Article Per Year (5 Year)
p-Index From 2021 - 2026
2.357
P-Index
This Author published in this journals
All Journal Universa Medicina Jurnal Respirologi Indonesia Jurnal Respirasi (JR) Heart Science Journal Respiratory Science Narra J Indonesian Journal of Cancer Journal of International Surgery and Clinical Medicine
Yunita Arliny
Faculty of Medicine, University of Indonesia, Persahabatan Hospital, Jakarta
Biochemistry, Genetics & Molecular Biology Health Professions Immunology & microbiology Medicine & Pharmacology Public Health

Published : 14 Documents Claim Missing Document
Claim Missing Document
Check
Articles

Found 14 Documents
Search

 1   2 
Anti-TB Drug Side-Effects on the Treatment of Drug-Resistant Tuberculosis (DR-TB) in dr. Zainoel Abidin Hospital Banda Aceh Arliny, Yunita; Muarif, Muhammad Fadjar; Mahdani, Wilda; Yanifitri, Dewi Behtri
Jurnal Respirologi Indonesia Vol 45 No 1 (2025)
Publisher : Perhimpunan Dokter Paru Indonesia (PDPI)/The Indonesian Society of Respirology (ISR)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36497/jri.45i1.507

Abstract

Background: Drug-resistant tuberculosis (DR-TB) is treated with second-line anti-tuberculosis (anti-TB) drugs which are comparatively less effective and more toxic. The increased toxicity of the drugs may lead to the occurrence of side effects throughout the treatment. The study aims to assess DR-TB patients' side effects and clinical profile at the dr. Zainoel Abidin Hospital, Banda Aceh. Methods: Observational descriptive study of DR-TB patients who underwent treatment from 2020 to 2022 at dr. Zainoel Abidin Hospital, Banda Aceh. The data was taken from medical records of patients which are then analysed using univariate analysis. Results: Out of 49 patients, most of them were male with 23 people (65,3%), belonging to the age group of 46-55 with 11 people (22,4%), worked as entrepreneurs with 11 people (22,4%), and most came from Banda Aceh and Aceh Besar with 14 people each (28,6%). Twenty-seven patients (65,1%) were suspected of secondary infection, most of which were cases of relapse from 10 people (20,4%). 39 of the patients (79,6%) had rifampicin-resistant tuberculosis. 36 patients (73,4%) were given individualized treatment with Lfx – Bdq – Lzd – Cfz – Cs being the most common drug combination given to 16 people (32.7%). All patients experienced side effects from the treatment, with the most common being nausea from 28 people (57,1%) followed by peripheral neuropathy from 19 people (38,8%). Conclusion: Side effects are commonly found in the treatment of DR-TB and may become more prevalent as the treatment continues. Educating the patient and treating side effects is important to maintain patient compliance.
Analysis of Monocyte to Lymphocyte Ratio and Clinical Symptoms of Clinically Confirmed Pulmonary Tuberculosis New Case Patients Before Treatment and After Intensive Phase Handoko, Basti; Arliny, Yunita; Priyanto, Herry; Andayani, Novita; Yanifitri, Dewi Behtri
Jurnal Respirologi Indonesia Vol 45 No 1 (2025)
Publisher : Perhimpunan Dokter Paru Indonesia (PDPI)/The Indonesian Society of Respirology (ISR)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36497/jri.v45i1.533

Abstract

Background: Treatment evaluation of clinically confirmed pulmonary tuberculosis (TB) is limited to clinical symptoms and chest X-rays that tend to be subjective and no better than bacteriological examination. Monocytes and lymphocytes mediate the immunopathology of TB infection as a form of host defense that affects the systemic concentration of the body’s defense cells. The study assesses the monocyte-to-lymphocyte ratio (MLR) to evaluate TB treatment. Methods: Longitudinal prospective paired t-test with characteristics of clinically confirmed pulmonary TB new cases then compared to monocytes, lymphocytes, and monocyte-lymphocyte ratio (MLR) before administration of anti-tuberculosis drugs (ATD) and the end of the intensive phase. Results: In thirty clinically confirmed pulmonary TB patients before and after the anti-tuberculosis drug (ATD) there was no difference in monocytes pre 8.3 - post 8.5 (P=0.82), there was a difference in lymphocytes pre 17.8 - post 25.6 (P<0.05) that affected the MLR ratio value pre 0.57 - post 0.39 (P<0.05). Conclusion: This study identifies there is a significant difference in MLR before treatment and after the intensive phase of clinically confirmed pulmonary TB.
Analysis of Latent Tuberculosis Risk Factors Detected by Tuberculin Skin Tests in Chronic Kidney Disease Patients Undergoing Routine Hemodialysis Mardiansyah, Muhammad Andi; Arliny, Yunita; Yusuf, Nurrahmah; Abdullah, Abdullah
Jurnal Respirologi Indonesia Vol 45 No 1 (2025)
Publisher : Perhimpunan Dokter Paru Indonesia (PDPI)/The Indonesian Society of Respirology (ISR)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36497/jri.v45i1.633

