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Co-incidence of COVID-19 and hepatocellular carcinoma during pregnancy: Double punches to disease severity and mortality? Abubakar, Azzaki; Yusuf, Fauzi; Firdausa, Sarah; Maghfirah, Desi; Gunawan , Andrie; Sari, Fitrah
Narra J Vol. 3 No. 3 (2023): December 2023
Publisher : Narra Sains Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52225/narra.v3i3.264

Hepatocellular carcinoma (HCC), a considerable leading cause of cancer-related deaths worldwide, is the most common primary liver cancer with poor prognosis and outcome. Many advances in prevention, screening, and new technologies in diagnostics and therapy have been achieved, but its incidence and mortality remain increasing. Co-infection of another viral disease in HCC patients with pregnancy might exacerbate the condition and double the mortality rate. The aim of this case report was to describe the co-infection of coronavirus disease 2019 (COVID-19) in an HCC patient during pregnancy. A 26-year-old woman with 16–17weeks of gestation was admitted to Dr. Zainoel Abidin Hospital, Banda Aceh, Indonesia with shortness of breath. The patient also reported that the abdomen expanded rapidly in the last three weeks, followed by severe pain and collateral vein appearance. Laboratory findings revealed anemia, leukocytosis, HBsAg reactive, hypoalbuminemia, hyperbilirubinemia, elevated liver enzymes, increased alpha-fetoprotein (AFP), and cancer antigen 125 (CA-125). Ultrasonography indicated gestation with a single fetus, an enlarged liver with a 9.9 x 9.4 cm nodule, and massive ascites. The patient was also RT-PCR-confirmed COVID-19. On day 8 of hospitalization, the patient suddenly reported severe abdominal pain. Ultrasonography revealed fetal distress immediately followed by fetal death. Adequate management of cancer pain, continuous evacuation of ascites, and other supportive care could not save the patient who died on the day 17 of hospitalization. In this case, we found no proof that the patient experienced cirrhosis prior to HCC. Pregnancy through hormonal alteration is thought to be the aggravating factor that accelerates the progression of pre-existing liver disease into carcinoma and infection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) worsened the outcome in this patient.

THE IMPACT OF ADVERSE DRUG REACTION OCCURRENCE TO DRUG ADHERENCE LEVEL: A CROSS-SECTIONAL STUDY IN PATIENTS WITH TUBERCULOSIS Bakri, Tedy Kurniawan; Akmal, Raihanul; Vonna, Azizah; Sari, Fitrah
JURNAL FARMASI GALENIKA Vol 8 No 2 (2021): Jurnal Farmasi Galenika Vol 8 No 2
Publisher : Universitas Bhakti Kencana

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.70410/jfg.v8i2.194

Tuberculosis is well-known as an ancient disease that remains a global challenge until this era. The main goals of the treatment are to eradicate the colonization of acid-resistant basil and to prevent the occurrence of drug resistance. However, the accomplishment of this multi-drugs therapy is not always achieved due to several obstacles, one of is patient adherence to the treatment. Patient adherence is a considerable determinator that influenced by a number factors including the adverse drug reaction (ADR) which appeared to the patients. This study aimed to examine the correlation between adverse drug reaction and patients’ adherence to the anti-tuberculosis category 1 regimen during the intensive phase. This observational analytic study used cross sectional method and involved 35 subjects. Drug adherence level was measured using Medication Adherence Scale-8 (MMAS-8) questionnaire, the characteristics of ADR were collected using check list sheet of ADR, and the probability of ADR was analyzed using Naranjo Algorithm. The results showed that the majority of patients in this study were adherence to anti tuberculosis drugs (62,8%) and experienced ADR (74,3%). Bivariate analysis using chi-square statistical test showed there was significant correlation between adverse drug reaction and adherence to anti-tuberculosis drugs during the intensive phase treatment (P-value = 0,02288).

