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All Journal Jurnal Pustakawan Indonesia Jurnal Ilmu Lingkungan PREMISE LAW JURNAL Jurnal Online Mahasiswa (JOM) Bidang Ilmu Ekonomi Tadrib: Jurnal Pendidikan Agama Islam JURNAL TARBIYAH Jurnal Pendidikan Edutama Journal of English Education and Teaching (JEET) JURNAL ANSIRU PAI : Jurnal Pengembangan Profesi Guru Pendidikan Agama Islam AT-TASYRI' Jurnal Ilmiah Prodi Muamalah JDP (Jurnal Dinamika Pemerintahan) Indonesian Journal of Chemical Science and Technology INTERNATIONAL JOURNAL OF CULTURAL AND SOCIAL SCIENCE Jurnal Pustakawan Indonesia Cendekiawan: Jurnal Pendidikan dan Studi Keislaman Amkop Management Accounting Review (AMAR) Jurnal An-Najat: Jurnal Ilmu Farmasi dan Kesehatan Siyasah Wa Qanuniyah: Jurnal Ilmiah Ma'had Aly Raudhatul Ma'arif Neraca Manajemen, Akuntansi, dan Ekonomi Demagogi: Journal of Social Sciences, Economics and Education Maklumat: Journal of Da'wah and Islamic Studies Obat: Jurnal Riset Ilmu Farmasi dan Kesehatan
Muhammad Fadhli
Unknown Affiliation
Religion Humanities Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Dentistry Economics, Econometrics & Finance Education Energy Environmental Science Health Professions Languange, Linguistic, Communication & Media Law, Crime, Criminology & Criminal Justice Library & Information Science Materials Science & Nanotechnology Mechanical Engineering Nursing Public Health Social Sciences Veterinary Other

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Review Artikel: Tinjauan Aplikasi LC-MS/MS dalam Analisis Senyawa Alamiah dari Berbagai Sumber Daya Alam Muhammad Fadhli; M. Chaidir Hafidz; Hidayatur Rizky; Luthfia Raisah Ahyati; Nor Hilalliyah; Regina Nabila; Sri Muliany
An-Najat Vol. 3 No. 3 (2025): Agustus : An-Najat : Jurnal Ilmu Farmasi dan Kesehatan
Publisher : STIKes Ibnu Sina Ajibarang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.59841/an-najat.v3i3.3147

Abstract

This study provides a comprehensive review of the application of Liquid Chromatography–Tandem Mass Spectrometry (LC-MS/MS) in the analysis of various natural product sources. LC-MS/MS has emerged as one of the most reliable and sensitive instrumental techniques for the identification, characterization, and quantification of bioactive compounds. Its strength lies in the ability to detect minute quantities of analytes, even in complex matrices such as plant extracts, microorganisms, and marine organisms. Numerous studies reviewed in this research demonstrate the effectiveness of LC-MS/MS in profiling chemical constituents from natural sources. Plants such as Allium ascalonicum L., Zingiber officinale, Uncaria sclerophylla, Momordica charantia L., Artocarpus integer, Garcinia xanthochymus, Piper nigrum Linn., Pometia pinnata, and Synsepalum dulcificum have been successfully analyzed using this method. Additionally, microorganisms like Aspergillus flavus and marine organisms such as Callyspongia aerizusa have also been studied with the same approach. The identified compounds belong to several major classes of secondary metabolites, including alkaloids, flavonoids, terpenoids, and saponins. These compounds have been reported to exhibit significant biological activities such as antioxidant, antidiabetic, anticancer, antimalarial, and enzyme-inhibiting properties. The successful identification and profiling of these bioactives provide a strong scientific foundation for the development of natural product-based innovations, including herbal medicines, health supplements, natural cosmetics, and functional foods. LC-MS/MS also plays a critical role in pharmacokinetic studies, method validation, and quality control of natural products. The advancement of data analysis software and improvements in instrument resolution have further strengthened the capability of LC-MS/MS to support multidisciplinary research based on biodiversity. In conclusion, LC-MS/MS is a key analytical tool that facilitates efficient and systematic exploration of bioactive compounds from nature. This review highlights the importance of integrating advanced technology in the sustainable utilization of natural resources to drive innovation in the health, industrial, and scientific research sectors.
Effect of Sugar, Salt, and Flavorings Addition on Temperature Changes and Specific Heat Capacity in Citric Acid, Acetic Acid, and Ascorbic Acid Solutions Alfira Julian Pratiwi; Ekin Dwi Arif Kurniawan; Rafidah Almira Samosir; Mutia Ardila; Gioni Thesia Boru Simbolon; Afrilia Tria Ivanka; Muhammad Fadhli; Tetra Tasya Anggraini Butar; Eren Nazura; Moondra Zubir; Abd Hakim S
Indonesian Journal of Chemical Science and Technology (IJCST) Vol. 8 No. 2 (2025): JULY 2025
Publisher : Universitas Negeri Medan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24114/ijcst.v8i2.68735

