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All Journal Jurnal Abdi Insani Jurnal Layanan Masyarakat (Journal of Public Service) journal of Basic Medical Veterinary Bima Abdi: Jurnal Pengabdian Masyarakat
Rahmawati, Kadek
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Journal : journal of Basic Medical Veterinary

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Toxicity Testing Of White Pomegranate (Punica granatum L.) Fruit Extracts Using Brine Shrimp Lethality Test Method As A Candidate Of Anti-Cancer Drug Firnanda, Ferian; Herupradoto, Eduardus Bimo Aksono; Rahmawati, Kadek; Kurnijasanti, Rochmah; Sukmanadi, Mohammad; Hidajati, Nove
Journal of Basic Medical Veterinary Vol. 10 No. 2 (2021): Journal of Basic Medical Veterinary, December 2021
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/jbmv.v10i2.31810

Abstract

This research aimed to determine the effects of toxic white pomegranate fruit extract (Punica granatum L) against larvae of brine shrimp (Artemia salina Leach) indicated LC50 values below 1000 µg/ml. This study is purely experimental by using Brine Shrimp Lethality Test (BSLT). The study was divided into seven groups, namely ethanol extract of white pomegranate fruit (Punica granatum L) with a concentration of 31,25; 62,5; 125; 250; 500; 1000 µg/ml and negative control (seawater). Mortality data percentage of Artemia salina Leach analyzed by probit analysis. Results showed that the extract of white pomegranate fruit extract (Punica Granatum L) has a toxic effect with LC50 values of 248,6 µg/ml calculate from probit analysis. From these results, it can conclude that white pomegranate extract is toxic to larval shrimp (Artemia salina Leach) with Brine Shrimp Lethality Test (BSLT) method which means white pomegranate extract has the potential to be an anticancer drug.
Leukocyte Profile Analysis in Cats with Otitis Caused by Otodectes cynotis Infestation Following Ivermectin Treatment Rahmawati, Kadek; Hannifa, Bentary; Tita, Yessa; Yunita, Rizky; Lyonis, Arszheta; Krisna, Ibrahim; Khairani, Balqis
Journal of Basic Medical Veterinary Vol. 14 No. 2 (2025): Journal of Basic Medical Veterinary, December 2025
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/jbmv.v14i2.67137

Abstract

Otitis in domestic cats is an inflammation of the ear caused by bacterial, fungal, or parasitic infections, especially ear mites (Otodectes cynotis). It is common in cats and can cause itching, discomfort, and more severe secondary infections if left untreated. Ivermectin is an antiparasitic agent that is effective in controlling various parasitic infections, including ear mites in cats. The mechanism of action of ivermectin is by inhibiting the nerve activity of the parasite, causing paralysis and death of the parasite. This study aimed to evaluate the effectiveness of ivermectin therapy on leukocyte profile in cats with otitis due to ear mite Otodectes cynotis parasite infestation. This study used a Pretest-Posttest Control Group Design involving two groups of domestic cats: a treatment group (K+) receiving ivermectin therapy and a control group (K-) receiving no treatment. Leukocyte profiles were analyzed using a hematology analyzer. The results showed that ivermectin was effective in reducing the total leukocyte count. A decrease in the number of leukocytes, especially eosinophils and neutrophils, indicates an improvement in the inflammation and healing stage of the cat's body. Thus, ivermectin was shown to be effective in suppressing Otodectes cynotis parasite invasion and improving the immunological status of domestic cats through its effect on leukocyte profile.
Co-Authors Aksono HP., Eduardus Bimo Al arif, Mohammad Anam Al-Arif, Anam Erma Safitri Fatin Fadhilah Hasib Firnanda, Ferian Hannifa, Bentary Hasib, Fatin Hidajati, Nove Hidanah, Sri Ira Sari Yudaniayanti Irfani, Dyah Khairani, Balqis Krisna, Ibrahim Kurniasari, Pitaloka Lyonis, Arszheta Pasang, Gabriel Sampe Rahmahani, Jola Rochmah Kurnijasanti Rosyada, Zulfi Nur Amrina Sabdoningrum, Emy Koestanti Soeharsono Soeharsono Sukmanadi, Mohammad Supriyadi Supriyadi Suwarno Suwarno Tita, Yessa Yudaniayanti, Ira Yunita, Rizky