Hubungan Pengetahuan Dan Laporan Ibu Terkait Kejadian Ikutan Pasca Imunisasi Pada Bayi 0-24 Bulan Di Puskesmas Batoh Banda Aceh Bakri, Tedy Kurniawan; Fitria, Nanda; Desiyana, Lydia Septa; Vonna, Azizah; Sari, Fitrah
JURNAL FARMASI GALENIKA Vol 8 No 3 (2021): Jurnal Farmasi Galenika Vol 8 No 3
Publisher : Universitas Bhakti Kencana

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.70410/jfg.v8i3.195

Kejadian Ikutan Pasca Imunisasi (KIPI) merupakan semua kejadian medis yang tidak diinginkan terjadi dalam satu bulan setelah imunisasi dan belum tentu memiliki hubungan kausalitas dengan vaksin. Data laporan KIPI dicatat apabila ibu dari anak yang mengalami KIPI melapor ke pelayanan kesehatan. Salah satu hal yang mempengaruhi penanganan dan sikap ibu terkait KIPI pada anak adalah pengetahuan ibu. Tujuan penelitian ini adalah untuk mengetahui reaksi KIPI yang dialami oleh bayi 0-24 bulan, mengetahui proporsi tingkat pengetahuan ibu yang melaporkan KIPI atau tidak melaporkan KIPI serta hubungan antara pengetahuan ibu dan laporan ibu terkait KIPI pada anak. Penelitian ini merupakan jenis penelitian observasional analitik dengan menggunakan metode cross-sectional. Dilakukan wawancara terhadap 68 responden yang diperoleh berdasarkan teknik quota sampling. Data pengetahuan ibu diperoleh dengan menggunakan kuesioner pengetahuan ibu dan data terkait KIPI diperoleh dari formulir KIPI yang diterbitkan oleh Menteri Kesehatan RI. Hasil penelitian menunjukkan bahwa semua reaksi KIPI termasuk dalam reaksi KIPI ringan diantaranya demam (85,2%), bengkak (29,4%) dan kemerahan di lokasi penyuntikan (22%), diare (4,4%), muntah (4,4%), alergi (1,4%), sesak napas (1,4%), dan abses (1,4%). Ibu yang tidak melaporkan KIPI sebanyak 86,7% didominasi oleh ibu dengan tingkat pengetahuan cukup yaitu 47%, sedangkan ibu yang melaporkan KIPI sebanyak 13,2% didominasi oleh ibu dengan tingkat pengetahuan baik yaitu 5,8%. Berdasarkan hasil analisis menggunakan Fisher’s Exact sebagai uji alternatif menunjukkan bahwa tidak terdapat hubungan yang signifikan antara pengetahuan ibu dengan laporan ibu terkait KIPI pada anak (p-value = 0,231).

Analisis Pengaruh Tingkat Pendidikan Dan Kompensasi Terhadap Produktivitas Kerja Pegawai Kantor Dinas Pasar Kota Padang Gustina, Leni; Rahmi Aswin, Ullya; Sari, Fitrah
Jurnal Ekonomika Dan Bisnis (JEBS) Vol. 2 No. 2 (2022): Jurnal Ekonomika dan Bisnis (JEBS)
Publisher : CV. ITTC INDONESIA

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.47233/jebs.v2i3.230

This study aims to examine and analyze the effect of education level and compensation on work productivity of employees of the Padang City Market Service Office. The independent variables used are education level (X1) and compensation (X2). The dependent variable is employee work productivity (Y). The type of research methodology used is the causative method. The data used are primary and secondary data. Primary data was obtained by interviewing a sample of 97 Padang City Market Service employees. The analysis tool used is Multiple Linear Regression with the SPSS version 19.0 program. The results of the study show that the first hypothesis (H1) can be accepted. It can be seen that the tcount value for this variable is 3.137. Meanwhile the value in the 5% distribution table is 2.376. Then tcount (3.137) > ttable (2.376). This means that the education level variable (X1) has a positive influence. This is also reinforced by the significance value (0.004 <0.050) meaning that the education level variable (X1) has a positive and significant effect on the work productivity of Padang City Market Service employees. Whereas the second hypothesis (H2) is also accepted, seen in the tcount value for this variable of 5.020. Meanwhile the value in the 5% distribution table is 2.376. Then tcount (5.020) > ttable (2.376). This means that the compensation variable (X2) has a positive influence. This is also reinforced by the significance value (0.000 <0.050) meaning that the compensation variable (X2) has a positive and significant effect on the work productivity of Padang City Market Service employees. For the third hypothesis (H3) it is also accepted that Fcount is 15.535, while the results of Ftable in the distribution table with an error rate of 5% are 3.44. This means Fcount > Ftable (15.535 > 3.44). These calculations show that the variable level of education (X1) and compensation (X2) together have a positive and significant influence on employee productivity variables (Y).

