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All Journal JMM (Jurnal Masyarakat Mandiri) The Indonesian Journal of Infectious Diseases Poltekita : Jurnal Ilmu Kesehatan Jurnal Ners Budapest International Research and Critics Institute-Journal (BIRCI-Journal): Humanities and Social Sciences Budapest International Research in Exact Sciences (BirEx Journal) Pharmacy Reports Fidelity : Jurnal Teknik Elektro Formosa Journal of Science and Technology (FJST) Jurnal Pengabdian Masyarakat Bidang Sains dan Teknologi Pharmaceutical Sciences and Research (PSR) International Journal of Applied Mathematics, Sciences, and Technology for National Defense
Syahrul Tuba
Universitas Pertahanan RI
Religion Aerospace Engineering Agriculture, Biological Sciences & Forestry Arts Humanities Automotive Engineering Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Civil Engineering, Building, Construction & Architecture Computer Science & IT Control & Systems Engineering Decision Sciences, Operations Research & Management Dentistry Economics, Econometrics & Finance Education Electrical & Electronics Engineering Engineering Health Professions Immunology & microbiology Industrial & Manufacturing Engineering Mathematics Mechanical Engineering Medicine & Pharmacology Nursing Physics Public Health Social Sciences Transportation Veterinary Other

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Hubungan Pengetahuan, Sikap, dan Pengalaman Keluarga Sakit Demam Berdarah Dengue dengan Pencegahannya Syahrul Tuba; Ria Mariani; Ana Faizah; Agung Sutriyawan; Afif Ramadhan
The Indonesian Journal of Infectious Diseases Vol. 9 No. 2 (2023): The Indonesian Journal of Infectious Disease
Publisher : Rumah Sakit Penyakit Infeksi Prof Dr. Sulianti Saroso

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32667/ijid.v9i2.168

Abstract

Latar Belakang: Jumlah kasus demam berdarah dengue di kota Bandung masih tinggi yaitu 2.790 kasus. Upaya untuk mengatasi jumlah kasus dan kematian yang terus meningkat, salah satu program pencegahan adalah memutus rantai penularan dengan pemberantasan sarang nyamuk. Tujuan: Penelitian ini untuk menganalisis hubungan pengalaman sakit demam berdarah dengue, pengetahuan dan sikap dengan praktik pemberantasan sarang nyamuk. Metode: Penelitian ini menggunakan desain cross sectional. Populasi dalam penelitian ini adalah seluruh keluarga di wilayah kerja Puskesmas Ujung Berung Indah. Sampel diambil secara simple random sampling sebanyak 116 ibu rumah tangga. Subjek penelitian ini adalah ibu rumah tangga. Instrumen yang digunakan dalam penelitian ini adalah kuesioner. Uji statistik yang digunakan adalah chi square. Hasil: Hasil penelitian didapatkan sebagian besar responden ada pengalaman sakit demam berdarah dengue (61,2%) dan memiliki sikap kurang mendukung terhadap pencegahan demam berdarah (73,3%). Lebih dari setengah responden melakukan praktik pemberantasan sarang nyamuk kurang baik (56%) dan berpengetahuan rendah (54,3%). Variabel yang berhubungan dengan praktik pemberantasan sarang nyamuk adalah pengalaman sakit demam berdarah dengue (p=0,003, POR=3,4), pengetahuan (p=0,007, POR=3,0), dan sikap (p=0,013, POR=3,1). Kesimpulan: Pencegahan demam berdarah dengue dapat dilakukan dengan meningkatkan pengetahuan dan sikap ibu rumah tangga, serta pengalaman sakit dapat mengubah perilaku ibu rumah tangga untuk melakukan pemberantasan sarang nyamuk.
Potential of pharmacological and herbal for COVID-19: a narrative review Tuba, Syahrul; Rahmania, Tesia Aisyah
Pharmacy Reports Vol. 1 No. 1 (2021): Pharmacy Reports
Publisher : Indonesian Young Scientist Group and UPN Veteran Jakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (137.051 KB) | DOI: 10.51511/pr.2

