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All Journal Jurnal Ilmiah Farmasi EKSAKTA: Journal of Sciences and Data Analysis Indonesian Journal of Pharmaceutical Science and Technology Jurnal Farmasi Galenika (Galenika Journal of Pharmacy) CHEESA: Chemical Engineering Research Articles JSFK (Jurnal Sains Farmasi & Klinis) Medfarm: Jurnal Farmasi dan Kesehatan Jurnal Ilmiah Ibnu Sina (JIIS): Ilmu Farmasi dan Kesehatan Jurnal Farmasi Sains dan Praktis Indonesian Journal of Pharmacology and Therapy
Arba Pramundita Ramadani
Jurusan Farmasi Universitas Islam Indonesia
Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Computer Science & IT Earth & Planetary Sciences Health Professions Immunology & microbiology Materials Science & Nanotechnology Medicine & Pharmacology Public Health

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AKTIVITAS ANTIBAKTERI DAN ANTIBIOFILM DARI EKSTRAK DAUN BANGUN-BANGUN (Coleus amboinicus L.) TERHADAP BAKTERI Staphylococcus aureus Fitra, Romadhonsyah; Romadhonsyah, Fitra; Aisha Nanda Caela Amry; Annisa Fitria; Arde Toga Nugraha; Arba Pramundita Ramadani; Nangim Khasanah
Jurnal Ilmiah Ibnu Sina (JIIS): Ilmu Farmasi dan Kesehatan Vol 9 No 2 (2024): JIIS
Publisher : Sekolah Tinggi Ilmu Kesehatan ISFI Banjarmasin

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36387/jiis.v9i2.2173

Abstract

Biofilm formation by bacteria, especially the genus Staphylococcus, is a serious health problem. Various medicinal plants have been used to control the infection, but research related to the antibiofilm activity of Coleus amboinicus is still limited. Bangun-bangun leaves (C. amboinicus) are plants from the Lamiaceae family that contain secondary metabolites such as terpenoids, flavonoids, and phenolics that are thought to be responsible as antibacterial and antibiofilm. This study aims to examine the antibacterial and antibiofilm activity of C. amboinicus against S. aureus. C. amboinicus leaves were extracted using 96% ethanol. The ethanol extract was then screened for phytochemicals using Thin Layer Chromatography (TLC) using several spray reagents. Antibacterial activity was analyzed using microdilution technique to obtain the value of Minimum Inhibitory Concentration (MIC) and Minimum Bactericidal Concentration (MBC). Antibiofilm activity was analyzed using crystal violet method. The result showed that the ethanol extract of C. amboinicus leaves contained flavonoids, phenolic terpenoids, and tannins. Antibacterial assays were obtained for the MIC value of 8 mg/mL and MBC of 16 mg/mL. The ethanol extract showed biofilm inhibitory activity with an IC50 value of 2,40 mg/mL. Based on these results, C. amboinicus has potential antibacterial and antibiofilm activity to inhibit S. aureus.
Profil Ketoksikan Akut SNEDDS Propolis Ramadani, Arba Pramundita; Syukri, Yandi; Hakim, Sherina Nabila Putri; Fitria, Annisa
JSFK (Jurnal Sains Farmasi & Klinis) Vol 9 No 2 (2022): J Sains Farm Klin 9(2), Agustus 2022
Publisher : Fakultas Farmasi Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25077/jsfk.9.2.105-110.2022