Human Capital Quality and Marketing Performance: A Strategic Management Perspective Gustina, Leni; Aswin, Ullya Rahmi; Sari, Fitrah
Jurnal Informatika Ekonomi Bisnis Vol. 8, No. 1 (March 2026)
Publisher : SAFE-Network

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37034/infeb.v8i1.1347

This study examines the influence of human capital quality on marketing performance from a strategic management perspective. In an increasingly competitive business environment, organizations are required to leverage internal strategic resources to achieve superior marketing outcomes. Human capital quality, reflected in employees’ knowledge, skills, experience, and capabilities, is considered a critical intangible asset that supports effective marketing strategy implementation. This research employs a quantitative explanatory approach using a survey method. Data were collected through structured questionnaires distributed to employees and managers involved in marketing and strategic functions within business organizations. The data were analyzed using descriptive statistics and regression analysis to test the proposed relationship between human capital quality and marketing performance. The results indicate that human capital quality has a positive and statistically significant effect on marketing performance, demonstrating that organizations with higher-quality human resources tend to achieve better marketing outcomes, including sales growth, customer acquisition, and market competitiveness. These findings confirm that marketing performance is not only shaped by external market conditions but is also strongly influenced by internal strategic resources. The study concludes that human capital quality plays a crucial role in enhancing marketing performance and should be integrated into organizational strategic and marketing planning. The results provide valuable insights for managers in aligning human resource development with marketing objectives to achieve sustainable competitive advantage.

Human Capital Quality and Marketing Performance: A Strategic Management Perspective Gustina, Leni; Aswin, Ullya Rahmi; Sari, Fitrah
Jurnal Informatika Ekonomi Bisnis Vol. 8, No. 1 (March 2026)
Publisher : SAFE-Network

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37034/infeb.v8i1.1347

This study examines the influence of human capital quality on marketing performance from a strategic management perspective. In an increasingly competitive business environment, organizations are required to leverage internal strategic resources to achieve superior marketing outcomes. Human capital quality, reflected in employees’ knowledge, skills, experience, and capabilities, is considered a critical intangible asset that supports effective marketing strategy implementation. This research employs a quantitative explanatory approach using a survey method. Data were collected through structured questionnaires distributed to employees and managers involved in marketing and strategic functions within business organizations. The data were analyzed using descriptive statistics and regression analysis to test the proposed relationship between human capital quality and marketing performance. The results indicate that human capital quality has a positive and statistically significant effect on marketing performance, demonstrating that organizations with higher-quality human resources tend to achieve better marketing outcomes, including sales growth, customer acquisition, and market competitiveness. These findings confirm that marketing performance is not only shaped by external market conditions but is also strongly influenced by internal strategic resources. The study concludes that human capital quality plays a crucial role in enhancing marketing performance and should be integrated into organizational strategic and marketing planning. The results provide valuable insights for managers in aligning human resource development with marketing objectives to achieve sustainable competitive advantage.

Customer Trust as a Mediator of Digital Marketing Effects on Consumer Behavior: A Systematic Review Sari, Fitrah; Rahman, Ahmad Vajri; Mirsal
Journal of Management and Social Sciences Vol. 5 No. 2 (2026): May: Journal of Management and Social Sciences
Publisher : Sekolah Tinggi Ilmu Administrasi (STIA) Yappi Makassar

