberculosis have hearing loss with significant difference (p<0.05). Balance test showed 7 people (100%) of 2nd category tuberculosis having positive Romberg test and 11 people (100%) of 2nd category tuberculosis having positive tandem Romberg test. Hearing and balance impairment found higher in patients with 2nd category antituberculosis treatment with significantly different.
Co-Authors Abdul Rachman Saragih Andrina Yunita Murni Rambe Asnir, Rizalina A Delfitri Munir Delfitri Munir Ester Lantika Ronauli Silaen Fahat Fahat Farrel Farrel Harahap, M. Pahala H. Haryuna, Tengku Siti Hajar Hellena Miranda Iman Dwi Winanto Indri Adriztina Izry Naomi Tobing Maesyara Adinda Sari Manullang, Frenky Sorimuda Muhammad Arfiza Putra Saragih Parluhutan Siagian Putri Anggilina Manullang Putri Chairani Eyanoer, Putri Chairani Qatrunnada Medina Salim Renold Yurensa Rina Yunita Rizalina A Asnir Simatupang, Sholahuddin Adlan Siska Indriany Siti Hajar Haryuna Sorimuda Sarumpaet Tobing, Izry Naomi