Abstract

Propolis memiliki efek imunostimulan yang tinggi namun tidak larut air dan memiliki bioavailabilitas yang rendah. Formulasi propolis dalam bentuk SNEDDS terbukti mampu meningkatkan aktivitas imunostimulannya, namun juga memberikan potensi ketoksikan dikarenakan kecilnya ukuran partikel nano dan akumulasi nya di dalam tubuh. Penelitian ini bertujuan untuk mengevaluasi efek ketoksikan akut SNEDDS propolis. Dengan metode standar OECD 425, tikus Wistar jantan digunakan sebagai hewan uji. Pengujian diawali dengan uji batas dosis 2000 mg/kgBB dan dilanjutkan uji utama yang diawali dengan dosis 175 mg/kgBB serta mengikuti faktor 1,3 untuk kenaikan maupun penurunan dosisnya. Pengamatan gejala klinis ketoksikan secara intensif dilakukan 4 jam pertama setelah pemejanan dan dilanjutkan secara periodik mulai 24 jam hingga 14 hari dengan pengukuran berat badan tiap minggunya. Pada akhir penelitian, tikus dikorbankan dan diisolasi hepar maupun ginjalnya untuk pembuatan preparat histopatologis. Hasil uji menunjukkan tidak adanya gejala ketoksikan, berat badan hewan uji meningkat dan nilai LD50 > 2000 mg/kgBB. Pengamatan histopatologis juga tidak menemukan adanya abnormalitas di hepar maupun ginjal. Sehingga dapat disimpulkan bahwa SNEDDS propolis tidak menimbulkan efek koetoksikan akut pada tikus jantan secara per oralPropolis memiliki efek imunostimulan yang tinggi namun tidak larut air dan memiliki bioavailabilitas yang rendah. Formulasi propolis dalam bentuk SNEDDS terbukti mampu meningkatkan aktivitas imunostimulannya, namun juga memberikan potensi ketoksikan dikarenakan kecilnya ukuran partikel nano dan akumulasi nya di dalam tubuh. Penelitian ini bertujuan untuk mengevaluasi efek ketoksikan akut SNEDDS propolis. Dengan metode standar OECD 425, tikus Wistar jantan digunakan sebagai hewan uji. Pengujian diawali dengan uji batas dosis 2000 mg/kgBB dan dilanjutkan uji utama yang diawali dengan dosis 175 mg/kgBB serta mengikuti faktor 1,3 untuk kenaikan maupun penurunan dosisnya. Pengamatan gejala klinis ketoksikan secara intensif dilakukan 4 jam pertama setelah pemejanan dan dilanjutkan secara periodik mulai 24 jam hingga 14 hari dengan pengukuran berat badan tiap minggunya. Pada akhir penelitian, tikus dikorbankan dan diisolasi hepar maupun ginjalnya untuk pembuatan preparat histopatologis. Hasil uji menunjukkan tidak adanya gejala ketoksikan, berat badan hewan uji meningkat dan nilai LD50 > 2000 mg/kgBB. Pengamatan histopatologis juga tidak menemukan adanya abnormalitas di hepar maupun ginjal. Sehingga dapat disimpulkan bahwa SNEDDS propolis tidak menimbulkan efek koetoksikan akut pada tikus jantan secara per oral
POTENTIAL PHARMACOLOGICAL ACTIVITIES OF FALOAK BARK (STERCULIA QUADRIFIDA R. BR) AS AN HERBAL PLANT FROM EAST NUSA TENGGARA: A SCOPING REVIEW Fuadah, Shofiatul; Istikharah, Rochmy; Tenda, Priska Ernestina; Ramadani, Arba Pramundita
Jurnal Farmasi Sains dan Praktis Vol 11 No 1 (January-April 2025)
Publisher : Universitas Muhammadiyah Magelang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31603/pharmacy.v11i1.10862

Abstract

Faloak bark (Sterculia quadrifida R. Br) is part of the faloak plant, which has been used for a long time in traditional medicine to treat a variety of medical conditions. Faloak bark is claimed to possess medicinal properties that can treat liver, kidney, and bladder diseases, cure gastroenteritis, hepatitis, anemia, malaria, back pain, and function as an energy booster. Recent studies in pharmacology have found that faloak bark has several interesting biological properties, thus strengthening its potential as a new source of active ingredients for pharmaceutical development. This study literature aims to provide a concise overview of the evaluations of the secondary metabolite chemicals found in faloak bark, thus highlighting their potential pharmacological properties. To find articles for the review of the pharmacological activities of faloak bark, a search was conducted on research journal databases using Publish or Perish 8, and 43 papers relevant to the evaluation were found. Literature review showed that faloak bark contains many different chemicals, such as alkaloids, gallic acid derivatives, flavonoids, polyphenols, saponins, steroids, tannins, terpenoids, triterpenoids, quinone, glycoside, as well as isolates of 2,3-dihydro-6-hydroxy-2-methylenenaphtho[1,2-b] furan-4,5-dione, and 2-iminoethyl 2-(1-hydroxypentan-2-yl) phenyl) acetate. Faloak bark has such pharmacological properties as antiaging, antibacterial, antibiofilm, anti-dengue, antifungal, anti-hepatitis C, anti-hyperglycemia, anticancer, antimalarial, antioxidant, antipyretic, and immunomodulatory effects. Therefore, faloak bark has considerable potential for the advancement of herbal remedies.
A Comprehensive Review of Solid Self Nano Emulsifying Drug Delivery System (S-SNEDDS) Technology to Enhance Nanoemulsion Stability Yandi Syukri; Syafira Tri Nurmala Sari; Arba Pramundita Ramadani
JSFK (Jurnal Sains Farmasi & Klinis) Vol 12 No 1 (2025): J Sains Farm Klin 12(1), April 2025
Publisher : Fakultas Farmasi Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25077/jsfk.12.1.15-28.2025

