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All Journal Universa Medicina Jurnal Respirologi Indonesia Jurnal Respirasi (JR) Indonesian Journal of Global Health research Respiratory Science Narra J Indonesian Journal of Cancer Journal of International Surgery and Clinical Medicine
Yunita Arliny
Faculty of Medicine, University of Indonesia, Persahabatan Hospital, Jakarta
Biochemistry, Genetics & Molecular Biology Education Health Professions Immunology & microbiology Languange, Linguistic, Communication & Media Medicine & Pharmacology Nursing Public Health

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Analysis of Clinical Manifestation at Admission and Comorbidity on Clinical Outcome of COVID-19 Patients in RSUDZA Banda Aceh Isma, Heliyana; Arliny, Yunita; Yanifitri, Dewi Behtri; Budiyanti, Budiyanti; Zulfikar, Teuku
Jurnal Respirologi Indonesia Vol 42 No 4 (2022)
Publisher : Perhimpunan Dokter Paru Indonesia (PDPI)/The Indonesian Society of Respirology (ISR)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36497/jri.v42i4.288

Abstract

Background: Coronavirus disease (COVID-19) is an infectious disease caused by the SARS-CoV- 2 virus and has become a pandemic until now. Clinical outcomes in patients vary depending on many factors, such as demographics, vital signs, laboratory results, and comorbidities.Methods: This study aims to analyze clinical outcomes in COVID-19 patients associated with the patient's general information (age, sex), demographic factors, admission vital signs, degree of symptoms at admission, blood laboratory results at admission, and comorbidities. This study is an analytic observational study with a cross-sectional design. All variables were examined based on medical records at the time of admission to the hospital. A multivariate analysis was conducted to determine what factors most influence clinical outcomes in treated COVID-19 patients.Results: There were 183 COVID-19 patients included in this study with moderate to critical degrees. Factors that influence the clinical outcome of COVID-19 patients are the presence of comorbidities, old age, high blood pressure and heart rate, anemia, leukocytosis, and increased blood sugar and creatinine at admission. Multivariate analysis showed that clinical symptoms of severe COVID-19 were a factor that influenced poor clinical outcomes in COVID-19 patients, with OR=5.6 (95% CI=2.223-13.90).Conclusion: Age, comorbidity, blood pressure, heart rate, hemoglobin, random blood glucose, and creatinine at admission influence the clinical outcome of admitted COVID-19 patients.
Anti-TB Drug Side-Effects on the Treatment of Drug-Resistant Tuberculosis (DR-TB) in dr. Zainoel Abidin Hospital Banda Aceh Arliny, Yunita; Muarif, Muhammad Fadjar; Mahdani, Wilda; Yanifitri, Dewi Behtri
Jurnal Respirologi Indonesia Vol 45 No 1 (2025)
Publisher : Perhimpunan Dokter Paru Indonesia (PDPI)/The Indonesian Society of Respirology (ISR)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36497/jri.45i1.507

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Background: Drug-resistant tuberculosis (DR-TB) is treated with second-line anti-tuberculosis (anti-TB) drugs which are comparatively less effective and more toxic. The increased toxicity of the drugs may lead to the occurrence of side effects throughout the treatment. The study aims to assess DR-TB patients' side effects and clinical profile at the dr. Zainoel Abidin Hospital, Banda Aceh. Methods: Observational descriptive study of DR-TB patients who underwent treatment from 2020 to 2022 at dr. Zainoel Abidin Hospital, Banda Aceh. The data was taken from medical records of patients which are then analysed using univariate analysis. Results: Out of 49 patients, most of them were male with 23 people (65,3%), belonging to the age group of 46-55 with 11 people (22,4%), worked as entrepreneurs with 11 people (22,4%), and most came from Banda Aceh and Aceh Besar with 14 people each (28,6%). Twenty-seven patients (65,1%) were suspected of secondary infection, most of which were cases of relapse from 10 people (20,4%). 39 of the patients (79,6%) had rifampicin-resistant tuberculosis. 36 patients (73,4%) were given individualized treatment with Lfx – Bdq – Lzd – Cfz – Cs being the most common drug combination given to 16 people (32.7%). All patients experienced side effects from the treatment, with the most common being nausea from 28 people (57,1%) followed by peripheral neuropathy from 19 people (38,8%). Conclusion: Side effects are commonly found in the treatment of DR-TB and may become more prevalent as the treatment continues. Educating the patient and treating side effects is important to maintain patient compliance.
Analysis of Monocyte to Lymphocyte Ratio and Clinical Symptoms of Clinically Confirmed Pulmonary Tuberculosis New Case Patients Before Treatment and After Intensive Phase Handoko, Basti; Arliny, Yunita; Priyanto, Herry; Andayani, Novita; Yanifitri, Dewi Behtri
Jurnal Respirologi Indonesia Vol 45 No 1 (2025)
Publisher : Perhimpunan Dokter Paru Indonesia (PDPI)/The Indonesian Society of Respirology (ISR)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36497/jri.v45i1.533

