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All Journal Journal of Food and Pharmaceutical Science Pharmaciana: Jurnal Kefarmasian Media Farmasi : Jurnal Ilmu Farmasi (Journal Of Pharmaceutical Science) Indonesian Journal of Pharmaceutical Science and Technology Journal of Islamic Pharmacy Jurnal Farmasi Sains dan Komunitas Akta Kimia Indonesia Eksakta : Berkala Ilmiah Bidang MIPA Jurnal Mandala Pharmacon Indonesia World Nutrition Journal Journal of Halal Science and Research Journal of Food and Pharmaceutical Sciences
Mayu Rahmayanti
Program Studi Farmasi, Fakultas Kedokteran Dan Ilmu Kesehatan, Universitas Islam Negeri Maulana Malik Ibrahim Malang
Agriculture, Biological Sciences & Forestry Astronomy Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Civil Engineering, Building, Construction & Architecture Computer Science & IT Energy Engineering Environmental Science Immunology & microbiology Materials Science & Nanotechnology Mathematics Mechanical Engineering Medicine & Pharmacology Neuroscience Public Health Other

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Optimization of Liquid Shampoo Formula from Chia Seed Oil (Salvia hispanica L) Using the Simplex Lattice Design Method Amalina, Faidatul; Rahmayanti, Mayu; Afrizal, Muhammad; Nastiti, Ginanjar Putri; Syarifuddin, Sadli
Media Farmasi: Jurnal Ilmu Farmasi Vol. 21 No. 2: September 2024
Publisher : Universitas Ahmad Dahlan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.12928/mf.v21i2.28081

Abstract

Hair is one of the most essential parts of the human body, both men and women; one of the problems with hair that often occurs is hair loss. Chia plants contain sebum gland-stimulating agents with a keratin protein concentration of 23%. The sebaceous glands play a role in facilitating the growth of hair follicles so that hair can thrive and prevent hair loss. This research aims to determine the optimum composition of the prediction formula using Design Expert software and the physical characteristics and stability of liquid shampoo preparations. Optimization was carried out using Design Expert 13 software with two material components, namely HPMC and SLS, and two responses, namely viscosity and foam height. The optimum formula obtained was subjected to characteristic tests and stability tests. The stability test was carried out using the cycling test method by storing the preparation at temperatures of 4◦C and 40◦C for 48 hours. The results of the prediction formula show that component X1 is 0.589307% and X2 is 9.41069%. The one-sample t-test showed that the results were not significantly different at p>0.05 in the two responses. Testing of the optimum formula's physical characteristics and physical stability meets the reasonable requirements for organoleptic tests, homogeneity tests, viscosity tests 414,80±9,94 cPs, foam height tests 7,060±0,11 cm, and pH tests 7,39±0. The 8th run is the optimum formula with a composition of X1 0.589307% and X2 9.41069 % meets the requirements for good physical characteristics tests and physical stability tests.
Determination of Sun Protection Factor Value and Physical Stability of Wungu Leaf (Graptophylum pictum (L.) Griff) Extract Spray Sunscreen Rahmayanti, Mayu; Buana Putra, M. Bayu Firdaus; Maulidina, Annisa Tri
Jurnal Farmasi Sains dan Komunitas (Journal of Pharmaceutical Sciences and Community) Vol 22, No 1 (2025)
Publisher : Sanata Dharma University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24071/jpsc.006632

Abstract

Sunscreen can protect the skin from ultraviolet (UV) radiation. The inorganic active ingredients in sunscreens can have detrimental effects on the skin. Wungu leaf (Graptophylum pictum (L.) Griff) is a suitable alternative due to its antioxidant activity and similar mechanism of action to other antioxidants with lower side effects. This study employed a true experimental method, and the data were analyzed using one-way ANOVA and T-tests. The effectiveness of sunscreen is determined by the Sun Protection Factor (SPF) value. This study aims to determine the SPF value and physical stability of Wungu leaf extract spray sunscreen at concentrations of 500 ppm, 1,000 ppm, and 1,500 ppm. The results show that the spray sunscreens provide ultra-protection. The difference in extract concentration significantly affected the SPF value (p0.05). Stability tests showed a negligible effect on color variation and a notable effect on pH and spray diameter. Despite its noticeable impact, the outcome remains within an acceptable range. The study concluded that the Wungu leaf extract spray sunscreen provides excellent photoprotection, as demonstrated by the high SPF values observed for Formula 1 (18.63), Formula 2 (23.87) and Formula 3 (29.56). In addition, the product exhibits robust physical stability, as assessed by relevant parameters.
Pengembangan Formula Sediaan Lipstik dari Kombinasi Ekstrak Daun Jati (Tectona grandis L.) dan Daun Pacar (Lawsonia inermis L.) Sebagai Pewarna Alami Rahmayanti, Mayu; Haryadi, Mahardika Chory; Syarifuddin, Sadli; Nastiti, Ginanjar Putri; Anggraini, Dwi; Hasanah, Imrotul; Amiruddin, Muhammad
Jurnal Mandala Pharmacon Indonesia Vol. 10 No. 2 (2024): Jurnal Mandala Pharmacon Indonesia
Publisher : Program Studi Farmasi Universitas Mandala Waluya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35311/jmpi.v10i2.570