Abstract

The pandemic coronavirus disease 2019 (COVID-19) caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) presents an unprecedented challenge to identify effective drugs in the prevention and treatment process. At present, there is no proven therapy for this disease, although therapeutic approaches continue to be carried out using traditional medicines (herbal) and pharmacological therapy. Information about SARS-CoV-2 virology has rapidly developed and scientists try to provide a number of potential drugs. Remdesivir has strong in vitro activity against SARS-CoV-2. Several potential drugs are currently underway in a clinical trial. Chloroquine, hydroxychloroquine, and oseltamivir have not been proven to have efficacy, and the benefits of corticosteroids are still diverse. Current clinical evidence does not support the termination of angiotensin-converting enzyme 2 (ACE2) inhibitors or angiotensin receptor blockers, coagulation therapy in patients with COVID-19 concomitant with comorbidities.
Optimization of External Disintegrating Materials in Wet Granulation Formulation of Ondansetron Tablets Permana, Yandi; Tuba, Syahrul; Riyadi, Taufik; Sugindro, Sugindro
Pharmaceutical Sciences and Research
Publisher : UI Scholars Hub

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Abstract

Inadequate management of chemotherapy-induced side effects, including nausea and vomiting, can impact the healing response of cancer patients. Ondansetron, a preferred medication for the treatment, is classified as a biopharmaceutic classification system (BCS) class II drug, which limits its bioavailability. To enhance its solubility, sodium starch glycolate (SSG) and pregelatinized starch (PG) are used as super disintegrants. This study investigates the impact of these super disintegrants on ondansetron dissolution and identifies the optimal formulation. Ondansetron tablets were prepared using the wet granulation method, with nine formulations varying in SSG and PG concentrations (0%, 1%, 3%, 5%, and 7%). The tablets underwent physical and chemical quality evaluations. The results indicate that ondansetron dissolution improved with SSG and PG at concentrations of 1% and 3% but decreased at higher concentrations (5% and 7%). Statistical analysis revealed significant differences in dissolution fraction parameters and efficiency across varying SSG and PG concentrations (p < 0.05). The optimal formulation for enhancing ondansetron dissolution was found to be with 3% PG, achieving a dissolution efficiency value of 79.88% + 0.11%.
Single nucleotide polymorphism analysis of the peroxisome proliferator-activated receptor gamma gene in type 2 diabetes mellitus patients at Ministry of Defense Hospital, RSPPN Soedirman Jakarta Sakdiyyah, Luluk; Hadi, Apip; Maladan, Yustinus; Tuba, Syahrul
International Journal of Applied Mathematics, Sciences, and Technology for National Defense Vol 3, No 2 (2025): International Journal of Applied Mathematics, Sciences, and Technology for Natio
Publisher : FoundAE

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.58524/app.sci.def.v3i2.830

Abstract

Type 2 diabetes mellitus is a metabolic disorder influenced by genetic and environmental factors. The Peroxisome Proliferator-Activated Receptor Gamma gene is known to play a role in T2DM pathogenesis, but its polymorphism profile in Indonesian patients remains poorly characterized. This study aimed to analyze single nucleotide polymorphisms in the PPAR-γ gene of T2DM patients at Rumah Sakit Pusat Pertahanan Negara (RSPPN) Soedirman Jakarta using adaptive sampling with nanopore sequencing. Eighteen DNA samples that passed quality control were analyzed using UGENE v52.1. A total of 26 SNPs were identified in 8 subjects, including C161T, which has a reported protective effect in T2DM. The clinical significance of the remaining SNPs remains unclear. This study provides initial insights into genetic variation in T2DM, which may contribute to personalized medical strategies for military personnel and support the development of a more resilient national defense health system by improving disease prevention and management in high-risk populations.
Co-Authors Achmad Nizar Hidayanto Afif Ramadhan Ana Faizah Ati Surya Mediati Bantari Wisnu Kusuma Wardhani Deni Setiawati Eva Fitri Yuanita Gilang Bhakti Nusantara Hadi, Apip Ilham Arief Jane Thomason Kholis Ernawati Maladan, Yustinus Mirza Salsabila Sri Kusumawati Muhamad Bakhar Muhammad Rifly Aprianto Permana, Yandi Putri Diana Nurul Adha Rahmania, Tesia Aisyah Reynatha CA Pangsibidang Reynatha Chrestella Amandara Pangsibidan Reynatha Chrestella Amandara Pangsibidang Ria Mariani Riyadi, Taufik Rr. Tutik Sri Hariyati Sakdiyyah, Luluk Setyowati Setyowati Sudasman, Fuad Hilmi Sugindro, Sugindro Sutriyawan, Agung Timbul Partogi Haposan Simorangkir Timbul Partogi Haposan Simorangkir Widyati Widyati Yahdiana Harahap Yahdiana Harahap