Abstract

Background: Treatment evaluation of clinically confirmed pulmonary tuberculosis (TB) is limited to clinical symptoms and chest X-rays that tend to be subjective and no better than bacteriological examination. Monocytes and lymphocytes mediate the immunopathology of TB infection as a form of host defense that affects the systemic concentration of the body’s defense cells. The study assesses the monocyte-to-lymphocyte ratio (MLR) to evaluate TB treatment. Methods: Longitudinal prospective paired t-test with characteristics of clinically confirmed pulmonary TB new cases then compared to monocytes, lymphocytes, and monocyte-lymphocyte ratio (MLR) before administration of anti-tuberculosis drugs (ATD) and the end of the intensive phase. Results: In thirty clinically confirmed pulmonary TB patients before and after the anti-tuberculosis drug (ATD) there was no difference in monocytes pre 8.3 - post 8.5 (P=0.82), there was a difference in lymphocytes pre 17.8 - post 25.6 (P<0.05) that affected the MLR ratio value pre 0.57 - post 0.39 (P<0.05). Conclusion: This study identifies there is a significant difference in MLR before treatment and after the intensive phase of clinically confirmed pulmonary TB.
Analysis of Latent Tuberculosis Risk Factors Detected by Tuberculin Skin Tests in Chronic Kidney Disease Patients Undergoing Routine Hemodialysis Mardiansyah, Muhammad Andi; Arliny, Yunita; Yusuf, Nurrahmah; Abdullah, Abdullah
Jurnal Respirologi Indonesia Vol 45 No 1 (2025)
Publisher : Perhimpunan Dokter Paru Indonesia (PDPI)/The Indonesian Society of Respirology (ISR)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36497/jri.v45i1.633

Abstract

Background: Due to changes in the immune system, chronic kidney disease (CKD) patients on routine hemodialysis (HD) are at increased risk for latent tuberculosis (LTB). Latent tuberculosis requires special attention to prevent its development into active form because infection increases mortality in CKD patients. This study aims to determine the prevalence and risk factors associated with LTB in CKD in routine HD patients. Method: This research uses a cross-sectional design and is an analytical observational study. The study was conducted in the Hemodialysis Unit at dr. Zainoel Abidin Hospital between June and August 2023, using consecutive non-probability sampling. Results: Of the 289 CKD patients undergoing routine hemodialysis, 54 met the inclusion criteria. The prevalence of latent tuberculosis among these patients was 27.8%, as determined by the Tuberculin Skin Test (TST). Statistical analysis revealed no significant association between LTB and risk factors such as age, gender, body mass index, smoking status, or CKD etiology (P>0.05). Due to value of P>0.25, multivariate analysis could not be performed. Conclusion: There is a high prevalence of latent tuberculosis among chronic kidney disease patients undergoing dialysis. The risk factors for LTB remain unclear. However, early diagnosis and treatment are recommended to prevent progression to active TB.
Co-Authors Abdullah Abdullah Budiyanti Budiyanti Habibie, Yopie Afriandi Handoko, Basti Hayati, Rahmi Irmaini, Irmaini Isma, Heliyana Karunia, Yuris Hikman Kurniawan, Ferry Dwi Mahdani, Wilda Mardhatillah Mardiansyah, Muhammad Andi Maulina, Novi Muarif, Muhammad Fadjar Muhammad Fachri Mursalin, Diennisa Novita Andayani, Novita Priyanto, Herry Purqan, Muhammad Rahman, Muhammad Sakdiah Teuku Zulfikar Utami, Wilia Aprilisa Wira Winardi, Wira Yanifitri , Dewi Behtri Yanifitri, Dewi B. Yanifitri, Dewi Behtri Yanti, Budi Yusuf, Nurrahmah