Abstract

Lipstik merupakan suatu produk kosmetik yang paling banyak digunakan oleh konsumen, khususnya wanita. Namun, berdasarkan laporan BPOM mulai tahun 2018 hingga 2022, telah ditemukan banyak peredaran kosmetika ilegal yang beredar di pasaran karena mengandung zat warna berbahaya berupa pewarna Merah K3 dan Merah K10. Oleh karena itu, dibutuhkan zat warna alternatif untuk membuat sediaan lipstik agar kesehatan konsumen terjamin. Contoh tanaman yang bisa dijadikan sebagai zat warna alternatif yaitu daun jati muda (Tectona grandis L.) dan daun pacar (Lawsonia inermis L.). Penelitian ini bertujuan untuk memformulasikan sediaan lipstik ekstrak kombinasi daun jati muda (Tectona grandis L.) dan daun pacar (Lawsonia inermis L.) yang memenuhi semua standar evaluasi fisik sediaan lipstik. Daun jati muda diekstraksi dengan metode Ultrasonic Assisted Extraction (UAE), sedangkan daun pacar diekstraksi dengan metode maserasi. Uji evaluasi yang dilakukan meliputi uji organoleptis, uji homogenitas, uji pH, uji oles, uji kekerasan, uji titik lebur, dan uji stabilitas cycling test. Hasil yang diperoleh yaitu semua sediaan lipstik telah memenuhi standar evaluasi sediaan lipstik tapi tidak stabil pada siklus keenam. Kesimpulan penelitian ini yaitu sediaan lipstik memenuhi standar karakteristik sediaan lipstik yang baik tapi tidak stabil setelah uji stabilitas cycling test pada parameter uji pH, uji titik lebur, dan uji kekerasan.
Utilization of Wungu leaf extract (Graptophyllum pictum (L.) Griff.) in the formulation of spray sunscreen as a halal cosmetic preparation Amalina, Faidatul; Rahmayanti, Mayu; Syarifuddin, Sadli; Fadilia Aktifa, Ana
Journal of Halal Science and Research Vol. 5 No. 1 (2024): February
Publisher : Universitas Ahmad Dahlan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.12928/jhsr.v5i1.9303

Abstract

Ultraviolet (UV) A and Ultraviolet (UV) B rays can also hurt the skin, and sunscreen helps keep the skin awake. Wungu leaf has some potential for sunscreen because it has antioxidant activity that allows it to absorb UV light. Besides considering the security aspect, the formulation of the sunscreen spray also observes the halal critical points of the ingredients used. This study aims to formulate a more comprehensive sunscreen spray halal extract of wungu leaves with variations in the concentration of glycerin, a humectant. Data collection techniques run through descriptive analysis. This is made with variations in glycerin concentration: 5%, 10%, and 15%. The availability of formulated physical evaluations then included organoleptic tests, homogeneity tests, pH tests, viscosity tests, and test patterns of spraying. According to this study, availability in green, homogenous pH stands at 5.42 – 5.73, viscosity in the 1571 – 1983 cPs, and the targeting pattern at about 3 cm, 5 cm, 10 cm, and 15 cm at 5.67 – 16.6 cm. Therefore, in this study, the conclusion is that the availability of sunscreen spray with variations of glycerin has more physical properties that could be used. The more glycerin is used, the more available viscosity will increase.
Production and characterization of halal-based gelatin derived from Red Nile Tilapia (Oreochromis niloticus) fishbone Rahmayanti, Mayu; Irsyadulibad, Mohamad; Dewi, Tanaya Jati Dharma; Firdausi, Amalia Salsa Billah; Megawati, Dewi Sinta; Jebreen, Ali
Journal of Halal Science and Research Vol. 6 No. 1 (2025): February
Publisher : Universitas Ahmad Dahlan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.12928/jhsr.v6i1.11409