Abstract

Patients and practitioners prefer oral medication administration for systemic or local treatment due to its convenience and pleasurable experience. Nevertheless, numerous oral pharmaceutical formulations encounter various delivery challenges as a result of the hostile conditions of the gastrointestinal tract and a multitude of physiological barriers, including gastrointestinal architectural traits, biochemical variables, and physiological factors. Nanoparticle technology is often employed to surmount these challenges. Nanoemulsions, a form of nanotechnology, have been shown to improve the bioavailability and solubility of active pharmaceutical ingredients. However, despite these advantages, they often encounter adjustment challenges related to physical and chemical stability, necessitating the development of advanced delivery systems to ensure their therapeutic efficacy. Furthermore, liquid dosage forms may present several limitations for oral administration, such as inadequate masking of unpleasant tastes in the absence of flavoring agents or sweeteners, as well as difficulties in achieving accurate doses. Another potential method to enhance the stability of the drugs is the Solid Self Nano Emulsifying Drug Delivery System (S-SNEDDS). This lipid-based drug delivery device utilizes a particular porosity carrier and a Liquid SNEDDS compaction process. The S-SNEDDS formulation is a potential method of delivering medications for active substances not soluble in water, sensitive to light, or unstable in liquid form. It also exhibits benefits such as excellent stability, straightforward scalability, consistent content distribution, precise dosage accuracy, and improved patient adherence. Encapsulation of hydrophobic pharmaceuticals protects against the aqueous environment, impeding hydrolysis and enhancing the drug's stability when exposed to moisture. Another mechanism of S-SNEDDS is the controlled release mechanism, which can also enhance the drug's stability in terms of its chemical composition and therapeutic effectiveness. Therefore, S-SNEDDS have the potential to provide a viable approach to improving the stability of nanoemulsions.
Antiplasmodial activity of faloak bark (Sterculia quadrifida, R.Br.) extract from East Nusa Tenggara, Indonesia Tenda, Priska Ernestina; Hilaria, Maria; Ramadani, Arba Pramundita
Indonesian Journal of Pharmacology and Therapy Vol 2 No 2 (2021)
Publisher : Faculty of Medicine, Public Health, and Nursing Universitas Gadjah Mada and Indonesian Pharmacologist Association or Ikatan Farmakologi Indonesia (IKAFARI)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/ijpther.1975

Abstract

The current development of antimalarial drug resistance encourages researchers to discover and develop novel antimalarials. One of its alternatives for antimalarial discovery is using medicinal plants remembering the success of artemisinin. Sterculia quardrifida R. Br. bark, locally name as faloak, is an endemic medicinal plant from East Nusa Tenggara that has been used traditionally to treat malaria. However, its antimalarial activity has not been investigated, yet. This study was aimed to evaluate the antiplasmodial activity of ethanolic extract of faloak bark against Plasmodium falciparum in vitro. Using FCR-3 P. falciparum strain, the ethanolic extract was evaluated on various concentration (1, 10, 50, and 100 μg/mL, respectively). The IC50 value was determined by the relationship between concentration and percentage of growth inhibition. The result showed that the percentage of inhibition of P. falciparum was concentration dependent, higher concentration resulting on higher percentage of inhibition with the IC50 42.399 ± 9.517 μg/mL. It can be concluded that the ethanolic extract of faloak bark have moderate antiplasmodial activity against P. falciparum in vitro.
IMMUNOSTIMULANT EFFECTS OF PROPOLIS: A study of cytokine production Putri, Mutiara Sani Demira; Fitriani, Hannie; Syukri, Yandi; Ramadani, Arba Pramundita
Jurnal Ilmiah Ibnu Sina (JIIS): Ilmu Farmasi dan Kesehatan Vol 11 No 1 (2026): Jurnal Ilmiah Ibnu Sina
Publisher : Sekolah Tinggi Ilmu Kesehatan ISFI Banjarmasin

