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All Journal Jurnal Medik Veteriner Journal Of Widya Medika Junior Journal of the Indonesian Medical Association : Majalah Kedokteran Indonesia
Hendrata, Adi Pramono
Department Of Clinical Pathology, Medicine, Widya Mandala Surabaya Catholic University
Biochemistry, Genetics & Molecular Biology Education Health Professions Medicine & Pharmacology Public Health Veterinary

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PROFIL ISOLAT CORYNEBACTERIUM DIPHTHERIAE TOKSIGENIK DI JAWA TIMUR TAHUN 2012-2017 Soegianto, Sugi Deny Pranoto; Hendrata, Adi Pramono; Irawan, Eveline; Ismoedijanto; Husada, Dominicus
Majalah Kedokteran Indonesia Vol 69 No 2 (2019): Journal of the Indonesian Medical Association Majalah Kedokteran Indonesia Volum
Publisher : PENGURUS BESAR IKATAN DOKTER INDONESIA (PB IDI)

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Abstract

Pendahuluan: Penyakit difteri telah ditetapkan menjadi kejadian luar biasa di berbagai wilayah di Indonesia, sebagian besar kasus berasal dari Jawa Timur. Tujuan: Mengetahui profil isolat Corynebacterium diphtheriae toksigenik di Jawa Timur. Metode. Penelitian deskriptif, dilakukan 20 Agustus sampai 30 November 2018. Isolat yang diteliti dipilih secara cluster random sampling kemudian dilakukan uji viabilitas dan toksigenisitas di BBLK Surabaya. Isolat yang viabel dan toksigenik dilakukan analisis karakteristik. Hasil: Penelitian ini melibatkan 114 isolat, 6 tidak viabel, 108 viabel dan toksigenik. Jenis kelamin pejamu ialah 58,3% laki-laki, 41,7% perempuan. Usia median 6,5 tahun (termuda 1 tahun, tertua 14 tahun). Mayoritas pada kelompok usia 1-5 tahun (50%) disusul 6-10 tahun (30,6%) dan 11-15 tahun (19,4%). Wilayah asal isolat didominasi dari Madura (47,2%) dan Jawa Timur tapal kuda (32,4%), sedangkan Jawa Timur bukan tapal kuda hanya 20,4%. Lokasi pengambilan sampel 74,1% dari usap tenggorok dan 25,4% dari usap hidung. Varian mitis mendominasi sejumlah 76,9%, sedangkan varian gravis hanya 23,1%. Kesimpulan: Isolat Corynebacterium diphtheriae toksigenik terbanyak didapatkan pada pejamu kelompok usia 1-5 tahun, mayoritas berdomisili di Madura dan Jawa Timur tapal kuda. Isolat terutama didapat dari usap tenggorok pasien. Varian mitis mendominasi dalam penelitian ini.
THE EFFECT OF DRY RED JUJUBE FRUIT EXTRACT ON RATE ALKALINE PHOSPHATASE INDUCED WISTAR RATS ACETAMINOPHEN Maria Aloysia Praldinya Ere; Adi Pramono Hendrata; Laura Wihanto
JOURNAL OF WIDYA MEDIKA JUNIOR Vol 5, No 3 (2023): July
Publisher : FAKULTAS KEDOKTERAN UNIVERSITAS KATOLIK WIDYA MANDALA SURABAYA

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33508/jwmj.v5i3.4828

Abstract

Background: Many things can cause hepatotoxicity, including the use of chemicals such as acetaminophen consumed in toxic doses. Acetaminophen destroyed can damage liver tissue, block the biliary tract and end the release of ALP into the blood. Jujube fruit has antioxidants like flavonoids and phenolic, which can ward off free radicals due to excessive consumption of acetaminophen. Purpose: Knowing how giving dried red jujube fruit extract affects ALP levels of induced Wistar rats acetaminophen. Method: The method used is Posttest-Only Control Group Design. The technique used in examining ALP levels is using a colorimetric test essay which refers to the International Federation of Clinical Chemistry and Laboratory Medicine. The experimental animals used were Wistar rats which were given dried red jujube fruit extract doses of 70, 140, and 280 mg/kg BW for ten days. On the 9th day, the rats have induced with an acetaminophen dose of 3 g/kg BW, and on the 11th day, termination was carried out to examine ALP levels in the blood. Results: In this study, the normality test was generally distributed with a value of K(-) = 0.086, K(+) = 0.600, Kp1 = 0.156, Kp2 = 0.074, and Kp3 = 0.446. In the homogeneity test, the value of p = 0.0254 was obtained. On testone-way ANOVA, significant results were obtained with a p = 0.00. In the correlation test, a matter of 0.00 was obtained, which means a relationship exists between dried red jujube fruit extract and ALP levels. Conclusion: Giving dried red jujube fruit extract has an effect on ALP levels in induced rats' acetaminophen toxic dose.
THE RELATIONSHIP OF SMOKING HABITS WITH HBA1C LEVELS IN TYPE TWO DM PATIENTS AT GOTONG ROYONG HOSPITAL Valencia Dewangker, Audrey Jesie; Muliono, Ari Christy; Hendrata, Adi Pramono
JOURNAL OF WIDYA MEDIKA JUNIOR Vol 6, No 2 (2024): April
Publisher : FAKULTAS KEDOKTERAN UNIVERSITAS KATOLIK WIDYA MANDALA SURABAYA

