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Journal : Proceeding ISETH (International Summit on Science, Technology, and Humanity)

Effectiveness of Chemopreventive and Life Style as Breast Cancer Prevention: a Literature Review Min, Diya; Alfajri, Asri; Nurul, Fika; Mugi, Virjinia; Husna, Zahira; Pradani, Ninda
Proceeding ISETH (International Summit on Science, Technology, and Humanity) 2024: Proceeding ISETH (International Summit on Science, Technology, and Humanity)
Publisher : Universitas Muhammadiyah Surakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.23917/iseth.5504

Abstract

Background: Breast cancer is the most common cancer in women worldwide, including Indonesia. Breast cancer patients have an inherited genetic predisposition, including mutations in genes such as BRCA1 and BRCA2. Breast cancer prevention can be done through various ways, such as healthy lifestyle changes, early screening, and chemopreventive. Purpose : This study aims to assess various breast cancer prevention strategies, both through chemopreventive and lifestyle modification to determine the effectiveness of each treatment. Methods: This study used the PRISMA-ScR method (Preferred Reporting Items for Systematic Reviews and Meta-Analyses extension for Scoping Reviews). Article searches were in the form of English articles relevant to the research theme with data for the last 5 years (2020-2024) and types of articles Randomized controlled trial, case control, and prospective cohort studies through PubMed, Science direct, and SpringerLink. Results: This study shows that chemopreventive, particularly low-dose tamoxifen, and lifestyle modification are promising approaches in preventing breast cancer. Low-dose tamoxifen was shown to be effective in lowering breast cancer risk with milder side effects and improved patient compliance. In addition, lifestyle modifications such as healthy diet and physical activity also play an important role in breast cancer prevention. Conclusion: The combination of chemopreventive and lifestyle modification can be a comprehensive strategy to reduce the risk of breast cancer.
Correlation of Length of Fever before Hospital Admission, Hematocrit, Platelet Count, and Leukocytes with Length of Hospitalization Dengue Virus Infection Patients in Children Pambudi, Nasrurrofiq Risvana Bayu; Puspitasari, Metana; Jatmiko, Safari Wahyu; Aisyah, Riandini; Alfajri, Asri
Proceeding ISETH (International Summit on Science, Technology, and Humanity) 2024: Proceeding ISETH (International Summit on Science, Technology, and Humanity)
Publisher : Universitas Muhammadiyah Surakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.23917/iseth.5525

Abstract

Purpose: To analyze the relationship between fever duration before admission, hematocrit, platelet count, and leukocyte count with length of hospital stay in pediatric patients with dengue infection. Methodology: This observational study with cross-sectional design was conducted at PKU Muhammadiyah Sampangan Hospital, Surakarta, using secondary data from medical records. Forty pediatric patients were selected through consecutive non-probability sampling technique. Statistical analysis was performed with Spearman correlation test using statistical applications. Results: There was a significant association between fever duration before admission and length of hospitalization (r = -0.407, p = 0.009). However, there was no significant association between hematocrit (r = 0.136, p = 0.403), platelet count (r = 0.101, p = 0.536), or leukocyte count (r = 0.111, p = 0.496) with length of hospitalization. Applications/Originality/Value: This study highlights the importance of early detection and intervention in managing pediatric dengue cases. The significant correlation found between fever duration prior to admission and length of stay underscores the need for prompt treatment to minimize hospital stay due to associated inflammation in the body. In contrast, the lack of significant associations between hematocrit, platelet count, leukocyte level and duration of hospitalization highlights the complexity of factors influencing outcomes and the need to explore other prognostic markers. This study conducted in an endemic region of Indonesia contributes to understanding the management of dengue virus infection and underscores the importance of a comprehensive multifactorial approach to improve patient care strategies.