Abstract

This study aims to evaluate the effect of the addition of additives in the form of sugar, salt, and flavorings on changes in temperature and type heat capacity in citric acid, acetic acid, and ascorbic acid solutions. The methodology used is a quantitative experimental approach with direct observation of temperature changes as well as calculation of enthalpy changes (ΔH) in various combinations of acidic and additive solutions. The results of the analysis showed that the types of additives exerted different effects on the thermal stability and heat capacity of each acidic solution. Sugars tend to provide the most optimal thermal stability with minimal fluctuations in ΔH change, while salts cause the greatest fluctuations. Flavorings show a more varied and inconsistent pattern of change. These findings provide in-depth insights into the thermal characteristics of organic acid solutions with additive modification, contributing to the development of applications in the fields of food, pharmaceutical, and applied chemistry education.
The Effect of Principal Leadership, Financing, and Community Participation on the Effectiveness of Facilities and Infrastructure Management at Al-Khoir Islamic Boarding School Denny Fitriani Hasibuan; Muhammad Fadhli
Amkop Management Accounting Review (AMAR) Vol. 5 No. 1 (2025): January - June
Publisher : Pascasarjana STIE Amkop Makassar

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37531/amar.v5i1.2531

Abstract

This study contains three objectives, including knowing the effect of principal leadership, financing, and community participation on the effectiveness of facilities and infrastructure management. This research method is quantitative. On the other hand, the use of sampling techniques is the Krinj and Morgan table of 45 respondents at Al-Khoir Islamic Boarding School. The data collection technique is a questionnaire. The results of the study interpreted that the principal's leadership variable had an influence (rho_a) of 0.622. Data analysis techniques using SmartPLS. While financing has an influence (rho_a) of 0.962. And community participation has an influence (rho_a) of 0.870 on the effectiveness of facilities and infrastructure management. Financing is the most dominant factor in this study. This implies that the success of facilities and infrastructure management in schools is highly dependent on how effectively funds are managed, allocated, and utilized to support operational activities and the development of educational facilities.
Co-Authors Abd Hakim S Afrilia Tria Ivanka Alfira Julian Pratiwi Denny Fitriani Hasibuan Ekin Dwi Arif Kurniawan Eren Nazura Fikri Sholehuddin SN, Abdullah Gioni Thesia Boru Simbolon Hidayatur Rizky Julita - Kamaliah - Kheqal Fitra Dinata Kheqal Fitradinata Luthfia Raisah Ahyati M Fajar Anugerah M. Chaidir Hafidz Mhd Rafi Yahya Moondra Zubir Muhammad Rifa'i Mutia Ardila Nor Hilalliyah Nor Latifah Putri, Seva Zakiyyah Rafidah Almira Samosir Regina Nabila Rifardi Riyandi Fatur Nugraha Rubino Sri Muliany Sri Wahyuni Nasir Suardi Tarumun Suwandi Simangunsong Syafryadin Syafryadin Syamsuddin Tetra Tasya Anggraini Butar Yahfizham Yuni Dhea Utari Zulfikar Zulfikar Hasan