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All Journal Jurnal Biologi Tropis Buletin Farmatera Oto Rhino Laryngologica Indonesiana International Journal of Nasopharyngeal Carcinoma eJournal Kedokteran Indonesia Jurnal Praba: Jurnal Rumpun Kesehatan Umum Kesmas: Jurnal Kesehatan Masyarakat Nasional (National Public Health Journal)
Adlin Adnan
Departemen Ilmu Kesehatan Telinga Hidung Tenggorok - Bedah Kepala Dan Leher Fakultas Kedokteran Universitas Sumatera Utara/Rumah Sakit Haji Adam Malik Medan
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Health Professions Immunology & microbiology Medicine & Pharmacology Neuroscience Nursing Public Health Veterinary

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The Relationship Betweem PTEN Gene Expression And Hispathological Types In Patients With Nasopharyngeal Carcinoma Aditya Rachmansyah Pinem; Farhat; Adlin Adnan; Inayyah Nur Fitry Sirajuddin
Jurnal Praba : Jurnal Rumpun Kesehatan Umum Vol. 4 No. 3 (2026): September : Jurnal Praba : Jurnal Rumpun Kesehatan Umum
Publisher : STIKES Columbia Asia Medan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.62027/praba.v4i3.962

Abstract

Background: Nasopharyngeal carcinoma (NPC) is a type of epithelial cancer arising from the nasopharyngeal mucosa, with tumors most commonly found in the fossa of Rosenmüller. NPC ranks as the fourth most prevalent cancer in Indonesia, after cervical, breast, and skin cancers. However, its exact pathogenesis remains unclear. Aims: This study aimed to determine the relationship between PTEN gene expression and histopathological types in NPC patients, and to explore its potential as a diagnostic and therapeutic target. Methods: This was an analytic study with a cross-sectional design. Samples were obtained from paraffin-embedded tissue blocks, followed by RNA isolation and synthesis. RT-PCR was subsequently performed and analyzed using a Rotor-Gene system. Statistical analysis was conducted using SPSS software. Results: Of 38 NPC patients, the majority were male (57.9%), with the most common age group being 41–60 years (71.1%). Based on histopathological type, 60.5% were diagnosed with non-keratinizing squamous cell carcinoma (SCC) and 39.5% with undifferentiated carcinoma. Statistical analysis of the relationship between PTEN expression levels and histopathological type yielded a p-value of 0.413 (p > 0.05). Conclusion: B There was no statistically significant relationship between PTEN expression levels and the histopathological type of NPC.
Co-Authors Abdul Rachman Saragih Aditya Rachmansyah Pinem Andrina Yunita Murni Rambe Asnir, Rizalina A Delfitri Munir Delfitri Munir Ester Lantika Ronauli Silaen Fahat Fahat Farhat Farrel Farrel Harahap, M. Pahala H. Haryuna, Tengku Siti Hajar Hellena Miranda Iman Dwi Winanto Inayyah Nur Fitry Sirajuddin Indri Adriztina Izry Naomi Tobing Maesyara Adinda Sari Manullang, Frenky Sorimuda Muhammad Arfiza Putra Saragih Parluhutan Siagian Putri Anggilina Manullang Putri Chairani Eyanoer, Putri Chairani Qatrunnada Medina Salim Renold Yurensa Rina Yunita Rizalina A Asnir Simatupang, Sholahuddin Adlan Siska Indriany Siti Hajar Haryuna Sorimuda Sarumpaet Tobing, Izry Naomi