Abstract

Gelatin is one of the chemical products derived from protein hydrolysis. The demand for gelatin in Indonesia increases yearly, but domestic production still needs to meet the demand, leading to imports. International gelatin production statistics indicate that 58% is derived from pig skin, which is prohibited for Muslims. Therefore, this research aims to produce halal-based gelatin that meets quality standards. Red Nile Tilapia (Oreochromis niloticus) fishbones are used as the raw material for this study, as their halal status is clear in the Quran and Hadith. The fishbones are soaked in different concentrations of phosphoric acid, namely F1 (4%), F2 (6%), and F3 (8%), for 48 hours, then extracted using distilled water solvent in a water bath for 6 hours. The extracted solution is filtered, and the filtrate is dried in an oven at 50°C for 48 hours. The gelatin yield is statistically analyzed using correlation methods, and its functional groups are identified using FTIR spectroscopy. Compared to existing standards, gelatin characteristics are evaluated through organoleptic tests, such as pH, gel strength, viscosity, moisture content, and ash content. The gelatin yield for F1 is 8.15 ± 0.18%; F2 is 12.08 ± 0.12%, and F3 is 15.66 ± 0.26%. The research demonstrates that phosphoric acid concentration significantly influences gelatin yield, with higher concentrations resulting in higher yields. The FTIR spectra also indicate that the synthesized gelatin resembles commercial gelatin in spectra and absorption peaks. All gelatin variations meet the requirements for organoleptic properties, gel strength, moisture content, and ash content, while only F1 and F2 meet the pH requirements.   Keywords: FTIR, halal gelatin, Red Nile Tilapia (Oreochromis niloticus) fishbone.
Design, Formulation, and Evaluation of Vitamin C Tablets Using Co-Processed Excipient Combination of Jackfruit Seed Starch and Avicel®️ PH 101 Rahmayanti, Mayu; Dewi, Tanaya Jati Dharma; Aktifa, Ana Fadilia; Paramitha, Sella; Nikmah, Rahayu Hikmatul; Septianshar, Lumen Muzaidi
Jurnal Farmasi Sains dan Komunitas (Journal of Pharmaceutical Sciences and Community) Vol 22, No 2 (2025)
Publisher : Sanata Dharma University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24071/jpsc.008319

Abstract

Tablet is a popular pharmaceutical dosage form among the public. One method of making tablets is direct compression. This method must consider the flow properties and compressibility of the excipients. But many excipients do not meet these criteria, leading to the alternative use of co-processed excipients of jackfruit seed starch and avicel®️ PH 101. This research aims to determine the physical characteristics of direct compression vitamin C tablets using co-processed excipient of PBN-A (Jackfruit Seed Starch and Avicel®️ PH 101) with varying ratios of 1:3, 3:1, and 1:1. The research methods include powder preparation, powder evaluation, tablet compression, and physical evaluation of tablet. Descriptive and statistical data analysis using one-way ANOVA. The research results show that tablets exhibit favorable physical characteristics in F1, but F2 and F3 show suboptimal hardness and friability values. The statistical analysis results indicate a significant difference with a p-value of (0.000) and post-hoc tests explain that these significant differences are particularly noticeable between F1 and F2, K1, and K2. This study concludes that vitamin C tablets using co-processed excipients of PBN-A with ratios of 1:3, 3:1, and 1:1 exhibit good physical characteristics in all evaluations, except for the hardness and friability of F2 (3:1) and the hardness of F3 (1:1).
Co-Authors Akhfas Faisal Amin Aktifa, Ana Fadilia Amalia Salsa Billah Firdausi Amalina, Faidatul Asyifaul Khasanah Buana Putra, M. Bayu Firdaus Dhia Fadhilah Salsabila Dwi Anggraini Fadila, Safa Aulia Nur Fadilia Aktifa, Ana Faza Saiqur Rahmah Faza Saiqur Rahmah Febrian Rezky, Dimas Firdausi, Amalia Salsa Billah Ginanjar Putri Nastiti Haryadi, Mahardika Chory Hasanah, Imrotul Irfan Yogik Ferdianiko Irsyadulibad, Mohamad Jebreen, Ali Ludy Wiji Lestari Maulidina, Annisa Tri Muhammad Abbas Ar-Riziq Muhammad afrizal Muhammad Amiruddin Mutia Azkia Fitri Mutia Azkia Fitri Nikmah, Rahayu Hikmatul Oktavia, Reza Putri Paramitha, Sella Reza Maulinda Nur Cahya Berlianti Ria Indah Lestari Sadli Syarifuddin Salsabila Eka Setia Ningrum Sella Paramitha Septianshar, Lumen Muzaidi Siti Fadilla Syifa Annaura Tanaya Jati Dharma Dewi