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55606/jimas.v5i2.2534

This study aims to examine the role of customer trust as a mediating variable in the relationship between digital marketing strategies and consumer behavior. As digital marketing evolves, companies are required not only to create engaging content but also to build strong trust to influence purchase intention, loyalty, and customer engagement. This research employs a systematic literature review (SLR) following PRISMA guidelines, selecting 52 empirical articles from reputable international databases such as Scopus, Web of Science, EBSCOhost, and ScienceDirect, published between 2015 and 2026. The analysis involved thematic and descriptive synthesis to assess the strength of digital marketing’s impact on customer trust and consumer behavior outcomes. The results indicate that digital marketing has a significant positive effect on customer trust formation (β=0.652; p<0.001). Customer trust functions as a partial mediator that strengthens the impact of digital marketing on purchase intention, loyalty, and engagement. The direct effect of digital marketing on consumer behavior is weaker when trust is not optimally established. These findings emphasize that effective digital marketing strategies must focus on transparency, security, credibility, and personalization to maximize consumer behavior outcomes. Practically, this study provides important implications for companies and digital marketing practitioners, highlighting that successful campaigns rely not only on content and visibility but also on the ability to build customer trust. The study also opens avenues for future research to examine more specific trust dimensions, including platform integrity, information quality, and social proof, within increasingly complex digital marketing contexts.

Transformasi Digital UMKM di Sumatera Barat : Anteseden Kemampuan Digital untuk Meningkatkan Daya Saing Sari, Fitrah; Gustina, Leni
Jurnal Pustaka Aktiva (Pusat Akses Kajian Akuntansi, Manajemen, Investasi, dan Valuta) Vol 6 No 1 (2026): Jurnal Pustaka Aktiva (Pusat Akses Kajian Akuntansi, Manajemen, Investasi, dan Va
Publisher : Pustaka Galeri Mandiri

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55382/jurnalpustakaaktiva.v6i1.1876

Studi ini meneliti transformasi digital Usaha Mikro, Kecil, dan Menengah (UMKM) di Sumatera Barat dengan menganalisis faktor-faktor pendahulu kemampuan digital yang meningkatkan daya saing. Meskipun peran strategis UMKM dalam pengembangan ekonomi regional, tingkat adopsi digital mereka tetap relatif rendah, membatasi kemampuan mereka untuk bersaing di pasar yang semakin dinamis dan didorong oleh teknologi. Penelitian ini bertujuan untuk menyelidiki bagaimana tantangan kewirausahaan, berbagi teknologi, dan daya saing karakter mempengaruhi pengembangan ketangkasan digital sebagai manifestasi utama dari kapabilitas digital. Pendekatan penelitian kuantitatif digunakan dengan metode survei yang melibatkan 383 UMKM di Sumatera Barat, yang dipilih melalui pengambilan sampel acak proporsional dari populasi 94.392 UMKM. Data dikumpulkan melalui kuesioner terstruktur dan dianalisis menggunakan Pemodelan Persamaan Struktural dengan pendekatan Partial Least Squares (SEM-PLS). Hasilnya mengungkapkan bahwa tantangan kewirausahaan secara signifikan mempengaruhi berbagi teknologi dan daya saing sifat, yang pada gilirannya berpengaruh positif terhadap kelincahan digital, yang tercermin dalam kemampuan untuk beradaptasi dan kemauan untuk mengambil risiko. Selain itu, berbagi teknologi dan daya saing karakter ditemukan dapat memediasi hubungan antara tantangan kewirausahaan dan ketangkasan digital. Temuan ini menunjukkan bahwa ketangkasan digital di antara UMKM tidak hanya didorong oleh adopsi teknologi tetapi muncul dari interaksi mekanisme kolaborasi organisasi dan sifat perilaku individu. Studi ini berkontribusi pada literatur transformasi digital dengan mengintegrasikan perspektif struktural dan perilaku dalam kerangka kerja yang terpadu serta memberikan implikasi praktis bagi pembuat kebijakan dan lembaga pendukung bisnis untuk mendorong ekosistem digital kolaboratif dan memperkuat pola pikir kompetitif di kalangan UMKM. Pada akhirnya, meningkatkan kemampuan digital sangat penting untuk meningkatkan daya saing UMKM dan keberlanjutan jangka panjang dalam ekonomi digital.

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