Abstract

Background: Due to changes in the immune system, chronic kidney disease (CKD) patients on routine hemodialysis (HD) are at increased risk for latent tuberculosis (LTB). Latent tuberculosis requires special attention to prevent its development into active form because infection increases mortality in CKD patients. This study aims to determine the prevalence and risk factors associated with LTB in CKD in routine HD patients. Method: This research uses a cross-sectional design and is an analytical observational study. The study was conducted in the Hemodialysis Unit at dr. Zainoel Abidin Hospital between June and August 2023, using consecutive non-probability sampling. Results: Of the 289 CKD patients undergoing routine hemodialysis, 54 met the inclusion criteria. The prevalence of latent tuberculosis among these patients was 27.8%, as determined by the Tuberculin Skin Test (TST). Statistical analysis revealed no significant association between LTB and risk factors such as age, gender, body mass index, smoking status, or CKD etiology (P>0.05). Due to value of P>0.25, multivariate analysis could not be performed. Conclusion: There is a high prevalence of latent tuberculosis among chronic kidney disease patients undergoing dialysis. The risk factors for LTB remain unclear. However, early diagnosis and treatment are recommended to prevent progression to active TB.
The role of N-terminal pro-brain natriuretic peptide as an early alert of pulmonary hypertension in chronic lung disease Hulaimi; Yanti, Budi; Ridwan, Muhammad; Arliny, Yunita; Nurrahmah
Heart Science Journal Vol. 7 No. 2 (2026): The Evolving Landscape of Heart Failure
Publisher : Universitas Brawijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21776/ub.hsj.2026.007.02.12

Abstract

BACKGROUND: One of the primary causes of illness and dying in worldwide was chronic lung disease (CLD). Pulmonary hypertension (PH) was among the most popular issues linked to CLD, often remaining undiagnosed in the early stages. N-terminal pro-brain natriuretic peptide (NT-proBNP) and electrocardiographic abnormalities could be early alert of pulmonary hypertension. OBJECTIVES: This study aims to ascertain the role of NT-proBNP as early markers of pulmonary hypertension in CLD. METHOD: This study used a cross-sectional design in 2024, and there where 35 patients with CLD were analyzed. A group of normal individuals without cardiac and pulmonary abnormalities was used as a control group. Data on patient characteristics, symptoms, typical electrocardiography (ECG) results of pulmonary hypertension, as well as serum NT-proBNP levels was measured at baseline before any intervention. RESULTS: Most patients were male (85.7%) and aged ≥60 years (51.4%), and Chronic Obstructive Pulmonary Disease (COPD) is the most popular CLD (65.7%). Prolonged QT (20%) was the most prevalent ECG abnormality, followed by right axis deviation (14.7%) and Right Bundle Branch Block (11.42%). The COPD group had the most elevated NT-proBNP levels (mean 90.22 pg/mL), then the Pulmonary Tuberculosis Lung Disease group at 74.34 pg/mL, and in normal individuals (57.89 pg/mL). The NTproBNP levels differed significantly amongst the groups (p = 0.0215). CONCLUSION: COPD, which is the most CLD, showed the highest prevalence of early pulmonary hypertension, characterized by increased NT-proBNP and QT prolongation. In CLD, NT-proBNP could be utilized as an indicator of the initial identification of pulmonary hypertension. 
Co-Authors Abdullah Abdullah Budiyanti Budiyanti Habibie, Yopie Afriandi Handoko, Basti Hayati, Rahmi HULAIMI Isma, Heliyana Kurniawan, Ferry Dwi Mahdani, Wilda Mardhatillah Mardiansyah, Muhammad Andi Maulina, Novi Muarif, Muhammad Fadjar Muhammad Fachri Muhammad Ridwan Mursalin, Diennisa Novita Andayani, Novita Priyanto, Herry Purqan, Muhammad Rahman, Muhammad Sakdiah Teuku Zulfikar Utami, Wilia Aprilisa Wira Winardi, Wira Yanifitri , Dewi Behtri Yanifitri, Dewi B. Yanifitri, Dewi Behtri Yanti, Budi Yusuf, Nurrahmah