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33508/jwmj.v6i2.5489

Abstract

Background: Diabetes Mellitus (DM) is a disease whose prevalence continues to increase every year. In 2019, Indonesia was ranked number 7 with the highest number of DM sufferers, namely 10.7 million. Diabetes mellitus is a chronic metabolic disease characterized by increased blood glucose levels, this occurs because there is not enough insulin produced by the pancreas or a condition where the body cannot use the insulin produced effectively. One examination that can be used to assess a patient's glycemic control is the Glycated Hemoglobin (HbA1c) examination. Smoking habit is known to be a risk factor for diabetes mellitus. Even though there are many disadvantages, the number of smokers in Indonesia is still difficult to reduce due to the lack of education and control regulations that suppress smoking behavior in society. This causes smoking to become a risk factor for many uncontrolled diseases in the world of health.Objective: The aim of this study was to analyze the relationship between smoking habits and HbA1c levels in male patients with type two DM at the Gotong Royong Hospital.Research method: This research uses observational analytical research with a case control study approach. In the research sample, namely type two Diabetes Mellitus patients who had their HbA1c levels checked at the Gotong Royong Hospital, a questionnaire was completed regarding the patient's smoking habits. From the results of the questionnaire, patients will be classified into non-smokers, light smokers, moderate smokers, and heavy smokers.Result: There is no significant relationship between smoking habits and HbA1c levels in type two diabetes mellitus patients at Gotong Royong Hospital with a P-value = 0.681.
Optimized RT-qPCR Detection of Hepatic Lipopolysaccharide-Binding Protein in Diet-Induced Obese Mice Tjahjono, Yudy; Wedharga, I Gede Putu Adhi; Novita, Bernadette Dian; Tahalele, Paul; Wijaya, Hendy; Soediono, Endang Isbandiati; Hendrata, Adi Pramono; Dewi, Sianty; Wijaya, Sumi; Ervina, Martha; Kuncorojakti, Suryo
Jurnal Medik Veteriner Vol. 8 No. 2 (2025): October
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/jmv.vol8.iss2.2025.308-317

Abstract

High-throughput RT-qPCR results on hepatic lipopolysaccharide-binding protein (LBP) expression in obese subjects are essential, as they reveal the endotoxin’s role in the development of obesity and non-communicable disease (NCD). This study aimed to optimize RT-qPCR detection of LBP in diet-induced obese mice. This study primarily focused on addressing high variability through reference gene normalization. A total of six male C57BL/6 mice aged 6 weeks were randomly allocated into two dietary treatments (n = 3), consisting of mice fed with the standard chow diet (SCD group) and mice fed with the high-fat and high sucrose diet (HFHS group) ad libitum for 8 weeks. Relative quantification strategies involving the standard 2-ΔΔCt method (calibrator as mean) and the modified 2-ΔΔCt method (calibrator as individual sample-matched biological replicates) were compared in terms of their variability. Obesity was successfully induced in the HFHS treatment group, as indicated by significantly higher body weight, calorie intake, and LBP relative expressions compared to the SCD group. In addition, a sample-specific calibrator approach using the modified 2-ΔΔCt method resulted in lower variability in relative gene expression levels. A modified 2-ΔΔCt method, which utilizes a sample-specific calibrator to counteract sample-specific variability, was successfully employed to address high variability in RT-qPCR results.
Profil Isolat Corynebacterium diphtheriae Toksigenik di Jawa Timur Tahun 2012-2017 Soegianto, Sugi Deny Pranoto; Hendrata, Adi Pramono; Irawan, Eveline; Ismoedijanto; Husada, Dominicus
Majalah Kedokteran Indonesia Vol 69 No 2 (2019): Journal of The Indonesian Medical Association - Majalah Kedokteran Indonesia, Vo
Publisher : PENGURUS BESAR IKATAN DOKTER INDONESIA (PB IDI)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.47830/jinma-vol.69.2-2019-75

Abstract

Introduction: Diphtheria has been reported as an outbreak in some regions inIndonesia, most of the cases are from East Java.Objective: To describe the profile of toxigenic Corynebacterium diphtheriaeisolates in East Java. Methods. An descriptive study from August 20th -November 30th, 2018. Isolates was selected by cluster random sampling. The viability and toxigenicity testwere done in BBLK Surabaya. Viable and toxigenic isolates were done forcharacteristic analysis. Result: A total of 114 isolates, 6 were non-viable, 108 were viable and toxi-genic. The majority of the hosts were male (58,3%), median age 6,5-year-old(minimum 1, maximum 14-year-old), 50% from the 1-5-year-old age group. Highest origin of isolates from patients (78,7%) rather than carriers (21,3%).The most isolates from Madura (47,2%) and horseshoe area (20,4%). Most ofthem (74.1%) were taken from a pharyngeal swab rather than a nasal swab(25,4%). Mitis was 76,9% and gravis was 23,1%. Conclusion: In this study, the majority of toxigenic Corynebacterium diphtheriae were found in the 1-5-year-old age group and most of them domi-cile in Madura and horseshoe area. Most of the isolates were taken from apharyngeal swab of patients. Mitis was the major variant.
Co-Authors Ari Christy Muliono Dominicus Husada Irawan, Eveline Irawan, Eveline Ismoedijanto Kuncorojakti, Suryo Laura Wihanto Maria Aloysia Praldinya Ere Martha Ervina Novita, Bernadette Dian Paul L Tahalele Sianty Dewi Soediono, Endang Isbandiati Soegianto, Sugi Deny Pranoto Soegianto, Sugi Deny Pranoto Sumi WIjaya, Sumi Tjahjono, Yudy Valencia Dewangker, Audrey Jesie Wedharga, I Gede Putu Adhi Wijaya, Hendy