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36387/jiis.v11i1.2926

Abstract

Propolis is a natural substance derived from bee resin and has long been used in traditional medicine because of its diverse bioactive compounds, especially flavonoids. This study aims to assess the immunostimulant effects of propolis on cytokine expression based on existing scientific research. A narrative review was conducted by collecting literature from PubMed, ScienceDirect, and Google Scholar. Initially, 48 articles were identified, and 15 articles that met the inclusion criteria were further analyzed. The results show that propolis has immunomodulatory activity through multiple mechanisms, including inhibiting the NF-κB pathway, reducing COX-2 expression, and suppressing nitric oxide (NO) production. Propolis also boosts macrophage activation, promotes phagocytosis, and increases the expression of pro-inflammatory cytokines such as IL-1β, IL-6, IL-2, and IFN-γ. However, under excessive inflammatory conditions, propolis decreases pro-inflammatory cytokine expression, indicating an adaptive immunoregulatory response. In conclusion, propolis has strong potential as a natural immunostimulant that works contextually according to the host’s immunological status and may be developed as a future herbal therapeutic agent.
Acute Toxicity Evaluation of Phyllanthus niruri SNEDDS Formulation According to OECD 425 Hikmah, Uzulul; Ramadani, Arba Pramundita; Canastie, Putri Julia; Ma'wa, Nurul Jannatul
EKSAKTA: Journal of Sciences and Data Analysis VOLUME 7, ISSUE 1, April 2026
Publisher : Fakultas Matematika dan Ilmu Pengetahuan Alam

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20885/EKSAKTA.vol7.iss1.art2

Abstract

A self-nanoemulsifying drug delivery system (SNEDDS) is a preparation that can increase the solubility of poorly soluble compounds, including Phyllanthus niruri. However, increasing solubility and bioavailability carries the risk of increased toxicity. Previous research showed that SNEDDS of Phyllanthus niruri (SNPN) at a dose of 100 mg/kgBW has hepatoprotective activity through decreasing ALT and AST enzyme levels after administering paracetamol at a dose of 3 g/kgBW in rats. However, at a dose of 200 mg/kg, ALT and AST levels increased, indicating potential toxicity. This study aims to determine the LD50 and to conduct histopathological observations of the liver and kidneys following oral administration of SNPN, in accordance with OECD 425 guidelines. Dose determination follows the recommendations of the AOT 425 StatPgm software, which includes the limit test (2000 mg/kg BW) and the main test (175, 550, and 2000 mg/kg BW), with observations made over 14 days. Next, the animals were sacrificed and necropsied to collect the liver and kidney organs for histopathological observation. LD50 determination was performed using AOT 425 StatPgm, and the level of organ damage was assessed using histopathological scoring. The result showed that the LD₅₀ value of SNPN exceeded 2000 mg/kgBW, placing it in category 5 (mild toxicity). Histopathological tests showed varying severity of changes between doses, indicating a toxic effect of SNPNadministration on the microscopic structure of the target organs. In conclusion, SNPN administration has the potential to cause mild acute toxicity, as indicated by the LD50 results and histological changes in the liver and kidneys.
Co-Authors Aisha Nanda Caela Amry Annisa Fitria Annisa Fitria Annisa Fitria Arde Toga Nugraha Ari Marstiyani Arismunandar, Arif Baruna, Renno Ramadhani Ika Canastie, Putri Julia Cynthia Astiti Putri Diesty Anita Nugraheni Fanny Rahma Maulida Fitra, Romadhonsyah Fitriani, Hannie Fuadah, Shofiatul Hakim, Sherina Nabila Putri Hayati, Farida Hikmah, Uzulul Jasno Jasno Kamarulzaman, Ezatul Ezleen Larysa Fernenda Lutfi Chabib, Lutfi Ma'wa, Nurul Jannatul Maria Hilaria Maulidha Amanati Muhammad Sulaiman Zubair Mustafidah, Mabrurotul Nangim Khasanah Poluan, Jesica Carine Priska Ernestina Tenda Putri, Mutiara Sani Demira Rochmy Istikharah Romadhonsyah, Fitra Sherina Nabila Putri Hakim Suryani, Arman Syafira Tri Nurmala Sari Tamhid, Hady Anshory Tika Luthfi Sadrina Trianloka, A. M. Bagas Yandi Syukri