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All Journal Jurnal Entomologi Indonesia Kesmas: Jurnal Kesehatan Masyarakat Nasional (National Public Health Journal)
Syahrani, Lepa
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Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Health Professions Public Health

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Aminolevulinic Acid Dehydratase Allelic Frequency and Lead Toxicity in Children Under-Five in a Former Used Lead-Acid Battery Area Irawati, Yana; Kusnoputranto, Haryoto; Achmadi, Umar Fahmi; Safrudin, Ahmad; Sitorus, Alfred; Risandi, Rifqi; Wangsamuda, Suradi; Permana, Dendi Hadi; Syahrani, Lepa; Dewayanti, Farahana Kresno; Asih, Puji B S; Syafruddin, Din
Kesmas Vol. 17, No. 1
Publisher : UI Scholars Hub

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Abstract

Polymorphisms in the Aminolevulinic Acid Dehydratase (ALAD) gene responsible for the ALAD1 and ALAD2 alleles have been implicated in susceptibility to lead toxicity. This study aimed to determine the allelic frequency of ALAD2 among children living in Bogor District, Indonesia, and its association with blood lead levels (BLLs) and lead toxicity. A cross-sectional study involving 128 children was conducted during September-October 2019 in the former ULAB area in Cinangka Village. The ALAD polymorphism, BLLs, and hematological parameters were evaluated. Blood samples were taken for dried blood spotting on filter paper, blood film, and BLL measurement. The PCR amplification and sequencing of the genomic DNA revealed the presence of two forms of the ALAD2 allele: 177C and 177T with a frequency of 0.05. Analysis of the correlation between the ALAD2 allele, BLLs, and basophilic stippling revealed that ALAD2 carriers had a five times higher risk of high BLLs, (OR = 5.359, p-value = 0.155) and had a slightly higher risk of exhibiting basophilic stippling (OR = 1.09, p-value = 1.000). Although not statistically significant, these findings suggested that the ALAD genotype may modify BLLs and lead to toxicity. The ALAD2 allele(177T) is firstly reported in any population in the world.
Anopheles species diversity and potential vectors of zoonotic malaria in Central Kalimantan, Indonesia: Diversitas spesies Anopheles dan vektor potensial malaria zoonotik di Kalimantan Tengah, Indonesia Permana, Dendi Hadi; Asih, Puji Budi Setia; Suryandari, Dwi Anita; Murhandarwati, Elsa Herdiana; Rozi, Ismail Ekoprayitno; Syahrani, Lepa; Kartapradja, Hannie Dewi Hadyani; Hidayah, Najdah; Bahrani; Irdayanti; Juliawaty, Rita; Coutrier , Elisabeth Farah Novita; Syafruddin, Din
Jurnal Entomologi Indonesia Vol 22 No 3 (2025): November
Publisher : Perhimpunan Entomologi Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.5994/jei.22.3.165

Abstract

Zoonotic malaria is an emerging public health issue in Indonesia, particularly in regions with significant forest cover and frequent interaction between humans and non-human primates. Information regarding the diversity and behaviour of mosquito vectors in these areas is very limited. This study aims to identify the diversity and bionomics of mosquitoes, particularly Anopheles sp., across five ecologically diverse locations in Palangkaraya, Central Kalimantan, to gain an understanding of their potential role in zoonotic malaria transmission. Cross-sectional entomological surveys were conducted during November 2022 (during the rainy season) and October 2024 (at the beginning of the rainy season). Adult mosquitoes were collected using human landing catches (HLC) from 18:00 to 06:00, and larval habitats were surveyed and characterized following the WHO protocol. A total of 1,278 mosquitoes were collected from six genera, with Anopheles letifer Sandosham dominating the Anopheles group (97%), particularly in swampy secondary forests, such as Nyaru Menteng. This species exhibited peak outdoor biting activity shortly after dusk and late at night, posing a greater risk to those outside or in unscreened homes. Larval surveys conducted at 48 sites revealed Anopheles larvae in 27% of habitats, predominantly in swamps (67% positive). Although no significant associations were found with environmental factors, natural and semi-natural water bodies appear key to sustaining vector populations. These findings highlight the ecological flexibility of An. letifer and its potential impact on zoonotic malaria transmission in forest-edge communities. Vector control strategies should include integrated methods, such as larval source management and community-based interventions, particularly in peat swamp regions where interactions between humans and non-human primates are frequent.
Co-Authors Ahmad Safrudin Asih, Puji B S Bahrani Coutrier , Elisabeth Farah Novita Dewayanti, Farahana Kresno Din Syafruddin Dwi Anita Suryandari E. Elsa Herdiana Murhandarwati Haryoto Kusnoputranto Hidayah, Najdah Irawati, Yana Irdayanti Juliawaty, Rita Kartapradja, Hannie Dewi Hadyani Permana, Dendi Hadi Puji Budi Setia Asih, Puji Budi Risandi, Rifqi Rozi, Ismail Ekoprayitno Sitorus, Alfred Umar Fahmi Achmadi Wangsamuda, Suradi